ENTRY D05480 Drug NAME Pimecrolimus (JAN/USAN/INN); Elidel (TN) PRODUCT GENERIC PIMECROLIMUS (Actavis Pharma) PIMECROLIMUS (Bryant Ranch Prepack) PIMECROLIMUS (Glenmark Pharmaceuticals) PIMECROLIMUS (Oceanside Pharmaceuticals) FORMULA C43H68ClNO11 EXACT_MASS 809.4481 MOL_WEIGHT 810.45 CLASS Immunological agent DG03129 Calcineurin inhibitor REMARK ATC code: D11AH02 Product: D05480 EFFICACY Immunosuppressant, Calcineurin inhibitor DISEASE Atopic dermatitis [DS:H01358] COMMENT Treatment of inflammatory skin disease TARGET PPP3C/PPP3R/CHP [HSA:5530 5532 5533 5534 5535 11261 63928] [KO:K04348 K06268 K17610 K17611] PATHWAY hsa04010(5530+5532+5533+5534+5535) MAPK signaling pathway hsa04218(5530+5532+5533+5534+5535) Cellular senescence hsa04380(5530+5532+5533+5534+5535) Osteoclast differentiation hsa04650(5530+5532+5533+5534+5535) Natural killer cell mediated cytotoxicity hsa04658(5530+5532+5533+5534+5535) Th1 and Th2 cell differentiation hsa04659(5530+5532+5533+5534+5535) Th17 cell differentiation hsa04660(5530+5532+5533+5534+5535) T cell receptor signaling pathway BRITE Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D11 OTHER DERMATOLOGICAL PREPARATIONS D11A OTHER DERMATOLOGICAL PREPARATIONS D11AH Agents for dermatitis, excluding corticosteroids D11AH02 Pimecrolimus D05480 Pimecrolimus (JAN/USAN/INN) <US> USP drug classification [BR:br08302] Dermatological Agents Dermatitis and Pruitus Agents Dermatitis and Pruitus Agents, Other Pimecrolimus D05480 Pimecrolimus (JAN/USAN/INN) Drug groups [BR:br08330] Immunological agent DG03129 Calcineurin inhibitor D05480 Pimecrolimus Target-based classification of drugs [BR:br08310] Enzymes Hydrolases (EC3) Phosphatases PPP3C/PPP3R/CHP D05480 Pimecrolimus (JAN/USAN/INN) <US> New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D05480 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D05480 DBLINKS CAS: 137071-32-0 PubChem: 47207149 LigandBox: D05480 J-GLOBAL: J1.625.653F ATOM 56 1 C1y C 32.5631 -12.8796 2 C1x C 33.7316 -13.5601 3 C1y C 34.9330 -12.8730 4 C1y C 34.9387 -11.4891 5 C1x C 33.7710 -10.8085 6 C1x C 32.5696 -11.4956 7 C1y C 24.2303 -19.0941 8 O2x O 24.2303 -17.7102 9 C1z C 22.9847 -17.0182 10 C5a C 24.2303 -14.9422 11 C5a C 22.9847 -15.6342 12 O6a O 26.5830 -14.9422 13 C7a C 26.5830 -13.5582 14 C1y C 25.4066 -12.8662 15 N1y N 24.2303 -13.5582 16 C1c C 25.4066 -19.7861 17 C1c C 29.0050 -14.9422 18 C1c C 29.0050 -13.5582 19 O7a O 27.8286 -12.8662 20 C1b C 30.1814 -17.0182 21 C1c C 30.1814 -15.6342 22 C2c C 29.0050 -19.0941 23 C2b C 30.1814 -19.7861 24 C1c C 31.4270 -19.0941 25 C5a C 31.4270 -17.7102 26 C1b C 27.8286 -19.7861 27 O5a O 25.4066 -15.6342 28 O5a O 21.8083 -14.9422 29 C1x C 25.4066 -11.4822 30 C1x C 24.2303 -10.7903 31 C1x C 22.9847 -11.4822 32 C1x C 22.9847 -12.8662 33 C1y C 21.8083 -17.7102 34 C1x C 21.8083 -19.0941 35 C1y C 22.9847 -19.7861 36 C1b C 25.4066 -21.1701 37 C1c C 27.8738 -21.1701 38 O2a O 26.6080 -19.0990 39 O2a O 22.9677 -21.1700 40 C1a C 20.6069 -17.0230 41 C1a C 27.8036 -15.6293 42 O1a O 31.3828 -14.9470 43 C1a C 28.7855 -22.1699 44 C1b C 32.6198 -19.7960 45 O5a O 32.6198 -17.0083 46 C1a C 29.0050 -17.7102 47 C1a C 26.6034 -17.7104 48 C1a C 21.7737 -21.8401 49 C2c C 30.2064 -12.8711 50 C1a C 33.8156 -19.1186 51 C2b C 31.3812 -13.5559 52 C1a C 30.2121 -11.4825 53 X Cl 36.1561 -10.7928 54 O2a O 36.1428 -13.5785 55 C1a C 37.3451 -12.8911 56 O1a O 23.1247 -18.4182 BOND 59 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 1 6 1 7 7 8 1 8 8 9 1 9 10 11 1 10 9 11 1 11 12 13 2 12 13 14 1 13 14 15 1 14 10 15 1 15 7 16 1 16 17 18 1 17 18 19 1 18 13 19 1 19 20 21 1 20 17 21 1 21 22 23 2 22 23 24 1 23 24 25 1 24 20 25 1 25 26 22 1 26 10 27 2 27 11 28 2 28 14 29 1 29 29 30 1 30 30 31 1 31 31 32 1 32 15 32 1 33 9 33 1 34 33 34 1 35 34 35 1 36 35 7 1 37 16 36 1 38 37 26 1 39 36 37 1 40 16 38 1 #Up 41 35 39 1 #Up 42 33 40 1 #Up 43 17 41 1 #Up 44 21 42 1 #Up 45 37 43 1 #Down 46 24 44 1 #Down 47 25 45 2 48 22 46 1 49 38 47 1 50 39 48 1 51 18 49 1 52 44 50 1 53 49 51 2 54 49 52 1 55 1 51 1 56 4 53 1 #Down 57 3 54 1 #Down 58 54 55 1 59 9 56 1 #Up ///