ENTRY D11927 Drug NAME Setmelanotide (USAN/INN); Imcivree (TN) FORMULA C49H68N18O9S2 EXACT_MASS 1116.4858 MOL_WEIGHT 1117.31 REMARK ATC code: A08AA12 Chemical structure group: DG03132 Product (DG03132): D11928 EFFICACY Antiobesity, Melanocortin receptor 4 agonist COMMENT Treatment of obesity TARGET MC4R [HSA:4160] [KO:K04202] PATHWAY hsa04080(4160) Neuroactive ligand-receptor interaction BRITE Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS A08AA Centrally acting antiobesity products A08AA12 Setmelanotide D11927 Setmelanotide (USAN/INN) Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Melanocortin MC4R D11927 Setmelanotide (USAN/INN) New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D11927 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D11927 DBLINKS CAS: 920014-72-8 PubChem: 497620340 ATOM 78 1 C1a C 13.3000 -18.4800 2 C1c C 14.5600 -19.2500 3 N1b N 15.7500 -18.4800 4 N1a N 18.1300 -18.4800 5 C5a C 19.3200 -19.2500 6 C1c C 20.5100 -18.4800 7 N1b N 21.7700 -19.2500 8 C5a C 14.5600 -20.6500 9 N1b N 15.7500 -21.3500 10 O5a O 13.3000 -21.3500 11 C1c C 15.7500 -22.7500 12 C5a C 15.7500 -17.0800 13 O5a O 14.4900 -16.4500 14 C1b C 20.5100 -17.0800 15 O5a O 19.3200 -20.6500 16 C5a C 21.7700 -20.6500 17 C1c C 22.9600 -21.3500 18 O5a O 20.5800 -21.3500 19 C1b C 24.0800 -20.6500 20 N1b N 22.9600 -22.7500 21 C5a C 21.7700 -23.4500 22 O5a O 20.5100 -22.7500 23 C1c C 21.7700 -24.7800 24 C8y C 25.2000 -21.3500 25 C8x C 25.2000 -22.7500 26 N4x N 26.6000 -23.1000 27 C8y C 27.3700 -22.0500 28 C8y C 26.6000 -20.8600 29 C8x C 28.7700 -22.0500 30 C8x C 29.4700 -20.7900 31 C8x C 28.7700 -19.6000 32 C8x C 27.3700 -19.6000 33 C1b C 22.9600 -25.4800 34 N1b N 20.5800 -25.4800 35 C5a C 19.3200 -24.7800 36 C1c C 18.1300 -25.4800 37 O5a O 19.3200 -23.4500 38 C1b C 24.1500 -24.7800 39 C1b C 25.2000 -25.4800 40 N1b N 26.4600 -24.7800 41 C2c C 27.6500 -25.4800 42 N1a N 28.8400 -24.7800 43 N2a N 27.6500 -26.8800 44 N1b N 16.9400 -24.7800 45 C1b C 18.1300 -26.8800 46 C8y C 19.3900 -27.5800 47 C8x C 19.3900 -28.9800 48 C8x C 20.5800 -29.6800 49 C8x C 21.8400 -28.9800 50 C8x C 21.8400 -27.5800 51 C8x C 20.5800 -26.8800 52 C5a C 16.9400 -23.4500 53 O5a O 18.2000 -22.6800 54 C1b C 14.5600 -23.4500 55 C8y C 14.5600 -24.7800 56 C8x C 13.4400 -25.6200 57 N5x N 13.8600 -26.9500 58 C8x C 15.2600 -26.9500 59 N4x N 15.6800 -25.5500 60 C1c C 16.9400 -16.3100 61 S3a S 19.3200 -16.3100 62 S3a S 19.3200 -14.9100 63 C1b C 16.9400 -14.9100 64 N1b N 15.7500 -15.6100 65 C5a C 15.7500 -14.2100 66 C1c C 14.4900 -13.5100 67 O5a O 16.9400 -13.5100 68 N1b N 13.3000 -14.2800 69 C1b C 14.4900 -12.1100 70 C5a C 12.1100 -13.5800 71 C1a C 10.9200 -14.2800 72 O5a O 12.1100 -12.1800 73 C1b C 15.6800 -11.4100 74 C1b C 16.8700 -12.1100 75 N1b N 18.0600 -11.4100 76 C2c C 19.2500 -12.1100 77 N1a N 20.4400 -11.4100 78 N2a N 19.2500 -13.5100 BOND 82 1 2 1 1 #Up 2 2 3 1 3 4 5 1 4 6 5 1 #Down 5 6 7 1 6 2 8 1 7 8 9 1 8 8 10 2 9 9 11 1 10 3 12 1 11 12 13 2 12 6 14 1 13 5 15 2 14 7 16 1 15 16 17 1 16 16 18 2 17 17 19 1 #Down 18 17 20 1 19 20 21 1 20 21 22 2 21 21 23 1 22 19 24 1 23 24 25 2 24 25 26 1 25 26 27 1 26 27 28 1 27 24 28 1 28 27 29 2 29 29 30 1 30 30 31 2 31 31 32 1 32 32 28 2 33 23 33 1 #Down 34 23 34 1 35 34 35 1 36 35 36 1 37 35 37 2 38 33 38 1 39 38 39 1 40 39 40 1 41 40 41 1 42 41 42 1 43 41 43 2 44 36 44 1 45 36 45 1 #Up 46 45 46 1 47 46 47 2 48 47 48 1 49 48 49 2 50 49 50 1 51 50 51 2 52 46 51 1 53 44 52 1 54 52 11 1 55 52 53 2 56 11 54 1 #Down 57 54 55 1 58 55 56 2 59 56 57 1 60 57 58 2 61 58 59 1 62 55 59 1 63 12 60 1 64 61 14 1 65 61 62 1 66 60 63 1 67 62 63 1 68 60 64 1 #Up 69 64 65 1 70 65 66 1 71 65 67 2 72 66 68 1 #Up 73 66 69 1 74 68 70 1 75 70 71 1 76 70 72 2 77 69 73 1 78 73 74 1 79 74 75 1 80 75 76 1 81 76 77 1 82 76 78 2 ///