ENTRY       D00462                      Drug
NAME        Oxandrolone (JAN/USP/INN);
            Oxandrin (TN)
FORMULA     C19H30O3
EXACT_MASS  306.2195
MOL_WEIGHT  306.44
CLASS       Hormonal agent
             DG01590  Androgen receptor agonist
              DG01605  Anabolic steroid
REMARK      Same as: C07346
            ATC code: A14AA08
EFFICACY    Anabolic, Androgen receptor agonist
  DISEASE   Osteoporosis [DS:H01593]
COMMENT     Androstan derivative
TARGET      NR3C4 (AR) [HSA:367] [KO:K08557]
INTERACTION  
STR_MAP     map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
BRITE       Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
             A ALIMENTARY TRACT AND METABOLISM
              A14 ANABOLIC AGENTS FOR SYSTEMIC USE
               A14A ANABOLIC STEROIDS
                A14AA Androstan derivatives
                 A14AA08 Oxandrolone
                  D00462  Oxandrolone (JAN/USP/INN)
            USP drug classification [BR:br08302]
             Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
              Anabolic Steroids
               Oxandrolone
                D00462  Oxandrolone (JAN/USP/INN)
            Drug groups [BR:br08330]
             Hormonal agent
              DG01590  Androgen receptor agonist
               DG01605  Anabolic steroid
                D00462  Oxandrolone
            Target-based classification of drugs [BR:br08310]
             Nuclear receptors
              Estrogen like receptors
               3-Ketosteroid receptor
                NR3C4 (AR)
                 D00462  Oxandrolone (JAN/USP/INN)
DBLINKS     CAS: 53-39-4
            PubChem: 7847528
            ChEBI: 7820
            LigandBox: D00462
            J-GLOBAL: J1.367F
ATOM        22
            1   C1y C    26.1861  -17.6636
            2   C1y C    25.0132  -16.9750
            3   C1y C    27.3706  -16.9984
            4   C1x C    26.1861  -19.0231
            5   C1z C    23.8228  -17.6519
            6   C1x C    25.0249  -15.6153
            7   C1z C    27.3706  -15.6387
            8   C1x C    29.7280  -16.9984
            9   C1x C    25.0016  -19.7000
            10  C1y C    23.8170  -19.0114
            11  C1x C    22.6558  -16.9691
            12  C1a C    23.8111  -16.4149
            13  C1x C    26.2035  -14.9501
            14  C1z C    28.5493  -14.9618
            15  C1a C    27.3997  -14.2734
            16  C1x C    29.7280  -15.6387
            17  C1x C    22.6558  -19.6942
            18  O7x O    21.4713  -17.6519
            19  C1a C    29.7922  -14.4017
            20  O1a O    28.5493  -13.5323
            21  C7x C    21.4713  -19.0114
            22  O6a O    20.2925  -19.6942
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    5  12 1 #Up
            12    6  13 1
            13    7  14 1
            14    7  15 1 #Up
            15    8  16 1
            16   10  17 1
            17   11  18 1
            18   14  19 1 #Down
            19   14  20 1 #Up
            20   17  21 1
            21   21  22 2
            22    7  13 1
            23    9  10 1
            24   14  16 1
            25   18  21 1
///