ENTRY R03126 Reaction NAME dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase DEFINITION Dihydrokaempferol + 2-Oxoglutarate + Oxygen <=> Kaempferol + Succinate + CO2 + H2O EQUATION C00974 + C00026 + C00007 <=> C05903 + C00042 + C00011 + C00001 COMMENT Dihydrokaempferol dioxygenase flavonol synthase RCLASS RC00657 C00974_C05903 ENZYME 1.14.20.6 PATHWAY rn00941 Flavonoid biosynthesis rn01100 Metabolic pathways rn01110 Biosynthesis of secondary metabolites BRITE Enzymatic reactions [BR:br08201] 1. Oxidoreductase reactions 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated 1.14.20.6 R03126 Dihydrokaempferol + 2-Oxoglutarate + Oxygen <=> Kaempferol + Succinate + CO2 + H2O IUBMB reaction hierarchy [BR:br08202] 1. Oxidoreductase reactions 1.14.20.6 R07368 Dihydroflavonol <=> Flavonol R03126 Dihydrokaempferol <=> Kaempferol ORTHOLOGY K05278 flavonol synthase [EC:1.14.20.6] DBLINKS RHEA: 61135 /// ENTRY R03125 Reaction NAME dihydrokaempferol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase DEFINITION Dihydrokaempferol + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> Dihydromyricetin + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O EQUATION C00974 + 2 C03024 + 2 C00007 <=> C02906 + 2 C03161 + 2 C00001 COMMENT two-step reaction (see R03124+R03639) ENZYME 1.14.14.81 BRITE Enzymatic reactions [BR:br08201] 1. Oxidoreductase reactions 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor 1.14.14.81 R03125 Dihydrokaempferol + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> Dihydromyricetin + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O IUBMB reaction hierarchy [BR:br08202] 1. Oxidoreductase reactions 1.14.14.81 R10069 Flavanone <=> 3',5'-Dihydroxyflavanone R03125 Dihydrokaempferol <=> Dihydromyricetin DBLINKS RHEA: 61111 /// ENTRY R03124 Reaction NAME dihydrokaempferol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating) DEFINITION Dihydrokaempferol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Taxifolin + [Oxidized NADPH---hemoprotein reductase] + H2O EQUATION C00974 + C03024 + C00007 <=> C01617 + C03161 + C00001 COMMENT the first step of two-step reaction (see R03125, R03124+R03639) subsequently R03639, catalyzed by flavonoid 3',5'-hydroxylase (ec 1.14.13.88) RCLASS RC00046 C00974_C01617 ENZYME 1.14.14.81 1.14.14.82 PATHWAY rn00941 Flavonoid biosynthesis rn01100 Metabolic pathways rn01110 Biosynthesis of secondary metabolites BRITE Enzymatic reactions [BR:br08201] 1. Oxidoreductase reactions 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor 1.14.14.81 R03124 Dihydrokaempferol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Taxifolin + [Oxidized NADPH---hemoprotein reductase] + H2O 1.14.14.82 R03124 Dihydrokaempferol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Taxifolin + [Oxidized NADPH---hemoprotein reductase] + H2O IUBMB reaction hierarchy [BR:br08202] 1. Oxidoreductase reactions 1.14.14.81 R07369 Flavanone <=> 3'-Hydroxyflavanone R03124 Dihydrokaempferol <=> Taxifolin 1.14.14.82 R03615 Flavonoid <=> 3'-Hydroxyflavonoid R03124 Dihydrokaempferol <=> Taxifolin ORTHOLOGY K05280 flavonoid 3'-monooxygenase [EC:1.14.14.82] K13083 flavonoid 3',5'-hydroxylase [EC:1.14.14.81] DBLINKS RHEA: 61115 /// ENTRY R06959 Reaction DEFINITION Abscisic alcohol <=> Abscisate EQUATION C13456 <=> C06082 COMMENT oxidoreduction possibly multi-step reaction RCLASS RC01621 C06082_C13456 PATHWAY rn00906 Carotenoid biosynthesis /// ENTRY R06958 Reaction DEFINITION Abscisic aldehyde <=> Abscisic alcohol EQUATION C13455 <=> C13456 RCLASS RC00649 C13455_C13456 PATHWAY rn00906 Carotenoid biosynthesis /// ENTRY R03129 Reaction NAME GDP-D-mannuronate:alginate D-mannuronyltransferase DEFINITION GDP-D-mannuronate + (Alginate)n <=> GDP + (Alginate)n EQUATION C00976 + C01768 <=> C00035 + C01768 COMMENT C5-epimerization is also required for L-guluronate unit formation (see R08692+R08693) RCLASS RC00005 C00035_C00976 ENZYME 2.4.1.33 BRITE Enzymatic reactions [BR:br08201] 2. Transferase reactions 2.4 Glycosyltransferases 2.4.1 Hexosyltransferases 2.4.1.33 R03129 GDP-D-mannuronate + (Alginate)n <=> GDP + (Alginate)n DBLINKS RHEA: 15640 /// ENTRY R03128 Reaction DEFINITION Dihydroxyfumarate <=> 2-Hydroxy-3-oxosuccinate EQUATION C00975 <=> C03459 COMMENT non-enzymatic RCLASS RC00854 C00975_C03459 PATHWAY rn00630 Glyoxylate and dicarboxylate metabolism rn01100 Metabolic pathways /// ENTRY R09296 Reaction NAME UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase DEFINITION UDP-N-acetyl-D-glucosamine + G13052 <=> UDP + G13053 EQUATION G10610 + G13052 <=> G10619 + G13053 ENZYME 2.4.1.222 PATHWAY rn00514 Other types of O-glycan biosynthesis BRITE Enzymatic reactions [BR:br08201] 2. Transferase reactions 2.4 Glycosyltransferases 2.4.1 Hexosyltransferases 2.4.1.222 R09296 UDP-N-acetyl-D-glucosamine + G13052 <=> UDP + G13053 Glycosyltransferase reactions [br08203.html] N-Acetylglucosaminyltransferase reactions R09296 ORTHOLOGY K05948 fringe [EC:2.4.1.222] DBLINKS RHEA: 70514 70534 /// ENTRY R09600 Reaction NAME 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase DEFINITION UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate EQUATION C19725 <=> C19745 RCLASS RC00290 C19725_C19745 ENZYME 5.1.3.23 PATHWAY rn00541 Biosynthesis of various nucleotide sugars rn01100 Metabolic pathways rn01250 Biosynthesis of nucleotide sugars BRITE Enzymatic reactions [BR:br08201] 5. Isomerase reactions 5.1 Racemases and epimerases 5.1.3 Acting on carbohydrates and derivatives 5.1.3.23 R09600 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate ORTHOLOGY K13019 UDP-GlcNAc3NAcA epimerase [EC:5.1.3.23] DBLINKS RHEA: 24767 /// ENTRY C00099 Compound NAME beta-Alanine; 3-Aminopropionic acid; 3-Aminopropanoate FORMULA C3H7NO2 EXACT_MASS 89.0477 MOL_WEIGHT 89.09 REMARK Same as: D07561 REACTION R00489 R00904 R00905 R00906 R00907 R00908 R00909 R00910 R00911 R00912 R00913 R00914 R00915 R00916 R00917 R01164 R01166 R02473 R02474 R02741 R03286 R03288 R03935 R09379 R09648 R10821 PATHWAY map00240 Pyrimidine metabolism map00410 beta-Alanine metabolism map00640 Propanoate metabolism map00770 Pantothenate and CoA biosynthesis map01100 Metabolic pathways map01110 Biosynthesis of secondary metabolites map01240 Biosynthesis of cofactors map04080 Neuroactive ligand-receptor interaction map04974 Protein digestion and absorption MODULE M00046 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate M00913 Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate ENZYME 1.2.1.3 1.2.1.5 1.2.1.19 1.5.1.26 2.6.1.18 2.6.1.19 2.6.1.55 2.6.1.120 2.8.3.- 3.4.13.4 3.4.13.5 3.4.13.18 3.4.13.20 3.5.1.6 3.5.1.21 3.5.1.22 3.5.1.100 3.5.3.17 4.1.1.11 4.1.1.15 6.3.2.1 6.3.2.11 6.3.2.23 6.3.2.36 6.3.2.44 BRITE Compounds with biological roles [BR:br08001] Peptides Amino acids Other amino acids C00099 beta-Alanine Amines Biogenic amines C00099 beta-Alanine DBLINKS CAS: 107-95-9 PubChem: 3399 ChEBI: 16958 KNApSAcK: C00001333 PDB-CCD: BAL NIKKAJI: J4.070C ATOM 6 1 C1b C 25.6778 -16.8919 2 C6a C 24.4732 -16.1936 3 C1b C 26.8940 -16.1936 4 O6a O 23.2571 -16.8978 5 O6a O 24.4732 -14.7912 6 N1a N 28.1045 -16.8919 BOND 5 1 1 2 1 2 1 3 1 3 2 4 1 4 2 5 2 5 3 6 1 ///