ENTRY       D06053                      Drug
NAME        Teduglutide (USAN/INN);
            Teduglutide (genetical recombination) (JAN);
            Gattex (TN);
            Revestive (TN)
PRODUCT     GATTEX (Takeda Pharmaceuticals America)
FORMULA     C164H252N44O55S
EXACT_MASS  3749.7995
MOL_WEIGHT  3752.08
SEQUENCE    His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn
            Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
            Asp
  TYPE      Peptide
REMARK      Therapeutic category: 2499
            ATC code: A16AX08
            Product: D06053<JP/US>
EFFICACY    Mucosal growth promotor, Glucagon-like peptide 2 receptor agonist
  DISEASE   Short bowel syndrome [DS:H01469]
COMMENT     Human glucagon-like peptide 2 (GLP-2) [CPD:C16049] analog
            Treatment of intestinal diseases characterized by chemical or surgical damage of the intestinal epithelium such as Short Bowel Syndrome (SBS) or damage to the intestinal epithelium due to disease
TARGET      GLP2R [HSA:9340] [KO:K04582]
BRITE       Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
             A ALIMENTARY TRACT AND METABOLISM
              A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
               A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
                A16AX Various alimentary tract and metabolism products
                 A16AX08 Teduglutide
                  D06053  Teduglutide (USAN/INN) &lt;JP/US&gt;
            USP drug classification [BR:br08302]
             Gastrointestinal Agents
              Gastrointestinal Agents, Other
               Teduglutide
                D06053  Teduglutide (USAN/INN)
            Therapeutic category of drugs in Japan [BR:br08301]
             2  Agents affecting individual organs
              24  Hormones
               249  Miscellaneous
                2499  Others
                 D06053  Teduglutide (USAN/INN); Teduglutide (genetical recombination) (JAN)
            Target-based classification of drugs [BR:br08310]
             G Protein-coupled receptors
              Secretin receptor family
               Glucagon
                GLP2R
                 D06053  Teduglutide (USAN/INN) &lt;JP/US&gt;
            New drug approvals in the USA [br08319.html]
             New molecular entities and new therapeutic biological products
              D06053
            New drug approvals in Europe [br08329.html]
             European public assessment reports (EPAR) authorised medicine
              D06053
            New drug approvals in Japan [br08318.html]
             Drugs with new active ingredients
              D06053
            New drug approvals in the USA, Europe and Japan [br08328.html]
             Approval dates by FDA, EMA and PMDA
              D06053
DBLINKS     CAS: 197922-42-2
            PubChem: 47207711
            ChEBI: 72305
///