ENTRY ppp00061 Pathway NAME Fatty acid biosynthesis - Physcomitrium patens (spreading earthmoss) CLASS Metabolism; Lipid metabolism PATHWAY_MAP ppp00061 Fatty acid biosynthesis MODULE ppp_M00082 Fatty acid biosynthesis, initiation [PATH:ppp00061] ppp_M00083 Fatty acid biosynthesis, elongation [PATH:ppp00061] ppp_M00086 beta-Oxidation, acyl-CoA synthesis [PATH:ppp00061] DBLINKS GO: 0006633 ORGANISM Physcomitrium patens (spreading earthmoss) [GN:ppp] GENE 112281694 acetyl-CoA carboxylase 1-like [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15] 112290690 acetyl-CoA carboxylase 1-like [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15] 112272799 uncharacterized protein LOC112272799 [KO:K01962] [EC:6.4.1.2 2.1.3.15] 112274477 uncharacterized protein LOC112274477 [KO:K01962] [EC:6.4.1.2 2.1.3.15] 112275096 uncharacterized protein LOC112275096 [KO:K01962] [EC:6.4.1.2 2.1.3.15] 112278522 biotin carboxyl carrier protein of acetyl-CoA carboxylase, chloroplastic-like [KO:K02160] 112293072 biotin carboxyl carrier protein of acetyl-CoA carboxylase, chloroplastic-like isoform X1 [KO:K02160] 112276517 biotin carboxylase 1, chloroplastic-like [KO:K01961] [EC:6.4.1.2 6.3.4.14] 112285309 biotin carboxylase 1, chloroplastic-like [KO:K01961] [EC:6.4.1.2 6.3.4.14] 2546800 accD; acetyl-CoA carboxylase beta subunit [KO:K01963] [EC:6.4.1.2 2.1.3.15] 112284600 malonate--CoA ligase-like [KO:K18660] [EC:6.2.1.76 6.2.1.-] 112296160 malonate--CoA ligase-like isoform X1 [KO:K18660] [EC:6.2.1.76 6.2.1.-] 112273646 uncharacterized protein LOC112273646 [KO:K00645] [EC:2.3.1.39] 112279191 3-oxoacyl-[acyl-carrier-protein] synthase 3 A, chloroplastic-like isoform X1 [KO:K00648] [EC:2.3.1.180] 112284603 3-oxoacyl-[acyl-carrier-protein] synthase 3 A, chloroplastic-like isoform X1 [KO:K00648] [EC:2.3.1.180] 112288972 3-oxoacyl-[acyl-carrier-protein] synthase III, chloroplastic-like isoform X1 [KO:K00648] [EC:2.3.1.180] 112277887 3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic-like isoform X1 [KO:K09458] [EC:2.3.1.179] 112281478 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic-like [KO:K09458] [EC:2.3.1.179] 112281716 3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic-like [KO:K09458] [EC:2.3.1.179] 112289566 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic-like [KO:K09458] [EC:2.3.1.179] 112290212 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial-like [KO:K09458] [EC:2.3.1.179] 112289977 3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic-like [KO:K09458] [EC:2.3.1.179] 112290697 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic-like [KO:K09458] [EC:2.3.1.179] 112290879 3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic-like [KO:K09458] [EC:2.3.1.179] 112272853 3-oxoacyl-[acyl-carrier-protein] reductase 4-like [KO:K00059] [EC:1.1.1.100] 112295544 3-oxoacyl-[acyl-carrier-protein] reductase 4-like [KO:K00059] [EC:1.1.1.100] 112276234 uncharacterized protein LOC112276234 [KO:K02372] [EC:4.2.1.59] 112276754 uncharacterized protein LOC112276754 [KO:K02372] [EC:4.2.1.59] 112291006 uncharacterized protein LOC112291006 [KO:K02372] [EC:4.2.1.59] 112287039 enoyl-[acyl-carrier-protein] reductase [NADH] 1, chloroplastic-like [KO:K00208] [EC:1.3.1.9 1.3.1.10] 112292915 enoyl-[acyl-carrier-protein] reductase [NADH] 1, chloroplastic-like [KO:K00208] [EC:1.3.1.9 1.3.1.10] 112287087 enoyl-[acyl-carrier-protein] reductase, mitochondrial-like isoform X1 [KO:K07512] [EC:1.3.1.- 1.3.1.38] 112274334 enoyl-[acyl-carrier-protein] reductase, mitochondrial-like [KO:K07512] [EC:1.3.1.- 1.3.1.38] 112274563 palmitoyl-acyl carrier protein thioesterase, chloroplastic-like isoform X1 [KO:K10781] [EC:3.1.2.14 3.1.2.21] 112274729 palmitoyl-acyl carrier protein thioesterase, chloroplastic-like [KO:K10781] [EC:3.1.2.14 3.1.2.21] 112295522 palmitoyl-acyl carrier protein thioesterase, chloroplastic-like [KO:K10781] [EC:3.1.2.14 3.1.2.21] 112292328 palmitoyl-acyl carrier protein thioesterase, chloroplastic-like [KO:K10781] [EC:3.1.2.14 3.1.2.21] 112294324 palmitoyl-acyl carrier protein thioesterase, chloroplastic-like [KO:K10781] [EC:3.1.2.14 3.1.2.21] 112277618 oleoyl-acyl carrier protein thioesterase 2, chloroplastic-like isoform X1 [KO:K10782] [EC:3.1.2.14] 112291669 oleoyl-acyl carrier protein thioesterase 2, chloroplastic-like [KO:K10782] [EC:3.1.2.14] 112294154 oleoyl-acyl carrier protein thioesterase 2, chloroplastic-like [KO:K10782] [EC:3.1.2.14] 112293081 oleoyl-acyl carrier protein thioesterase 1, chloroplastic-like isoform X1 [KO:K10782] [EC:3.1.2.14] 112280634 stearoyl-[acyl-carrier-protein] 9-desaturase 2, chloroplastic-like [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26] 112281526 stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic-like [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26] 112281424 stearoyl-[acyl-carrier-protein] 9-desaturase 5, chloroplastic-like [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26] 112289744 stearoyl-[acyl-carrier-protein] 9-desaturase 5, chloroplastic-like [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26] 112290196 stearoyl-[acyl-carrier-protein] 9-desaturase 2, chloroplastic-like [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26] 112290071 stearoyl-[acyl-carrier-protein] 9-desaturase 2, chloroplastic-like [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26] 112288071 stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic-like [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26] 112274105 long chain acyl-CoA synthetase 9, chloroplastic-like [KO:K01897] [EC:6.2.1.3] 112274403 long chain acyl-CoA synthetase 6, peroxisomal-like [KO:K01897] [EC:6.2.1.3] 112275069 long chain acyl-CoA synthetase 6, peroxisomal-like isoform X1 [KO:K01897] [EC:6.2.1.3] 112275998 probable acyl-activating enzyme 16, chloroplastic [KO:K01897] [EC:6.2.1.3] 112282782 long chain acyl-CoA synthetase 9, chloroplastic-like [KO:K01897] [EC:6.2.1.3] 112280039 long chain acyl-CoA synthetase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3] 112282871 long chain acyl-CoA synthetase 4-like [KO:K01897] [EC:6.2.1.3] 112284102 long chain acyl-CoA synthetase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3] 112289934 long chain acyl-CoA synthetase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3] 112295703 long-chain-fatty-acid--[acyl-carrier-protein] ligase AEE15, chloroplastic-like [KO:K01897] [EC:6.2.1.3] 112295588 long chain acyl-CoA synthetase 6, peroxisomal-like isoform X1 [KO:K01897] [EC:6.2.1.3] COMPOUND C00024 Acetyl-CoA C00083 Malonyl-CoA C00154 Palmitoyl-CoA C00173 Acyl-[acyl-carrier protein] C00229 Acyl-carrier protein C00249 Hexadecanoic acid C00383 Malonate C00638 Long-chain fatty acid C00685 3-Oxoacyl-[acyl-carrier protein] C00693 trans-2,3-Dehydroacyl-[acyl-carrier protein] C00712 (9Z)-Octadecenoic acid C01203 Oleoyl-[acyl-carrier protein] C01209 Malonyl-[acyl-carrier protein] C01271 (3R)-3-Hydroxyacyl-[acyl-carrier protein] C01530 Octadecanoic acid C01571 Decanoic acid C02679 Dodecanoic acid C02843 Long-chain acyl-CoA C03939 Acetyl-[acyl-carrier protein] C04088 Octadecanoyl-[acyl-carrier protein] C04180 cis-Dec-3-enoyl-[acp] C04246 But-2-enoyl-[acyl-carrier protein] C04618 (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] C04619 (3R)-3-Hydroxydecanoyl-[acyl-carrier protein] C04620 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] C04633 (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] C04688 (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] C05223 Dodecanoyl-[acyl-carrier protein] C05744 Acetoacetyl-[acp] C05745 Butyryl-[acp] C05746 3-Oxohexanoyl-[acp] C05747 (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein] C05748 trans-Hex-2-enoyl-[acp] C05749 Hexanoyl-[acp] C05750 3-Oxooctanoyl-[acp] C05751 trans-Oct-2-enoyl-[acp] C05752 Octanoyl-[acp] C05753 3-Oxodecanoyl-[acp] C05754 trans-Dec-2-enoyl-[acp] C05755 Decanoyl-[acp] C05756 3-Oxododecanoyl-[acp] C05757 (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein] C05758 trans-Dodec-2-enoyl-[acp] C05759 3-Oxotetradecanoyl-[acp] C05760 trans-Tetradec-2-enoyl-[acp] C05761 Tetradecanoyl-[acp] C05762 3-Oxohexadecanoyl-[acp] C05763 trans-Hexadec-2-enoyl-[acp] C05764 Hexadecanoyl-[acp] C06423 Octanoic acid C06424 Tetradecanoic acid C08362 (9Z)-Hexadecenoic acid C16219 3-Oxostearoyl-[acp] C16220 (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein] C16221 (2E)-Octadecenoyl-[acp] C16520 Hexadecenoyl-[acyl-carrier protein] C20683 Long-chain acyl-[acyl-carrier protein] C20794 n-7 Unsaturated acyl-[acyl-carrier protein] REFERENCE PMID:12061798 AUTHORS Salas JJ, Ohlrogge JB. TITLE Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases. JOURNAL Arch Biochem Biophys 403:25-34 (2002) DOI:10.1016/S0003-9861(02)00017-6 REFERENCE PMID:12518017 AUTHORS Zhang YM, Marrakchi H, White SW, Rock CO. TITLE The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase. JOURNAL J Lipid Res 44:1-10 (2003) DOI:10.1194/jlr.R200016-JLR200 REFERENCE PMID:11337402 AUTHORS Voelker T, Kinney AJ. TITLE VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS. JOURNAL Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001) DOI:10.1146/annurev.arplant.52.1.335 REFERENCE PMID:17573542 AUTHORS Barker GC, Larson TR, Graham IA, Lynn JR, King GJ. TITLE Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome. JOURNAL Plant Physiol 144:1827-42 (2007) DOI:10.1104/pp.107.096172 REFERENCE PMID:30201289 AUTHORS Bowman CE, Wolfgang MJ TITLE Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism. JOURNAL Adv Biol Regul 71:34-40 (2019) DOI:10.1016/j.jbior.2018.09.002 REFERENCE PMID:25203508 AUTHORS Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z TITLE Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. JOURNAL Nat Commun 5:4805 (2014) DOI:10.1038/ncomms5805 REFERENCE PMID:19686777 AUTHORS Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ TITLE Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism. JOURNAL Prog Lipid Res 49:27-45 (2010) DOI:10.1016/j.plipres.2009.08.001 REFERENCE PMID:27553474 AUTHORS Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK TITLE Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology. JOURNAL Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017) DOI:10.1016/j.bbalip.2016.08.011 REL_PATHWAY ppp00020 Citrate cycle (TCA cycle) ppp00062 Fatty acid elongation ppp00071 Fatty acid degradation ppp00410 beta-Alanine metabolism ppp00561 Glycerolipid metabolism ppp00564 Glycerophospholipid metabolism ppp00620 Pyruvate metabolism ppp00785 Lipoic acid metabolism KO_PATHWAY ko00061 ///