ENTRY D00089 Drug NAME Oxytocin (JP19/USP/INN); Oxytocin (TN); Pitocin (TN); Syntocinon (TN) PRODUCT OXYTOCIN (Cardinal Health 107) OXYTOCIN (Fresenius Kabi USA) OXYTOCIN (Fresenius Kabi USA) OXYTOCIN (Fresenius Kabi USA) OXYTOCIN (REMEDYREPACK) PITOCIN (Par Health USA) PITOCIN (Par Health USA) PITOCIN (Par Health USA) PITOCIN (Par Health USA) GENERIC OXYTOCIN (West-Ward Pharmaceuticals Corp) FORMULA C43H66N12O12S2 EXACT_MASS 1006.4365 MOL_WEIGHT 1007.19 SEQUENCE Cys Tyr Ile Gln Asn Cys Pro Leu Gly (Disulfide bridge: 1-6) TYPE Peptide REMARK Same as: C00746 Therapeutic category: 2414 ATC code: H01BB02 Product: D00089 EFFICACY Oxytocic, Oxytocin receptor agonist COMMENT Posterior pituitary hormone TARGET OXTR [HSA:5021] [KO:K04229] PATHWAY hsa04080(5021) Neuroactive ligand-receptor interaction hsa04921(5021) Oxytocin signaling pathway INTERACTION BRITE Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES H01B POSTERIOR PITUITARY LOBE HORMONES H01BB Oxytocin and analogues H01BB02 Oxytocin D00089 Oxytocin (JP19/USP/INN) <JP/US> Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 24 Hormones 241 Pituitary hormone preparations 2414 Posterior pituitary hormones D00089 Oxytocin (JP19/USP/INN) Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Oxytocin OXTR D00089 Oxytocin (JP19/USP/INN) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00089 Oxytocin D00089 Oxytocin injection DBLINKS CAS: 50-56-6 PubChem: 7847157 ChEBI: 7872 LigandBox: D00089 J-GLOBAL: J1.360I ATOM 69 1 C8x C 26.7400 -15.1900 2 C8y C 26.7400 -16.5900 3 C8x C 27.9300 -17.2900 4 C8x C 29.1900 -16.5900 5 C8y C 29.1900 -15.1900 6 C8x C 27.9300 -14.4900 7 O1a O 25.5500 -17.2900 8 C1b C 30.3800 -14.4900 9 C1y C 32.1300 -15.1900 10 C5x C 33.3200 -14.4900 11 N1x N 32.1300 -16.5900 12 N1x N 34.5100 -15.1900 13 O5x O 33.3200 -13.0900 14 C5x C 30.9400 -17.2900 15 C1y C 30.9400 -18.6900 16 O5x O 29.7500 -16.5900 17 N1a N 29.7500 -19.3900 18 C1x C 32.1300 -19.3900 19 S3x S 32.1300 -20.7900 20 S3x S 33.3200 -21.4900 21 C1x C 34.5100 -20.7900 22 C1y C 35.7000 -21.4900 23 N1x N 36.8900 -20.7900 24 C5a C 35.7000 -22.8900 25 O5a O 34.5100 -23.5900 26 N1y N 36.8900 -23.5900 27 C1y C 36.8900 -24.9900 28 C1x C 38.2200 -25.4100 29 C1x C 39.0600 -24.2900 30 C1x C 38.2200 -23.1700 31 C5a C 35.7700 -25.8300 32 N1b N 34.5100 -25.2700 33 O5a O 35.7700 -27.2300 34 C5a C 32.1300 -25.2700 35 C1c C 33.3200 -25.9700 36 C1b C 33.3200 -27.3700 37 C1c C 32.1300 -28.0700 38 C1a C 30.9400 -27.3700 39 C1a C 32.1300 -29.4700 40 N1b N 30.9400 -25.9700 41 O5a O 32.1300 -23.8700 42 C1b C 29.7500 -25.2700 43 C5a C 28.5600 -25.9700 44 N1a N 27.3700 -25.2700 45 O5a O 28.5600 -27.3700 46 C5x C 36.8900 -19.3900 47 O5x O 35.7000 -18.6900 48 C1y C 38.0800 -18.6900 49 N1x N 38.0800 -17.2900 50 C5x C 39.2700 -16.5900 51 O5x O 40.5300 -17.2900 52 C1y C 39.2700 -15.1900 53 N1x N 38.0800 -14.4900 54 C5x C 36.8900 -15.1900 55 C1y C 35.7000 -14.4900 56 O5x O 36.8900 -16.5900 57 C1c C 35.7000 -13.0900 58 C1b C 36.8900 -12.3900 59 C1a C 38.0800 -13.0900 60 C1a C 34.5100 -12.3900 61 C1b C 39.3400 -19.3900 62 C1b C 40.4600 -14.4900 63 C1b C 41.7200 -15.1900 64 C5a C 42.9100 -14.4200 65 N1a N 44.1000 -15.1200 66 O5a O 42.9100 -13.0200 67 C5a C 39.3400 -20.7900 68 N1a N 40.5300 -21.4900 69 O5a O 38.1500 -21.4900 BOND 71 1 1 2 2 2 2 3 1 3 3 4 2 4 4 5 1 5 5 6 2 6 1 6 1 7 2 7 1 8 5 8 1 9 9 8 1 #Up 10 9 10 1 11 9 11 1 12 10 12 1 13 10 13 2 14 11 14 1 15 14 15 1 16 14 16 2 17 15 17 1 #Down 18 15 18 1 19 18 19 1 20 19 20 1 21 20 21 1 22 21 22 1 23 22 23 1 24 22 24 1 #Down 25 24 25 2 26 24 26 1 27 26 27 1 28 27 28 1 #Up 29 28 29 1 30 29 30 1 31 26 30 1 32 27 31 1 33 31 32 1 34 31 33 2 35 34 35 1 36 35 32 1 37 35 36 1 #Up 38 36 37 1 39 37 38 1 40 37 39 1 41 34 40 1 42 34 41 2 43 40 42 1 44 42 43 1 45 43 44 1 46 43 45 2 47 23 46 1 48 46 47 2 49 46 48 1 50 48 49 1 51 49 50 1 52 50 51 2 53 50 52 1 54 52 53 1 55 53 54 1 56 55 54 1 #Up 57 55 12 1 58 54 56 2 59 55 57 1 60 57 58 1 61 58 59 1 62 57 60 1 #Up 63 48 61 1 #Up 64 52 62 1 #Up 65 62 63 1 66 63 64 1 67 64 65 1 68 64 66 2 69 61 67 1 70 67 68 1 71 67 69 2 ///