ENTRY D00105 Drug NAME Estradiol (JAN/USP/INN); Climara (TN); Divigel (TN); Estrace (TN); Estraderm (TN); Estrasorb (TN); Estring (TN); Estrogel (TN); Innofem (TN); Vagifem (TN); Vivelle (TN) PRODUCT CLIMARA (Bayer HealthCare Pharmaceuticals) DIVIGEL (Vertical Pharmaceuticals) ESTRADIOL (Trigen Laboratories) ESTRING (Pfizer Laboratories Div Pfizer) ESTROGEL (ASCEND Therapeutics US) MENOSTAR (Bayer HealthCare Pharmaceuticals) MINIVELLE (Noven Therapeutics) VAGIFEM (Novo Nordisk) VIVELLE-DOT (Sandoz) GENERIC DOTTI (Amneal Pharmaceuticals LLC) DOTTI (Bryant Ranch Prepack) DOTTI (Bryant Ranch Prepack) DOTTI (Bryant Ranch Prepack) DOTTI (Bryant Ranch Prepack) DOTTI (Bryant Ranch Prepack) ESTRACE (A-S Medication Solutions) ESTRACE (Allergan) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (A-S Medication Solutions) ESTRADIOL (ANI Pharmaceuticals) ESTRADIOL (ANI Pharmaceuticals) ESTRADIOL (ANI Pharmaceuticals) ESTRADIOL (American Health Packaging) ESTRADIOL (Amneal Pharmaceuticals NY LLC) ESTRADIOL (Amneal Pharmaceuticals NY LLC) ESTRADIOL (Amneal Pharmaceuticals NY LLC) ESTRADIOL (Amneal Pharmaceuticals of New York LLC) ESTRADIOL (Asclemed USA) ESTRADIOL (Asclemed USA) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Bryant Ranch Prepack) ESTRADIOL (Coupler LLC) ESTRADIOL (Direct_Rx) ESTRADIOL (Direct_Rx) ESTRADIOL (Direct_Rx) ESTRADIOL (EPIC PHARMA) ESTRADIOL (Encube Ethicals) ESTRADIOL (NorthStar Rx LLC) ESTRADIOL (NorthStar Rx LLC) ESTRADIOL (Northwind Health Company) ESTRADIOL (Northwind Health Company) ESTRADIOL (Northwind Health Company) ESTRADIOL (Northwind Health Company) ESTRADIOL (Northwind Health Company) ESTRADIOL (Noven Therapeutics) ESTRADIOL (NuCare Pharmaceuticals) ESTRADIOL (NuCare Pharmaceuticals) ESTRADIOL (NuCare Pharmaceuticals) ESTRADIOL (NuCare Pharmaceuticals) ESTRADIOL (NuCare Pharmaceuticals) ESTRADIOL (NuCare Pharmaceuticals) ESTRADIOL (PD-Rx Pharmaceuticals) ESTRADIOL (PD-Rx Pharmaceuticals) ESTRADIOL (PD-Rx Pharmaceuticals) ESTRADIOL (PURACAP LABORATORIES) ESTRADIOL (Padagis Israel Pharmaceuticals) ESTRADIOL (PharmPak) ESTRADIOL (PharmPak) ESTRADIOL (Preferred Pharmaceuticals) ESTRADIOL (Preferred Pharmaceuticals) ESTRADIOL (Preferred Pharmaceuticals) ESTRADIOL (Proficient Rx LP) ESTRADIOL (REMEDYREPACK) ESTRADIOL (REMEDYREPACK) ESTRADIOL (REMEDYREPACK) ESTRADIOL (REMEDYREPACK) ESTRADIOL (REMEDYREPACK) ESTRADIOL (Redpharm Drug) ESTRADIOL (Sandoz) ESTRADIOL (Solaris Pharma Corporation) ESTRADIOL (Teva Pharmaceuticals USA) ESTRADIOL (Teva Pharmaceuticals USA) ESTRADIOL (Xiromed) ESTRADIOL (Zydus Lifesciences Limited) ESTRADIOL (Zydus Lifesciences Limited) ESTRADIOL (Zydus Lifesciences Limited) ESTRADIOL (Zydus Pharmaceuticals USA) ESTRADIOL (Zydus Pharmaceuticals USA) ESTRADIOL (Zydus Pharmaceuticals USA) ESTRADIOL GEL (Encube Ethicals) ESTRADIOL TRANSDERMAL SYSTEM (Sandoz) ESTRADIOL VAGINAL (A-S Medication Solutions) ESTRADIOL VAGINAL (A-S Medication Solutions) ESTRADIOL VAGINAL (AvKARE) ESTRADIOL VAGINAL (Bryant Ranch Prepack) ESTRADIOL VAGINAL (Bryant Ranch Prepack) ESTRADIOL VAGINAL (Bryant Ranch Prepack) ESTRADIOL VAGINAL (NuCare Pharmaceuticals) ESTRADIOL VAGINAL (Padagis Israel Pharmaceuticals) ESTRADIOL VAGINAL (Redpharm Drug) ESTRADIOL VAGINAL CREAM (Prasco Laboratories) LYLLANA (Amneal Pharmaceuticals LLC) YUVAFEM (Amneal Pharmaceuticals LLC) YUVAFEM (AvKARE) FORMULA C18H24O2 EXACT_MASS 272.1776 MOL_WEIGHT 272.38 CLASS Hormonal agent DG01986 Estrogen DG01584 Estrogen receptor agonist Musculo-skeletal system agent DG03232 Osteoporosis agent Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate REMARK Same as: C00951 Therapeutic category: 2473 ATC code: G03CA03 Chemical structure group: DG00462 Product (DG00462): D00105 D01413 D04061 D04063 D07918 Product (mixture): D09187 D09188 D12226 D12497 EFFICACY Menstruation disorder agent, Estrogen receptor agonist DISEASE Postmenopausal osteoporosis [DS:H01593] Primary ovarian failure [DS:H00627] COMMENT Estrogen TARGET NR3A (ESR) [HSA:2099 2100] [KO:K08550 K08551] PATHWAY hsa04915(2099+2100) Estrogen signaling pathway hsa04961(2099) Endocrine and other factor-regulated calcium reabsorption METABOLISM Enzyme: CYP3A4 [HSA:1576] INTERACTION STR_MAP map07047 Osteoporosis drugs map07226 Progesterone, androgen and estrogen receptor agonists/antagonists BRITE Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] G GENITO URINARY SYSTEM AND SEX HORMONES G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM G03C ESTROGENS G03CA Natural and semisynthetic estrogens, plain G03CA03 Estradiol D00105 Estradiol (JAN/USP/INN) <JP/US> USP drug classification [BR:br08302] Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers) Estrogens Estradiol D00105 Estradiol (JAN/USP/INN) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 24 Hormones 247 Estrogen and progesterone preparations 2473 Estradiols D00105 Estradiol (JAN/USP/INN) Classification of Japanese OTC drugs [BR:br08313] Drugs for women 51 Other drugs for women D00105 Estradiol (JAN/USP/INN) Risk category of Japanese OTC drugs [BR:br08312] Designated second-class OTC drugs Inorganic and organic chemicals Estradiol D00105 Estradiol (JAN/USP/INN) Second-class OTC drugs Inorganic and organic chemicals Estradiol D00105 Estradiol (JAN/USP/INN) Drug groups [BR:br08330] Hormonal agent DG01986 Estrogen DG00462 Estradiol D00105 Estradiol DG01584 Estrogen receptor agonist DG00462 Estradiol D00105 Estradiol Musculo-skeletal system agent DG03232 Osteoporosis agent D00105 Estradiol Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00462 Estradiol D00105 Estradiol Target-based classification of drugs [BR:br08310] Nuclear receptors Estrogen like receptors Estrogen receptor NR3A (ESR) D00105 Estradiol (JAN/USP/INN) <JP/US> Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00105 Drug groups [BR:br08330] Hormonal agent DG01986 Estrogen DG00462 Estradiol DG01584 Estrogen receptor agonist DG00462 Estradiol Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00462 Estradiol DBLINKS CAS: 50-28-2 PubChem: 7847173 ChEBI: 16469 PDB-CCD: EST LigandBox: D00105 J-GLOBAL: J4.100I ATOM 20 1 C8x C 19.0779 -11.8363 2 C8y C 19.0779 -13.2006 3 C8x C 20.2594 -13.8828 4 C8y C 21.4411 -13.2006 5 C8y C 21.4411 -11.8363 6 C8x C 20.2594 -11.1541 7 C1x C 22.6226 -13.8828 8 C1x C 23.8041 -13.2006 9 C1y C 23.8041 -11.8363 10 C1y C 22.6226 -11.1541 11 C1y C 24.9857 -11.1541 12 C1z C 24.9857 -9.7898 13 C1x C 23.8041 -9.1076 14 C1x C 22.6226 -9.7898 15 C1x C 27.3487 -11.1541 16 C1x C 27.3487 -9.7898 17 C1y C 26.1672 -9.1076 18 O1a O 26.1672 -7.7433 19 O1a O 17.8964 -13.8828 20 C1a C 24.9857 -8.4255 BOND 23 1 1 2 1 2 2 3 2 3 3 4 1 4 4 5 2 5 5 6 1 6 1 6 2 7 4 7 1 8 7 8 1 9 8 9 1 10 9 10 1 11 5 10 1 12 9 11 1 13 11 12 1 14 12 13 1 15 13 14 1 16 10 14 1 17 11 15 1 18 15 16 1 19 16 17 1 20 12 17 1 21 17 18 1 #Up 22 2 19 1 23 12 20 1 #Up ///