ENTRY R06635 Reaction DEFINITION Acetyl-CoA + 7 Malonyl-CoA + Acyl-carrier protein <=> 3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] + 7 CO2 + 7 CoA EQUATION C00024 + 7 C00083 + C00229 <=> C12348 + 7 C00011 + 7 C00010 RCLASS RC00004 C00010_C00024 C00010_C00083 RC02729 C00024_C12348 RC02931 C00083_C12348 RC02932 C00083_C12348 ENZYME 2.3.1.- PATHWAY rn01056 Biosynthesis of type II polyketide backbone BRITE Enzymatic reactions [BR:br08201] 2. Transferase reactions 2.3 Acyltransferases 2.3.1 Transferring groups other than aminoacyl groups 2.3.1.- R06635 Acetyl-CoA + 7 Malonyl-CoA + Acyl-carrier protein <=> 3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] + 7 CO2 + 7 CoA ORTHOLOGY K05551 minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] K05552 minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] K05553 minimal PKS acyl carrier protein /// ENTRY R06637 Reaction DEFINITION Butanoyl-CoA + 7 Malonyl-CoA + Acyl-carrier protein <=> 3,5,7,9,11,13,15-Heptaoxo-octadecanoyl-[acp] + 7 CO2 + 7 CoA EQUATION C00136 + 7 C00083 + C00229 <=> C12350 + 7 C00011 + 7 C00010 COMMENT minimal PKS RCLASS RC00004 C00010_C00083 C00010_C00136 RC00039 C00229_C12350 RC02728 C00136_C12350 RC02931 C00083_C12350 RC02932 C00083_C12350 ENZYME 2.3.1.- PATHWAY rn01056 Biosynthesis of type II polyketide backbone BRITE Enzymatic reactions [BR:br08201] 2. Transferase reactions 2.3 Acyltransferases 2.3.1 Transferring groups other than aminoacyl groups 2.3.1.- R06637 Butanoyl-CoA + 7 Malonyl-CoA + Acyl-carrier protein <=> 3,5,7,9,11,13,15-Heptaoxo-octadecanoyl-[acp] + 7 CO2 + 7 CoA ORTHOLOGY K05551 minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] K05552 minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] K05553 minimal PKS acyl carrier protein /// ENTRY R11472 Reaction NAME dTDP-D-glucuronate:NAD+ oxidoreductase (decarboxylating) DEFINITION dTDP-D-glucuronate + NAD+ <=> dTDP-4-oxo-alpha-D-xylose + CO2 + NADH + H+ EQUATION C06017 + C00003 <=> C21351 + C00011 + C00004 + C00080 RCLASS RC01812 C06017_C21351 ENZYME 1.1.1.- PATHWAY rn00523 Polyketide sugar unit biosynthesis rn01110 Biosynthesis of secondary metabolites BRITE Enzymatic reactions [BR:br08201] 1. Oxidoreductase reactions 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD+ or NADP+ as acceptor 1.1.1.- R11472 dTDP-D-glucuronate + NAD+ <=> dTDP-4-oxo-alpha-D-xylose + CO2 + NADH + H+ ORTHOLOGY K21332 dTDP-alpha-D-glucuronic acid decarboxylase [EC:1.1.1.-] /// ENTRY R09129 Reaction NAME S-(hydroxymethyl)mycothiol:NAD+ oxidoreductase DEFINITION S-(Hydroxymethyl)mycothiol + NAD+ <=> S-Formylmycothiol + NADH + H+ EQUATION C18235 + C00003 <=> C06718 + C00004 + C00080 RCLASS RC00001 C00003_C00004 RC01715 C06718_C18235 ENZYME 1.1.1.306 BRITE Enzymatic reactions [BR:br08201] 1. Oxidoreductase reactions 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD+ or NADP+ as acceptor 1.1.1.306 R09129 S-(Hydroxymethyl)mycothiol + NAD+ <=> S-Formylmycothiol + NADH + H+ ORTHOLOGY K00153 S-(hydroxymethyl)mycothiol dehydrogenase [EC:1.1.1.306] DBLINKS RHEA: 28505 /// ENTRY R09128 Reaction NAME 2-chloroethanol:cytochrome c oxidoreductase DEFINITION 2-Chloroethanol + 2 Ferricytochrome cL <=> Chloroacetaldehyde + 2 Ferrocytochrome cL + 2 H+ EQUATION C06753 + 2 C18233 <=> C06754 + 2 C18234 + 2 C00080 RCLASS RC00087 C06753_C06754 ENZYME 1.1.2.7 PATHWAY rn00625 Chloroalkane and chloroalkene degradation rn01100 Metabolic pathways rn01120 Microbial metabolism in diverse environments BRITE Enzymatic reactions [BR:br08201] 1. Oxidoreductase reactions 1.1 Acting on the CH-OH group of donors 1.1.2 With a cytochrome as acceptor 1.1.2.7 R09128 2-Chloroethanol + 2 Ferricytochrome cL <=> Chloroacetaldehyde + 2 Ferrocytochrome cL + 2 H+ IUBMB reaction hierarchy [BR:br08202] 1. Oxidoreductase reactions 1.1.2.7 R10713 Primary alcohol <=> Aldehyde R09128 2-Chloroethanol <=> Chloroacetaldehyde ORTHOLOGY K14028 methanol dehydrogenase (cytochrome c) subunit 1 [EC:1.1.2.7] K14029 methanol dehydrogenase (cytochrome c) subunit 2 [EC:1.1.2.7] /// ENTRY R09659 Reaction NAME all-trans-zeta-carotene:acceptor oxidoreductase DEFINITION all-trans-zeta-Carotene + 2 Acceptor <=> Lycopene + 2 Reduced acceptor EQUATION C05430 + 2 C00028 <=> C05432 + 2 C00030 COMMENT two-step reaction (see R04798+R04800) RCLASS RC01959 C05430_C05432 ENZYME 1.3.99.26 BRITE Enzymatic reactions [BR:br08201] 1. Oxidoreductase reactions 1.3 Acting on the CH-CH group of donors 1.3.99 With unknown physiological acceptors 1.3.99.26 R09659 all-trans-zeta-Carotene + 2 Acceptor <=> Lycopene + 2 Reduced acceptor DBLINKS RHEA: 30622 /// ENTRY R09658 Reaction NAME 7,9,9'-tricis-neurosporene:quinone oxidoreductase DEFINITION 7,9,9'-tricis-Neurosporene + Quinone <=> 7,9,7',9'-tetracis-Lycopene + Hydroquinone EQUATION C19759 + C15602 <=> C15858 + C15603 COMMENT 9,9'-dicis-zeta-carotene desaturase the second step of two-step reaction (see R07511, R09656+R09658) following after R09656 RCLASS RC01214 C15858_C19759 ENZYME 1.3.5.6 PATHWAY rn00906 Carotenoid biosynthesis rn01100 Metabolic pathways rn01110 Biosynthesis of secondary metabolites MODULE M00097 beta-Carotene biosynthesis, GGAP => beta-carotene BRITE Enzymatic reactions [BR:br08201] 1. Oxidoreductase reactions 1.3 Acting on the CH-CH group of donors 1.3.5 With a quinone or related compound as acceptor 1.3.5.6 R09658 7,9,9'-tricis-Neurosporene + Quinone <=> 7,9,7',9'-tetracis-Lycopene + Hydroquinone ORTHOLOGY K00514 zeta-carotene desaturase [EC:1.3.5.6] DBLINKS RHEA: 30966 /// ENTRY R00407 Reaction NAME succinyl-CoA hydrolase DEFINITION Succinyl-CoA + H2O <=> CoA + Succinate EQUATION C00091 + C00001 <=> C00010 + C00042 RCLASS RC00004 C00010_C00091 RC00014 C00042_C00091 ENZYME 3.1.2.3 BRITE Enzymatic reactions [BR:br08201] 3. Hydrolase reactions 3.1 Acting on ester bonds 3.1.2 Thioester hydrolases 3.1.2.3 R00407 Succinyl-CoA + H2O <=> CoA + Succinate DBLINKS RHEA: 11519 /// ENTRY R10665 Reaction NAME UDP-2-acetamido-2,6-dideoxy-L-talose:NADP+ oxidoreductase DEFINITION UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NADP+ <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose + NADPH + H+ EQUATION C20768 + C00006 <=> C19823 + C00005 + C00080 COMMENT two-step reaction (see R12553+R12552) RCLASS RC00001 C00005_C00006 RC00182 C19823_C20768 ENZYME 1.1.1.367 BRITE Enzymatic reactions [BR:br08201] 1. Oxidoreductase reactions 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD+ or NADP+ as acceptor 1.1.1.367 R10665 UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NADP+ <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose + NADPH + H+ DBLINKS RHEA: 30838 /// ENTRY C00099 Compound NAME beta-Alanine; 3-Aminopropionic acid; 3-Aminopropanoate FORMULA C3H7NO2 EXACT_MASS 89.0477 MOL_WEIGHT 89.09 REMARK Same as: D07561 REACTION R00489 R00904 R00905 R00906 R00907 R00908 R00909 R00910 R00911 R00912 R00913 R00914 R00915 R00916 R00917 R01164 R01166 R02473 R02474 R02741 R03286 R03288 R03935 R09379 R09648 R10821 PATHWAY map00240 Pyrimidine metabolism map00410 beta-Alanine metabolism map00640 Propanoate metabolism map00770 Pantothenate and CoA biosynthesis map01100 Metabolic pathways map01110 Biosynthesis of secondary metabolites map01240 Biosynthesis of cofactors map04080 Neuroactive ligand-receptor interaction map04974 Protein digestion and absorption MODULE M00046 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate M00913 Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate ENZYME 1.2.1.3 1.2.1.5 1.2.1.19 1.5.1.26 2.6.1.18 2.6.1.19 2.6.1.55 2.6.1.120 2.8.3.- 3.4.13.4 3.4.13.5 3.4.13.18 3.4.13.20 3.5.1.6 3.5.1.21 3.5.1.22 3.5.1.100 3.5.3.17 4.1.1.11 4.1.1.15 6.3.2.1 6.3.2.11 6.3.2.23 6.3.2.36 6.3.2.44 BRITE Compounds with biological roles [BR:br08001] Peptides Amino acids Other amino acids C00099 beta-Alanine Amines Biogenic amines C00099 beta-Alanine DBLINKS CAS: 107-95-9 PubChem: 3399 ChEBI: 16958 KNApSAcK: C00001333 PDB-CCD: BAL NIKKAJI: J4.070C ATOM 6 1 C1b C 25.6778 -16.8919 2 C6a C 24.4732 -16.1936 3 C1b C 26.8940 -16.1936 4 O6a O 23.2571 -16.8978 5 O6a O 24.4732 -14.7912 6 N1a N 28.1045 -16.8919 BOND 5 1 1 2 1 2 1 3 1 3 2 4 1 4 2 5 2 5 3 6 1 ///