ENTRY       D00116                      Drug
NAME        Glucagon (USP/INN);
            Glucagon (genetical recombination) (JP19)
PRODUCT     BAQSIMI (Amphastar Pharmaceuticals)
            BAQSIMI (Sportpharm LLC)
            GLUCAGON (Fresenius Kabi USA)
            GLUCAGON (HF Acquisition Co LLC)
            GLUCAGON INJECTION, SOLUTION (Xeris Pharmaceuticals)
            GVOKE VIALDX (American Regent)
  GENERIC   GLUCAGON (A-S Medication Solutions)
            GLUCAGON (Amphastar Pharmaceuticals)
            GLUCAGON (Cipla USA)
            GLUCAGON (Lupin Pharmaceuticals)
            GLUCAGON (Mylan Pharmaceuticals)
            GLUCAGON (Sportpharm LLC)
            GLUCAGON (Sportpharm LLC)
            GLUCAGON (Sportpharm LLC)
FORMULA     C153H225N43O49S
EXACT_MASS  3480.6157
MOL_WEIGHT  3482.75
SEQUENCE    His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser
            Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr
  TYPE      Peptide
REMARK      Same as: C01501
            Therapeutic category: 2492 7229
            ATC code: H04AA01
            Chemical structure group: DG00511
            Product (DG00511): D00116<JP/US> D02118<US>
EFFICACY    Antidiabetic, Diagnostic, Glucagon receptor agonist
COMMENT     Glucagon is a single-chain polypeptide that contains 29 amino acid residues.
TARGET      GCGR [HSA:2642] [KO:K04583]
  PATHWAY   hsa04080(2642)  Neuroactive ligand-receptor interaction
            hsa04922(2642)  Glucagon signaling pathway
INTERACTION  
BRITE       Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
             H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
              H04 PANCREATIC HORMONES
               H04A GLYCOGENOLYTIC HORMONES
                H04AA Glycogenolytic hormones
                 H04AA01 Glucagon
                  D00116  Glucagon (USP/INN) &lt;JP/US&gt;
            USP drug classification [BR:br08302]
             Blood Glucose Regulators
              Glycemic Agents
               Glucagon
                D00116  Glucagon (USP/INN)
            Therapeutic category of drugs in Japan [BR:br08301]
             2  Agents affecting individual organs
              24  Hormones
               249  Miscellaneous
                2492  Pancreatic hormones
                 D00116  Glucagon (USP/INN); Glucagon (genetical recombination) (JP19)
             7  Agents not mainly for therapeutic purpose
              72  Intracorporeal diagnostic agents
               722  Various function testing reagents
                7229  Others
                 D00116  Glucagon (USP/INN); Glucagon (genetical recombination) (JP19)
            Target-based classification of drugs [BR:br08310]
             G Protein-coupled receptors
              Secretin receptor family
               Glucagon
                GCGR
                 D00116  Glucagon (USP/INN) &lt;JP/US&gt;
            Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
             Chemicals
              D00116  Glucagon (genetical recombination)
            New drug approvals in Europe [br08329.html]
             European public assessment reports (EPAR) authorised medicine
              D00116
DBLINKS     CAS: 9007-92-5
            PubChem: 7847184
            ChEBI: 5391
            J-GLOBAL: J9.063H
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