ENTRY D08856 Drug NAME Anamorelin hydrochloride (JAN/USAN); Adlumiz (TN) FORMULA C31H42N6O3. HCl EXACT_MASS 582.3085 MOL_WEIGHT 583.16 CLASS Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate REMARK Therapeutic category: 3999 Product: D08856 EFFICACY Antineoplastic, Growth hormone secretagogue receptor (GHSR) agonist COMMENT Anamorelin is a non-peptidic ghrelin [CPD:C16025] mimetic Treatment of cancer anorexia and cancer cachexia TARGET GHSR [HSA:2693] [KO:K04284] PATHWAY hsa04080(2693) Neuroactive ligand-receptor interaction METABOLISM Enzyme: CYP3A4 [HSA:1576] INTERACTION BRITE Therapeutic category of drugs in Japan [BR:br08301] 3 Agents affecting metabolism 39 Other agents affecting metabolism 399 Miscellaneous 3999 Others D08856 Anamorelin hydrochloride (JAN/USAN) Drug groups [BR:br08330] Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate D08856 Anamorelin hydrochloride Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Ghrelin GHSR D08856 Anamorelin hydrochloride (JAN/USAN) <JP> New drug approvals in Japan [br08318.html] Drugs with new active ingredients D08856 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D08856 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D08856 DBLINKS CAS: 861998-00-7 PubChem: 96025539 LigandBox: D08856 ATOM 41 1 N1y N 20.6417 -13.6668 2 C1x C 20.6417 -15.0758 3 C1x C 21.8620 -15.7803 4 C1x C 23.0822 -15.0758 5 C1z C 23.0822 -13.6668 6 C1x C 21.8620 -12.9623 7 C5a C 19.4216 -12.9623 8 C1c C 18.2013 -13.6668 9 N1b N 16.9811 -12.9623 10 C5a C 15.7609 -13.6668 11 C1d C 14.5407 -12.9623 12 O5a O 19.4216 -11.5535 13 C1a C 13.3204 -12.2579 14 N1a N 15.2451 -11.7421 15 C1a C 13.8361 -14.1825 16 C1b C 18.2013 -15.0756 17 O5a O 15.7609 -15.0757 18 C5a C 23.7867 -12.4466 19 N1c N 25.2207 -12.4462 20 O5a O 23.0983 -11.2542 21 C1a C 25.9356 -13.6834 22 N1c N 25.9150 -11.2430 23 C1a C 27.3340 -11.2424 24 C1a C 25.2250 -10.0490 25 C1b C 24.4911 -13.6668 26 C8y C 25.2017 -14.8979 27 C8x C 24.5162 -16.0846 28 C8x C 25.2207 -17.3049 29 C8x C 26.6297 -17.3051 30 C8x C 27.3150 -16.1185 31 C8x C 26.6106 -14.8980 32 C8y C 19.2444 -16.5864 33 C8y C 19.6559 -17.9245 34 C8y C 21.0558 -17.9467 35 N4x N 21.5094 -16.6222 36 C8x C 20.3899 -15.7815 37 C8x C 18.9369 -19.1258 38 C8x C 19.6176 -20.3491 39 C8x C 21.0175 -20.3712 40 C8x C 21.7365 -19.1700 41 X Cl 31.0682 -14.8644 BOND 43 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 1 6 1 7 1 7 1 8 7 8 1 9 8 9 1 10 9 10 1 11 10 11 1 12 7 12 2 13 11 13 1 14 11 14 1 15 11 15 1 16 8 16 1 #Up 17 10 17 2 18 5 18 1 #Up 19 18 19 1 20 18 20 2 21 19 21 1 22 19 22 1 23 22 23 1 24 22 24 1 25 5 25 1 #Down 26 25 26 1 27 26 27 2 28 27 28 1 29 28 29 2 30 29 30 1 31 30 31 2 32 26 31 1 33 32 33 1 34 33 34 1 35 34 35 1 36 35 36 1 37 32 36 2 38 16 32 1 39 33 37 2 40 37 38 1 41 38 39 2 42 39 40 1 43 34 40 2 ///