ENTRY D10537 Drug NAME Methylthioninium chloride hydrate (JAN); Methylene blue (TN) FORMULA C16H18N3S. Cl. xH2O CLASS Metabolizing enzyme inhibitor DG01634 CYP1A2 inhibitor DG02892 CYP2B6 inhibitor DG01643 CYP2C9 inhibitor DG01933 CYP2C19 inhibitor REMARK Therapeutic category: 3929 ATC code: V03AB17 V04CG05 Chemical structure group: DG01156 Product (DG01156): D02312 D10537 EFFICACY Antimethemoglobinemic INTERACTION CYP inhibition: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557] BRITE Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] V VARIOUS V03 ALL OTHER THERAPEUTIC PRODUCTS V03A ALL OTHER THERAPEUTIC PRODUCTS V03AB Antidotes V03AB17 Methylthioninium chloride D10537 Methylthioninium chloride hydrate (JAN) <JP> V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CG Tests for gastric secretion V04CG05 Methylthioninium chloride D10537 Methylthioninium chloride hydrate (JAN) <JP> Therapeutic category of drugs in Japan [BR:br08301] 3 Agents affecting metabolism 39 Other agents affecting metabolism 392 Antidotes 3929 Others D10537 Methylthioninium chloride hydrate (JAN) Drug groups [BR:br08330] Metabolizing enzyme inhibitor DG01634 CYP1A2 inhibitor DG01156 Methylthioninium chloride D10537 Methylthioninium chloride hydrate DG02892 CYP2B6 inhibitor DG01156 Methylthioninium chloride D10537 Methylthioninium chloride hydrate DG01643 CYP2C9 inhibitor DG01156 Methylthioninium chloride D10537 Methylthioninium chloride hydrate DG01933 CYP2C19 inhibitor DG01156 Methylthioninium chloride D10537 Methylthioninium chloride hydrate New drug approvals in Japan [br08318.html] Drugs with new active ingredients D10537 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D10537 Drug groups [BR:br08330] Metabolizing enzyme inhibitor DG01634 CYP1A2 inhibitor DG01156 Methylthioninium chloride DG02892 CYP2B6 inhibitor DG01156 Methylthioninium chloride DG01643 CYP2C9 inhibitor DG01156 Methylthioninium chloride DG01933 CYP2C19 inhibitor DG01156 Methylthioninium chloride DBLINKS PubChem: 254741499 ATOM 22 1 C8y C 19.8100 -15.2600 2 C8y C 19.8100 -16.6600 3 S2x S 21.0000 -17.3600 #+ 4 C8y C 22.2600 -16.6600 5 C8y C 22.2600 -15.2600 6 N5x N 21.0000 -14.5600 7 C8x C 23.4500 -17.3600 8 C8y C 24.6400 -16.6600 9 C8x C 24.6400 -15.2600 10 C8x C 23.4500 -14.5600 11 C8x C 18.6200 -14.5600 12 C8x C 17.3600 -15.2600 13 C8y C 17.3600 -16.6600 14 C8x C 18.6200 -17.3600 15 N1c N 25.8300 -17.3600 16 C1a C 27.0200 -16.6600 17 C1a C 25.8300 -18.7600 18 N1c N 16.1700 -17.3600 19 C1a C 14.9800 -16.6600 20 C1a C 16.1700 -18.7600 21 X Cl 21.0700 -18.9700 #- 22 O0 O 33.8800 -18.0600 BOND 22 1 1 2 1 2 2 3 2 3 3 4 1 4 4 5 2 5 5 6 1 6 1 6 2 7 4 7 1 8 7 8 2 9 8 9 1 10 9 10 2 11 5 10 1 12 1 11 1 13 11 12 2 14 12 13 1 15 13 14 2 16 2 14 1 17 8 15 1 18 15 16 1 19 15 17 1 20 13 18 1 21 18 19 1 22 18 20 1 BRACKET 1 31.7800 -18.8300 31.7800 -16.9400 1 34.5100 -16.9400 34.5100 -18.8300 1 x ORIGINAL 1 22 REPEAT 1 ///