ENTRY       D11113                      Drug
NAME        Levothyroxine sodium (INN);
            Levothyroxine sodium anhydrous
PRODUCT     LEVOTHYROXINE SODIUM (ENDO USA)
            LEVOTHYROXINE SODIUM (Fresenius Kabi USA)
            LEVOTHYROXINE SODIUM (Fresenius Kabi USA)
            LEVOTHYROXINE SODIUM (Fresenius Kabi USA)
            LEVOTHYROXINE SODIUM (Fresenius Kabi USA)
            LEVOTHYROXINE SODIUM (Fresenius Kabi USA)
            LEVOTHYROXINE SODIUM (Hikma Pharmaceuticals USA)
  GENERIC   LEVOTHYROXINE SODIUM (Fosun Pharma USA)
            LEVOTHYROXINE SODIUM (MAIA Pharmaceuticals)
            LEVOTHYROXINE SODIUM (ONESOURCE SPECIALTY PHARMA LIMITED)
            LEVOTHYROXINE SODIUM (Piramal Critical Care)
            LEVOTHYROXINE SODIUM (Sagent Pharmaceuticals)
            LEVOTHYROXINE SODIUM (Zydus Lifesciences Limited)
            LEVOTHYROXINE SODIUM (Zydus Pharmaceuticals USA)
FORMULA     C15H10I4NO4. Na
EXACT_MASS  798.6686
MOL_WEIGHT  798.85
CLASS       Hormonal agent
             DG01953  Thyroid preparation
              DG01608  Thyroid hormone replenisher
REMARK      Same as: C08212
            ATC code: H03AA01
            Chemical structure group: DG00510
            Product (DG00510): D01010<JP/US> D11113<US>
EFFICACY    Replenisher (thyroid hormone)
COMMENT     Treatment of myxedema coma
TARGET      NR1A (THR) [HSA:7067 7068] [KO:K05547 K08362]
  PATHWAY   hsa04080(7067+7068)  Neuroactive ligand-receptor interaction
            hsa04919(7067+7068)  Thyroid hormone signaling pathway
INTERACTION  
BRITE       Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
             H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
              H03 THYROID THERAPY
               H03A THYROID PREPARATIONS
                H03AA Thyroid hormones
                 H03AA01 Levothyroxine sodium
                  D11113  Levothyroxine sodium (INN) &lt;US&gt;
            USP drug classification [BR:br08302]
             Hormonal Agents, Stimulant/Replacement/Modifying (Thyroid)
              Levothyroxine
               D11113  Levothyroxine sodium (INN)
            Drug groups [BR:br08330]
             Hormonal agent
              DG01953  Thyroid preparation
               DG01608  Thyroid hormone replenisher
                DG00510  Levothyroxine
                 D11113  Levothyroxine sodium
            Target-based classification of drugs [BR:br08310]
             Nuclear receptors
              Thyroid hormone like receptors
               Thyroid hormone receptor (THR)
                NR1A (THR)
                 D11113  Levothyroxine sodium (INN) &lt;US&gt;
            Drug groups [BR:br08330]
             Hormonal agent
              DG01953  Thyroid preparation
               DG01608  Thyroid hormone replenisher
                DG00510  Levothyroxine
DBLINKS     CAS: 55-03-8
            PubChem: 376219037
ATOM        25
            1   C8y C    23.1126  -16.8804
            2   O2a O    21.9219  -16.1800
            3   C8x C    23.1126  -18.2813
            4   C8x C    24.3734  -16.1800
            5   C8y C    20.7311  -15.4795
            6   C8y C    24.3734  -18.9817
            7   C8y C    25.5641  -16.8804
            8   C8y C    19.5404  -16.1800
            9   C8y C    20.7311  -14.0787
            10  C8y C    25.5641  -18.2813
            11  X   I    24.3734  -20.3826
            12  X   I    26.7548  -16.1099
            13  C8x C    18.2796  -15.4795
            14  X   I    19.5404  -17.5808
            15  C8x C    19.5404  -13.3782
            16  X   I    21.9219  -13.3782
            17  O1a O    26.8249  -18.9116
            18  C8y C    18.2796  -14.0787
            19  C1b C    17.0889  -13.3782
            20  C1c C    15.8982  -14.0787
            21  C6a C    14.7074  -13.3782
            22  N1a N    15.8982  -15.4795
            23  O6a O    14.7074  -11.9774
            24  O6a O    13.5167  -14.0787 #-
            25  Z   Na   10.4348  -14.1487 #+
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1
            8     5   9 2
            9     6  10 2
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13    8  14 1
            14    9  15 1
            15    9  16 1
            16   10  17 1
            17   13  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   20  22 1 #Down
            22   21  23 2
            23   21  24 1
            24    7  10 1
            25   15  18 2
///