ENTRY D08509 Drug NAME Sermorelin (INN); Geref (TN) FORMULA C149H246N44O42S EXACT_MASS 3355.8187 MOL_WEIGHT 3357.89 SEQUENCE Tyr Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg TYPE Peptide REMARK ATC code: H01AC04 V04CD03 Chemical structure group: DG00494 EFFICACY Diagnostic (pituitary function determination), Growth hormone releasing hormone receptor agonist COMMENT Growth hormone releasing hormone (GH-RH) analog TARGET GHRHR [HSA:2692] [KO:K04584] PATHWAY hsa04080(2692) Neuroactive ligand-receptor interaction BRITE Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES H01AC Somatropin and somatropin agonists H01AC04 Sermorelin D08509 Sermorelin (INN) V VARIOUS V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CD Tests for pituitary function V04CD03 Sermorelin D08509 Sermorelin (INN) Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Secretin receptor family Growth hormone-releasing hormone GHRHR D08509 Sermorelin (INN) DBLINKS CAS: 86168-78-7 PubChem: 96025194 ChEBI: 9118 ATOM 236 1 C1c C 27.5779 -10.7092 2 C1b C 27.5779 -12.0390 3 N1b N 26.3880 -9.9392 4 C5a C 28.8378 -9.9392 5 C8y C 28.8378 -12.7390 6 C5a C 25.1981 -10.7092 7 N1b N 30.0277 -10.6392 8 O5a O 28.8378 -8.6093 9 C8x C 28.8378 -14.1389 10 C8x C 30.0277 -12.0390 11 C1c C 23.9382 -10.0092 12 O5a O 25.1981 -12.0390 13 C1c C 31.2176 -9.9392 14 C8x C 30.0277 -14.8388 15 C8x C 31.2176 -12.7390 16 N1b N 22.7483 -10.7092 17 C1c C 23.9382 -8.6093 18 C5a C 32.4075 -10.6392 19 C1c C 31.2176 -8.5393 20 C8x C 31.2176 -14.1389 21 C5a C 21.5584 -10.0092 22 C1b C 25.2681 -7.9094 23 C1a C 22.8183 -7.9094 24 N1b N 33.6674 -9.9392 25 O5a O 32.4075 -12.0390 26 C1a C 32.4075 -7.9094 27 O1a O 30.0277 -7.9094 28 C1c C 20.3685 -10.7092 29 O5a O 21.5584 -8.6093 30 C1a C 25.2681 -6.5095 31 C1c C 34.8573 -10.6392 32 N1b N 19.1086 -10.0092 33 C1a C 20.3685 -12.0390 34 C5a C 36.0472 -9.9392 35 C1b C 34.8573 -12.0390 36 C5a C 17.9187 -10.7092 37 N1b N 37.3071 -10.6392 38 O5a O 36.0472 -8.5393 39 C5a C 36.1172 -12.7390 40 C1c C 16.7288 -10.0092 41 O5a O 17.9187 -12.1090 42 C1c C 38.4970 -9.9392 43 N1a N 36.1172 -14.0689 44 O5a O 37.3071 -12.0390 45 N1b N 15.4689 -10.7092 46 C1b C 16.7288 -8.6093 47 C5a C 39.6869 -10.6392 48 C1b C 38.4970 -8.5393 49 C5a C 14.2790 -10.0092 50 C6a C 17.9187 -7.9094 51 N1b N 40.8768 -9.9392 52 O5a O 39.6869 -12.0390 53 O1a O 39.6869 -7.9094 54 C1c C 13.0891 -10.7092 55 O5a O 14.2790 -8.6093 56 O6a O 19.1086 -8.6093 57 O6a O 17.9187 -6.5095 58 C1c C 42.1367 -10.6392 59 N1b N 11.8992 -10.0092 60 C1a C 13.0891 -12.1090 61 C1b C 43.3266 -9.9392 62 C5a C 42.1367 -12.0390 63 C5a C 10.6393 -10.7092 64 C8y C 43.3266 -8.5393 65 N1b N 43.3266 -12.6690 66 O5a O 40.8768 -12.6690 67 C1c C 9.4494 -10.0092 68 O5a O 10.6393 -12.1090 69 C8x C 44.5165 -7.8394 70 C8x C 42.1367 -7.8394 71 C1c C 43.3266 -14.9088 72 C1b C 9.4494 -8.6793 73 N1a N 8.2595 -10.7092 74 C8x C 44.5165 -6.4395 75 C8x C 42.1367 -6.5095 76 C5a C 42.1367 -15.6087 77 C1b C 44.5165 -15.6087 78 C8y C 10.6393 -7.9794 79 C8y C 43.3266 -5.7396 80 N1b N 42.1367 -17.0086 81 O5a O 40.8768 -14.9088 82 C1b C 44.5165 -17.0086 83 C8x C 11.8992 -8.6093 84 C8x C 10.6393 -6.5795 85 O1a O 43.3266 -4.4097 86 C1c C 40.8768 -17.7086 87 C1b C 45.7764 -17.7086 88 C8x C 13.0891 -7.9094 89 C8x C 11.8292 -5.8795 90 C5a C 39.6869 -17.0086 91 C1b C 40.8768 -19.1085 92 N1b N 45.7764 -19.0385 93 C8y C 13.0891 -6.5795 94 N1b N 38.4970 -17.7086 95 O5a O 39.6869 -15.6087 96 C1b C 42.1367 -19.7384 97 C2c C 44.5165 -19.7384 98 O1a O 14.2790 -5.8795 99 C1c C 37.2371 -17.0086 100 C1b C 42.1367 -21.1383 101 N1a N 44.5165 -21.1383 102 N2a N 43.3266 -19.0385 103 C5a C 36.0472 -17.6386 104 C1c C 37.2371 -15.6087 105 C1b C 43.3266 -21.8382 106 N1b N 34.8573 -16.9386 107 O5a O 36.0472 -19.0385 108 C1a C 38.4270 -14.9088 109 C1a C 35.9772 -14.9088 110 N1a N 43.3266 -23.2381 111 C1c C 33.5974 -17.6386 112 C5a C 32.4075 -16.9386 113 C1b C 33.5974 -19.0385 114 N1b N 31.2176 -17.6386 115 O5a O 32.4075 -15.5388 116 C1c C 32.4075 -19.7384 117 C1b C 29.9577 -16.9386 118 C1a C 31.1476 -19.0385 119 C1a C 32.4075 -21.0683 120 C5a C 28.7678 -17.5686 121 N1b N 27.5779 -16.8686 122 O5a O 28.7678 -18.9685 123 C1c C 26.3180 -17.5686 124 C5a C 25.1281 -16.8686 125 C1b C 26.3180 -18.9685 126 N1b N 23.9382 -17.5686 127 O5a O 25.1281 -15.4688 128 C1b C 25.1281 -19.6684 129 C1c C 22.7483 -16.8686 130 C5a C 25.1281 -21.0683 131 C5a C 21.4884 -17.5686 132 C1b C 22.7483 -15.4688 133 N1a N 26.3180 -21.6982 134 O5a O 23.9382 -21.6982 135 N1b N 20.2985 -16.8686 136 O5a O 21.4884 -18.9685 137 C1c C 21.4884 -14.8388 138 C1c C 19.1086 -17.5686 139 C1a C 21.4884 -13.4389 140 C1a C 20.2985 -15.4688 141 C5a C 17.8487 -16.8686 142 C1b C 19.1086 -18.9685 143 N1b N 16.6588 -17.5686 144 O5a O 17.8487 -15.4688 145 O1a O 17.8487 -19.6684 146 C1c C 15.4689 -16.8686 147 C5a C 14.2090 -17.5686 148 C1a C 15.4689 -15.4688 149 N1b N 13.0191 -16.8686 150 O5a O 14.2090 -18.9685 151 C1c C 11.8292 -17.5686 152 C5a C 11.8292 -18.9685 153 C1b C 10.6393 -16.8686 154 N1b N 10.5693 -19.6684 155 O5a O 13.0191 -19.6684 156 C1b C 10.6393 -15.4688 157 C1c C 10.5693 -21.0683 158 C1b C 9.3794 -14.8388 159 C5a C 9.3794 -21.6982 160 C1b C 11.8292 -21.6982 161 N1b N 8.1895 -15.4688 162 N1b N 9.3794 -23.0981 163 O5a O 8.1895 -21.0683 164 C1b C 13.0191 -21.0683 165 C2c C 8.1895 -16.8686 166 C1c C 10.5693 -23.7981 167 C1b C 14.2090 -21.6982 168 N1a N 6.9296 -17.5686 169 N2a N 9.3794 -17.5686 170 C5a C 10.5693 -25.1980 171 C1b C 11.8292 -23.0981 172 C1b C 15.4689 -20.9983 173 N1b N 11.7592 -25.8979 174 O5a O 9.3794 -25.8979 175 C1c C 13.0191 -23.7981 176 N1a N 16.6588 -21.6982 177 C1c C 11.7592 -27.2978 178 C1a C 13.0191 -25.1980 179 C1a C 14.2090 -23.0981 180 C5a C 13.0191 -27.9977 181 C1b C 10.5693 -27.9977 182 N1b N 14.2090 -27.2978 183 O5a O 13.0191 -29.3976 184 C1c C 10.5693 -29.3976 185 C1c C 15.4689 -27.9977 186 C1a C 9.3094 -30.0976 187 C1a C 11.7592 -30.0976 188 C5a C 16.6588 -27.2978 189 C1b C 15.4689 -29.3976 190 N1b N 17.9187 -27.9977 191 O5a O 16.6588 -25.8979 192 C1b C 16.6588 -30.0976 193 C1c C 19.1086 -27.2978 194 C5a C 16.6588 -31.5674 195 C5a C 20.2985 -27.9977 196 C1b C 19.1086 -25.8979 197 N1a N 17.8487 -32.2674 198 O5a O 15.3989 -32.1974 199 N1b N 21.5584 -27.3678 200 O5a O 20.2985 -29.4676 201 C6a C 20.3685 -25.1980 202 C1c C 22.8183 -28.0677 203 O6a O 21.5584 -25.8979 204 O6a O 20.3685 -23.7981 205 C5a C 24.0082 -27.3678 206 C1c C 22.8183 -29.4676 207 N1b N 25.1981 -28.0677 208 O5a O 24.0082 -25.9679 209 C1b C 21.5584 -30.1675 210 C1a C 24.0082 -30.1675 211 C1c C 26.4580 -27.3678 212 C1a C 21.5584 -31.5674 213 C5a C 27.6479 -27.9977 214 C1b C 26.4580 -25.9679 215 N1b N 28.9078 -27.2978 216 O5a O 27.6479 -29.4676 217 C1b C 27.6479 -25.1980 218 C1c C 30.0977 -27.9977 219 S2a S 27.6479 -23.7981 220 C5a C 31.2876 -27.2978 221 C1b C 30.0977 -29.3976 222 C1a C 28.8378 -23.0981 223 N1b N 32.5475 -27.9977 224 O5a O 31.2876 -25.8979 225 O1a O 28.8378 -30.1675 226 C1c C 33.8074 -27.2978 227 C1b C 33.8074 -25.8279 228 C5a C 34.9973 -27.9277 229 C1b C 35.0673 -25.1280 230 N1a N 36.1872 -27.2278 231 O5a O 34.9973 -29.3976 232 C1b C 35.0673 -23.7281 233 N1b N 36.3272 -23.0281 234 C2c C 36.3272 -21.6283 235 N1a N 37.5171 -20.8583 236 N2a N 35.0673 -20.9283 BOND 238 1 1 2 1 2 1 3 1 3 1 4 1 4 2 5 1 5 3 6 1 6 4 7 1 7 4 8 2 8 5 9 2 9 5 10 1 10 6 11 1 11 6 12 2 12 7 13 1 13 9 14 1 14 10 15 2 15 11 16 1 16 11 17 1 17 13 18 1 18 13 19 1 19 14 20 2 20 16 21 1 21 17 22 1 22 17 23 1 23 18 24 1 24 18 25 2 25 19 26 1 26 19 27 1 27 21 28 1 28 21 29 2 29 22 30 1 30 24 31 1 31 28 32 1 32 28 33 1 33 31 34 1 34 31 35 1 35 32 36 1 36 34 37 1 37 34 38 2 38 35 39 1 39 36 40 1 40 36 41 2 41 37 42 1 42 39 43 1 43 39 44 2 44 40 45 1 45 40 46 1 46 42 47 1 47 42 48 1 48 45 49 1 49 46 50 1 50 47 51 1 51 47 52 2 52 48 53 1 53 49 54 1 54 49 55 2 55 50 56 1 56 50 57 2 57 51 58 1 58 54 59 1 59 54 60 1 60 58 61 1 61 58 62 1 62 59 63 1 63 61 64 1 64 62 65 1 65 62 66 2 66 63 67 1 67 63 68 2 68 64 69 2 69 64 70 1 70 65 71 1 71 67 72 1 72 67 73 1 73 69 74 1 74 70 75 2 75 71 76 1 76 71 77 1 77 72 78 1 78 74 79 2 79 76 80 1 80 76 81 2 81 77 82 1 82 78 83 2 83 78 84 1 84 79 85 1 85 80 86 1 86 82 87 1 87 83 88 1 88 84 89 2 89 86 90 1 90 86 91 1 91 87 92 1 92 88 93 2 93 90 94 1 94 90 95 2 95 91 96 1 96 92 97 1 97 93 98 1 98 94 99 1 99 96 100 1 100 97 101 1 101 97 102 2 102 99 103 1 103 99 104 1 104 100 105 1 105 103 106 1 106 103 107 2 107 104 108 1 108 104 109 1 109 105 110 1 110 106 111 1 111 111 112 1 112 111 113 1 113 112 114 1 114 112 115 2 115 113 116 1 116 114 117 1 117 116 118 1 118 116 119 1 119 117 120 1 120 120 121 1 121 120 122 2 122 121 123 1 123 123 124 1 124 123 125 1 125 124 126 1 126 124 127 2 127 125 128 1 128 126 129 1 129 128 130 1 130 129 131 1 131 129 132 1 132 130 133 1 133 130 134 2 134 131 135 1 135 131 136 2 136 132 137 1 137 135 138 1 138 137 139 1 139 137 140 1 140 138 141 1 141 138 142 1 142 141 143 1 143 141 144 2 144 142 145 1 145 143 146 1 146 146 147 1 147 146 148 1 148 147 149 1 149 147 150 2 150 149 151 1 151 151 152 1 152 151 153 1 153 152 154 1 154 152 155 2 155 153 156 1 156 154 157 1 157 156 158 1 158 157 159 1 159 157 160 1 160 158 161 1 161 159 162 1 162 159 163 2 163 160 164 1 164 161 165 1 165 162 166 1 166 164 167 1 167 165 168 1 168 165 169 2 169 166 170 1 170 166 171 1 171 167 172 1 172 170 173 1 173 170 174 2 174 171 175 1 175 172 176 1 176 173 177 1 177 175 178 1 178 175 179 1 179 177 180 1 180 177 181 1 181 180 182 1 182 180 183 2 183 181 184 1 184 182 185 1 185 184 186 1 186 184 187 1 187 185 188 1 188 185 189 1 189 188 190 1 190 188 191 2 191 189 192 1 192 190 193 1 193 192 194 1 194 193 195 1 195 193 196 1 196 194 197 1 197 194 198 2 198 195 199 1 199 195 200 2 200 196 201 1 201 199 202 1 202 201 203 1 203 201 204 2 204 202 205 1 205 202 206 1 206 205 207 1 207 205 208 2 208 206 209 1 209 206 210 1 210 207 211 1 211 209 212 1 212 211 213 1 213 211 214 1 214 213 215 1 215 213 216 2 216 214 217 1 217 215 218 1 218 217 219 1 219 218 220 1 220 218 221 1 221 219 222 1 222 220 223 1 223 220 224 2 224 221 225 1 225 223 226 1 226 226 227 1 227 226 228 1 228 227 229 1 229 228 230 1 230 228 231 2 231 229 232 1 232 232 233 1 233 233 234 1 234 234 235 1 235 234 236 2 236 15 20 1 237 75 79 1 238 89 93 1 ///