ENTRY 672 CDS T01001 SYMBOL BRCA1, BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53 NAME (RefSeq) breast cancer type 1 susceptibility protein isoform 1 ORTHOLOGY K10605 breast cancer type 1 susceptibility protein [EC:2.3.2.27] ORGANISM hsa Homo sapiens (human) PATHWAY hsa01524 Platinum drug resistance hsa03440 Homologous recombination hsa03460 Fanconi anemia pathway hsa04120 Ubiquitin mediated proteolysis hsa04151 PI3K-Akt signaling pathway hsa05206 MicroRNAs in cancer hsa05224 Breast cancer NETWORK nt06506 Double-strand break repair nt06508 Interstrand crosslink repair ELEMENT N01446 DNA end resection and RPA loading N01452 Homologous recombination N01466 Homologous recombination in ICLR DISEASE H00019 Pancreatic cancer H00027 Ovarian cancer H00031 Breast cancer H00238 Fanconi anemia H01554 Fallopian tube cancer H01665 Primary peritoneal carcinoma H02531 Familial breast-ovarian cancer BRITE KEGG Orthology (KO) [BR:hsa00001] 09120 Genetic Information Processing 09123 Folding, sorting and degradation 04120 Ubiquitin mediated proteolysis 672 (BRCA1) 09124 Replication and repair 03440 Homologous recombination 672 (BRCA1) 03460 Fanconi anemia pathway 672 (BRCA1) 09130 Environmental Information Processing 09132 Signal transduction 04151 PI3K-Akt signaling pathway 672 (BRCA1) 09160 Human Diseases 09161 Cancer: overview 05206 MicroRNAs in cancer 672 (BRCA1) 09162 Cancer: specific types 05224 Breast cancer 672 (BRCA1) 09176 Drug resistance: antineoplastic 01524 Platinum drug resistance 672 (BRCA1) 09180 Brite Hierarchies 09181 Protein families: metabolism 01009 Protein phosphatases and associated proteins [BR:hsa01009] 672 (BRCA1) 09182 Protein families: genetic information processing 04121 Ubiquitin system [BR:hsa04121] 672 (BRCA1) 03036 Chromosome and associated proteins [BR:hsa03036] 672 (BRCA1) 03400 DNA repair and recombination proteins [BR:hsa03400] 672 (BRCA1) Enzymes [BR:hsa01000] 2. Transferases 2.3 Acyltransferases 2.3.2 Aminoacyltransferases 2.3.2.27 RING-type E3 ubiquitin transferase 672 (BRCA1) Protein phosphatases and associated proteins [BR:hsa01009] Protein serine/threonine phosphatases Phosphoprotein phosphatases (PPPs) Protein phosphatase-1 PP1-interacting proteins (PIPs) 672 (BRCA1) Ubiquitin system [BR:hsa04121] Ubiquitin ligases (E3) Single Ring-finger type E3 Other single Ring-finger type E3 672 (BRCA1) Multi subunit type E3 BRCC complex 672 (BRCA1) Chromosome and associated proteins [BR:hsa03036] Eukaryotic type Centrosome formation proteins Centrosome duplication proteins Regulators of centriole replication 672 (BRCA1) DNA repair and recombination proteins [BR:hsa03400] Eukaryotic type DSBR (double strand breaks repair) HR (homologous recombination) BRCA1-core complex 672 (BRCA1) BRCA1-A complex 672 (BRCA1) BRCA1-B complex 672 (BRCA1) BRCA1-C complex 672 (BRCA1) BRCA complex 672 (BRCA1) FA (Fanconi anemia) pathway Downstream FA components 672 (BRCA1) POSITION 17:complement(43044295..43170327) MOTIF Pfam: BRCT_assoc BRCT zf-C3HC4 zf-C3HC4_2 zf-RING_UBOX zf-C3HC4_4 zf-C3HC4_3 zf-RING_2 zf-RING_5 RING_XB3-XBAT31 BRCT_2 zf-Nse zf-RING_6 zf-ANAPC11 zf-RING_10 zf-rbx1 Prok-RING_4 RTT107_BRCT_5 DBLINKS NCBI-GeneID: 672 NCBI-ProteinID: NP_001394522 OMIM: 113705 HGNC: 1100 UniProt: P38398 STRUCTURE PDB AASEQ 1863 MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQ CPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKD EVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYI ELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQ PSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVE KAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPC SENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVD EYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTEN LIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTE QNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNI HNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPV RHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKE FVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQ ESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHS RETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVT FECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRG NETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIP STVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKL NAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSS HASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQ GYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENL LSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGS SKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSE DCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALE DLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSK CPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEG TPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTT DTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLI TEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDV VNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTL GTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPH SHY NTSEQ 5592 atggatttatctgctcttcgcgttgaagaagtacaaaatgtcattaatgctatgcagaaa atcttagagtgtcccatctgtctggagttgatcaaggaacctgtctccacaaagtgtgac cacatattttgcaaattttgcatgctgaaacttctcaaccagaagaaagggccttcacag tgtcctttatgtaagaatgatataaccaaaaggagcctacaagaaagtacgagatttagt caacttgttgaagagctattgaaaatcatttgtgcttttcagcttgacacaggtttggag tatgcaaacagctataattttgcaaaaaaggaaaataactctcctgaacatctaaaagat gaagtttctatcatccaaagtatgggctacagaaaccgtgccaaaagacttctacagagt gaacccgaaaatccttccttgcaggaaaccagtctcagtgtccaactctctaaccttgga actgtgagaactctgaggacaaagcagcggatacaacctcaaaagacgtctgtctacatt gaattgggatctgattcttctgaagataccgttaataaggcaacttattgcagtgtggga gatcaagaattgttacaaatcacccctcaaggaaccagggatgaaatcagtttggattct gcaaaaaaggctgcttgtgaattttctgagacggatgtaacaaatactgaacatcatcaa cccagtaataatgatttgaacaccactgagaagcgtgcagctgagaggcatccagaaaag tatcagggtagttctgtttcaaacttgcatgtggagccatgtggcacaaatactcatgcc agctcattacagcatgagaacagcagtttattactcactaaagacagaatgaatgtagaa aaggctgaattctgtaataaaagcaaacagcctggcttagcaaggagccaacataacaga tgggctggaagtaaggaaacatgtaatgataggcggactcccagcacagaaaaaaaggta gatctgaatgctgatcccctgtgtgagagaaaagaatggaataagcagaaactgccatgc tcagagaatcctagagatactgaagatgttccttggataacactaaatagcagcattcag aaagttaatgagtggttttccagaagtgatgaactgttaggttctgatgactcacatgat ggggagtctgaatcaaatgccaaagtagctgatgtattggacgttctaaatgaggtagat gaatattctggttcttcagagaaaatagacttactggccagtgatcctcatgaggcttta atatgtaaaagtgaaagagttcactccaaatcagtagagagtaatattgaagacaaaata tttgggaaaacctatcggaagaaggcaagcctccccaacttaagccatgtaactgaaaat ctaattataggagcatttgttactgagccacagataatacaagagcgtcccctcacaaat aaattaaagcgtaaaaggagacctacatcaggccttcatcctgaggattttatcaagaaa gcagatttggcagttcaaaagactcctgaaatgataaatcagggaactaaccaaacggag cagaatggtcaagtgatgaatattactaatagtggtcatgagaataaaacaaaaggtgat tctattcagaatgagaaaaatcctaacccaatagaatcactcgaaaaagaatctgctttc aaaacgaaagctgaacctataagcagcagtataagcaatatggaactcgaattaaatatc cacaattcaaaagcacctaaaaagaataggctgaggaggaagtcttctaccaggcatatt catgcgcttgaactagtagtcagtagaaatctaagcccacctaattgtactgaattgcaa attgatagttgttctagcagtgaagagataaagaaaaaaaagtacaaccaaatgccagtc aggcacagcagaaacctacaactcatggaaggtaaagaacctgcaactggagccaagaag agtaacaagccaaatgaacagacaagtaaaagacatgacagcgatactttcccagagctg aagttaacaaatgcacctggttcttttactaagtgttcaaataccagtgaacttaaagaa tttgtcaatcctagccttccaagagaagaaaaagaagagaaactagaaacagttaaagtg tctaataatgctgaagaccccaaagatctcatgttaagtggagaaagggttttgcaaact gaaagatctgtagagagtagcagtatttcattggtacctggtactgattatggcactcag gaaagtatctcgttactggaagttagcactctagggaaggcaaaaacagaaccaaataaa tgtgtgagtcagtgtgcagcatttgaaaaccccaagggactaattcatggttgttccaaa gataatagaaatgacacagaaggctttaagtatccattgggacatgaagttaaccacagt cgggaaacaagcatagaaatggaagaaagtgaacttgatgctcagtatttgcagaataca ttcaaggtttcaaagcgccagtcatttgctccgttttcaaatccaggaaatgcagaagag gaatgtgcaacattctctgcccactctgggtccttaaagaaacaaagtccaaaagtcact tttgaatgtgaacaaaaggaagaaaatcaaggaaagaatgagtctaatatcaagcctgta cagacagttaatatcactgcaggctttcctgtggttggtcagaaagataagccagttgat aatgccaaatgtagtatcaaaggaggctctaggttttgtctatcatctcagttcagaggc aacgaaactggactcattactccaaataaacatggacttttacaaaacccatatcgtata ccaccactttttcccatcaagtcatttgttaaaactaaatgtaagaaaaatctgctagag gaaaactttgaggaacattcaatgtcacctgaaagagaaatgggaaatgagaacattcca agtacagtgagcacaattagccgtaataacattagagaaaatgtttttaaagaagccagc tcaagcaatattaatgaagtaggttccagtactaatgaagtgggctccagtattaatgaa ataggttccagtgatgaaaacattcaagcagaactaggtagaaacagagggccaaaattg aatgctatgcttagattaggggttttgcaacctgaggtctataaacaaagtcttcctgga agtaattgtaagcatcctgaaataaaaaagcaagaatatgaagaagtagttcagactgtt aatacagatttctctccatatctgatttcagataacttagaacagcctatgggaagtagt catgcatctcaggtttgttctgagacacctgatgacctgttagatgatggtgaaataaag gaagatactagttttgctgaaaatgacattaaggaaagttctgctgtttttagcaaaagc gtccagaaaggagagcttagcaggagtcctagccctttcacccatacacatttggctcag ggttaccgaagaggggccaagaaattagagtcctcagaagagaacttatctagtgaggat gaagagcttccctgcttccaacacttgttatttggtaaagtaaacaatataccttctcag tctactaggcatagcaccgttgctaccgagtgtctgtctaagaacacagaggagaattta ttatcattgaagaatagcttaaatgactgcagtaaccaggtaatattggcaaaggcatct caggaacatcaccttagtgaggaaacaaaatgttctgctagcttgttttcttcacagtgc agtgaattggaagacttgactgcaaatacaaacacccaggatcctttcttgattggttct tccaaacaaatgaggcatcagtctgaaagccagggagttggtctgagtgacaaggaattg gtttcagatgatgaagaaagaggaacgggcttggaagaaaataatcaagaagagcaaagc atggattcaaacttaggtgaagcagcatctgggtgtgagagtgaaacaagcgtctctgaa gactgctcagggctatcctctcagagtgacattttaaccactcagcagagggataccatg caacataacctgataaagctccagcaggaaatggctgaactagaagctgtgttagaacag catgggagccagccttctaacagctacccttccatcataagtgactcttctgcccttgag gacctgcgaaatccagaacaaagcacatcagaaaaagcagtattaacttcacagaaaagt agtgaataccctataagccagaatccagaaggcctttctgctgacaagtttgaggtgtct gcagatagttctaccagtaaaaataaagaaccaggagtggaaaggtcatccccttctaaa tgcccatcattagatgataggtggtacatgcacagttgctctgggagtcttcagaataga aactacccatctcaagaggagctcattaaggttgttgatgtggaggagcaacagctggaa gagtctgggccacacgatttgacggaaacatcttacttgccaaggcaagatctagaggga accccttacctggaatctggaatcagcctcttctctgatgaccctgaatctgatccttct gaagacagagccccagagtcagctcgtgttggcaacataccatcttcaacctctgcattg aaagttccccaattgaaagttgcagaatctgcccagagtccagctgctgctcatactact gatactgctgggtataatgcaatggaagaaagtgtgagcagggagaagccagaattgaca gcttcaacagaaagggtcaacaaaagaatgtccatggtggtgtctggcctgaccccagaa gaatttatgctcgtgtacaagtttgccagaaaacaccacatcactttaactaatctaatt actgaagagactactcatgttgttatgaaaacagatgctgagtttgtgtgtgaacggaca ctgaaatattttctaggaattgcgggaggaaaatgggtagttagctatttctgggtgacc cagtctattaaagaaagaaaaatgctgaatgagcatgattttgaagtcagaggagatgtg gtcaatggaagaaaccaccaaggtccaaagcgagcaagagaatcccaggacagaaagatc ttcagggggctagaaatctgttgctatgggcccttcaccaacatgcccacagatcaactg gaatggatggtacagctgtgtggtgcttctgtggtgaaggagctttcatcattcaccctt ggcacaggtgtccacccaattgtggttgtgcagccagatgcctggacagaggacaatggc ttccatgcaattgggcagatgtgtgaggcacctgtggtgacccgagagtgggtgttggac agtgtagcactctaccagtgccaggagctggacacctacctgataccccagatcccccac agccactactga ///