ENTRY D02913 Drug NAME Amlintide (USAN/INN) FORMULA C165H261N51O55S2 EXACT_MASS 3900.8636 MOL_WEIGHT 3903.28 SEQUENCE KCNTATCATQ RLANFLVHSS NNFGAILSST NVGSNTY (C-terminal amide: Tyr37; Disulfide bridge: 2-7) TYPE Peptide EFFICACY Antidiabetic COMMENT Amylin derivative TARGET CALCR [HSA:799] [KO:K04576] CALCRL [HSA:10203] [KO:K04577] PATHWAY hsa04080(10203+799) Neuroactive ligand-receptor interaction hsa04081(799) Hormone signaling BRITE Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Secretin receptor family Calcitonin CALCR D02913 Amlintide (USAN/INN) CALCRL D02913 Amlintide (USAN/INN) DBLINKS CAS: 122384-88-7 PubChem: 17397070 ATOM 273 1 C8y C 10.3705 -52.3395 2 C8x C 10.3705 -50.9491 3 C8x C 9.1191 -50.2540 4 C8y C 7.9373 -50.9491 5 C8x C 7.9373 -52.3395 6 C8x C 9.1191 -53.0347 7 O1a O 6.7556 -50.1844 8 O5a O 9.1191 -54.4251 9 C5a C 10.3705 -55.1204 10 C1c C 11.5524 -54.4251 11 C1b C 11.5524 -53.0347 12 N1a N 10.3705 -56.5107 13 N1b N 12.7342 -55.1204 14 C5a C 13.9856 -54.4251 15 O5a O 13.9856 -53.0347 16 O1a O 13.9856 -57.2058 17 C1c C 15.1674 -56.5107 18 C1c C 15.1674 -55.1204 19 C1a C 16.3492 -57.2058 20 O5a O 17.6006 -56.5107 21 C5a C 17.6006 -55.1204 22 N1b N 16.3492 -54.4251 23 O5a O 18.7824 -57.2058 24 C5a C 19.9642 -56.5107 25 C1b C 19.9642 -55.1204 26 C1c C 18.7824 -54.4251 27 N1b N 18.7824 -53.0347 28 N1a N 21.2155 -57.2058 29 C5a C 19.9642 -52.3395 30 C1c C 19.9642 -50.9491 31 C1b C 18.7824 -50.2540 32 O1a O 17.6006 -50.9491 33 N1b N 21.2155 -50.2540 34 C5a C 21.2155 -48.8636 35 O5a O 19.9642 -48.1683 36 C1b C 22.3974 -48.1683 37 N1b N 22.3974 -46.7779 38 C5a C 23.5793 -46.0828 39 C1c C 23.5793 -44.6923 40 C1c C 22.3974 -43.9972 41 C1a C 21.2155 -44.6923 42 C1a C 22.3974 -42.6068 43 O5a O 21.2155 -53.0347 44 O5a O 24.8307 -46.7779 45 N1b N 24.8307 -43.9972 46 C5a C 24.8307 -42.6068 47 O5a O 23.5793 -41.9116 48 C1c C 26.0124 -41.9116 49 C1b C 26.0124 -40.5211 50 C5a C 24.8307 -39.8260 51 O5a O 23.5793 -40.5211 52 N1a N 24.8307 -38.4356 53 N1b N 27.1943 -42.6068 54 O1a O 28.4456 -44.6923 55 C1c C 29.6274 -43.9972 56 C1c C 29.6274 -42.6068 57 C5a C 28.4456 -41.9116 58 O5a O 28.4456 -40.5211 59 C1a C 30.8093 -44.6923 60 O5a O 31.9912 -43.9972 61 C5a C 31.9912 -42.6068 62 N1b N 30.8093 -41.9116 63 N1b N 34.4243 -42.6068 64 C1c C 33.2424 -41.9116 65 C1b C 33.2424 -40.5211 66 O1a O 32.0606 -39.8260 67 C5a C 35.6061 -41.9116 68 O5a O 35.6061 -40.5211 69 C1c C 36.8575 -42.6068 70 N1b N 38.0393 -41.9116 71 C5a C 39.2211 -42.6068 72 C1c C 40.4725 -41.9116 73 N1b N 40.4725 -40.5211 74 C1b C 41.6543 -42.6068 75 O5a O 42.8361 -40.5211 76 C5a C 41.6543 -39.8260 77 C1b C 36.8575 -43.9972 78 O5a O 39.2211 -43.9972 79 C1a C 40.4725 -44.6923 80 C1c C 41.6543 -43.9972 81 C1a C 42.8361 -44.6923 82 O1a O 35.6061 -44.6923 83 C1c C 41.6543 -38.4356 84 C1c C 40.4725 -37.7404 85 C1b C 39.2211 -38.4356 86 C1a C 40.4725 -36.3501 87 C1a C 38.0393 -37.7404 88 N1b N 42.8361 -37.7404 89 C5a C 42.8361 -36.3501 90 O5a O 41.6543 -35.6549 91 C1c C 44.0875 -35.6549 92 N1b N 44.0875 -34.2644 93 C5a C 45.2693 -33.5693 94 C1b C 45.2693 -32.1789 95 N1b N 46.4512 -31.4837 96 C5a C 46.4512 -30.0933 97 O5a O 45.2693 -29.3982 98 C1c C 47.7025 -29.3982 99 C1b C 47.7025 -28.0077 100 C8y C 46.4512 -27.3125 101 C8x C 45.2693 -28.0077 102 C1a C 45.2693 -36.3501 103 O5a O 46.4512 -34.2644 104 C8x C 46.4512 -25.9221 105 C8x C 45.2693 -25.2269 106 C8x C 44.0875 -25.9221 107 C8x C 44.0875 -27.3125 108 O5a O 48.8844 -31.4837 109 N1b N 48.8844 -30.0933 110 C5a C 50.0662 -29.3982 111 O5a O 50.0662 -28.0077 112 C5a C 50.0662 -32.1789 113 C1b C 51.3175 -31.4837 114 C1c C 51.3175 -30.0933 115 N1a N 50.0662 -33.5693 116 O5a O 53.6811 -31.4837 117 C5a C 53.6811 -30.0933 118 N1b N 52.4993 -29.3982 119 O5a O 54.9325 -32.1789 120 C5a C 56.1143 -31.4837 121 C1b C 56.1143 -30.0933 122 C1c C 54.9325 -29.3982 123 O5a O 57.2962 -28.0077 124 C5a C 56.1143 -27.3125 125 N1b N 54.9325 -28.0077 126 C1c C 56.1143 -25.9221 127 N1a N 57.2962 -32.1789 128 C1b C 54.8630 -25.2269 129 O1a O 53.6811 -25.9221 130 N1b N 57.2962 -25.2269 131 O1a O 59.7294 -25.2269 132 C1b C 59.7294 -23.8365 133 C1c C 58.5476 -23.1414 134 C5a C 57.2962 -23.8365 135 O5a O 56.1143 -23.1414 136 N1b N 58.5476 -21.7509 137 O5a O 60.9112 -21.7509 138 C5a C 59.7294 -21.0557 139 C8x C 62.1626 -21.0557 140 C8y C 62.1626 -19.6653 141 C1b C 60.9112 -18.9701 142 C1c C 59.7294 -19.6653 143 N1b N 58.5476 -18.9701 144 O5a O 59.7294 -16.8847 145 C5a C 58.5476 -17.5798 146 N5x N 63.4834 -21.5424 147 C8x C 64.2481 -20.3605 148 N4x N 63.4834 -19.2482 149 N1b N 57.2962 -15.4942 150 C1c C 57.2962 -16.8847 151 C1c C 56.1143 -13.4086 152 C5a C 56.1143 -14.7990 153 O5a O 54.9325 -15.4942 154 C1a C 54.9325 -16.8847 155 C1c C 56.1143 -17.5798 156 C1b C 54.9325 -12.7135 157 C1a C 56.1143 -18.9701 158 C1c C 53.6811 -13.4086 159 C1a C 53.6811 -14.7990 160 C1a C 52.4993 -12.7135 161 N1b N 57.2962 -12.7135 162 C5a C 57.2962 -11.3231 163 O5a O 56.1143 -10.6279 164 C8x C 56.1143 -9.2374 165 C8x C 54.9325 -8.5422 166 C1c C 58.5476 -10.6279 167 C1b C 58.5476 -9.2374 168 C8y C 57.2962 -8.5422 169 C8x C 57.2962 -7.1518 170 C8x C 56.1143 -6.4567 171 C8x C 54.9325 -7.1518 172 N1b N 59.7294 -11.3231 173 C5a C 60.9112 -10.6279 174 O5a O 60.9112 -9.2374 175 C1c C 62.1626 -11.3231 176 N1b N 63.3443 -10.6279 177 C1b C 62.1626 -12.7135 178 C5a C 60.9112 -13.4086 179 N1a N 60.9112 -14.7990 180 O5a O 59.7294 -12.7135 181 C5a C 64.5262 -11.3231 182 C1c C 65.7775 -10.6279 183 O5a O 64.5262 -12.7135 184 N1b N 65.7775 -9.2374 185 C5a C 66.9594 -8.5422 186 O5a O 66.9594 -7.1518 187 C1c C 68.1413 -9.2374 188 N1b N 69.3926 -8.5422 189 C1b C 68.1413 -11.9515 190 O5a O 70.5744 -10.6279 191 C5a C 70.5744 -9.2374 192 C1c C 71.7561 -8.5422 193 C1b C 71.7561 -7.1518 194 C1b C 70.5744 -6.4567 195 C1b C 70.5744 -5.0663 196 N1b N 69.3926 -4.3711 197 N1b N 72.9381 -9.2374 198 C5a C 74.1894 -8.5422 199 O5a O 74.1894 -7.1518 200 C2c C 69.3926 -2.9807 201 N1a N 68.1413 -2.2854 202 N2a N 70.5744 -2.2854 203 C1c C 75.3712 -9.2374 204 C1b C 76.5532 -8.5422 205 C1b C 77.7349 -9.2374 206 C5a C 78.9167 -8.5422 207 N1a N 80.0986 -9.2374 208 O5a O 78.9167 -7.1518 209 C1c C 76.6144 -13.6924 210 C5a C 75.3631 -12.9973 211 C1c C 77.7963 -12.9973 212 C1a C 79.0477 -13.6228 213 O5a O 74.1812 -13.7619 214 C1c C 77.8659 -17.1684 215 C1a C 76.6840 -17.8636 216 C5a C 77.8659 -15.7780 217 N1b N 76.6144 -15.0827 218 O5a O 79.0477 -15.0827 219 C1y C 80.2991 -19.8100 220 C1x C 81.4809 -19.1150 221 N1x N 80.3685 -21.2005 222 O5x O 81.5504 -21.8957 223 C5x C 81.6198 -23.2861 224 C1y C 82.8017 -23.9117 225 N1x N 83.9836 -23.2166 226 C1a C 82.8712 -25.3021 227 O5x O 85.2349 -25.3021 228 C5x C 85.2349 -23.9117 229 C1y C 86.4168 -23.1471 230 C5x C 79.1867 -21.9651 231 C1y C 79.1867 -23.3556 232 N1x N 80.4380 -23.9813 233 O5x O 77.9353 -21.2700 234 C1a C 76.7536 -23.3556 235 C1c C 78.0048 -24.0508 236 O1a O 78.0048 -25.4412 237 N1x N 87.5985 -23.8423 238 C5x C 88.8500 -23.0775 239 C1y C 88.7804 -21.6871 240 N1x N 87.5985 -21.0615 241 O5x O 90.0317 -23.7726 242 C1b C 89.9623 -20.9919 243 C5a C 91.2135 -21.6176 244 N1a N 92.3955 -20.9225 245 O5a O 91.2135 -23.0079 246 C1c C 86.4168 -22.0349 247 O1a O 84.5392 -21.4092 248 C1a C 86.6262 -20.5054 249 O5x O 88.7109 -18.9063 250 C5x C 87.5290 -19.6710 251 C5a C 87.4595 -16.8903 252 N1b N 86.2777 -17.5855 253 C1y C 86.3472 -18.9758 254 N1a N 88.6413 -14.7352 255 C1c C 87.4595 -15.4999 256 C1b C 86.2082 -14.8047 257 S3x S 82.7321 -19.7405 258 S3x S 83.9140 -19.0453 259 C1x C 85.0958 -19.7405 260 C1b C 86.2082 -13.4142 261 C1b C 84.9568 -11.3287 262 C1b C 84.9568 -12.7191 263 N1a N 83.7055 -10.7031 264 O5a O 88.7109 -17.5159 265 C5a C 79.1172 -19.1844 266 O5a O 77.9353 -19.8796 267 N1b N 79.1172 -17.7940 268 O1a O 77.7963 -11.6068 269 N1b N 75.3631 -11.6068 270 C1c C 69.3750 -12.6567 271 C1a C 69.3832 -14.0719 272 C1a C 70.5938 -11.9444 273 C1a C 66.9990 -11.3462 BOND 277 1 1 2 2 2 2 3 1 3 3 4 2 4 4 5 1 5 5 6 2 6 1 6 1 7 4 7 1 8 8 9 2 9 9 10 1 10 10 11 1 11 1 11 1 12 9 12 1 13 13 14 1 14 14 15 2 15 10 13 1 16 14 18 1 17 18 17 1 18 17 19 1 19 20 21 2 20 21 22 1 21 23 24 2 22 24 25 1 23 25 26 1 24 21 26 1 25 17 16 1 26 18 22 1 27 26 27 1 28 24 28 1 29 27 29 1 30 29 30 1 31 30 31 1 32 31 32 1 33 33 34 1 34 34 35 2 35 34 36 1 36 36 37 1 37 37 38 1 38 38 39 1 39 39 40 1 40 40 41 1 41 40 42 1 42 30 33 1 43 29 43 2 44 38 44 2 45 45 46 1 46 46 47 2 47 39 45 1 48 48 46 1 49 48 49 1 50 49 50 1 51 50 51 2 52 50 52 1 53 55 56 1 54 56 57 1 55 53 57 1 56 48 53 1 57 57 58 2 58 55 59 1 59 60 61 2 60 61 62 1 61 64 61 1 62 64 65 1 63 65 66 1 64 63 67 1 65 67 68 2 66 55 54 1 67 56 62 1 68 67 69 1 69 70 71 1 70 71 72 1 71 72 74 1 72 75 76 2 73 76 73 1 74 64 63 1 75 69 77 1 76 71 78 2 77 79 80 1 78 74 80 1 79 80 81 1 80 77 82 1 81 69 70 1 82 72 73 1 83 76 83 1 84 83 84 1 85 84 85 1 86 85 87 1 87 88 89 1 88 89 90 2 89 89 91 1 90 84 86 1 91 83 88 1 92 92 93 1 93 93 94 1 94 94 95 1 95 95 96 1 96 96 97 2 97 96 98 1 98 98 99 1 99 99 100 1 100 100 101 1 101 91 92 1 102 91 102 1 103 93 103 2 104 100 104 2 105 104 105 1 106 105 106 2 107 106 107 1 108 107 101 2 109 109 110 1 110 110 111 2 111 108 112 2 112 112 113 1 113 113 114 1 114 110 114 1 115 112 115 1 116 116 117 2 117 117 118 1 118 98 109 1 119 114 118 1 120 119 120 2 121 120 121 1 122 121 122 1 123 117 122 1 124 123 124 2 125 124 125 1 126 124 126 1 127 120 127 1 128 122 125 1 129 126 128 1 130 128 129 1 131 131 132 1 132 132 133 1 133 133 134 1 134 134 130 1 135 126 130 1 136 134 135 2 137 133 136 1 138 137 138 2 139 136 138 1 140 139 140 2 141 140 141 1 142 141 142 1 143 138 142 1 144 144 145 2 145 143 145 1 146 142 143 1 147 139 146 1 148 146 147 2 149 147 148 1 150 140 148 1 151 145 150 1 152 151 152 1 153 149 152 1 154 152 153 2 155 154 155 1 156 150 155 1 157 151 156 1 158 150 149 1 159 155 157 1 160 156 158 1 161 158 159 1 162 158 160 1 163 161 162 1 164 162 163 2 165 164 165 2 166 151 161 1 167 162 166 1 168 166 167 1 169 167 168 1 170 164 168 1 171 168 169 2 172 169 170 1 173 170 171 2 174 171 165 1 175 172 173 1 176 173 174 2 177 173 175 1 178 175 177 1 179 166 172 1 180 175 176 1 181 177 178 1 182 178 179 1 183 178 180 2 184 176 181 1 185 181 182 1 186 181 183 2 187 184 185 1 188 185 186 2 189 185 187 1 190 182 184 1 191 187 189 1 192 190 191 2 193 188 191 1 194 191 192 1 195 192 193 1 196 193 194 1 197 194 195 1 198 195 196 1 199 187 188 1 200 192 197 1 201 197 198 1 202 198 199 2 203 196 200 1 204 200 201 1 205 200 202 2 206 198 203 1 207 203 204 1 208 204 205 1 209 205 206 1 210 206 207 1 211 206 208 2 212 209 210 1 213 209 211 1 214 211 212 1 215 210 213 2 216 214 215 1 217 214 216 1 218 216 217 1 219 216 218 2 220 219 220 1 221 219 221 1 222 222 223 2 223 223 224 1 224 224 225 1 225 227 228 2 226 225 228 1 227 228 229 1 228 221 230 1 229 230 231 1 230 231 232 1 231 223 232 1 232 230 233 2 233 234 235 1 234 231 235 1 235 235 236 1 236 224 226 1 237 229 237 1 238 237 238 1 239 238 239 1 240 239 240 1 241 238 241 2 242 239 242 1 243 242 243 1 244 243 244 1 245 243 245 2 246 229 246 1 247 246 247 1 248 246 248 1 249 249 250 2 250 250 240 1 251 251 252 1 252 250 253 1 253 251 255 1 254 255 256 1 255 253 252 1 256 220 257 1 257 257 258 1 258 258 259 1 259 259 253 1 260 256 260 1 261 261 262 1 262 260 262 1 263 261 263 1 264 251 264 2 265 255 254 1 266 219 265 1 267 265 266 2 268 265 267 1 269 214 267 1 270 209 217 1 271 211 268 1 272 210 269 1 273 203 269 1 274 189 270 1 275 270 271 1 276 270 272 1 277 182 273 1 ///