ENTRY M00373 Pathway Module NAME Ethylmalonyl pathway DEFINITION K00626 K00023 K17865 K14446 K14447 K14448 K14449 K08691 K14451 K01965+K01966 K05606 K01847 DIAGRAM M00373 Ethylmalonyl pathway CLASS Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism PATHWAY map00630 Glyoxylate and dicarboxylate metabolism map01200 Carbon metabolism map01100 Metabolic pathways map01120 Microbial metabolism in diverse environments ORTHOLOGY K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238] K00023 acetoacetyl-CoA reductase [EC:1.1.1.36] [RN:R01977] K17865 3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55] [RN:R03027] K14446 crotonyl-CoA carboxylase/reductase [EC:1.3.1.85] [RN:R09291] K14447 ethylmalonyl-CoA mutase [EC:5.4.99.63] [RN:R09292] K14448 (2S)-methylsuccinyl-CoA dehydrogenase [EC:1.3.8.12] [RN:R09293] K14449 2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [RN:R05076] K08691 malyl-CoA lyase [EC:4.1.3.24] [RN:R00934 R00473] K14451 (3S)-malyl-CoA thioesterase [RN:R10612] K01965+K01966 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] K05606 methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765 R09979] K01847 methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833] COMPLETE mens Methylobacterium sp. NMS14P sil Ruegeria pomeroyi sit Ruegeria sp. TM1040 rua Ruegeria sp. AD91A rut Ruegeria sp. THAF33 rcon Ruegeria conchae ruy Ruegeria sp. YS9 jan Jannaschia sp. CCS1 rde Roseobacter denitrificans rli Roseobacter litoralis rpon Roseobacter ponti rfu Roseobacter fucihabitans dsh Dinoroseobacter shibae pga Phaeobacter inhibens DSM 17395 pgl Phaeobacter inhibens 2.10 pgd Phaeobacter gallaeciensis DSM 26640 php Phaeobacter porticola ppic Phaeobacter piscinae phq Phaeobacter sp. LSS9 phae Phaeobacter sp. G2 oat Octadecabacter antarcticus oar Octadecabacter arcticus otm Octadecabacter temperatus oct Octadecabacter sp. SW4 lmd Leisingera methylohalidivorans lej Leisingera sp. NJS204 laqu Leisingera aquaemixtae lcae Leisingera caerulea leim Leisingera sp. M523 cid Celeribacter indicus cmar Celeribacter marinus ceh Celeribacter ethanolicus malg Marinovum algicola con Actibacterium sp. EMB200-NS6 ypac Alloyangia pacifica yan Salipiger sp. CCB-MM3 tpro Salipiger profundus paby Salipiger abyssi suam Sulfitobacter alexandrii sulz Sulfitobacter sp. SK012 suli Sulfitobacter sp. JL08 suld Sulfitobacter sp. D7 spot Sulfitobacter pontiacus smed Sulfitobacter mediterraneus sinl Sulfitobacter indolifex sfav Sulfitobacter faviae sdub Sulfitobacter dubius sulb Sulfitobacter sp. CB2047 suly Sulfitobacter sp. TCYB15 sulp Sulfitobacter sp. PM12 susq Sulfitobacter sp. S190 spse Pseudosulfitobacter pseudonitzschiae tom Tateyamaria omphalii tate Tateyamaria algicola taty Tateyamaria rhodophyticola rmm Roseovarius mucosus rok Roseovarius sp. AK1035 rid Roseovarius indicus rom Roseovarius faecimaris roh Roseovarius sp. THAF27 rpel Roseovarius pelagicus rphc Roseovarius phycicola aht Antarctobacter heliothermus malu Antarctobacter albus sagu Sagittula sp. P11 sstl Sagittula stellata sagz Sagittula sp. MA-2 thaa Thalassococcus sp. S3 ocd Oceanicola sp. D3 rot Roseivivax sp. THAF197b rmh Roseivivax marinus tgl Thalassovita gelatinovora palx Ponticoccus alexandrii lsal Loktanella salsilacus lalg Lentibacter algarum try Pacificoceanicola oceani maru Palleronia sp. THAF1 rmai Roseicyclus marinus acld Algirhabdus cladophorae seoh Seohaeicola sp. tig00000074 matg Marivita sp. tig00000067 boo Rhodophyticola sp. CCM32 rpoh Rhodophyticola porphyridii rsp Cereibacter sphaeroides 2.4.1 rsh Cereibacter sphaeroides ATCC 17029 rsq Cereibacter sphaeroides ATCC 17025 rsk Cereibacter sphaeroides KD131 cazt Cereibacter azotoformans rbl Pseudogemmobacter blasticus fyt Fuscovulum ytuae pde Paracoccus denitrificans pami Paracoccus aminophilus pye Paracoccus yeei pcon Paracoccus contaminans pzh Paracoccus zhejiangensis paro Paracoccus tegillarcae pamn Paracoccus aminovorans parr Paracoccus sp. Arc7-R13 paak Paracoccus sp. AK26 pkd Paracoccus kondratievae ppan Paracoccus pantotrophus plia Paracoccus liaowanqingii psan Paracoccus sanguinis pmau Paracoccus marcusii pmeh Paracoccus methylovorus psew Paracoccus seriniphilus psap Paracoccus saliphilus pfis Paracoccus fistulariae paex Paracoccus aestuarii pstl Paracoccus stylophorae palp Paracoccus alcaliphilus pver Paracoccus versutus pfeo Paracoccus ferrooxidans phoi Paracoccus homiensis ptp Planktomarina temperata rsu Rhodovulum sulfidophilum rhm Rhodovulum sp. MB263 rhc Rhodovulum sp. P5 rhov Rhodovulum sp. HP10 tsco Tritonibacter scottomollicae daa Frigidibacter mobilis don Marivivens sp. JLT3646 malc Marivivens sp. LCG002 rbz Aestuarium zhoushanense tec Thioclava electrotropha tlb Thioclava litoralis lvs Yoonia vestfoldensis yag Yoonia algicola yrh Yoonia rhodophyticola geh Paragemmobacter aquarius gfu Gemmobacter fulvus taw Tabrizicola piscis salo Silicimonas algicola sedi Parasedimentitalea marina ppso Parasedimentitalea psychrophila pseb Pseudorhodobacter turbinis ppru Paroceanicella profunda paed Pseudohalocynthiibacter aestuariivivens pamo Profundibacter amoris poz Pontivivens ytuae mon Pontivivens nitratireducens palw Pseudooceanicola algae pshq Pseudooceanicola spongiae cact Cognatishimia activa thas Pukyongiella litopenaei hdh Pikeienuella piscinae cmag Pacificitalea manganoxidans gce Gymnodinialimonas ceratoperidinii gyj Gymnodinialimonas sp. 57CJ19 nsm Neotabrizicola shimadae acro Aliiroseovarius crassostreae aalk Abyssibius alkaniclasticus amyl Amylibacter sp. IMCC11727 amaq Algicella marina pbae Roseinatronobacter sp. S2 rbg Roseinatronobacter bogoriensis subsp. barguzinensis bosg Boseongicola sp. MH-Pat-all_autometa_1-3 manh Marinibacterium anthonyi faq Rhodobacteraceae bacterium SC52 sinr Sinirhodobacter sp. HNIBRBA609 rcp Rhodobacter capsulatus rhp Rhodobacter xanthinilyticus rbx Rhodobacterales bacterium HKCCA1288 REACTION R00238 C00024 -> C00332 R01977 C00332 -> C03561 R03027 C03561 -> C00877 R09291 C00877 -> C18026 R09979 C18026 -> C20238 R09292 C20238 -> C18324 R09293 C18324 -> C06028 R05076 C06028 -> C06027 R00934 C06027 -> C00100 + C00048 R00473 C00048 -> C04348 R10612 C04348 -> C00149 R01859 C00100 -> C00683 R02765 C00683 -> C01213 R00833 C01213 -> C00091 COMPOUND C00024 Acetyl-CoA C00332 Acetoacetyl-CoA C03561 (R)-3-Hydroxybutanoyl-CoA C00877 Crotonoyl-CoA C18026 (2S)-Ethylmalonyl-CoA C20238 (2R)-Ethylmalonyl-CoA C18324 (2S)-Methylsuccinyl-CoA C06028 2-Methylfumaryl-CoA C06027 L-erythro-3-Methylmalyl-CoA C00100 Propanoyl-CoA C00048 Glyoxylate C04348 L-Malyl-CoA C00149 (S)-Malate C00683 (S)-Methylmalonyl-CoA C01213 (R)-Methylmalonyl-CoA C00091 Succinyl-CoA REFERENCE PMID:18065535 AUTHORS Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G TITLE Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria. JOURNAL J Bacteriol 190:1366-74 (2008) DOI:10.1128/JB.01621-07 REFERENCE PMID:18819910 AUTHORS Erb TJ, Retey J, Fuchs G, Alber BE TITLE Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases. JOURNAL J Biol Chem 283:32283-93 (2008) DOI:10.1074/jbc.M805527200 ///