ENTRY M00357 Pathway Module NAME Methanogenesis, acetate => methane DEFINITION ((K00925 K00625),K01895) (K00193+K00197+K00194) (K00577+K00578+K00579+K00580+K00581-K00582-K00583+K00584) (K00399+K00401+K00402) (K22480+K22481+K22482,K03388+K03389+K03390,K08264+K08265,K03388+K03389+K03390+K14127+(K14126+K14128,K22516+K00125)) DIAGRAM M00357 Methanogenesis, acetate => methane CLASS Pathway modules; Energy metabolism; Methane metabolism PATHWAY map00680 Methane metabolism map01200 Carbon metabolism map01100 Metabolic pathways map01120 Microbial metabolism in diverse environments ORTHOLOGY K00925 acetate kinase [EC:2.7.2.1] [RN:R00315] K00625 phosphate acetyltransferase [EC:2.3.1.8] [RN:R00230] K01895 acetyl-CoA synthetase [EC:6.2.1.1] [RN:R00235] K00193+K00197+K00194 acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R09096] K00577+K00578+K00579+K00580+K00581-K00582-K00583+K00584 tetrahydromethanopterin S-methyltransferase [EC:7.2.1.4] [RN:R04347] K00399+K00401+K00402 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] K22480+K22481+K22482 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] K03388+K03389+K03390 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] K08264+K08265 heterodisulfide reductase [EC:1.8.98.1] [RN:R04540] K14126+K14128 F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943] K14127 F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944] K22516+K00125 formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944] COMPLETE mfe Methanocaldococcus fervens mmp Methanococcus maripaludis S2 mmq Methanococcus maripaludis C5 mmx Methanococcus maripaludis C6 mmz Methanococcus maripaludis C7 mmd Methanococcus maripaludis X1 mmak Methanococcus maripaludis KA1 mmao Methanococcus maripaludis OS7 mmad Methanococcus maripaludis DSM 2067 mok Methanothermococcus okinawensis mth Methanothermobacter thermautotrophicus mmg Methanothermobacter marburgensis mwo Methanothermobacter wolfeii metc Methanothermobacter sp. CaT2 mete Methanothermobacter sp. EMTCatA1 metk Methanothermobacter sp. KEPCO-1 mthm Methanothermobacter sp. THM-1 metj Methanothermobacter sp. THM-2 maro Methanobrevibacter arboriphilus mel Methanobacterium lacus mew Methanobacterium paludis meth Methanobacterium sp. MB1 mfc Methanobacterium formicicum BRM9 mfi Methanobacterium formicicum DSM1535 mcub Methanobacterium congolense msub Methanobacterium subterraneum metn Methanobacterium sp. MZ-A1 mett Methanobacterium sp. BRmetb2 meto Methanobacterium sp. BAmetb5 meme Methanobacterium alkalithermotolerans mfeg Methanobacterium ferruginis mrid Methanobacterium aridiramus mfv Methanothermus fervidus mba Methanosarcina barkeri Fusaro mby Methanosarcina barkeri MS mbw Methanosarcina barkeri Wiesmoor mbar Methanosarcina barkeri 227 mbak Methanosarcina barkeri 3 mac Methanosarcina acetivorans mma Methanosarcina mazei Go1 mmaz Methanosarcina mazei Tuc01 mmj Methanosarcina mazei S-6 mmac Methanosarcina mazei C16 mvc Methanosarcina vacuolata mek Methanosarcina sp. Kolksee mls Methanosarcina lacustris metm Methanosarcina sp. MTP4 mef Methanosarcina sp. WH1 meq Methanosarcina sp. WWM596 msj Methanosarcina siciliae C2J msz Methanosarcina siciliae HI350 msw Methanosarcina siciliae T4/M mthr Methanosarcina thermophila TM-1 mthe Methanosarcina thermophila CHTI-55 mhor Methanosarcina horonobensis mfz Methanosarcina flavescens mhab Methanosarcina hadiensis metw Methanosarcina sp. 795 mbu Methanococcoides burtonii mmet Methanococcoides methylutens melo Methanococcoides orientis mmh Methanohalophilus mahii mhaz Methanohalophilus halophilus mpot Methanohalophilus portucalensis mev Methanohalobium evestigatum mzh Methanosalsum zhilinae mpy Methanolobus psychrophilus mzi Methanolobus zinderi mmav Methanolobus mangrovi mseb Methanolobus sediminis mhz Methanomethylovorans hollandica mehf Methanimicrococcus hongohii mees Methanimicrococcus stummii mtp Methanothrix thermoacetophila mcj Methanothrix soehngenii mhi Methanothrix harundinacea mhu Methanospirillum hungatei mrtj Methanospirillum purgamenti mbg Methanoculleus bourgensis MS2 mema Methanoculleus bourgensis MAB1 mbn Methanoregula boonei mfo Methanoregula formicica mpl Methanosphaerula palustris rci Methanocella arvoryzae REACTION R00315 C00033 -> C00227 R00230 C00227 -> C00024 R00235 C00033 -> C00024 R09096 C00024 -> C04488 R04347 C04488 + C03576 -> C03920 R04541 C03920 + C04628 -> C01438 + C04832 R11931,R04540,R11928,R11943,R11944 C04832 -> C04628 + C03576 COMPOUND C00033 Acetate C00227 Acetyl phosphate C00024 Acetyl-CoA C04488 5-Methyl-5,6,7,8-tetrahydromethanopterin C03576 Coenzyme M C03920 2-(Methylthio)ethanesulfonate C04628 Coenzyme B C01438 Methane C04832 Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide REFERENCE PMID:18378594 AUTHORS Liu Y, Whitman WB TITLE Metabolic, phylogenetic, and ecological diversity of the methanogenic archaea. JOURNAL Ann N Y Acad Sci 1125:171-89 (2008) DOI:10.1196/annals.1419.019 REFERENCE PMID:16024727 AUTHORS Welander PV, Metcalf WW TITLE Loss of the mtr operon in Methanosarcina blocks growth on methanol, but not methanogenesis, and reveals an unknown methanogenic pathway. JOURNAL Proc Natl Acad Sci U S A 102:10664-9 (2005) DOI:10.1073/pnas.0502623102 ///