ENTRY hsa00541 Pathway NAME Biosynthesis of various nucleotide sugars - Homo sapiens (human) CLASS Metabolism; Glycan biosynthesis and metabolism PATHWAY_MAP hsa00541 Biosynthesis of various nucleotide sugars MODULE hsa_M00955 CMP-Neu5Ac/Neu5Gc biosynthesis, animals, UDP-GlcNAc => CMP-Neu5Ac => CMP-Neu5Gc [PATH:hsa00541] hsa_M01016 GDP-L-Fuc biosynthesis, GDP-Man => GDP-L-Fuc [PATH:hsa00541] ORGANISM Homo sapiens (human) [GN:hsa] GENE 10020 GNE; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [KO:K12409] [EC:3.2.1.183 2.7.1.60] 123956252 RIPPLY2-CYB5R4; RIPPLY2-CYB5R4 readthrough [KO:K00326] [EC:1.6.2.2] 140838 NANP; N-acetylneuraminic acid phosphatase [KO:K01097] [EC:3.1.3.29] 1727 CYB5R3; cytochrome b5 reductase 3 [KO:K00326] [EC:1.6.2.2] 23483 TGDS; TDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46] 2762 GMDS; GDP-mannose 4,6-dehydratase [KO:K01711] [EC:4.2.1.47] 29925 GMPPB; GDP-mannose pyrophosphorylase B [KO:K00966] [EC:2.7.7.13] 29926 GMPPA; GDP-mannose pyrophosphorylase A [KO:K00966] [EC:2.7.7.13] 51167 CYB5R4; cytochrome b5 reductase 4 [KO:K00326] [EC:1.6.2.2] 51700 CYB5R2; cytochrome b5 reductase 2 [KO:K00326] [EC:1.6.2.2] 51706 CYB5R1; cytochrome b5 reductase 1 [KO:K00326] [EC:1.6.2.2] 54187 NANS; N-acetylneuraminate synthase [KO:K05304] [EC:2.5.1.56 2.5.1.57 2.5.1.132] 55907 CMAS; cytidine monophosphate N-acetylneuraminic acid synthetase [KO:K21749] [EC:2.7.7.43 2.7.7.92] 606495 CYB5RL; cytochrome b5 reductase like [KO:K00326] [EC:1.6.2.2] 6675 UAP1; UDP-N-acetylglucosamine pyrophosphorylase 1 [KO:K00972] [EC:2.7.7.23 2.7.7.83] 7264 GFUS; GDP-L-fucose synthase [KO:K02377] [EC:1.1.1.271] 7358 UGDH; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22] 7360 UGP2; UDP-glucose pyrophosphorylase 2 [KO:K00963] [EC:2.7.7.9] 80896 NPL; N-acetylneuraminate pyruvate lyase [KO:K01639] [EC:4.1.3.3] 91373 UAP1L1; UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 [KO:K00972] [EC:2.7.7.23 2.7.7.83] COMPOUND C00029 UDP-glucose C00043 UDP-N-acetyl-alpha-D-glucosamine C00096 GDP-mannose C00103 D-Glucose 1-phosphate C00128 CMP-N-acetylneuraminate C00167 UDP-glucuronate C00199 D-Ribulose 5-phosphate C00203 UDP-N-acetyl-D-galactosamine C00270 N-Acetylneuraminate C00275 D-Mannose 6-phosphate C00325 GDP-L-fucose C00501 CDP-glucose C00636 D-Mannose 1-phosphate C00645 N-Acetyl-D-mannosamine C00688 dTDP-4-dehydro-beta-L-rhamnose C00842 dTDP-glucose C00996 Ferricytochrome b5 C00999 Ferrocytochrome b5 C01112 D-Arabinose 5-phosphate C01170 UDP-N-acetyl-D-mannosamine C01187 3-Deoxy-D-manno-octulosonate C01219 CDP-4-dehydro-6-deoxy-D-glucose C01222 GDP-4-dehydro-6-deoxy-D-mannose C01788 CDP-abequose C02199 UDP-L-rhamnose C02330 UDP-L-iduronate C02977 GDP-6-deoxy-D-talose C03117 GDP-6-deoxy-D-mannose C03187 dTDP-6-deoxy-beta-L-talose C03319 dTDP-L-rhamnose C03410 N-Glycoloyl-neuraminate C03598 CDP-3,6-dideoxy-D-glucose C03599 CDP-3,6-dideoxy-D-mannose C03691 CMP-N-glycoloylneuraminate C04089 UDP-4-dehydro-6-deoxy-D-glucose C04121 CMP-3-deoxy-D-manno-octulosonate C04257 N-Acetyl-D-mannosamine 6-phosphate C04268 dTDP-4-amino-4,6-dideoxy-D-glucose C04297 CDP-4-dehydro-3,6-dideoxy-D-glucose C04346 dTDP-4-amino-4,6-dideoxy-D-galactose C04478 3-Deoxy-D-manno-octulosonate 8-phosphate C04501 N-Acetyl-alpha-D-glucosamine 1-phosphate C04573 UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate C04613 UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose C04630 UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose C05382 Sedoheptulose 7-phosphate C06018 dTDP-4-acetamido-4,6-dideoxy-D-glucose C06240 UDP-N-acetyl-D-mannosaminouronate C06241 N-Acetylneuraminate 9-phosphate C06397 ADP-D-glycero-beta-D-manno-heptose C06398 ADP-L-glycero-beta-D-manno-heptose C07277 dTDP-D-fucose C07836 D-glycero-beta-D-manno-Heptose 7-phosphate C07838 D-glycero-beta-D-manno-Heptose 1-phosphate C11472 D-glycero-beta-D-manno-Heptose 1,7-bisphosphate C11907 dTDP-4-oxo-6-deoxy-D-glucose C11908 dTDP-3-oxo-6-deoxy-D-glucose C11925 dTDP-3-amino-3,6-dideoxy-D-glucose C13952 UDP-N-acetyl-D-galactosaminuronic acid C16153 UDP-L-Ara4N C16154 UDP-L-Ara4FN C16155 UDP-L-Ara4O C16156 Undecaprenyl phosphate alpha-L-Ara4FN C16157 Undecaprenyl phosphate alpha-L-Ara4N C17326 CDP-4-dehydro-3,6-dideoxy-D-glucose epimer C17327 CDP-ascarylose C17328 UDP-4-keto-rhamnose C19725 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate C19745 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate C19823 UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose C19878 D-glycero-alpha-D-manno-Heptose 7-phosphate C19879 D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate C19880 D-glycero-alpha-D-manno-Heptose 1-phosphate C19881 GDP-D-glycero-alpha-D-manno-heptose C19947 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose C19960 dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose C19961 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine C19971 UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose C19972 2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose C20082 Pseudaminic acid C20083 CMP-pseudaminic acid C20156 dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose C20357 UDP-N,N'-diacetylbacillosamine C20359 UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate C20395 UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate C20415 dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose C20418 N,N'-Diacetyllegionaminate C20419 CMP-N,N'-diacetyllegionaminate C20424 2,4-Diacetamido-2,4,6-trideoxy-D-mannopyranose C20612 GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose C20613 GDP-beta-L-colitose C20638 GDP-4-amino-4,6-dideoxy-alpha-D-mannose C20672 GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose C20682 dTDP-alpha-D-fucofuranose C20768 UDP-2-acetamido-2,6-dideoxy-beta-L-talose C20769 UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-4-hexulose C20774 UDP-N-acetyl-beta-L-fucosamine C20934 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate C21383 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate C21384 CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate C22245 UDP-2-acetamido-2-deoxy-alpha-D-galacturonamide C22246 UDP-2,3-dideoxy-2-acetamido-3-acetamidino-alpha-D-mannuronic acid C22247 UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucopyranose C22248 UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-mannopyranose C22249 2-Acetamido-4-(D-alanylamino)-2,4,6-trideoxy-D-mannopyranose C22250 5-N-Acetyl-7-N-(D-alanyl)-legionaminic acid C22251 CMP-5-N-acetyl-7-N-(D-alanyl)-legionaminic acid C22252 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-idose C22253 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-gulose C22254 2,4-Diacetamido-2,4,6-trideoxy-beta-L-gulose C22255 5,7-Diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid C22256 CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid C22257 dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose C22261 UDP-2-acetamido-2,6-dideoxy-alpha-D-galactose C22262 UDP-2-acetamido-2,6-dideoxy-alpha-D-glucose C22270 UDP-2,6-dideoxy-2-acetamidino-beta-L-galactose C22276 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine C22397 GDP-N-formyl-alpha-D-perosamine C22575 UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-galactose C22576 UDP-2-acetamido-2-deoxy-L-altruronic acid C22938 UDP-N-acetyl-alpha-D-xylosamine C22973 UDP-yelosamine REFERENCE PMID:14670712 AUTHORS Samuel G, Reeves P TITLE Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly. JOURNAL Carbohydr Res 338:2503-19 (2003) DOI:10.1016/j.carres.2003.07.009 REFERENCE PMID:8939432 AUTHORS Burrows LL, Charter DF, Lam JS TITLE Molecular characterization of the Pseudomonas aeruginosa serotype O5 (PAO1) B-band lipopolysaccharide gene cluster. JOURNAL Mol Microbiol 22:481-95 (1996) DOI:10.1046/j.1365-2958.1996.1351503.x REFERENCE PMID:10627048 AUTHORS Belanger M, Burrows LL, Lam JS TITLE Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide. JOURNAL Microbiology 145 ( Pt 12):3505-21 (1999) DOI:10.1099/00221287-145-12-3505 REFERENCE PMID:10828401 AUTHORS Dean CR, Goldberg JB TITLE The wbpM gene in Pseudomonas aeruginosa serogroup O17 resides on a cryptic copy of the serogroup O11 O antigen gene locus. JOURNAL FEMS Microbiol Lett 187:59-63 (2000) DOI:10.1111/j.1574-6968.2000.tb09137.x REFERENCE PMID:15629947 AUTHORS Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L TITLE Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay. JOURNAL J Bacteriol 187:758-64 (2005) DOI:10.1128/JB.187.2.758-764.2005 REFERENCE PMID:18621892 AUTHORS Westman EL, Preston A, Field RA, Lam JS TITLE Biosynthesis of a rare di-N-acetylated sugar in the lipopolysaccharides of both Pseudomonas aeruginosa and Bordetella pertussis occurs via an identical scheme despite different gene clusters. JOURNAL J Bacteriol 190:6060-9 (2008) DOI:10.1128/JB.00579-08 REFERENCE PMID:19710102 AUTHORS King JD, Kocincova D, Westman EL, Lam JS TITLE Review: Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa. JOURNAL Innate Immun 15:261-312 (2009) DOI:10.1177/1753425909106436 REFERENCE PMID:20331420 AUTHORS Perepelov AV, Liu B, Senchenkova SN, Shashkov AS, Shevelev SD, Feng L, Wang L, Knirel YA TITLE Structure of the O-antigen and characterization of the O-antigen gene cluster of Escherichia coli O108 containing 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic (8-epilegionaminic) acid. JOURNAL Biochemistry (Mosc) 75:19-24 (2010) DOI:10.1134/s0006297910010037 REFERENCE PMID:26207987 AUTHORS Hwang S, Aronov A, Bar-Peled M TITLE The Biosynthesis of UDP-D-QuiNAc in Bacillus cereus ATCC 14579. JOURNAL PLoS One 10:e0133790 (2015) DOI:10.1371/journal.pone.0133790 REFERENCE PMID:30315110 AUTHORS McDonald ND, DeMeester KE, Lewis AL, Grimes CL, Boyd EF TITLE Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide. JOURNAL J Biol Chem 293:19113-19126 (2018) DOI:10.1074/jbc.RA118.004966 REL_PATHWAY hsa00030 Pentose phosphate pathway hsa00051 Fructose and mannose metabolism hsa00520 Amino sugar and nucleotide sugar metabolism KO_PATHWAY ko00541 ///