ENTRY map00590 Pathway NAME Arachidonic acid metabolism CLASS Metabolism; Lipid metabolism PATHWAY_MAP map00590 Arachidonic acid metabolism DBLINKS GO: 0019369 REFERENCE PMID:14636671 AUTHORS Spector AA, Fang X, Snyder GD, Weintraub NL. TITLE Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. JOURNAL Prog Lipid Res 43:55-90 (2004) DOI:10.1016/S0163-7827(03)00049-3 REFERENCE PMID:15292194 AUTHORS Harman CA, Rieke CJ, Garavito RM, Smith WL. TITLE Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid. JOURNAL J Biol Chem 279:42929-35 (2004) DOI:10.1074/jbc.M403013200 REFERENCE PMID:15205388 AUTHORS Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA. TITLE The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. JOURNAL Drug Metab Dispos 32:727-33 (2004) DOI:10.1124/dmd.32.7.727 REFERENCE PMID:14660610 AUTHORS Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B. TITLE CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. JOURNAL J Biol Chem 279:6305-14 (2004) DOI:10.1074/jbc.M311830200 REFERENCE PMID:14626496 AUTHORS Sacerdoti D, Gatta A, McGiff JC. TITLE Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology. JOURNAL Prostaglandins Other Lipid Mediat 72:51-71 (2003) DOI:10.1016/S1098-8823(03)00077-7 REFERENCE PMID:14622984 AUTHORS Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB. TITLE Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450. JOURNAL Arch Biochem Biophys 420:142-52 (2003) DOI:10.1016/j.abb.2003.09.026 REFERENCE PMID:11679404 AUTHORS Fleming I. TITLE Cytochrome p450 and vascular homeostasis. JOURNAL Circ Res 89:753-62 (2001) DOI:10.1161/hh2101.099268 REFERENCE PMID:11328810 AUTHORS Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC. TITLE Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain. JOURNAL J Biol Chem 276:25467-79 (2001) DOI:10.1074/jbc.M100545200 REFERENCE PMID:10908295 AUTHORS Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA. TITLE CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract. JOURNAL Mol Pharmacol 58:279-87 (2000) DOI:10.1124/mol.58.2.279 REFERENCE PMID:9812980 AUTHORS Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB. TITLE Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta. JOURNAL J Biol Chem 273:30879-87 (1998) DOI:10.1074/jbc.273.47.30879 REL_PATHWAY map00591 Linoleic acid metabolism map07034 Eicosanoids KO_PATHWAY ko00590 ///