ENTRY       D02691                      Drug
NAME        Somatropin (USP/INN);
            Somatropin (genetical recombination) (JAN);
            Human growth hormone (JAN);
            Asellacrin (TN);
            Humatrope (TN);
            Nutropin (TN);
            Omnitrope (TN)
PRODUCT     GENOTROPIN (Pfizer Laboratories Div Pfizer)
            HUMATROPE (Eli Lilly and Company)
            NORDITROPIN (Novo Nordisk)
            OMNITROPE (Sandoz)
            SEROSTIM (EMD Serono)
            ZOMACTON (Ferring Pharmaceuticals)
FORMULA     C990H1528N262O300S7
EXACT_MASS  22111.0409
MOL_WEIGHT  22124.77
SEQUENCE    FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT
            PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG
            IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV
            QCRSVEGSCG F
            (Disulfide bridge: 53-165, 182-189)
  TYPE      Peptide
CLASS       Hormonal agent
             DG03170  Growth hormone receptor agonist
            Metabolizing enzyme inhibitor
             DG01933  CYP2C19 inhibitor
REMARK      Therapeutic category: 2412
            ATC code: H01AC01
            Product: D02691<JP/US>
EFFICACY    Growth hormone (GH) receptor agonist
  DISEASE   HIV patient [DS:H01563]
            Growth hormone deficiency [DS:H00254]
COMMENT     human growth hormone derivative
TARGET      GHR [HSA:2690] [KO:K05080]
  PATHWAY   hsa04060(2690)  Cytokine-cytokine receptor interaction
            hsa04080(2690)  Neuroactive ligand-receptor interaction
            hsa04935(2690)  Growth hormone synthesis, secretion and action
  NETWORK   nt06324  GHRH-GH-IGF signaling
INTERACTION CYP inhibition: CYP2C19 [HSA:1557]
BRITE       Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
             H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
              H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
               H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
                H01AC Somatropin and somatropin agonists
                 H01AC01 Somatropin
                  D02691  Somatropin (USP/INN) &lt;JP/US&gt;
            USP drug classification [BR:br08302]
             Gastrointestinal Agents
              Gastrointestinal Agents, Other
               Somatropin
                D02691  Somatropin (USP/INN)
             Hormonal Agents, Stimulant/Replacement/Modifying (Pituitary)
              Somatropin
               D02691  Somatropin (USP/INN)
            Therapeutic category of drugs in Japan [BR:br08301]
             2  Agents affecting individual organs
              24  Hormones
               241  Pituitary hormone preparations
                2412  Anterior pituitary hormones
                 D02691  Somatropin (USP/INN); Somatropin (genetical recombination) (JAN); Human growth hormone (JAN)
            Drug groups [BR:br08330]
             Hormonal agent
              DG03170  Growth hormone receptor agonist
               D02691  Somatropin
             Metabolizing enzyme inhibitor
              DG01933  CYP2C19 inhibitor
               D02691  Somatropin
            Target-based classification of drugs [BR:br08310]
             Signaling molecules and receptors
              Cytokine receptors
               CSF and other factor receptors
                GHR
                 D02691  Somatropin (USP/INN) &lt;JP/US&gt;
            New drug approvals in Europe [br08329.html]
             European public assessment reports (EPAR) authorised medicine
              D02691
            Drug metabolizing enzymes and transporters [br08309.html]
             Drug metabolizing enzymes
              D02691
DBLINKS     CAS: 12629-01-5
            PubChem: 17396860
            J-GLOBAL: J246.949I
///