ENTRY D02007 Drug NAME Protirelin tartrate hydrate (JP19); Hirtonin (TN) FORMULA C16H22N6O4. C4H6O6. H2O EXACT_MASS 530.1973 MOL_WEIGHT 530.49 REMARK Therapeutic category: 1190 7223 ATC code: V04CJ02 Chemical structure group: DG01171 Product (DG01171): D00176 D02007 EFFICACY Thyrotropin-releasing hormone receptor agonist COMMENT tripeptide TARGET TRHR [HSA:7201] [KO:K04282] PATHWAY hsa04020(7201) Calcium signaling pathway hsa04080(7201) Neuroactive ligand-receptor interaction BRITE Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] V VARIOUS V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CJ Tests for thyreoidea function V04CJ02 Protirelin D02007 Protirelin tartrate hydrate (JP19) <JP> Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 119 Miscellaneous 1190 Miscellaneous D02007 Protirelin tartrate hydrate (JP19) 7 Agents not mainly for therapeutic purpose 72 Intracorporeal diagnostic agents 722 Various function testing reagents 7223 Diagnostic reagents for endocrine function D02007 Protirelin tartrate hydrate (JP19) Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Thyrotropin-releasing hormone TRHR D02007 Protirelin tartrate hydrate (JP19) <JP> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D02007 Protirelin tartrate hydrate DBLINKS CAS: 53935-32-3 PubChem: 7849069 LigandBox: D02007 J-GLOBAL: J391.511E ATOM 37 1 C1x C 16.1545 -21.0629 2 C1y C 16.5734 -19.7134 3 N1x N 15.4564 -18.8757 4 C5x C 14.2929 -19.7134 5 C1x C 14.7583 -21.0629 6 C8y C 21.4135 -16.9676 7 C8x C 22.8097 -16.9676 8 N5x N 23.2285 -15.6177 9 C8x C 22.1116 -14.8266 10 N4x N 20.9946 -15.6177 11 C1x C 24.4385 -17.7122 12 C1x C 24.9039 -19.0618 13 C1y C 23.7404 -19.8996 14 N1y N 22.6235 -19.0618 15 C1x C 23.0424 -17.7122 16 C5a C 21.4135 -19.7599 17 C1c C 20.2035 -19.0618 18 N1b N 18.9933 -19.7599 19 C5a C 17.7834 -19.0618 20 O5a O 17.7834 -17.6657 21 C1b C 20.2035 -17.6657 22 C5a C 23.7404 -21.2956 23 O5a O 22.5304 -21.9937 24 N1a N 24.9505 -21.9937 25 O5a O 21.4135 -21.1560 26 O5x O 12.9897 -19.2945 27 O6a O 27.9304 -17.6636 28 C6a C 29.1429 -16.9636 29 C1c C 30.3553 -17.6636 30 C1c C 31.5677 -16.9636 31 C6a C 32.7802 -17.6636 32 O6a O 33.9926 -16.9636 33 O6a O 29.1429 -15.5636 34 O1a O 31.5677 -15.5636 35 O1a O 30.3553 -19.0636 36 O6a O 32.7802 -19.0636 37 O0 O 31.5001 -21.8634 BOND 37 1 11 12 1 2 12 13 1 3 13 14 1 4 14 15 1 5 15 11 1 6 4 5 1 7 14 16 1 8 6 7 2 9 16 17 1 10 7 8 1 11 17 18 1 12 8 9 2 13 18 19 1 14 9 10 1 15 19 20 2 16 10 6 1 17 17 21 1 #Up 18 21 6 1 19 5 1 1 20 13 22 1 #Up 21 22 23 2 22 1 2 1 23 22 24 1 24 2 3 1 25 16 25 2 26 2 19 1 #Down 27 3 4 1 28 4 26 2 29 27 28 1 30 28 29 1 31 29 30 1 32 30 31 1 33 31 32 1 34 28 33 2 35 30 34 1 #Up 36 29 35 1 #Up 37 31 36 2 ///