ENTRY       D03328                      Drug
NAME        Carperitide (USAN/INN);
            Carperitide (genetical recombination) (JAN);
            Hanp (TN)
FORMULA     C127H203N45O39S3
EXACT_MASS  3078.4447
MOL_WEIGHT  3080.45
SEQUENCE    Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
            Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr
            (Disulfide bridge: 7-23)
  TYPE      Peptide
REMARK      Therapeutic category: 2179
            Product: D03328<JP>
EFFICACY    Vasodilator, Atrial natriuretic peptide receptor agonist
COMMENT     Recombinant of human alpha atrial natriuretic polypeptide (ANP) [HSA:4878]
TARGET      NPR1 [HSA:4881] [KO:K12323]
  PATHWAY   hsa04022(4881)  cGMP-PKG signaling pathway
            hsa04024(4881)  cAMP signaling pathway
            hsa04270(4881)  Vascular smooth muscle contraction
INTERACTION  
BRITE       Therapeutic category of drugs in Japan [BR:br08301]
             2  Agents affecting individual organs
              21  Cardiovascular agents
               217  Vasodilators
                2179  Others
                 D03328  Carperitide (USAN/INN); Carperitide (genetical recombination) (JAN)
            Target-based classification of drugs [BR:br08310]
             Protein kinases
              Serine/threonine kinases
               Other
                NPR1
                 D03328  Carperitide (USAN/INN) &lt;JP&gt;
DBLINKS     CAS: 89213-87-6
            PubChem: 17397478
            J-GLOBAL: J265.257I
///