ENTRY D00573 Drug NAME Goserelin acetate (JP19/USP); Zoladex (TN) PRODUCT ZOLADEX (TerSera Therapeutics LLC) ZOLADEX (TerSera Therapeutics LLC) FORMULA C59H84N18O14. (C2H4O2)x CLASS Hormonal agent DG01494 Gonadotropin-releasing hormone receptor agonist REMARK Therapeutic category: 2499 ATC code: L02AE03 Chemical structure group: DG00731 Product (DG00731): D00573 EFFICACY Antineoplastic, Gonadotropin-releasing hormone receptor agonist DISEASE Prostatic carcinoma [DS:H00024] Endometriosis [DS:H01639] Breast cancer [DS:H00031] TARGET GNRHR [HSA:2798] [KO:K04280] PATHWAY hsa04080(2798) Neuroactive ligand-receptor interaction hsa04912(2798) GnRH signaling pathway INTERACTION STR_MAP map07043 Antineoplastics - hormones BRITE Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS L02 ENDOCRINE THERAPY L02A HORMONES AND RELATED AGENTS L02AE Gonadotropin releasing hormone analogues L02AE03 Goserelin D00573 Goserelin acetate (JP19/USP) <JP/US> USP drug classification [BR:br08302] Antineoplastics Antineoplastics, Other Antineoplastics, Miscellaneous Goserelin D00573 Goserelin acetate (JP19/USP) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 24 Hormones 249 Miscellaneous 2499 Others D00573 Goserelin acetate (JP19/USP) Drug groups [BR:br08330] Hormonal agent DG01494 Gonadotropin-releasing hormone receptor agonist DG00731 Goserelin D00573 Goserelin acetate Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Gonadotropin-releasing hormone GNRHR D00573 Goserelin acetate (JP19/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00573 Goserelin acetate Drug groups [BR:br08330] Hormonal agent DG01494 Gonadotropin-releasing hormone receptor agonist DG00731 Goserelin DBLINKS CAS: 145781-92-6 PubChem: 7847639 ChEBI: 5523 LigandBox: D00573 J-GLOBAL: J589.987G ATOM 95 1 C6a C 43.0248 -27.7517 2 O6a O 44.2380 -28.4521 3 C1a C 41.8118 -28.4521 4 O6a O 43.0248 -26.3510 5 C8y C 20.5100 -20.2300 6 C8y C 21.0000 -18.9000 7 C1b C 19.3200 -20.9300 8 C8x C 21.7000 -21.0700 9 C8y C 22.4000 -18.9000 10 C8x C 20.3000 -17.6400 11 C1c C 19.3200 -22.3300 12 N4x N 22.8200 -20.2300 13 C8x C 23.1000 -17.6400 14 C8x C 21.0700 -16.4500 15 N1b N 18.1300 -23.0300 16 C5a C 20.5100 -23.0300 17 C8x C 22.4000 -16.4500 18 C5a C 16.8700 -22.3300 19 N1b N 21.7700 -22.3300 20 O5a O 20.5100 -24.4300 21 C1c C 15.6800 -23.0300 22 O5a O 16.8700 -20.9300 23 C1c C 22.9600 -23.0300 24 C1b C 15.6800 -24.4300 25 N1b N 14.4900 -22.3300 26 C5a C 24.2200 -22.3300 27 C1b C 22.9600 -24.4300 28 C8y C 16.8700 -25.0600 29 C5a C 13.3000 -23.0300 30 N1b N 25.4100 -23.0300 31 O5a O 24.2200 -20.9300 32 O1a O 24.2200 -25.0600 33 C8x C 18.2700 -24.7100 34 N5x N 16.8700 -26.5300 35 C1y C 12.0400 -22.3300 36 O5a O 13.3000 -24.4300 37 C1c C 26.6000 -22.3300 38 N4x N 18.9700 -25.9000 39 C8x C 18.1300 -27.0200 40 C1x C 10.7100 -22.7500 41 N1x N 12.0400 -20.9300 42 C1b C 26.6000 -20.9300 43 C5a C 27.7900 -23.0300 44 C1x C 9.8700 -21.6300 45 C5x C 10.7100 -20.5100 46 C8y C 27.7900 -20.2300 47 N1b N 29.0500 -22.3300 48 O5a O 27.7900 -24.4300 49 O5x O 10.2900 -19.1800 50 C8x C 29.0500 -20.9300 51 C8x C 27.7900 -18.8300 52 C1c C 30.2400 -23.0300 53 C8x C 30.2400 -20.2300 54 C8x C 29.0500 -18.1300 55 C5a C 31.5000 -22.3300 56 C1b C 30.2400 -24.4300 57 C8y C 30.2400 -18.8300 58 N1b N 32.6900 -23.0300 59 O5a O 31.5000 -20.9300 60 O2a O 29.0500 -25.0600 61 O1a O 31.4300 -18.1300 62 C1c C 33.8800 -22.3300 63 C1d C 29.0500 -26.5300 64 C5a C 35.0700 -23.0300 65 C1b C 33.8800 -20.9300 66 C1a C 29.0500 -28.0000 67 C1a C 30.4500 -26.5300 68 C1a C 27.7200 -26.5300 69 N1b N 36.2600 -22.3300 70 O5a O 35.0700 -24.4300 71 C1c C 35.0700 -20.2300 72 C1c C 37.5200 -23.0300 73 C1a C 35.0700 -18.8300 74 C1a C 36.2600 -20.9300 75 C5a C 38.7800 -22.3300 76 C1b C 37.5200 -24.4300 77 N1y N 39.9700 -23.0300 78 O5a O 38.7800 -20.9300 79 C1b C 36.2600 -25.0600 80 C1y C 41.3700 -23.0300 81 C1x C 39.5500 -24.3600 82 C1b C 36.2600 -26.5300 83 C1x C 41.7900 -24.2900 84 C5a C 42.5600 -22.2600 85 C1x C 40.6700 -25.1300 86 N1b N 35.0700 -27.2300 87 N1b N 43.7500 -22.9600 88 O5a O 42.5600 -20.9300 89 C2c C 33.8800 -26.5300 90 N1a N 32.6900 -27.2300 91 N2a N 33.8800 -25.0600 92 N1b N 45.0100 -22.2600 93 C5a C 46.2000 -22.9600 94 N1a N 47.3900 -22.2600 95 O5a O 46.2000 -24.3600 BOND 99 1 1 2 1 2 1 3 1 3 1 4 2 4 5 6 1 5 5 7 1 6 5 8 2 7 6 9 2 8 6 10 1 9 7 11 1 10 8 12 1 11 9 13 1 12 10 14 2 13 11 15 1 14 11 16 1 #Up 15 13 17 2 16 15 18 1 17 16 19 1 18 16 20 2 19 18 21 1 20 18 22 2 21 23 19 1 #Down 22 21 24 1 #Down 23 21 25 1 24 23 26 1 25 23 27 1 26 24 28 1 27 25 29 1 28 26 30 1 29 26 31 2 30 27 32 1 31 28 33 2 32 28 34 1 33 35 29 1 #Down 34 29 36 2 35 30 37 1 36 33 38 1 37 34 39 2 38 35 40 1 39 35 41 1 40 37 42 1 #Up 41 37 43 1 42 40 44 1 43 41 45 1 44 42 46 1 45 43 47 1 46 43 48 2 47 45 49 2 48 46 50 2 49 46 51 1 50 47 52 1 51 50 53 1 52 51 54 2 53 52 55 1 54 52 56 1 #Up 55 53 57 2 56 55 58 1 57 55 59 2 58 56 60 1 59 57 61 1 60 58 62 1 61 60 63 1 62 62 64 1 63 62 65 1 #Up 64 63 66 1 65 63 67 1 66 63 68 1 67 64 69 1 68 64 70 2 69 65 71 1 70 69 72 1 71 71 73 1 72 71 74 1 73 72 75 1 74 72 76 1 #Down 75 75 77 1 76 75 78 2 77 76 79 1 78 77 80 1 79 77 81 1 80 79 82 1 81 80 83 1 82 80 84 1 #Down 83 81 85 1 84 82 86 1 85 84 87 1 86 84 88 2 87 86 89 1 88 89 90 1 89 89 91 2 90 9 12 1 91 14 17 1 92 38 39 1 93 44 45 1 94 54 57 1 95 83 85 1 96 87 92 1 97 92 93 1 98 93 94 1 99 93 95 2 BRACKET 1 39.8300 -29.2600 39.8300 -25.5500 1 45.7100 -25.5500 45.7100 -29.2600 1 x ORIGINAL 1 1 2 3 4 REPEAT 1 ///