ENTRY D11542 Drug NAME Elamipretide hydrochloride (USAN); Forzinity (TN) PRODUCT FORZINITY (Stealth Biotherapeutics) FORMULA C32H49N9O5. 3HCl EXACT_MASS 747.3157 MOL_WEIGHT 749.17 REMARK Chemical structure group: DG03046 Product (DG03046): D11542 EFFICACY Mitochondrial protective DISEASE Barth syndrome [DS:H00654] COMMENT Mitochondrial protective agent to improve cell viability TARGET Citochondrial cardiolipin [CPD:C05980] BRITE New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D11542 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D11542 DBLINKS CAS: 2244098-12-0 PubChem: 384585518 ATOM 49 1 N1a N 10.9315 -16.8878 2 C1c C 12.1228 -16.1871 3 C5a C 13.3141 -16.8878 4 N1b N 14.5053 -16.1871 5 C1c C 15.6966 -16.8878 6 C5a C 16.8878 -16.1871 7 N1b N 18.0791 -16.8878 8 C1c C 19.2704 -16.1871 9 C5a C 20.4616 -16.8878 10 N1b N 21.6529 -16.1871 11 C1c C 22.8441 -16.8878 12 C5a C 23.9653 -16.1871 13 N1a N 25.1566 -16.8878 14 O5a O 23.9653 -14.7856 15 C1b C 22.8441 -18.2192 16 C8y C 23.9653 -18.9200 17 C8x C 23.9653 -20.2514 18 C8x C 25.1566 -20.9521 19 C8x C 26.3478 -20.2514 20 C8x C 26.3478 -18.9200 21 C8x C 25.1566 -18.2192 22 O5a O 20.4616 -18.2192 23 C1b C 19.2704 -14.7856 24 O5a O 16.8878 -14.7856 25 C1b C 20.4616 -14.0849 26 C1b C 20.4616 -12.7535 27 C1b C 21.6529 -12.0527 28 N1a N 21.6529 -10.6513 29 C1b C 15.6966 -19.6207 30 C8y C 16.8878 -20.3215 31 C8y C 16.8878 -21.6529 32 C8x C 18.0791 -22.3536 33 C8y C 19.2704 -21.6529 34 C8x C 19.2704 -20.3215 35 C8y C 18.0791 -19.6207 36 O1a O 20.4616 -22.3536 37 C1a C 15.6966 -22.3536 38 C1a C 18.0791 -18.2192 39 O5a O 13.3141 -18.2192 40 C1b C 12.1228 -14.7856 41 C1b C 13.3141 -14.0849 42 C1b C 13.3141 -12.7535 43 N1b N 14.5053 -12.0527 44 C2c C 14.5053 -10.6513 45 N1a N 15.6966 -10.0206 46 N2a N 13.3141 -10.0206 47 X Cl 27.6500 -11.6900 48 X Cl 27.6500 -11.6900 49 X Cl 27.6500 -11.6900 BOND 47 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 6 7 1 7 7 8 1 8 8 9 1 9 9 10 1 10 10 11 1 11 11 12 1 12 12 13 1 13 12 14 2 14 11 15 1 #Down 15 15 16 1 16 16 17 2 17 17 18 1 18 18 19 2 19 19 20 1 20 20 21 2 21 16 21 1 22 9 22 2 23 8 23 1 #Up 24 6 24 2 25 23 25 1 26 25 26 1 27 26 27 1 28 27 28 1 29 5 29 1 #Down 30 29 30 1 31 30 31 2 32 31 32 1 33 32 33 2 34 33 34 1 35 34 35 2 36 30 35 1 37 33 36 1 38 31 37 1 39 35 38 1 40 3 39 2 41 2 40 1 #Down 42 40 41 1 43 41 42 1 44 42 43 1 45 43 44 1 46 44 45 1 47 44 46 2 BRACKET 1 25.9700 -12.3200 25.9700 -10.7800 1 28.4200 -10.7800 28.4200 -12.3200 1 3 ORIGINAL 1 47 REPEAT 1 48 49 ///