ENTRY       D12225                      Drug
NAME        Mazdutide (USAN/INN)
FORMULA     C210H322N46O67
EXACT_MASS  4560.3203
MOL_WEIGHT  4563.07
SEQUENCE    HXQGTFTSDY SKYLDEKKAK EFVEWLLEGG PSSG
  TYPE      Peptide
CLASS       Antidiabetic agent
             DG02044  Hypoglycemic agent
              DG01493  GLP-1 receptor agonist
             DG03355  Oxyntomodulin analog
EFFICACY    Antidiabetic, Antiobesity, Glucagon-like peptide 1 (GLP-1) receptor agonist, Glucagon receptor agonist
  TYPE      Modified peptide
COMMENT     Treatment of diabetes, NASH and obesity
TARGET      GLP1R [HSA:2740] [KO:K04581]
            GCGR [HSA:2642] [KO:K04583]
  PATHWAY   hsa04024(2641+2740)  cAMP signaling pathway
            hsa04080(2641+2740)  Neuroactive ligand-receptor interaction
            hsa04911(2641+2740)  Insulin secretion
            hsa04922(2641)  Glucagon signaling pathway
INTERACTION  
BRITE       Drug groups [BR:br08330]
             Antidiabetic agent
              DG02044  Hypoglycemic agent
               DG01493  GLP-1 receptor agonist
                D12225  Mazdutide
              DG03355  Oxyntomodulin analog
               D12225  Mazdutide
            Target-based classification of drugs [BR:br08310]
             G Protein-coupled receptors
              Secretin receptor family
               Glucagon
                GLP1R
                 D12225  Mazdutide (USAN/INN)
                GCGR
                 D12225  Mazdutide (USAN/INN)
DBLINKS     CAS: 2259884-03-0
            PubChem: 497620638
///