ENTRY       R02736                      Reaction
NAME        beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase
DEFINITION  beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
EQUATION    C01172 + C00006 <=> C01236 + C00005 + C00080
COMMENT     irreversible
RCLASS      RC00001  C00005_C00006
            RC00066  C01172_C01236
ENZYME      1.1.1.49        1.1.1.363
PATHWAY     rn00030  Pentose phosphate pathway
            rn00480  Glutathione metabolism
            rn01100  Metabolic pathways
            rn01110  Biosynthesis of secondary metabolites
            rn01120  Microbial metabolism in diverse environments
            rn01200  Carbon metabolism
MODULE      M00004  Pentose phosphate pathway (Pentose phosphate cycle)
            M00006  Pentose phosphate pathway, oxidative phase, glucose-6P => ribulose-5P
            M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate
BRITE       Enzymatic reactions [BR:br08201]
             1. Oxidoreductase reactions
              1.1  Acting on the CH-OH group of donors
               1.1.1  With NAD+ or NADP+ as acceptor
                1.1.1.49
                 R02736  beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
                1.1.1.363
                 R02736  beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
            IUBMB reaction hierarchy [BR:br08202]
             1. Oxidoreductase reactions
              1.1.1.49
               R00835  D-Glucose 6-phosphate
                R02736  beta-D-Glucose 6-phosphate
              1.1.1.363
               R00835  D-Glucose 6-phosphate
                R02736  beta-D-Glucose 6-phosphate
ORTHOLOGY   K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
            K13937  hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]
REFERENCE   1  [PMID:14275652]
  AUTHORS   SALAS M, VINUELA E, SOLS A.
  TITLE     SPONTANEOUS AND ENZYMATICALLY CATALYZED ANOMERIZATION OF GLUCOSE 6-PHOSPHATE AND  ANOMERIC SPECIFICITY OF RELATED ENZYMES.
  JOURNAL   J Biol Chem 240:561-8 (1965)
REFERENCE   2  [PMID:11457850]
  AUTHORS   Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F.
  TITLE     NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase.
  JOURNAL   J Biol Chem 276:34840-6 (2001)
            DOI:10.1074/jbc.M105174200
REFERENCE   3  [PMID:9485426]
  AUTHORS   Cosgrove MS, Naylor C, Paludan S, Adams MJ, Levy HR
  TITLE     On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.
  JOURNAL   Biochemistry 37:2759-67 (1998)
            DOI:10.1021/bi972069y
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