ENTRY       D12898                      Drug
NAME        Survodutide (USAN/INN)
FORMULA     C192H289N47O61
EXACT_MASS  4229.0957
MOL_WEIGHT  4231.63
SEQUENCE    (A chain)
            HXQGTFTSDY SKYLDERAAK DFIKWLESA
            (B chain)
            EGSGSGG
            (Amide bridge: A24-B7)
  TYPE      Peptide
CLASS       Antidiabetic agent
             DG02044  Hypoglycemic agent
              DG01493  GLP-1 receptor agonist
             DG03355  Oxyntomodulin analog
EFFICACY    Glucagon-like peptide 1 (GLP-1) receptor agonist, Glucagon receptor agonist
  TYPE      Modified peptide
COMMENT     Treatment of obesity and non-alcoholic steatohepatitis (NASH)
TARGET      GLP1R [HSA:2740] [KO:K04581]
            GCGR [HSA:2642] [KO:K04583]
  PATHWAY   hsa04024(2740)  cAMP signaling pathway
            hsa04080(2642+2740)  Neuroactive ligand-receptor interaction
            hsa04911(2740)  Insulin secretion
            hsa04922(2642)  Glucagon signaling pathway
INTERACTION  
BRITE       Drug groups [BR:br08330]
             Antidiabetic agent
              DG02044  Hypoglycemic agent
               DG01493  GLP-1 receptor agonist
                D12898  Survodutide
              DG03355  Oxyntomodulin analog
               D12898  Survodutide
            Target-based classification of drugs [BR:br08310]
             G Protein-coupled receptors
              Secretin receptor family
               Glucagon
                GLP1R
                 D12898  Survodutide (USAN/INN)
                GCGR
                 D12898  Survodutide (USAN/INN)
DBLINKS     CAS: 2805997-46-8
            PubChem: 497621311
///