ENTRY       D12430                      Drug
NAME        Retatrutide (USAN)
FORMULA     C221H342N46O68
EXACT_MASS  4728.4718
MOL_WEIGHT  4731.34
SEQUENCE    YXQGTFTSDY SILLDKKAQX AFIEYLLEGG PSSGAPPPS
  TYPE      Peptide
EFFICACY    Antidiabetic, Antiobesity
  TYPE      Modified peptide
COMMENT     Glycemic control and obesity
TARGET      GCGR [HSA:2642] [KO:K04583]
            GIPR [HSA:2696] [KO:K04580]
            GLP1R [HSA:2740] [KO:K04581]
  PATHWAY   hsa04080(2642+2696+2740)  Neuroactive ligand-receptor interaction
            hsa04911(2740)  Insulin secretion
            hsa04922(2642)  Glucagon signaling pathway
BRITE       Target-based classification of drugs [BR:br08310]
             G Protein-coupled receptors
              Secretin receptor family
               Glucagon
                GLP1R
                 D12430  Retatrutide (USAN)
                GCGR
                 D12430  Retatrutide (USAN)
               Gastric inhibitory polypeptide
                GIPR
                 D12430  Retatrutide (USAN)
DBLINKS     CAS: 2381089-83-2
            PubChem: 497620843
///