ENTRY hsa05200 Pathway NAME Pathways in cancer - Homo sapiens (human) CLASS Human Diseases; Cancer: overview PATHWAY_MAP hsa05200 Pathways in cancer NETWORK nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06161 Human immunodeficiency virus 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06166 Human papillomavirus (HPV) nt06167 Human cytomegalovirus (HCMV) nt06168 Herpes simplex virus 1 (HSV-1) nt06170 Influenza A virus (IAV) nt06181 Salmonella nt06210 ERK signaling (cancer) nt06213 Other RAS signaling (cancer) nt06214 PI3K signaling (cancer) nt06215 WNT signaling (cancer) nt06216 NOTCH signaling (cancer) nt06217 HH signaling (cancer) nt06218 TGFB signaling (cancer) nt06219 JAK-STAT signaling (cancer) nt06220 Calcium signaling (cancer) nt06225 HIF-1 signaling (cancer) nt06226 KEAP1-NRF2 signaling (cancer) nt06227 Nuclear receptor signaling (cancer) nt06230 Cell cycle (cancer) nt06231 Apoptosis (cancer) nt06232 Telomerase activity (cancer) nt06260 Colorectal cancer nt06261 Gastric cancer nt06262 Pancreatic cancer nt06263 Hepatocellular carcinoma nt06264 Renal cell carcinoma nt06265 Bladder cancer nt06266 Non-small cell lung cancer nt06267 Small cell lung cancer nt06268 Melanoma nt06269 Basal cell carcinoma nt06270 Breast cancer nt06271 Endometrial cancer nt06272 Prostate cancer nt06273 Glioma nt06274 Thyroid cancer nt06275 Acute myeloid leukemia nt06276 Chronic myeloid leukemia nt06324 GHRH-GH-IGF signaling nt06463 Parkinson disease nt06464 Amyotrophic lateral sclerosis nt06465 Prion disease nt06466 Pathways of neurodegeneration nt06501 HH signaling nt06505 WNT signaling nt06507 TGFB signaling nt06511 NOTCH signaling nt06524 Apoptosis nt06530 PI3K signaling nt06542 HIF signaling ELEMENT N00001 EGF-EGFR-RAS-ERK signaling pathway N00015 PDGF-PDGFR-RAS-ERK signaling pathway N00019 FGF-FGFR-RAS-ERK signaling pathway N00021 EGF-ERBB2-RAS-ERK signaling pathway N00023 EGF-EGFR-PLCG-ERK signaling pathway N00026 EGF-EGFR-PLCG-CAMK signaling pathway N00028 PDGF-PDGFR-PLCG-CAMK signaling pathway N00033 EGF-EGFR-PI3K signaling pathway N00037 FGF-FGFR-PI3K signaling pathway N00039 PDGF-PDGFR-PI3K signaling pathway N00043 HGF-MET-PI3K signaling pathway N00045 KITLG-KIT-PI3K signaling pathway N00053 Cytokine-Jak-STAT signaling pathway N00056 Wnt signaling pathway, Canonical pathway N00062 Hedgehog signaling pathway N00063 TGF-beta signaling pathway N00066 MDM2-p21-Cell cycle G1/S N00069 p16-Cell cycle G1/S N00079 HIF-1 signaling pathway N00083 Androgen receptor signaling pathway N00086 Notch signaling pathway N00090 p15-Cell cycle G1/S N00091 p27-Cell cycle G1/S N00094 EGF-Jak-STAT signaling pathway N00096 EGF-EGFR-RAS-RASSF1 signaling pathway N00098 Intrinsic apoptotic pathway N00101 DCC-apoptotic pathway N00103 EGF-EGFR-RAS-RalGDS signaling pathway N00215 KITLG-KIT-RAS-ERK signaling pathway N00216 HGF-MET-RAS-ERK signaling pathway N00217 FLT3LG-FLT3-RAS-ERK signaling pathway N00218 FLT3LG-FLT3-RAS-PI3K signaling pathway N00219 FLT3LG-FLT3-STAT5 signaling pathway N00220 PTEN-PIP3-AKT signaling pathway N00227 TGFA-EGFR-PLCG-PKC signaling pathway N00229 TGFA-EGFR-RAS-ERK signaling pathway N00231 TGFA-EGFR-PI3K signaling pathway N00233 IGF-IGF1R-RAS-ERK signaling pathway N00234 IGF2-IGF1R-PI3K signaling pathway N00239 Telomerase activity N00243 KEAP1-NRF2 signaling pathway DRUG D00094 Tretinoin (JAN/USP/INN) D00327 Fluoxymesterone (JAN/USP/INN) D00408 Methyltestosterone (JP19/USP/INN) D00554 Ethinyl estradiol (USP) D00586 Flutamide (JP19/USP/INN) D00745 Interferon alfa-2a (USAN/INN) D00747 Interferon gamma-1b (USAN/INN) D00748 Aldesleukin (USAN/INN) D00753 Sirolimus (JAN/USAN/INN) D00958 Testosterone enanthate (JP19/USP) D00961 Bicalutamide (JP19/USP/INN) D00965 Nilutamide (USAN/INN) D00966 Tamoxifen citrate (JP19/USP) D00967 Toremifene citrate (JAN/USAN) D01161 Fulvestrant (JAN/USP/INN) D01441 Imatinib mesylate (USAN) D01534 Dromostanolone propionate (USAN) D01977 Gefitinib (JP19/USAN/INN) D02106 Arsenic trioxide (JP19/USAN) D02714 Everolimus (JAN/USAN/INN) D02745 Interferon alfa-2b (USAN) D02748 Peginterferon alfa-2b (USAN/INN) D02815 Alitretinoin (USAN) D02970 Aprinocarsen sodium (USAN) D03061 Batimastat (USAN/INN) D03106 Bexarotene (JAN/USAN/INN) D03218 Axitinib (JAN/USAN) D03235 Filgrastim (USP/INN) D03247 Lenograstim (USAN/INN) D03252 Bosutinib (USAN) D03257 Trastuzumab (USAN/INN) D03305 Interferon alfa (NAMALWA) (JP19) D03350 Canertinib dihydrochloride (USAN) D03357 Interferon gamma-1a (genetical recombination) (JAN) D03455 Cetuximab (USAN/INN) D03658 Dasatinib (JAN/INN) D03682 Denileukin diftitox (USAN/INN) D03800 Rebimastat (USAN/INN) D03802 Tanomastat (USAN/INN) D04014 Enzastaurin hydrochloride (JAN/USAN) D04023 Erlotinib hydrochloride (JAN/USAN) D04024 Lapatinib ditosylate (USAN) D04025 Mubritinib (USAN/INN) D04162 Fenretinide (USAN/INN) D04696 Lestaurtinib (USAN/INN) D04862 Masoprocol (USAN/INN) D05029 Midostaurin (JAN/USAN/INN) D05350 Panitumumab (USAN/INN) D05380 Pazopanib hydrochloride (JAN/USAN) D05386 Pegaptanib sodium (JAN/USAN) D05399 Pelitinib (USAN/INN) D05446 Pertuzumab (USAN/INN) D05803 Sargramostim (USP/INN) D05819 Semaxanib (USAN/INN) D06005 Tandutinib (USAN/INN) D06068 Temsirolimus (JAN/USAN/INN) D06272 Sorafenib tosylate (USAN) D06285 Vatalanib (USAN/INN) D06320 Vorinostat (JAN/USAN) D06402 Sunitinib malate (JAN/USAN) D06407 Vandetanib (JAN/USAN/INN) D06409 Bevacizumab (USAN) D06413 Nilotinib hydrochloride hydrate (JAN) D06414 Dasatinib (USAN) D06554 Alvespimycin hydrochloride (USAN) D06563 Belagenpumatucel-L (USAN) D06610 Lapuleucel-T (USAN) D06637 Romidepsin (JAN/USAN/INN) D06678 Motesanib (USAN) D06889 Pegfilgrastim (USAN/INN) D07434 Polyestradiol phosphate (INN) D07741 Zibotentan (JAN/USAN/INN) D07907 Erlotinib (INN) D08066 Imatinib (INN) D08108 Lapatinib (INN) D08524 Sorafenib (USAN/INN) D08552 Sunitinib (INN) D08559 Tamoxifen (INN) D08805 Interferon gamma-n1 (JAN) D08870 Belinostat (USAN/INN) D08881 Cediranib (USAN/INN) D08883 Cediranib maleate (JAN/USAN) D08900 Ridaforolimus (JAN/USAN/INN) D08917 Ezatiostat hydrochloride (USAN) D08947 Motesanib diphosphate (USAN) D08950 Neratinib (USAN/INN) D08953 Nilotinib (USAN/INN) D08956 Omacetaxine mepesuccinate (USAN) D08971 Plerixafor (JAN/USAN/INN) D09328 Cixutumumab (USAN) D09338 Entinostat (JAN/USAN/INN) D09357 Mocetinostat dihydrobromide (USAN) D09574 Aflibercept (USAN/INN) D09604 Dinaciclib (USAN/INN) D09629 Imetelstat (USAN/INN) D09630 Imetelstat sodium (USAN) D09635 Linifanib (USAN/INN) D09641 Mocetinostat (USAN/INN) D09659 Rilotumumab (USAN/INN) D09660 Rindopepimut (USAN) D09683 Tivozanib (USAN/INN) D09689 Varlitinib (USAN/INN) D09690 Varlitinib tosylate (USAN) D09724 Afatinib (USAN/INN) D09728 Bosutinib hydrate (JAN) D09731 Crizotinib (JAN/USAN/INN) D09733 Afatinib dimaleate (USAN) D09746 Dalotuzumab (USAN) D09864 Amuvatinib (USAN/INN) D09865 Amuvatinib hydrochloride (USAN) D09908 Ganitumab (USAN/INN) D09909 Gataparsen (USAN/INN) D09910 Gataparsen sodium (USAN) D09919 Lenvatinib (USAN/INN) D09920 Lenvatinib mesylate (USAN) D09939 Olaratumab (USAN/INN) D09941 Onartuzumab (USAN/INN) D09950 Ponatinib (USAN/INN) D09951 Ponatinib hydrochloride (JAN/USAN) D09955 Quizartinib (USAN/INN) D09956 Quizartinib dihydrochloride (USAN) D09959 Ruxolitinib (USAN/INN) D09960 Ruxolitinib phosphate (JAN/USAN) D09980 Trastuzumab emtansine (USAN/INN) D09992 Vismodegib (USAN/INN) D09996 Vemurafenib (JAN/USAN/INN) D10015 Litgenprostucel-L (USAN) D10019 Panobinostat lactate (JAN) D10031 Zalutumumab (USAN/INN) D10060 Abexinostat (USAN) D10062 Cabozantinib (USAN) D10064 Dabrafenib (USAN) D10076 Olcorolimus (USAN) D10084 Abexinostat hydrochloride (USAN) D10095 Cabozantinib s-malate (USAN) D10102 Crenolanib (USAN) D10103 Crenolanib besylate (USAN) D10104 Dabrafenib mesylate (USAN) D10119 Sonidegib (USAN/INN) D10123 Ficlatuzumab (USAN) D10137 Regorafenib hydrate (JAN) D10138 Regorafenib (USAN/INN) D10164 Sepantronium bromide (JAN/USAN) D10173 Tivantinib (JAN/USAN/INN) D10175 Trametinib (USAN) D10176 Trametinib dimethyl sulfoxide (JAN/USAN) D10189 Pictilisib (USAN/INN) D10190 Tivozanib hydrochloride (USAN) D10218 Enzalutamide (JAN/USAN) D10224 Golvatinib (USAN) D10229 Masitinib (INN) D10242 Lipegfilgrastim (USAN) D10319 Panobinostat (USAN/INN) D10321 Quisinostat (USAN/INN) D10322 Quisinostat hydrochloride (USAN) D10324 Patidegib (USAN/INN) D10325 Patidegib hydrochloride (USAN) D10334 Rebastinib (USAN) D10372 Palbociclib (JAN/USAN) D10381 Afuresertib (USAN/INN) D10382 Afuresertib hydrochloride (USAN) D10396 Nintedanib esylate (USAN) D10399 Rebastinib Tosylate (USAN) D10405 Cobimetinib (USAN/INN) D10410 Vantictumab (USAN/INN) D10423 Ilorasertib (USAN/INN) D10426 Pimasertib (USAN/INN) D10437 Galunisertib (USAN/INN) D10446 Margetuximab (USAN/INN) D10450 Alectinib hydrochloride (JAN) D10464 Firtecan pegol (USAN/INN) D10465 Golvatinib tartrate (USAN) D10481 Nintedanib (USAN/INN) D10486 Pimasertib hydrochloride (USAN) D10542 Alectinib (USAN/INN) D10543 Apitolisib (USAN/INN) D10551 Ceritinib (JAN/USAN/INN) D10552 Dactolisib (USAN/INN) D10555 Duvelisib (USAN/INN) D10560 Idelalisib (JAN/USAN/INN) D10584 Buparlisib (USAN/INN) D10604 Binimetinib (JAN/USAN/INN) D10609 Buparlisib hydrochloride (JAN/USAN) D10615 Cobimetinib fumarate (USAN) D10616 Dactolisib tosylate (USAN) D10635 Gedatolisib (USAN/INN) D10636 Glasdegib (USAN/INN) D10641 Ipatasertib (USAN/INN) D10652 Palbociclib isethionate (USAN) D10671 Taladegib (USAN/INN) D10679 Venetoclax (JAN/USAN/INN) D10688 Abemaciclib (JAN/USAN/INN) D10696 Capmatinib (USAN/INN) D10709 Gilteritinib (USAN/INN) D10717 Napabucasin (JAN/USAN/INN) D10718 Omipalisib (USAN/INN) D10729 Sonidegib phosphate (USAN) D10766 Osimertinib mesylate (USAN) D10797 Copanlisib hydrochloride (USAN) D10798 Copanlisib hydrochloride hydrate (JAN) D10800 Gilteritinib fumarate (JAN/USAN) D10858 Rociletinib (USAN/INN) D10859 Olmutinib (USAN/INN) D10866 Brigatinib (JAN/USAN) D10867 Copanlisib (USAN/INN) D10883 Ribociclib (USAN/INN) D10891 Capmatinib hydrochloride (USAN) D10898 Neratinib maleate D10924 Dezapelisib (USAN/INN) D10926 Entrectinib (JAN/USAN/INN) D10927 Erdafitinib (JAN/USAN/INN) D10958 Naquotinib (USAN/INN) D10977 Remetinostat (USAN/INN) D10979 Ribociclib succinate (USAN) D10981 Rovalpituzumab tesirine (USAN/INN) D10993 Tucidinostat (JAN/USAN/INN) D11011 Alpelisib (JAN/USAN/INN) D11012 Lorlatinib (JAN/USAN/INN) D11032 Plitidepsin (INN) D11038 Ulixertinib (INN) D11040 Apalutamide (JAN/INN) D11045 Darolutamide (JAN/USAN/INN) D11053 Encorafenib (JAN/USAN/INN) D11073 Tepotinib hydrochloride (USAN) D11074 Ipatasertib hydrochloride (JAN) D11107 Glasdegib maleate (JAN) D11115 Olmutinib hydrochloride (USAN) D11117 Rovalpituzumab (USAN) D11125 Modotuximab (USAN/INN) D11126 Navicixizumab (USAN/INN) D11130 Trilaciclib (USAN/INN) D11136 Glesatinib (USAN/INN) D11137 Larotrectinib (USAN/INN) D11138 Larotrectinib sulfate (JAN/USAN) D11139 Savolitinib (JAN/USAN/INN) D11140 Sitravatinib (USAN/INN) D11141 Tucatinib (USAN/INN) D11151 Crenigacestat (USAN/INN) D11182 Tinostamustine (USAN/INN) D11184 Ralaniten (USAN/INN) D11185 Ralaniten acetate (USAN) D11229 Brontictuzumab (USAN/INN) D11234 Emactuzumab (USAN/INN) D11251 Icotinib D11264 Brilanestrant (USAN/INN) D11270 Pexidartinib (USAN/INN) D11271 Pexidartinib hydrochloride (JAN/USAN) D11279 Avapritinib (USAN/INN) D11285 Ravoxertinib (USAN/INN) D11296 Fedratinib hydrochloride (USAN) D11307 Telisotuzumab (USAN) D11323 Umbralisib tosylate (USAN) D11344 Telisotuzumab vedotin (USAN) D11346 Ensartinib (USAN) D11353 Ripretinib (JAN/USAN) D11356 Ensartinib hydrochloride (USAN) D11358 Tagraxofusp (USAN/INN) D11371 Capivasertib (JAN/USAN) D11403 Asciminib (USAN/INN) D11404 Asciminib hydrochloride (JAN/USAN) D11409 Miransertib (USAN/INN) D11410 Lifirafenib (USAN/INN) D11411 Lifirafenib maleate (USAN) D11417 Pemigatinib (JAN/USAN/INN) D11430 Nazartinib (USAN/INN) D11434 Nazartinib mesylate (USAN) D11437 Parsaclisib (USAN/INN) D11440 Bimiralisib (USAN/INN) D11442 Nanatinostat (USAN) D11454 Repotrectinib (JAN/USAN) D11455 Lerociclib (USAN) D11461 Derazantinib hydrochloride (USAN) D11501 Samotolisib (USAN) D11506 Parsaclisib hydrochloride (JAN/USAN) D11508 Miransertib mesylate (USAN) D11529 Trastuzumab deruxtecan (USAN/INN) D11541 Sitravatinib malate (USAN) D11589 Infigratinib (USAN/INN) D11599 Zotiraciclib (USAN) D11600 Zotiraciclib citrate (USAN) D11642 Dilpacimab (USAN/INN) D11658 Duvelisib hydrate (JAN) D11663 Onatasertib (USAN) D11669 Bempegaldesleukin (USAN/INN) D11671 Elacestrant (USAN/INN) D11672 Elacestrant hydrochloride (USAN) D11675 Mirdametinib (USAN) D11712 Pralsetinib (USAN/INN) D11713 Selpercatinib (JAN/USAN/INN) D11717 Tepotinib (USAN/INN) D11725 Futibatinib (JAN/USAN/INN) D11727 Voxtalisib (USAN/INN) D11737 Fisogatinib (USAN/INN) D11747 Inbakicept (USAN/INN) D11762 Lucitanib (USAN/INN) D11763 Merestinib (USAN/INN) D11768 Pacritinib (USAN/INN) D11772 Tesevatinib (USAN/INN) D11773 Tesevatinib tosylate (USAN) D11774 Taselisib (USAN/INN) D11775 Tarextumab (USAN/INN) D11786 Vodobatinib (USAN) D11803 Cetuximab sarotalocan (USAN/INN) D11805 Cetuximab sarotalocan sodium (genetical recombination) (JAN) D11821 Nogapendekin alfa (USAN/INN) D11872 Serclutamab (USAN/INN) D11874 Serclutamab talirine (USAN/INN) D11885 Surufatinib (USAN/INN) D11890 Emvododstat (USAN) D11894 Amivantamab (USAN/INN) D11935 Enzastaurin (USAN/INN) D11942 Inavolisib (USAN/INN) D11954 Belzutifan (JAN/USAN/INN) D11961 Giredestrant (USAN/INN) D11969 Mobocertinib succinate (JAN) D11980 Lazertinib (USAN/INN) D11987 Trilaciclib dihydrochloride D12001 Mobocertinib (USAN/INN) D12009 Zandelisib (JAN/USAN/INN) D12011 Zanidatamab (USAN/INN) D12049 Camizestrant (JAN/USAN) D12055 Sotorasib (JAN/USAN) D12059 Temuterkib (USAN) D12060 Temuterkib mesylate (USAN) D12128 Balixafortide (USAN/INN) D12145 Amcenestrant (JAN/USAN/INN) D12175 Olverembatinib (USAN/INN) D12216 Imlunestrant (USAN) D12217 Imlunestrant tosylate (USAN) D12229 Poziotinib (USAN/INN) D12230 Poziotinib hydrochloride (USAN) D12234 Tarlatamab (USAN) D12238 Vimseltinib (USAN/INN) D12245 Lazertinib mesylate (USAN) D12258 Aumolertinib (USAN/INN) D12259 Aumolertinib mesylate (USAN) D12281 Motixafortide (USAN/INN) D12282 Motixafortide acetate (USAN) D12291 Tovorafenib (JAN/USAN/INN) D12301 Adagrasib (USAN/INN) D12303 Deutenzalutamide (USAN) D12304 Elraglusib (USAN) D12307 Pivekimab (USAN) D12316 Bavdegalutamide (USAN) D12330 Zeteletinib (USAN) D12331 Zeteletinib adipate (USAN) D12354 Pralsetinib hydrate (JAN) D12363 Taletrectinib (USAN/INN) D12364 Taletrectinib adipate (JAN/USAN) D12394 Inobrodib (USAN) D12399 Sulanemadlin (USAN/INN) D12404 Tasurgratinib (INN) D12405 Tasurgratinib succinate (JAN) D12416 Petosemtamab (USAN/INN) D12424 Davutamig (USAN) D12432 Zurletrectinib (USAN) D12442 Tucatinib ethanolate (JAN) D12444 Nilotinib hydrochloride dihydrate (JAN) D12445 Foscenvivint (JAN/INN) D12457 Tuxobertinib (USAN/INN) D12476 Tuspetinib (USAN/INN) D12506 Sunvozertinib (USAN/INN) D12514 Amdizalisib (USAN/INN) D12515 Avutometinib (USAN/INN) D12526 Catequentinib (USAN/INN) D12531 Nadofaragene firadenovec (USAN/INN) D12534 Avutometinib potassium (USAN) D12537 Catequentinib hydrochloride (USAN) D12545 Tinengotinib (USAN/INN) D12551 Bocodepsin (USAN) D12552 Bocodepsin besylate (USAN) D12557 Elzovantinib (USAN/INN) D12558 Emzadirib (USAN) D12559 Enbezotinib (USAN/INN) D12583 Anvatabart opadotin (USAN/INN) D12584 Anvatabart pactil (USAN/INN) D12600 Bezuclastinib (USAN/INN) D12601 Tegtociclib (USAN) D12625 Pegenzileukin (USAN/INN) D12628 Vepdegestrant (JAN/USAN/INN) D12639 Divarasib (USAN/INN) D12640 Divarasib adipate (USAN) D12641 Emirodatamab (USAN/INN) D12643 Masofaniten (USAN/INN) D12646 Paltimatrectinib (USAN/INN) D12650 Zanzalintinib (USAN/INN) D12651 Zanzalintinib fumarate (USAN) D12705 Gumarontinib hydrate (JAN) D12730 Tigozertinib (USAN) D12768 Ficerafusp alfa (USAN) D12809 Bafisontamab (USAN/INN) D12827 Palazestrant (USAN/INN) D12831 Naporafenib (USAN/INN) D12834 Atirmociclib (USAN) D12836 Risovalisib (INN) D12837 Risovalisib mesilate hydrate (JAN) D12853 Olomorasib (USAN) D12854 Nilotinib laurylsulfate (USAN) D12859 Pebezertinib (USAN) D12865 Beroterkib (USAN) D12866 Gridegalutamide (USAN) D12879 Zongertinib (JAN/USAN/INN) D12883 Sonrotoclax (USAN/INN) D12888 Nogapendekin alfa inbakicept D12921 Tizaterkib (USAN/INN) D12922 Tizaterkib adipate (USAN) D12924 Pocenbrodib (USAN/INN) D12925 Pocenbrodib hydrochloride (USAN) D12928 Vopikitug (USAN/INN) D12943 Giredestrant tartrate (JAN/USAN) D12946 Certociclib (USAN) D12947 Claturafenib (USAN) D12956 Firmonertinib (USAN/INN) D12957 Firmonertinib mesylate (USAN) D12982 Rezatapopt (USAN/INN) D12988 Disitamab (USAN/INN) D13003 Imdatifan (USAN/INN) D13008 Nilotinib D-tartrate (USAN) D13021 Resminostat (INN) D13029 Bemarituzumab (USAN/INN) D13038 Opnurasib (USAN/INN) D13039 Nedometinib (USAN/INN) D13046 Vosilasarm (USAN/INN) D13052 Izalontamab (USAN/INN) D13059 Luxdegalutamide (USAN/INN) D13062 Zipalertinib (JAN/USAN/INN) D13066 Tilatamig (USAN/INN) D13067 Tilatamig samrotecan (USAN/INN) D13071 Ateganosine (USAN/INN) D13079 Neladalkib (USAN/INN) D13082 Surzetoclax (USAN/INN) D13098 Sevabertinib (USAN) D13116 Sevabertinib hydrate (JAN) D13132 Flezurafenib (USAN/INN) D13156 Pamvatamig (USAN/INN) D13161 Peluntamig (USAN/INN) D13166 Vimseltinib dihydrate D13174 Mosperafenib (USAN/INN) D13179 Nuvisertib (USAN/INN) D13180 Nuvisertib hydrochloride (USAN) D13203 Vepugratinib (USAN) D13204 Plixorafenib (USAN/INN) D13211 Orevandrodeg (USAN) D13217 Dezandrodeg (USAN) D13229 Amivantamab (genetical recombination) and vorhyaluronidase alfa (genetical recombination) D13235 Mifanertinib (INN) D13236 Tunlametinib (INN) D13250 Zoldonrasib (USAN/INN) D13251 Zocilurtatug (USAN) D13256 Cabozantinib laurylsulfate (USAN) D13257 Casdatifan (USAN/INN) D13265 Daraxonrasib (USAN/INN) D13266 Elironrasib (USAN/INN) D13267 Debecarasib (USAN) D13282 Gocatamig (USAN/INN) D13290 Tersolisib (USAN/INN) D13300 Silevertinib (USAN/INN) D13308 Nilotinib butanedisulfonate (USAN) D13350 Atebimetinib (USAN/INN) D13352 Elisrasib ORGANISM Homo sapiens (human) [GN:hsa] GENE 10000 AKT3; RAC-gamma serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1] 10018 BCL2L11; bcl-2-like protein 11 isoform 1 [KO:K16341] 10023 FRAT1; proto-oncogene FRAT1 [KO:K03069] 10125 RASGRP1; RAS guanyl-releasing protein 1 isoform a [KO:K04350] 10161 LPAR6; lysophosphatidic acid receptor 6 [KO:K04273] 1017 CDK2; cyclin-dependent kinase 2 isoform 1 [KO:K02206] [EC:2.7.11.22] 1019 CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22] 1021 CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22] 10235 RASGRP2; RAS guanyl-releasing protein 2 isoform a [KO:K12361] 1026 CDKN1A; cyclin-dependent kinase inhibitor 1 isoform 1 [KO:K06625] 1027 CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624] 1029 CDKN2A; cyclin-dependent kinase inhibitor 2A isoform p16INK4a [KO:K06621] 10297 APC2; adenomatous polyposis coli protein 2 isoform 1 [KO:K02085] 1030 CDKN2B; cyclin-dependent kinase 4 inhibitor B isoform 1 [KO:K04685] 10319 LAMC3; laminin subunit gamma-3 precursor [KO:K06247] 10342 TFG; protein TFG isoform 1 [KO:K09292] 1050 CEBPA; CCAAT/enhancer-binding protein alpha isoform a [KO:K09055] 10587 TXNRD2; thioredoxin reductase 2, mitochondrial isoform 1 precursor [KO:K22182] [EC:1.8.1.9] 10672 GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform 1 [KO:K04639] 10681 GNB5; guanine nucleotide-binding protein subunit beta-5 isoform b [KO:K04539] 10683 DLL3; delta-like protein 3 isoform 1 precursor [KO:K06051] 107 ADCY1; adenylate cyclase type 1 isoform 1 [KO:K08041] [EC:4.6.1.1] 108 ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1] 109 ADCY3; adenylate cyclase type 3 isoform 2 [KO:K08043] [EC:4.6.1.1] 10912 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402] 10928 RALBP1; ralA-binding protein 1 [KO:K08773] 110117499 P3R3URF-PIK3R3; LOC110117498-PIK3R3 readthrough [KO:K02649] 11040 PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1] 111 ADCY5; adenylate cyclase type 5 isoform 1 [KO:K08045] [EC:4.6.1.1] 11186 RASSF1; ras association domain-containing protein 1 isoform D [KO:K09850] 112 ADCY6; adenylate cyclase type 6 isoform 1 [KO:K08046] [EC:4.6.1.1] 11211 FZD10; frizzled-10 precursor [KO:K02842] 112398 EGLN2; prolyl hydroxylase EGLN2 [KO:K09592] [EC:1.14.11.29] 112399 EGLN3; prolyl hydroxylase EGLN3 isoform 1 [KO:K09592] [EC:1.14.11.29] 113 ADCY7; adenylate cyclase type 7 isoform 1 [KO:K08047] [EC:4.6.1.1] 114 ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1] 114112 TXNRD3; thioredoxin reductase 3 isoform 1 [KO:K22182] [EC:1.8.1.9] 1147 CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 [KO:K04467] [EC:2.7.11.10] 115 ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1] 115727 RASGRP4; RAS guanyl-releasing protein 4 isoform a [KO:K12363] 1163 CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219] 1164 CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219] 119391 GSTO2; glutathione S-transferase omega-2 isoform 1 [KO:K00799] [EC:2.5.1.18] 1282 COL4A1; collagen alpha-1(IV) chain isoform 1 preproprotein [KO:K06237] 1284 COL4A2; collagen alpha-2(IV) chain preproprotein [KO:K06237] 1285 COL4A3; collagen alpha-3(IV) chain precursor [KO:K06237] 1286 COL4A4; collagen alpha-4(IV) chain precursor [KO:K06237] 1287 COL4A5; collagen alpha-5(IV) chain isoform 1 precursor [KO:K06237] 1288 COL4A6; collagen alpha-6(IV) chain isoform A precursor [KO:K06237] 1387 CREBBP; CREB-binding protein isoform a [KO:K04498] [EC:2.3.1.48] 1398 CRK; adapter molecule crk isoform a [KO:K04438] 1399 CRKL; crk-like protein [KO:K04438] 1436 CSF1R; macrophage colony-stimulating factor 1 receptor isoform a precursor [KO:K05090] [EC:2.7.10.1] 1438 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor [KO:K05066] 1439 CSF2RB; cytokine receptor common subunit beta isoform 2 precursor [KO:K04738] 1441 CSF3R; granulocyte colony-stimulating factor receptor isoform a precursor [KO:K05061] 1487 CTBP1; C-terminal-binding protein 1 isoform 1 [KO:K04496] [EC:1.1.1.428] 1488 CTBP2; C-terminal-binding protein 2 isoform 1 [KO:K04496] [EC:1.1.1.428] 149233 IL23R; interleukin-23 receptor precursor [KO:K05065] 1495 CTNNA1; catenin alpha-1 isoform 1 [KO:K05691] 1496 CTNNA2; catenin alpha-2 isoform 3 [KO:K05691] 1499 CTNNB1; catenin beta-1 isoform 1 [KO:K02105] 1612 DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1] 1613 DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1] 1630 DCC; netrin receptor DCC [KO:K06765] 163688 CALML6; calmodulin-like protein 6 isoform 1 [KO:K02183] 1643 DDB2; DNA damage-binding protein 2 isoform WT [KO:K10140] 1647 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1 [KO:K04402] 1728 NQO1; NAD(P)H dehydrogenase [quinone] 1 isoform a [KO:K00355] [EC:1.6.5.2] 182 JAG1; protein jagged-1 precursor [KO:K06052] 183 AGT; angiotensinogen precursor [KO:K09821] 185 AGTR1; type-1 angiotensin II receptor [KO:K04166] 1855 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform 1 [KO:K02353] 1856 DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353] 1857 DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353] 1869 E2F1; transcription factor E2F1 [KO:K17454] 1870 E2F2; transcription factor E2F2 [KO:K09389] 1871 E2F3; transcription factor E2F3 isoform 1 [KO:K06620] 1902 LPAR1; lysophosphatidic acid receptor 1 isoform a [KO:K04289] 1906 EDN1; endothelin-1 isoform 1 preproprotein [KO:K16366] 1909 EDNRA; endothelin-1 receptor isoform a precursor [KO:K04197] 1910 EDNRB; endothelin receptor type B isoform 1 precursor [KO:K04198] 1950 EGF; pro-epidermal growth factor isoform 1 preproprotein [KO:K04357] 1956 EGFR; epidermal growth factor receptor isoform a precursor [KO:K04361] [EC:2.7.10.1] 196883 ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1] 2002 ELK1; ETS domain-containing protein Elk-1 isoform a [KO:K04375] 2033 EP300; histone acetyltransferase p300 isoform 1 [KO:K04498] [EC:2.3.1.48] 2034 EPAS1; endothelial PAS domain-containing protein 1 [KO:K09095] 2056 EPO; erythropoietin precursor [KO:K05437] 2057 EPOR; erythropoietin receptor precursor [KO:K05079] 2064 ERBB2; receptor tyrosine-protein kinase erbB-2 isoform a precursor [KO:K05083] [EC:2.7.10.1] 207 AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1] 208 AKT2; RAC-beta serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1] 2099 ESR1; estrogen receptor isoform 1 [KO:K08550] 2100 ESR2; estrogen receptor beta isoform 1 [KO:K08551] 2113 ETS1; protein C-ets-1 isoform 2 [KO:K02678] 2122 MECOM; histone-lysine N-methyltransferase MECOM isoform f [KO:K04462] [EC:2.1.1.367] 2147 F2; prothrombin preproprotein [KO:K01313] [EC:3.4.21.5] 2149 F2R; proteinase-activated receptor 1 isoform 1 precursor [KO:K03914] 221357 GSTA5; glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18] 2246 FGF1; fibroblast growth factor 1 isoform 1 precursor [KO:K18496] 2247 FGF2; fibroblast growth factor 2 isoform 34 kDa [KO:K18497] 2248 FGF3; fibroblast growth factor 3 precursor [KO:K04358] 2249 FGF4; fibroblast growth factor 4 precursor [KO:K04358] 2250 FGF5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358] 2251 FGF6; fibroblast growth factor 6 precursor [KO:K04358] 2252 FGF7; fibroblast growth factor 7 precursor [KO:K04358] 2253 FGF8; fibroblast growth factor 8 isoform E precursor [KO:K04358] 2254 FGF9; fibroblast growth factor 9 precursor [KO:K04358] 2255 FGF10; fibroblast growth factor 10 precursor [KO:K04358] 2260 FGFR1; fibroblast growth factor receptor 1 isoform 1 precursor [KO:K04362] [EC:2.7.10.1] 2261 FGFR3; fibroblast growth factor receptor 3 isoform 1 precursor [KO:K05094] [EC:2.7.10.1] 2263 FGFR2; fibroblast growth factor receptor 2 isoform 1 precursor [KO:K05093] [EC:2.7.10.1] 2264 FGFR4; fibroblast growth factor receptor 4 isoform 1 precursor [KO:K05095] [EC:2.7.10.1] 2271 FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2] 2277 VEGFD; vascular endothelial growth factor D preproprotein [KO:K05449] 22798 LAMB4; laminin subunit beta-4 isoform 1 precursor [KO:K06245] 2308 FOXO1; forkhead box protein O1 [KO:K07201] 2322 FLT3; receptor-type tyrosine-protein kinase FLT3 precursor [KO:K05092] [EC:2.7.10.1] 2323 FLT3LG; fms-related tyrosine kinase 3 ligand isoform 1 precursor [KO:K05454] 23236 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a [KO:K05858] [EC:3.1.4.11] 2324 FLT4; vascular endothelial growth factor receptor 3 isoform 1 precursor [KO:K05097] [EC:2.7.10.1] 2335 FN1; fibronectin isoform 1 precursor [KO:K05717] 23365 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform 1 [KO:K07532] 23401 FRAT2; GSK-3-binding protein FRAT2 [KO:K03096] 23462 HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform a [KO:K09091] 23493 HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091] 2353 FOS; protein c-Fos [KO:K04379] 23566 LPAR3; lysophosphatidic acid receptor 3 [KO:K04294] 23604 DAPK2; death-associated protein kinase 2 isoform 1 [KO:K08803] [EC:2.7.11.1] 238 ALK; ALK tyrosine kinase receptor isoform 1 precursor [KO:K05119] [EC:2.7.10.1] 2475 MTOR; serine/threonine-protein kinase mTOR isoform 1 [KO:K07203] [EC:2.7.11.1] 25 ABL1; tyrosine-protein kinase ABL1 isoform a [KO:K06619] [EC:2.7.10.2] 2535 FZD2; frizzled-2 precursor [KO:K02235] 25774 GSTT4; glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18] 25780 RASGRP3; ras guanyl-releasing protein 3 isoform 1 [KO:K12362] 26060 APPL1; DCC-interacting protein 13-alpha [KO:K08733] 26281 FGF20; fibroblast growth factor 20 [KO:K04358] 26291 FGF21; fibroblast growth factor 21 precursor [KO:K22429] 26508 HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091] 27006 FGF22; fibroblast growth factor 22 isoform 1 precursor [KO:K04358] 27113 BBC3; bcl-2-binding component 3 isoform 1 [KO:K10132] 2735 GLI1; zinc finger protein GLI1 isoform 1 [KO:K16797] 2736 GLI2; zinc finger protein GLI2 isoform 1 [KO:K16798] 2737 GLI3; transcriptional activator GLI3 [KO:K06230] 27436 EML4; echinoderm microtubule-associated protein-like 4 isoform a [KO:K15420] 2767 GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635] 2768 GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform 1 [KO:K04346] 2770 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [KO:K04630] 2771 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 1 [KO:K04630] 2773 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630] 2776 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634] 2778 GNAS; protein GNAS isoform XLas [KO:K04632] 2782 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1 [KO:K04536] 2783 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537] 2784 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1 [KO:K07825] 2785 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540] 2786 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541] 2787 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542] 2788 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543] 2790 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545] 2791 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor [KO:K04546] 2792 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor [KO:K04548] 2793 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549] 284217 LAMA1; laminin subunit alpha-1 precursor [KO:K05637] 2846 LPAR4; lysophosphatidic acid receptor 4 [KO:K04275] 28514 DLL1; delta-like protein 1 precursor [KO:K06051] 2885 GRB2; growth factor receptor-bound protein 2 isoform 1 [KO:K04364] 29119 CTNNA3; catenin alpha-3 isoform a [KO:K05691] 2932 GSK3B; glycogen synthase kinase-3 beta isoform 2 [KO:K03083] [EC:2.7.11.26] 2938 GSTA1; glutathione S-transferase A1 isoform 1 [KO:K00799] [EC:2.5.1.18] 2939 GSTA2; glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18] 2940 GSTA3; glutathione S-transferase A3 isoform 1 [KO:K00799] [EC:2.5.1.18] 2941 GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18] 2944 GSTM1; glutathione S-transferase Mu 1 isoform 1 [KO:K00799] [EC:2.5.1.18] 2946 GSTM2; glutathione S-transferase Mu 2 isoform 1 [KO:K00799] [EC:2.5.1.18] 2947 GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18] 2948 GSTM4; glutathione S-transferase Mu 4 isoform 1 [KO:K00799] [EC:2.5.1.18] 2949 GSTM5; glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18] 2950 GSTP1; glutathione S-transferase P [KO:K23790] 2952 GSTT1; glutathione S-transferase theta-1 isoform a [KO:K00799] [EC:2.5.1.18] 2953 GSTT2; glutathione S-transferase theta-2 isoform a [KO:K00799] [EC:2.5.1.18] 2956 MSH6; DNA mismatch repair protein Msh6 isoform 1 [KO:K08737] 3065 HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98] 3066 HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98] 3082 HGF; hepatocyte growth factor isoform 1 preproprotein [KO:K05460] 3091 HIF1A; hypoxia-inducible factor 1-alpha isoform 1 [KO:K08268] 3162 HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18] 317 APAF1; apoptotic protease-activating factor 1 isoform c [KO:K02084] 324 APC; adenomatous polyposis coli protein isoform b [KO:K02085] 3265 HRAS; GTPase HRas isoform 1 [KO:K02833] 3280 HES1; transcription factor HES-1 [KO:K06054] 329 BIRC2; baculoviral IAP repeat-containing protein 2 isoform 1 [KO:K16060] 330 BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060] 331 XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27] 332 BIRC5; baculoviral IAP repeat-containing protein 5 isoform 2 [KO:K08731] 3320 HSP90AA1; heat shock protein HSP 90-alpha isoform 2 [KO:K04079] 3326 HSP90AB1; heat shock protein HSP 90-beta isoform a [KO:K04079] 3439 IFNA1; interferon alpha-1 precursor [KO:K05414] 3440 IFNA2; interferon alpha-2 precursor [KO:K05414] 3441 IFNA4; interferon alpha-4 precursor [KO:K05414] 3442 IFNA5; interferon alpha-5 precursor [KO:K05414] 3443 IFNA6; interferon alpha-6 precursor [KO:K05414] 3444 IFNA7; interferon alpha-7 precursor [KO:K05414] 3445 IFNA8; interferon alpha-8 precursor [KO:K05414] 3446 IFNA10; interferon alpha-10 precursor [KO:K05414] 3447 IFNA13; interferon alpha-13 precursor [KO:K05414] 3448 IFNA14; interferon alpha-14 precursor [KO:K05414] 3449 IFNA16; interferon alpha-16 precursor [KO:K05414] 3451 IFNA17; interferon alpha-17 precursor [KO:K05414] 3452 IFNA21; interferon alpha-21 precursor [KO:K05414] 3454 IFNAR1; interferon alpha/beta receptor 1 isoform 2 precursor [KO:K05130] 3455 IFNAR2; interferon alpha/beta receptor 2 isoform a precursor [KO:K05131] 3458 IFNG; interferon gamma precursor [KO:K04687] 3459 IFNGR1; interferon gamma receptor 1 isoform 1 precursor [KO:K05132] 3460 IFNGR2; interferon gamma receptor 2 isoform 2 precursor [KO:K05133] 3479 IGF1; insulin-like growth factor 1 isoform 3 preproprotein [KO:K05459] 3480 IGF1R; insulin-like growth factor 1 receptor isoform 1 precursor [KO:K05087] [EC:2.7.10.1] 3481 IGF2; insulin-like growth factor 2 isoform 1 preproprotein [KO:K13769] 354 KLK3; prostate-specific antigen isoform 1 preproprotein [KO:K01351] [EC:3.4.21.77] 355 FAS; tumor necrosis factor receptor superfamily member 6 isoform 1 precursor [KO:K04390] 3551 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1 [KO:K07209] [EC:2.7.11.10] 3558 IL2; interleukin-2 precursor [KO:K05429] 3559 IL2RA; interleukin-2 receptor subunit alpha isoform 1 precursor [KO:K05068] 356 FASLG; tumor necrosis factor ligand superfamily member 6 isoform 1 [KO:K04389] 3560 IL2RB; interleukin-2 receptor subunit beta precursor [KO:K05069] 3561 IL2RG; cytokine receptor common subunit gamma isoform 1 precursor [KO:K05070] 3562 IL3; interleukin-3 precursor [KO:K04736] 3563 IL3RA; interleukin-3 receptor subunit alpha isoform 1 precursor [KO:K04737] 3565 IL4; interleukin-4 isoform 1 precursor [KO:K05430] 3566 IL4R; interleukin-4 receptor subunit alpha isoform a precursor [KO:K05071] 3567 IL5; interleukin-5 precursor [KO:K05428] 3568 IL5RA; interleukin-5 receptor subunit alpha isoform 1 precursor [KO:K05067] 3569 IL6; interleukin-6 isoform 1 precursor [KO:K05405] 3570 IL6R; interleukin-6 receptor subunit alpha isoform 1 precursor [KO:K05055] 3572 IL6ST; interleukin-6 receptor subunit beta isoform 1 precursor [KO:K05060] 3574 IL7; interleukin-7 isoform 1 precursor [KO:K05431] 3575 IL7R; interleukin-7 receptor subunit alpha isoform 1 precursor [KO:K05072] 3576 CXCL8; interleukin-8 isoform 1 precursor [KO:K10030] 3592 IL12A; interleukin-12 subunit alpha isoform 4 precursor [KO:K05406] 3593 IL12B; interleukin-12 subunit beta precursor [KO:K05425] 3594 IL12RB1; interleukin-12 receptor subunit beta-1 isoform 1 precursor [KO:K05063] 3595 IL12RB2; interleukin-12 receptor subunit beta-2 isoform a precursor [KO:K05064] 3596 IL13; interleukin-13 isoform 1 precursor [KO:K05435] 3597 IL13RA1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076] 3600 IL15; interleukin-15 isoform 1 preproprotein [KO:K05433] 3601 IL15RA; interleukin-15 receptor subunit alpha isoform 1 precursor [KO:K05074] 3655 ITGA6; integrin alpha-6 isoform 6 precursor [KO:K06485] 367 AR; androgen receptor isoform 1 [KO:K08557] 3673 ITGA2; integrin alpha-2 precursor [KO:K06481] 3674 ITGA2B; integrin alpha-IIb preproprotein [KO:K06476] 3675 ITGA3; integrin alpha-3 preproprotein [KO:K06482] 3685 ITGAV; integrin alpha-V isoform 1 preproprotein [KO:K06487] 3688 ITGB1; integrin beta-1 isoform 1A precursor [KO:K05719] 369 ARAF; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:2.7.11.1] 3714 JAG2; protein jagged-2 isoform a precursor [KO:K21635] 3716 JAK1; tyrosine-protein kinase JAK1 isoform 1 [KO:K11217] [EC:2.7.10.2] 3717 JAK2; tyrosine-protein kinase JAK2 isoform a [KO:K04447] [EC:2.7.10.2] 3718 JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2] 3725 JUN; transcription factor Jun [KO:K04448] 3728 JUP; junction plakoglobin [KO:K10056] 374654 KIF7; kinesin-like protein KIF7 [KO:K18806] 3815 KIT; mast/stem cell growth factor receptor Kit isoform 1 precursor [KO:K05091] [EC:2.7.10.1] 3827 KNG1; kininogen-1 isoform 1 precursor [KO:K03898] 3845 KRAS; GTPase KRas isoform a [KO:K07827] 387 RHOA; transforming protein RhoA isoform 1 precursor [KO:K04513] 388585 HES5; transcription factor HES-5 [KO:K06055] 3908 LAMA2; laminin subunit alpha-2 isoform a precursor [KO:K05637] 3909 LAMA3; laminin subunit alpha-3 isoform 1 precursor [KO:K06240] 3910 LAMA4; laminin subunit alpha-4 isoform 1 precursor [KO:K06241] 3911 LAMA5; laminin subunit alpha-5 precursor [KO:K06240] 3912 LAMB1; laminin subunit beta-1 precursor [KO:K05636] 3913 LAMB2; laminin subunit beta-2 precursor [KO:K06243] 3914 LAMB3; laminin subunit beta-3 precursor [KO:K06244] 3915 LAMC1; laminin subunit gamma-1 precursor [KO:K05635] 3918 LAMC2; laminin subunit gamma-2 isoform a precursor [KO:K06246] 4040 LRP6; low-density lipoprotein receptor-related protein 6 isoform b precursor [KO:K03068] 4041 LRP5; low-density lipoprotein receptor-related protein 5 isoform 1 precursor [KO:K03068] 405 ARNT; aryl hydrocarbon receptor nuclear translocator isoform 1 [KO:K09097] 4087 SMAD2; mothers against decapentaplegic homolog 2 isoform 1 [KO:K04500] 4088 SMAD3; mothers against decapentaplegic homolog 3 isoform 1 [KO:K23605] 4089 SMAD4; mothers against decapentaplegic homolog 4 isoform a [KO:K04501] 4149 MAX; protein max isoform a [KO:K04453] 4193 MDM2; E3 ubiquitin-protein ligase Mdm2 isoform 2 [KO:K06643] [EC:2.3.2.27] 4233 MET; hepatocyte growth factor receptor isoform b preproprotein [KO:K05099] [EC:2.7.10.1] 4254 KITLG; kit ligand isoform b precursor [KO:K05461] 4257 MGST1; microsomal glutathione S-transferase 1 isoform a [KO:K00799] [EC:2.5.1.18] 4258 MGST2; microsomal glutathione S-transferase 2 isoform 1 [KO:K00799] [EC:2.5.1.18] 4259 MGST3; glutathione S-transferase 3, mitochondrial [KO:K00799] [EC:2.5.1.18] 4286 MITF; microphthalmia-associated transcription factor isoform 9 [KO:K09455] 4292 MLH1; DNA mismatch repair protein Mlh1 isoform 1 [KO:K08734] 4312 MMP1; interstitial collagenase isoform 1 preproprotein [KO:K01388] [EC:3.4.24.7] 4313 MMP2; 72 kDa type IV collagenase isoform 1 preproprotein [KO:K01398] [EC:3.4.24.24] 4318 MMP9; matrix metalloproteinase-9 preproprotein [KO:K01403] [EC:3.4.24.35] 4436 MSH2; DNA mismatch repair protein Msh2 isoform 1 [KO:K08735] 4437 MSH3; DNA mismatch repair protein Msh3 [KO:K08736] 4609 MYC; myc proto-oncogene protein isoform 1 [KO:K04377] 4616 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402] 4780 NFE2L2; nuclear factor erythroid 2-related factor 2 isoform 1 [KO:K05638] 4790 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein [KO:K02580] 4791 NFKB2; nuclear factor NF-kappa-B p100 subunit isoform a [KO:K04469] 4792 NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734] 4824 NKX3-1; homeobox protein Nkx-3.1 isoform 1 [KO:K09348] 4843 NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39] 4851 NOTCH1; neurogenic locus notch homolog protein 1 preproprotein [KO:K02599] 4853 NOTCH2; neurogenic locus notch homolog protein 2 isoform 1 preproprotein [KO:K20994] 4854 NOTCH3; neurogenic locus notch homolog protein 3 precursor [KO:K20995] 4855 NOTCH4; neurogenic locus notch homolog protein 4 preproprotein [KO:K20996] 4893 NRAS; GTPase NRas [KO:K07828] 4914 NTRK1; high affinity nerve growth factor receptor isoform 2 precursor [KO:K03176] [EC:2.7.10.1] 51176 LEF1; lymphoid enhancer-binding factor 1 isoform 1 [KO:K04492] 51384 WNT16; protein Wnt-16 isoform 1 precursor [KO:K01558] 51426 POLK; DNA polymerase kappa isoform 1 [KO:K03511] [EC:2.7.7.7] 5154 PDGFA; platelet-derived growth factor subunit A isoform 1 preproprotein [KO:K04359] 5155 PDGFB; platelet-derived growth factor subunit B isoform 1 preproprotein [KO:K17386] 5156 PDGFRA; platelet-derived growth factor receptor alpha isoform 1 precursor [KO:K04363] [EC:2.7.10.1] 51561 IL23A; interleukin-23 subunit alpha precursor [KO:K05426] 5159 PDGFRB; platelet-derived growth factor receptor beta isoform 1 precursor [KO:K05089] [EC:2.7.10.1] 51684 SUFU; suppressor of fused homolog isoform 1 [KO:K06229] 51764 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547] 51806 CALML5; calmodulin-like protein 5 [KO:K02183] 5228 PGF; placenta growth factor isoform 2 precursor [KO:K16859] 5290 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153] 5291 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1 [KO:K00922] [EC:2.7.1.153] 5292 PIM1; serine/threonine-protein kinase pim-1 isoform 2 [KO:K04702] [EC:2.7.11.1] 5293 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1 [KO:K00922] [EC:2.7.1.153] 5295 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 [KO:K02649] 5296 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649] 5330 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1 [KO:K05858] [EC:3.1.4.11] 5331 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1 [KO:K05858] [EC:3.1.4.11] 5332 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b [KO:K05858] [EC:3.1.4.11] 5335 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform b [KO:K01116] [EC:3.1.4.11] 5336 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11] 5337 PLD1; phospholipase D1 isoform a [KO:K01115] [EC:3.1.4.4] 5338 PLD2; phospholipase D2 isoform PLD2A [KO:K01115] [EC:3.1.4.4] 5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 isoform 6 [KO:K10131] 5371 PML; protein PML isoform 1 [KO:K10054] [EC:2.3.2.-] 54205 CYCS; cytochrome c [KO:K08738] 54331 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor [KO:K07826] 54361 WNT4; protein Wnt-4 precursor [KO:K00408] 54567 DLL4; delta-like protein 4 precursor [KO:K06051] 54583 EGLN1; egl nine homolog 1 isoform 1 [KO:K09592] [EC:1.14.11.29] 5467 PPARD; peroxisome proliferator-activated receptor delta isoform 1 [KO:K04504] 5468 PPARG; peroxisome proliferator-activated receptor gamma isoform 2 [KO:K08530] 5566 PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 [KO:K04345] [EC:2.7.11.11] 5567 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11] 5568 PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11] 5578 PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13] 5579 PRKCB; protein kinase C beta type isoform 1 [KO:K19662] [EC:2.7.11.13] 5582 PRKCG; protein kinase C gamma type isoform 2 [KO:K19663] [EC:2.7.11.13] 5594 MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24] 5595 MAPK3; mitogen-activated protein kinase 3 isoform 1 [KO:K04371] [EC:2.7.11.24] 55970 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347] 5599 MAPK8; mitogen-activated protein kinase 8 isoform alpha2 [KO:K04440] [EC:2.7.11.24] 5601 MAPK9; mitogen-activated protein kinase 9 isoform alpha2 [KO:K04440] [EC:2.7.11.24] 5602 MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24] 5604 MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1 [KO:K04368] [EC:2.7.12.2] 5605 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform 1 [KO:K04369] [EC:2.7.12.2] 57121 LPAR5; lysophosphatidic acid receptor 5 [KO:K08390] 572 BAD; bcl2-associated agonist of cell death [KO:K02158] 5727 PTCH1; protein patched homolog 1 isoform L [KO:K06225] 5728 PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67] 5731 PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258] 5732 PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259] 5733 PTGER3; prostaglandin E2 receptor EP3 subtype isoform 4 [KO:K04260] 5734 PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261] 5743 PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1] 57449 PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform a [KO:K19464] 5747 PTK2; focal adhesion kinase 1 isoform 1 [KO:K05725] [EC:2.7.10.2] 578 BAK1; bcl-2 homologous antagonist/killer [KO:K14021] 581 BAX; apoptosis regulator BAX isoform alpha [KO:K02159] 5879 RAC1; ras-related C3 botulinum toxin substrate 1 isoform Rac1 [KO:K04392] 5880 RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860] 5881 RAC3; ras-related C3 botulinum toxin substrate 3 isoform 1 [KO:K07861] 5888 RAD51; DNA repair protein RAD51 homolog 1 isoform 1 [KO:K04482] 5894 RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform b [KO:K04366] [EC:2.7.11.1] 5898 RALA; ras-related protein Ral-A precursor [KO:K07834] 5899 RALB; ras-related protein Ral-B [KO:K07835] 5900 RALGDS; ral guanine nucleotide dissociation stimulator isoform 1 [KO:K08732] 5914 RARA; retinoic acid receptor alpha isoform 1 [KO:K08527] 5915 RARB; retinoic acid receptor beta isoform 3 [KO:K08528] 5925 RB1; retinoblastoma-associated protein isoform 1 [KO:K06618] 59345 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538] 595 CCND1; G1/S-specific cyclin-D1 [KO:K04503] 596 BCL2; apoptosis regulator Bcl-2 isoform alpha [KO:K02161] 5970 RELA; transcription factor p65 isoform 1 [KO:K04735] 5979 RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor [KO:K05126] [EC:2.7.10.1] 598 BCL2L1; bcl-2-like protein 1 isoform Bcl-X(L) [KO:K04570] 6093 ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39] 613 BCR; breakpoint cluster region protein isoform 1 [KO:K08878] [EC:2.7.11.1] 6198 RPS6KB1; ribosomal protein S6 kinase beta-1 isoform a [KO:K04688] [EC:2.7.11.1] 6199 RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1] 623 BDKRB1; B1 bradykinin receptor [KO:K03915] 624 BDKRB2; B2 bradykinin receptor [KO:K03916] 6256 RXRA; retinoic acid receptor RXR-alpha isoform a [KO:K08524] 6257 RXRB; retinoic acid receptor RXR-beta isoform 2 [KO:K08525] 6258 RXRG; retinoic acid receptor RXR-gamma isoform a [KO:K08526] 637 BID; BH3-interacting domain death agonist isoform 2 [KO:K04726] 6387 CXCL12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031] 64399 HHIP; hedgehog-interacting protein precursor [KO:K06231] 6469 SHH; sonic hedgehog protein isoform 1 preproprotein [KO:K11988] 650 BMP2; bone morphogenetic protein 2 preproprotein [KO:K21283] 6500 SKP1; S-phase kinase-associated protein 1 isoform b [KO:K03094] 6502 SKP2; S-phase kinase-associated protein 2 isoform 1 [KO:K03875] 6513 SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299] 652 BMP4; bone morphogenetic protein 4 isoform a preproprotein [KO:K04662] 653689 GSTT2B; glutathione S-transferase theta-2B isoform 1 [KO:K00799] [EC:2.5.1.18] 6608 SMO; protein smoothened precursor [KO:K06226] 6654 SOS1; son of sevenless homolog 1 isoform 1 [KO:K03099] 6655 SOS2; son of sevenless homolog 2 isoform 1 [KO:K03099] 6667 SP1; transcription factor Sp1 isoform a [KO:K04684] 6688 SPI1; transcription factor PU.1 isoform 2 [KO:K09438] 673 BRAF; serine/threonine-protein kinase B-raf isoform 1 [KO:K04365] [EC:2.7.11.1] 675 BRCA2; breast cancer type 2 susceptibility protein isoform 1 [KO:K08775] 6772 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform alpha [KO:K11220] 6773 STAT2; signal transducer and activator of transcription 2 isoform 1 [KO:K11221] 6774 STAT3; signal transducer and activator of transcription 3 isoform 1 [KO:K04692] 6775 STAT4; signal transducer and activator of transcription 4 [KO:K11222] 6776 STAT5A; signal transducer and activator of transcription 5A isoform 1 [KO:K11223] 6777 STAT5B; signal transducer and activator of transcription 5B [KO:K11224] 6778 STAT6; signal transducer and activator of transcription 6 isoform 1 [KO:K11225] 6789 STK4; serine/threonine-protein kinase 4 isoform 1 [KO:K04411] 6921 ELOC; elongin-C isoform a [KO:K03872] 6923 ELOB; elongin-B isoform a [KO:K03873] 6932 TCF7; transcription factor 7 isoform 1 [KO:K02620] 6934 TCF7L2; transcription factor 7-like 2 isoform 17 [KO:K04491] 7012 TERC; telomerase RNA component [KO:K22183] 7015 TERT; telomerase reverse transcriptase isoform 1 [KO:K11126] [EC:2.7.7.49] 7039 TGFA; protransforming growth factor alpha isoform 1 preproprotein [KO:K08774] 7040 TGFB1; transforming growth factor beta-1 proprotein preproprotein [KO:K13375] 7042 TGFB2; transforming growth factor beta-2 proprotein isoform 2 preproprotein [KO:K13376] 7043 TGFB3; transforming growth factor beta-3 proprotein isoform 1 preproprotein [KO:K13377] 7046 TGFBR1; TGF-beta receptor type-1 isoform 1 precursor [KO:K04674] [EC:2.7.11.30] 7048 TGFBR2; TGF-beta receptor type-2 isoform B precursor [KO:K04388] [EC:2.7.11.30] 7157 TP53; cellular tumor antigen p53 isoform a [KO:K04451] 7170 TPM3; tropomyosin alpha-3 chain isoform Tpm3.12st [KO:K09290] 7175 TPR; nucleoprotein TPR [KO:K09291] 7184 HSP90B1; endoplasmin precursor [KO:K09487] 7185 TRAF1; TNF receptor-associated factor 1 isoform a [KO:K03172] 7186 TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27] 7187 TRAF3; TNF receptor-associated factor 3 isoform 1 [KO:K03174] 7188 TRAF5; TNF receptor-associated factor 5 isoform b [KO:K09849] 7189 TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27] 7296 TXNRD1; thioredoxin reductase 1, cytoplasmic isoform 5 [KO:K22182] [EC:1.8.1.9] 7422 VEGFA; vascular endothelial growth factor A, long form isoform b [KO:K05448] 7423 VEGFB; vascular endothelial growth factor B isoform VEGFB-186 precursor [KO:K16858] 7424 VEGFC; vascular endothelial growth factor C preproprotein [KO:K05449] 7428 VHL; von Hippel-Lindau disease tumor suppressor isoform 1 [KO:K03871] 7471 WNT1; proto-oncogene Wnt-1 precursor [KO:K03209] 7472 WNT2; protein Wnt-2 precursor [KO:K00182] 7473 WNT3; proto-oncogene Wnt-3 precursor [KO:K00312] 7474 WNT5A; protein Wnt-5a isoform 1 precursor [KO:K00444] 7475 WNT6; protein Wnt-6 precursor [KO:K00445] 7476 WNT7A; protein Wnt-7a precursor [KO:K00572] 7477 WNT7B; protein Wnt-7b isoform 2 precursor [KO:K00572] 7478 WNT8A; protein Wnt-8a isoform 3 precursor [KO:K00714] 7479 WNT8B; protein Wnt-8b precursor [KO:K00714] 7480 WNT10B; protein Wnt-10b precursor [KO:K01357] 7481 WNT11; protein Wnt-11 precursor [KO:K01384] 7482 WNT2B; protein Wnt-2b isoform WNT-2B2 [KO:K00182] 7483 WNT9A; protein Wnt-9a precursor [KO:K01064] 7484 WNT9B; protein Wnt-9b isoform 1 precursor [KO:K01064] 7704 ZBTB16; zinc finger and BTB domain-containing protein 16 isoform 1 [KO:K10055] 7709 ZBTB17; zinc finger and BTB domain-containing protein 17 isoform 2 [KO:K10500] 7849 PAX8; paired box protein Pax-8 isoform PAX8A [KO:K09293] 7852 CXCR4; C-X-C chemokine receptor type 4 isoform b [KO:K04189] 7855 FZD5; frizzled-5 precursor [KO:K02375] 79444 BIRC7; baculoviral IAP repeat-containing protein 7 isoform alpha [KO:K16061] 7976 FZD3; frizzled-3 isoform 1 precursor [KO:K02329] 801 CALM1; calmodulin-1 isoform 2 [KO:K02183] 8030 CCDC6; coiled-coil domain-containing protein 6 [KO:K09288] 8031 NCOA4; nuclear receptor coactivator 4 isoform 3 [KO:K09289] 80326 WNT10A; protein Wnt-10a precursor [KO:K01357] 805 CALM2; calmodulin-2 isoform 2 [KO:K02183] 8074 FGF23; fibroblast growth factor 23 precursor [KO:K22428] 808 CALM3; calmodulin-3 isoform 1 [KO:K02183] 810 CALML3; calmodulin-like protein 3 [KO:K02183] 81029 WNT5B; protein Wnt-5b precursor [KO:K00444] 815 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [KO:K04515] [EC:2.7.11.17] 816 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1 [KO:K04515] [EC:2.7.11.17] 817 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3 [KO:K04515] [EC:2.7.11.17] 818 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7 [KO:K04515] [EC:2.7.11.17] 8202 NCOA3; nuclear receptor coactivator 3 isoform a [KO:K11256] [EC:2.3.1.48] 8312 AXIN1; axin-1 isoform a [KO:K02157] 8313 AXIN2; axin-2 isoform 1 [KO:K04385] 8321 FZD1; frizzled-1 [KO:K02432] 8322 FZD4; frizzled-4 precursor [KO:K02354] 8323 FZD6; frizzled-6 isoform a precursor [KO:K02376] 8324 FZD7; frizzled-7 precursor [KO:K02432] 8325 FZD8; frizzled-8 precursor [KO:K02375] 8326 FZD9; frizzled-9 precursor [KO:K02842] 83439 TCF7L1; transcription factor 7-like 1 [KO:K04490] 83593 RASSF5; ras association domain-containing protein 5 isoform A [KO:K08015] 836 CASP3; caspase-3 isoform a preproprotein [KO:K02187] [EC:3.4.22.56] 840 CASP7; caspase-7 isoform alpha precursor [KO:K04397] [EC:3.4.22.60] 841 CASP8; caspase-8 isoform 2 precursor [KO:K04398] [EC:3.4.22.61] 842 CASP9; caspase-9 isoform alpha precursor [KO:K04399] [EC:3.4.22.62] 8453 CUL2; cullin-2 isoform c [KO:K03870] 8454 CUL1; cullin-1 [KO:K03347] 8503 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1 [KO:K02649] 8517 IKBKG; NF-kappa-B essential modulator isoform a [KO:K07210] 861 RUNX1; runt-related transcription factor 1 isoform AML1b [KO:K08367] 862 RUNX1T1; protein CBFA2T1 isoform B [KO:K10053] 8643 PTCH2; protein patched homolog 2 isoform 1 [KO:K11101] 8648 NCOA1; nuclear receptor coactivator 1 isoform 1 [KO:K09101] [EC:2.3.1.48] 867 CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27] 8772 FADD; FAS-associated death domain protein [KO:K02373] 8817 FGF18; fibroblast growth factor 18 precursor [KO:K04358] 8822 FGF17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358] 8823 FGF16; fibroblast growth factor 16 [KO:K04358] 890 CCNA2; cyclin-A2 [KO:K06627] 8900 CCNA1; cyclin-A1 [KO:K06627] 894 CCND2; G1/S-specific cyclin-D2 [KO:K10151] 896 CCND3; G1/S-specific cyclin-D3 isoform 2 [KO:K10152] 89780 WNT3A; protein Wnt-3a precursor [KO:K00312] 898 CCNE1; G1/S-specific cyclin-E1 isoform 1 [KO:K06626] 9002 F2RL3; proteinase-activated receptor 4 preproprotein [KO:K04236] 9134 CCNE2; G1/S-specific cyclin-E2 [KO:K06626] 9138 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform 2 [KO:K12330] 9170 LPAR2; lysophosphatidic acid receptor 2 [KO:K04291] 91860 CALML4; calmodulin-like protein 4 isoform 1 [KO:K02183] 9252 RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform a [KO:K04445] [EC:2.7.11.1] 94235 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544] 9446 GSTO1; glutathione S-transferase omega-1 isoform 1 [KO:K00799] [EC:2.5.1.18] 9475 ROCK2; rho-associated protein kinase 2 isoform 1 [KO:K17388] [EC:2.7.11.39] 9618 TRAF4; TNF receptor-associated factor 4 [KO:K09848] 9817 KEAP1; kelch-like ECH-associated protein 1 [KO:K10456] 9826 ARHGEF11; rho guanine nucleotide exchange factor 11 isoform 1 [KO:K12331] 9915 ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589] 9965 FGF19; fibroblast growth factor 19 precursor [KO:K22603] 9978 RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32] 998 CDC42; cell division control protein 42 homolog isoform 1 precursor [KO:K04393] 999 CDH1; cadherin-1 isoform 1 preproprotein [KO:K05689] COMPOUND C00027 Hydrogen peroxide C00039 DNA C00076 Calcium cation C00122 Fumarate C00149 (S)-Malate C00165 Diacylglycerol C00187 Cholesterol C00280 Androstenedione C00410 Progesterone C00416 Phosphatidate C00533 Nitric oxide C00535 Testosterone C00575 3',5'-Cyclic AMP C00584 Prostaglandin E2 C00681 1-Acyl-sn-glycerol 3-phosphate C00704 Superoxide C00735 Cortisol C00762 Cortisone C00777 Retinoate C00951 Estradiol-17beta C01227 Dehydroepiandrosterone C01245 D-myo-Inositol 1,4,5-trisphosphate C01471 Acrolein C03917 Dihydrotestosterone C05981 Phosphatidylinositol-3,4,5-trisphosphate C07653 Flutamide C15493 9-cis-Retinoic acid C16038 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine C16844 Hydroxyl radical C21641 Hydroperoxyl radical C21642 4-Hydroxynonenal REFERENCE AUTHORS Weinberg RA. TITLE The biology of cancer JOURNAL Garland Science, Taylor & Francis Group, LLC (2007) REFERENCE PMID:10647931 AUTHORS Hanahan D, Weinberg RA TITLE The hallmarks of cancer. JOURNAL Cell 100:57-70 (2000) DOI:10.1016/S0092-8674(00)81683-9 REFERENCE PMID:15000146 AUTHORS Grady WM. TITLE Genomic instability and colon cancer. JOURNAL Cancer Metastasis Rev 23:11-27 (2004) DOI:10.1023/A:1025861527711 REFERENCE PMID:16555243 AUTHORS Soreide K, Janssen EA, Soiland H, Korner H, Baak JP. TITLE Microsatellite instability in colorectal cancer. JOURNAL Br J Surg 93:395-406 (2006) DOI:10.1002/bjs.5328 REFERENCE PMID:11078609 AUTHORS Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB. TITLE Hereditary non-polyposis colorectal cancer: an updated review. JOURNAL Eur J Surg Oncol 26:635-45 (2000) DOI:10.1053/ejso.2000.0974 REFERENCE PMID:16699851 AUTHORS Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y. TITLE Colorectal cancer: genetics of development and metastasis. JOURNAL J Gastroenterol 41:185-92 (2006) DOI:10.1007/s00535-006-1801-6 REFERENCE PMID:12621137 AUTHORS Lynch HT, de la Chapelle A. TITLE Hereditary colorectal cancer. JOURNAL N Engl J Med 348:919-32 (2003) DOI:10.1056/NEJMra012242 REFERENCE PMID:12951588 AUTHORS Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. TITLE The significance of unstable chromosomes in colorectal cancer. JOURNAL Nat Rev Cancer 3:695-701 (2003) DOI:10.1038/nrc1165 REFERENCE PMID:10505543 AUTHORS Behrens J. TITLE Cadherins and catenins: role in signal transduction and tumor progression. JOURNAL Cancer Metastasis Rev 18:15-30 (1999) DOI:10.1023/A:1006200102166 REFERENCE PMID:16042571 AUTHORS Behrens J. TITLE The role of the Wnt signalling pathway in colorectal tumorigenesis. JOURNAL Biochem Soc Trans 33:672-5 (2005) DOI:10.1042/BST0330672 REFERENCE PMID:15349822 AUTHORS Behrens J, Lustig B. TITLE The Wnt connection to tumorigenesis. JOURNAL Int J Dev Biol 48:477-87 (2004) DOI:10.1387/ijdb.041815jb REFERENCE PMID:9196022 AUTHORS Polakis P. TITLE The adenomatous polyposis coli (APC) tumor suppressor. JOURNAL Biochim Biophys Acta 1332:F127-47 (1997) DOI:10.1016/S0304-419X(97)00008-5 REFERENCE PMID:12737309 AUTHORS Janssen KP. TITLE Murine models of colorectal cancer: studying the role of oncogenic K-ras. JOURNAL Cell Mol Life Sci 60:495-506 (2003) DOI:10.1007/s000180300041 REFERENCE PMID:11459867 AUTHORS Adjei AA. TITLE Blocking oncogenic Ras signaling for cancer therapy. JOURNAL J Natl Cancer Inst 93:1062-74 (2001) DOI:10.1093/jnci/93.14.1062 REFERENCE PMID:15573119 AUTHORS Arakawa H. TITLE Netrin-1 and its receptors in tumorigenesis. JOURNAL Nat Rev Cancer 4:978-87 (2004) DOI:10.1038/nrc1504 REFERENCE PMID:15310786 AUTHORS Mehlen P, Fearon ER. TITLE Role of the dependence receptor DCC in colorectal cancer pathogenesis. JOURNAL J Clin Oncol 22:3420-8 (2004) DOI:10.1200/JCO.2004.02.019 REFERENCE PMID:11223406 AUTHORS Peltomaki P. TITLE DNA mismatch repair and cancer. JOURNAL Mutat Res 488:77-85 (2001) DOI:10.1016/S1383-5742(00)00058-2 REFERENCE PMID:15711891 AUTHORS Li F, Cao Y, Townsend CM Jr, Ko TC. TITLE TGF-beta signaling in colon cancer cells. JOURNAL World J Surg 29:306-11 (2005) DOI:10.1007/s00268-004-7813-6 REFERENCE PMID:11170304 AUTHORS Roman C, Saha D, Beauchamp R. TITLE TGF-beta and colorectal carcinogenesis. JOURNAL Microsc Res Tech 52:450-7 (2001) DOI:10.1002/1097-0029(20010215)52:4<450::AID-JEMT1030>3.0.CO;2-O REFERENCE PMID:16326109 AUTHORS Watson AJ. TITLE An overview of apoptosis and the prevention of colorectal cancer. JOURNAL Crit Rev Oncol Hematol 57:107-21 (2006) DOI:10.1016/j.critrevonc.2005.06.005 REFERENCE PMID:15479695 AUTHORS Watson AJ. TITLE Apoptosis and colorectal cancer. JOURNAL Gut 53:1701-9 (2004) DOI:10.1136/gut.2004.052704 REFERENCE PMID:11477132 AUTHORS Houlston RS. TITLE What we could do now: molecular pathology of colorectal cancer. JOURNAL Mol Pathol 54:206-14 (2001) DOI:10.1136/mp.54.4.206 REFERENCE AUTHORS Von Hoff D, Evans D, Hruban R (ed). TITLE Pancreatic cancer JOURNAL Jones and Bartlett publishers (2005) REFERENCE AUTHORS Niitsu Y, Yokota J (ed). TITLE [Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese) JOURNAL Nankodo (1999) REFERENCE PMID:12459728 AUTHORS Bardeesy N, DePinho RA. TITLE Pancreatic cancer biology and genetics. JOURNAL Nat Rev Cancer 2:897-909 (2002) DOI:10.1038/nrc949 REFERENCE PMID:11407945 AUTHORS Bardeesy N, Sharpless NE, DePinho RA, Merlino G. TITLE The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model. JOURNAL Semin Cancer Biol 11:201-18 (2001) DOI:10.1006/scbi.2000.0371 REFERENCE PMID:12946833 AUTHORS Cowgill SM, Muscarella P. TITLE The genetics of pancreatic cancer. JOURNAL Am J Surg 186:279-86 (2003) DOI:10.1016/S0002-9610(03)00226-5 REFERENCE PMID:16702400 AUTHORS Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA. TITLE Genetics and biology of pancreatic ductal adenocarcinoma. JOURNAL Genes Dev 20:1218-49 (2006) DOI:10.1101/gad.1415606 REFERENCE PMID:10740269 AUTHORS Shields JM, Pruitt K, McFall A, Shaub A, Der CJ. TITLE Understanding Ras: 'it ain't over 'til it's over'. JOURNAL Trends Cell Biol 10:147-54 (2000) DOI:10.1016/S0962-8924(00)01740-2 REFERENCE PMID:12648469 AUTHORS Holbro T, Civenni G, Hynes NE. TITLE The ErbB receptors and their role in cancer progression. JOURNAL Exp Cell Res 284:99-110 (2003) DOI:10.1016/S0014-4827(02)00099-X REFERENCE PMID:14967450 AUTHORS Marmor MD, Skaria KB, Yarden Y. TITLE Signal transduction and oncogenesis by ErbB/HER receptors. JOURNAL Int J Radiat Oncol Biol Phys 58:903-13 (2004) DOI:10.1016/j.ijrobp.2003.06.002 REFERENCE PMID:14586404 AUTHORS DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW. TITLE Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines. JOURNAL Oncogene 22:7781-95 (2003) DOI:10.1038/sj.onc.1206966 REFERENCE PMID:12545153 AUTHORS Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K. TITLE Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. JOURNAL Oncogene 22:319-29 (2003) DOI:10.1038/sj.onc.1206122 REFERENCE PMID:14580692 AUTHORS Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M. TITLE Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. JOURNAL Cancer Lett 201:107-16 (2003) DOI:10.1016/S0304-3835(03)00482-8 REFERENCE PMID:12079267 AUTHORS Schmid RM. TITLE Genetic basis of pancreatic cancer. JOURNAL Best Pract Res Clin Gastroenterol 16:421-33 (2002) DOI:10.1053/bega.2002.0316 REFERENCE PMID:15774796 AUTHORS Elliott RL, Blobe GC. TITLE Role of transforming growth factor Beta in human cancer. JOURNAL J Clin Oncol 23:2078-93 (2005) DOI:10.1200/JCO.2005.02.047 REFERENCE PMID:15823750 AUTHORS Rudkin TM, Foulkes WD. TITLE BRCA2: breaks, mistakes and failed separations. JOURNAL Trends Mol Med 11:145-8 (2005) DOI:10.1016/j.molmed.2005.02.003 REFERENCE PMID:11707511 AUTHORS Venkitaraman AR. TITLE Functions of BRCA1 and BRCA2 in the biological response to DNA damage. JOURNAL J Cell Sci 114:3591-8 (2001) REFERENCE PMID:15639402 AUTHORS Soni D, King JA, Kaye AH, Hovens CM. TITLE Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. JOURNAL J Clin Neurosci 12:1-5 (2005) DOI:10.1016/j.jocn.2004.04.001 REFERENCE PMID:12154354 AUTHORS Zhu Y, Parada LF. TITLE The molecular and genetic basis of neurological tumours. JOURNAL Nat Rev Cancer 2:616-26 (2002) DOI:10.1038/nrc866 REFERENCE PMID:11253051 AUTHORS Holland EC. TITLE Gliomagenesis: genetic alterations and mouse models. JOURNAL Nat Rev Genet 2:120-9 (2001) DOI:10.1038/35052535 REFERENCE PMID:16700615 AUTHORS Bansal K, Liang ML, Rutka JT. TITLE Molecular biology of human gliomas. JOURNAL Technol Cancer Res Treat 5:185-94 (2006) DOI:10.1177/153303460600500302 REFERENCE AUTHORS Tabuchi K (ed). TITLE [Gliomas: Research and therapy] (In Japanese) JOURNAL Springer-Verlag Tokyo (2006) REFERENCE PMID:12762887 AUTHORS Kapoor GS, O'Rourke DM. TITLE Mitogenic signaling cascades in glial tumors. JOURNAL Neurosurgery 52:1425-34; discussion 1434-5 (2003) DOI:10.1227/01.NEU.0000065135.28143.39 REFERENCE PMID:16095998 AUTHORS Hulleman E, Helin K. TITLE Molecular mechanisms in gliomagenesis. JOURNAL Adv Cancer Res 94:1-27 (2005) DOI:10.1016/S0065-230X(05)94001-3 REFERENCE PMID:11057895 AUTHORS Schlessinger J. TITLE Cell signaling by receptor tyrosine kinases. JOURNAL Cell 103:211-25 (2000) DOI:10.1016/S0092-8674(00)00114-8 REFERENCE PMID:9643506 AUTHORS Ng HK, Lam PY. TITLE The molecular genetics of central nervous system tumors. JOURNAL Pathology 30:196-202 (1998) DOI:10.1080/00313029800169236 REFERENCE PMID:12084351 AUTHORS Knobbe CB, Merlo A, Reifenberger G. TITLE Pten signaling in gliomas. JOURNAL Neuro-oncol 4:196-211 (2002) DOI:10.1093/neuonc/4.3.196 REFERENCE PMID:16557281 AUTHORS Kondo T, Ezzat S, Asa SL. TITLE Pathogenetic mechanisms in thyroid follicular-cell neoplasia. JOURNAL Nat Rev Cancer 6:292-306 (2006) DOI:10.1038/nrc1836 REFERENCE PMID:16551846 AUTHORS Chiloeches A, Marais R. TITLE Is BRAF the Achilles' Heel of thyroid cancer? JOURNAL Clin Cancer Res 12:1661-4 (2006) DOI:10.1158/1078-0432.CCR-06-0051 REFERENCE PMID:16946003 AUTHORS Reddi HV, McIver B, Grebe SK, Eberhardt NL TITLE The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis. JOURNAL Endocrinology 148:932-5 (2007) DOI:10.1210/en.2006-0926 REFERENCE PMID:17062879 AUTHORS Santoro M, Melillo RM, Fusco A. TITLE RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture. JOURNAL Eur J Endocrinol 155:645-653 (2006) DOI:10.1530/eje.1.02289 REFERENCE PMID:16242838 AUTHORS Pierotti MA, Greco A. TITLE Oncogenic rearrangements of the NTRK1/NGF receptor. JOURNAL Cancer Lett 232:90-8 (2006) DOI:10.1016/j.canlet.2005.07.043 REFERENCE PMID:16189702 AUTHORS Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P. TITLE Molecular pathology of well-differentiated thyroid carcinomas. JOURNAL Virchows Arch 447:787-93 (2005) DOI:10.1007/s00428-005-0065-5 REFERENCE PMID:11165748 AUTHORS Gimm O. TITLE Thyroid cancer. JOURNAL Cancer Lett 163:143-56 (2001) DOI:10.1016/S0304-3835(00)00697-2 REFERENCE PMID:12094241 AUTHORS Williams D. TITLE Cancer after nuclear fallout: lessons from the Chernobyl accident. JOURNAL Nat Rev Cancer 2:543-9 (2002) DOI:10.1038/nrc845 REFERENCE PMID:16236521 AUTHORS Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H. TITLE The molecular pathogenesis of acute myeloid leukemia. JOURNAL Crit Rev Oncol Hematol 56:195-221 (2005) DOI:10.1016/j.critrevonc.2004.10.012 REFERENCE PMID:12563308 AUTHORS Tenen DG. TITLE Disruption of differentiation in human cancer: AML shows the way. JOURNAL Nat Rev Cancer 3:89-101 (2003) DOI:10.1038/nrc989 REFERENCE PMID:16146838 AUTHORS Choudhary C, Muller-Tidow C, Berdel WE, Serve H. TITLE Signal transduction of oncogenic Flt3. JOURNAL Int J Hematol 82:93-9 (2005) DOI:10.1532/IJH97.05090 REFERENCE PMID:12951584 AUTHORS Stirewalt DL, Radich JP. TITLE The role of FLT3 in haematopoietic malignancies. JOURNAL Nat Rev Cancer 3:650-65 (2003) DOI:10.1038/nrc1169 REFERENCE PMID:16642045 AUTHORS Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L. TITLE Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. JOURNAL Leukemia 20:911-28 (2006) DOI:10.1038/sj.leu.2404245 REFERENCE PMID:15625120 AUTHORS Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R. TITLE Normal and oncogenic forms of the receptor tyrosine kinase kit. JOURNAL Stem Cells 23:16-43 (2005) DOI:10.1634/stemcells.2004-0117 REFERENCE PMID:11721960 AUTHORS Lorsbach RB, Downing JR. TITLE The role of the AML1 transcription factor in leukemogenesis. JOURNAL Int J Hematol 74:258-65 (2001) DOI:10.1007/BF02982058 REFERENCE PMID:12468433 AUTHORS Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H. TITLE Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. JOURNAL Blood 101:3164-73 (2003) DOI:10.1182/blood-2002-06-1677 REFERENCE PMID:17554387 AUTHORS Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C. TITLE The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia. JOURNAL Leukemia 21:1638-47 (2007) DOI:10.1038/sj.leu.2404732 REFERENCE PMID:16352814 AUTHORS Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG. TITLE ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression. JOURNAL Blood 107:3330-8 (2006) DOI:10.1182/blood-2005-07-3068 REFERENCE PMID:15719031 AUTHORS Ren R. TITLE Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. JOURNAL Nat Rev Cancer 5:172-83 (2005) DOI:10.1038/nrc1567 REFERENCE PMID:11071626 AUTHORS Deininger MW, Goldman JM, Melo JV. TITLE The molecular biology of chronic myeloid leukemia. JOURNAL Blood 96:3343-56 (2000) REFERENCE PMID:14982876 AUTHORS Calabretta B, Perrotti D. TITLE The biology of CML blast crisis. JOURNAL Blood 103:4010-22 (2004) DOI:10.1182/blood-2003-12-4111 REFERENCE PMID:10403855 AUTHORS Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM. TITLE The biology of chronic myeloid leukemia. JOURNAL N Engl J Med 341:164-72 (1999) DOI:10.1056/NEJM199907153410306 REFERENCE PMID:15156182 AUTHORS Mitani K. TITLE Molecular mechanisms of leukemogenesis by AML1/EVI-1. JOURNAL Oncogene 23:4263-9 (2004) DOI:10.1038/sj.onc.1207777 REFERENCE PMID:16484590 AUTHORS Dong M, Blobe GC. TITLE Role of transforming growth factor-beta in hematologic malignancies. JOURNAL Blood 107:4589-96 (2006) DOI:10.1182/blood-2005-10-4169 REFERENCE PMID:9834202 AUTHORS Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H. TITLE The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells. JOURNAL Blood 92:4003-12 (1998) REFERENCE PMID:12801837 AUTHORS Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA. TITLE p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase. JOURNAL Haematologica 88:622-30 (2003) REFERENCE PMID:11160144 AUTHORS Baldwin AS. TITLE Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. JOURNAL J Clin Invest 107:241-6 (2001) DOI:10.1172/JCI11991 REFERENCE PMID:12244301 AUTHORS Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL. TITLE PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. JOURNAL Nat Med 8:1145-52 (2002) DOI:10.1038/nm759 REFERENCE PMID:15948971 AUTHORS Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC. TITLE Molecular aetiology and pathogenesis of basal cell carcinoma. JOURNAL Br J Dermatol 152:1108-24 (2005) DOI:10.1111/j.1365-2133.2005.06587.x REFERENCE PMID:12588368 AUTHORS Saldanha G, Fletcher A, Slater DN. TITLE Basal cell carcinoma: a dermatopathological and molecular biological update. JOURNAL Br J Dermatol 148:195-202 (2003) DOI:10.1046/j.1365-2133.2003.05151.x REFERENCE PMID:15978322 AUTHORS Daya-Grosjean L, Couve-Privat S. TITLE Sonic hedgehog signaling in basal cell carcinomas. JOURNAL Cancer Lett 225:181-92 (2005) DOI:10.1016/j.canlet.2004.10.003 REFERENCE PMID:15468170 AUTHORS Tsai KY, Tsao H. TITLE The genetics of skin cancer. JOURNAL Am J Med Genet C Semin Med Genet 131C:82-92 (2004) DOI:10.1002/ajmg.c.30037 REFERENCE PMID:16881963 AUTHORS Athar M, Tang X, Lee JL, Kopelovich L, Kim AL. TITLE Hedgehog signalling in skin development and cancer. JOURNAL Exp Dermatol 15:667-77 (2006) DOI:10.1111/j.1600-0625.2006.00473.x REFERENCE PMID:16306523 AUTHORS Rubin AI, Chen EH, Ratner D. TITLE Basal-cell carcinoma. JOURNAL N Engl J Med 353:2262-9 (2005) DOI:10.1056/NEJMra044151 REFERENCE PMID:11276000 AUTHORS Saldanha G. TITLE The Hedgehog signalling pathway and cancer. JOURNAL J Pathol 193:427-32 (2001) DOI:10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N REFERENCE PMID:15270885 AUTHORS Saldanha G, Ghura V, Potter L, Fletcher A. TITLE Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation. JOURNAL Br J Dermatol 151:157-64 (2004) DOI:10.1111/j.1365-2133.2004.06048.x REFERENCE PMID:14737121 AUTHORS Pasca di Magliano M, Hebrok M. TITLE Hedgehog signalling in cancer formation and maintenance. JOURNAL Nat Rev Cancer 3:903-11 (2003) DOI:10.1038/nrc1229 REFERENCE PMID:15656799 AUTHORS Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G. TITLE Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. JOURNAL Br J Dermatol 152:43-51 (2005) DOI:10.1111/j.1365-2133.2005.06353.x REFERENCE PMID:14556242 AUTHORS Cohen MM Jr. TITLE The hedgehog signaling network. JOURNAL Am J Med Genet A 123:5-28 (2003) DOI:10.1002/ajmg.a.20495 REFERENCE PMID:11736900 AUTHORS Yamazaki F, Aragane Y, Kawada A, Tezuka T. TITLE Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma. JOURNAL Br J Dermatol 145:771-7 (2001) DOI:10.1046/j.1365-2133.2001.04468.x REFERENCE PMID:16054233 AUTHORS Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA. TITLE Role of apoptosis in basal cell and squamous cell carcinoma formation. JOURNAL Immunol Lett 100:68-72 (2005) DOI:10.1016/j.imlet.2005.06.008 REFERENCE PMID:11130178 AUTHORS Toftgard R. TITLE Hedgehog signalling in cancer. JOURNAL Cell Mol Life Sci 57:1720-31 (2000) DOI:10.1007/PL00000654 REFERENCE PMID:16822996 AUTHORS Miller AJ, Mihm MC Jr. TITLE Melanoma. JOURNAL N Engl J Med 355:51-65 (2006) DOI:10.1056/NEJMra052166 REFERENCE PMID:12894244 AUTHORS Chin L. TITLE The genetics of malignant melanoma: lessons from mouse and man. JOURNAL Nat Rev Cancer 3:559-70 (2003) DOI:10.1038/nrc1145 REFERENCE PMID:16750612 AUTHORS Takata M, Saida T. TITLE Genetic alterations in melanocytic tumors. JOURNAL J Dermatol Sci 43:1-10 (2006) DOI:10.1016/j.jdermsci.2006.05.002 REFERENCE PMID:15841168 AUTHORS Chudnovsky Y, Khavari PA, Adams AE. TITLE Melanoma genetics and the development of rational therapeutics. JOURNAL J Clin Invest 115:813-24 (2005) DOI:10.1172/JCI24808 REFERENCE PMID:16001050 AUTHORS Merlino G. TITLE Cancer biology: the weakest link? JOURNAL Nature 436:33-5 (2005) DOI:10.1038/436033a REFERENCE PMID:16001072 AUTHORS Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR. TITLE Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. JOURNAL Nature 436:117-22 (2005) DOI:10.1038/nature03664 REFERENCE PMID:16899407 AUTHORS Levy C, Khaled M, Fisher DE. TITLE MITF: master regulator of melanocyte development and melanoma oncogene. JOURNAL Trends Mol Med 12:406-14 (2006) DOI:10.1016/j.molmed.2006.07.008 REFERENCE PMID:15009714 AUTHORS Tsao H, Goel V, Wu H, Yang G, Haluska FG. TITLE Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. JOURNAL J Invest Dermatol 122:337-41 (2004) DOI:10.1046/j.0022-202X.2004.22243.x REFERENCE PMID:11224709 AUTHORS Gruss C, Herlyn M. TITLE Role of cadherins and matrixins in melanoma. JOURNAL Curr Opin Oncol 13:117-23 (2001) DOI:10.1097/00001622-200103000-00006 REFERENCE PMID:15721476 AUTHORS Thompson JF, Scolyer RA, Kefford RF. TITLE Cutaneous melanoma. JOURNAL Lancet 365:687-701 (2005) DOI:10.1016/S0140-6736(05)17951-3 REFERENCE PMID:14695152 AUTHORS Omholt K, Platz A, Kanter L, Ringborg U, Hansson J. TITLE NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. JOURNAL Clin Cancer Res 9:6483-8 (2003) REFERENCE PMID:15557758 AUTHORS Hussein MR. TITLE The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship? JOURNAL Tumour Biol 25:200-7 (2004) DOI:10.1159/000081103 REFERENCE PMID:10843728 AUTHORS Lazar-Molnar E, Hegyesi H, Toth S, Falus A. TITLE Autocrine and paracrine regulation by cytokines and growth factors in melanoma. JOURNAL Cytokine 12:547-54 (2000) DOI:10.1006/cyto.1999.0614 REFERENCE PMID:16339096 AUTHORS Cohen HT, McGovern FJ. TITLE Renal-cell carcinoma. JOURNAL N Engl J Med 353:2477-90 (2005) DOI:10.1056/NEJMra043172 REFERENCE PMID:15122209 AUTHORS Pavlovich CP, Schmidt LS. TITLE Searching for the hereditary causes of renal-cell carcinoma. JOURNAL Nat Rev Cancer 4:381-93 (2004) DOI:10.1038/nrc1364 REFERENCE PMID:14634372 AUTHORS Linehan WM, Walther MM, Zbar B. TITLE The genetic basis of cancer of the kidney. JOURNAL J Urol 170:2163-72 (2003) DOI:10.1097/01.ju.0000096060.92397.ed REFERENCE PMID:14685170 AUTHORS Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. TITLE Met, metastasis, motility and more. JOURNAL Nat Rev Mol Cell Biol 4:915-25 (2003) DOI:10.1038/nrm1261 REFERENCE PMID:15611513 AUTHORS Kim WY, Kaelin WG. TITLE Role of VHL gene mutation in human cancer. JOURNAL J Clin Oncol 22:4991-5004 (2004) DOI:10.1200/JCO.2004.05.061 REFERENCE PMID:17211469 AUTHORS Sudarshan S, Linehan WM, Neckers L. TITLE HIF and fumarate hydratase in renal cancer. JOURNAL Br J Cancer 96:403-7 (2007) DOI:10.1038/sj.bjc.6603547 REFERENCE PMID:17287871 AUTHORS Sudarshan S, Pinto PA, Neckers L, Linehan WM. TITLE Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. JOURNAL Nat Clin Pract Urol 4:104-10 (2007) DOI:10.1038/ncpuro0711 REFERENCE PMID:12351585 AUTHORS Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG. TITLE Understanding familial and non-familial renal cell cancer. JOURNAL Hum Mol Genet 11:2489-98 (2002) DOI:10.1093/hmg/11.20.2489 REFERENCE PMID:17158541 AUTHORS Mitra AP, Datar RH, Cote RJ. TITLE Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification. JOURNAL J Clin Oncol 24:5552-64 (2006) DOI:10.1200/JCO.2006.08.2073 REFERENCE PMID:16474624 AUTHORS Wolff EM, Liang G, Jones PA. TITLE Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer. JOURNAL Nat Clin Pract Urol 2:502-10 (2005) DOI:10.1038/ncpuro0318 REFERENCE PMID:16110317 AUTHORS Wu XR. TITLE Urothelial tumorigenesis: a tale of divergent pathways. JOURNAL Nat Rev Cancer 5:713-25 (2005) DOI:10.1038/nrc1697 REFERENCE PMID:11103787 AUTHORS Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R. TITLE Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. JOURNAL Cancer Res 60:6298-302 (2000) REFERENCE PMID:12850530 AUTHORS Bellmunt J, Hussain M, Dinney CP. TITLE Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family. JOURNAL Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003) DOI:10.1016/S1040-8428(03)00067-2 REFERENCE PMID:17149381 AUTHORS Sugano K, Kakizoe T. TITLE Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging. JOURNAL Nat Clin Pract Urol 3:642-52 (2006) DOI:10.1038/ncpuro0649 REFERENCE PMID:15746962 AUTHORS Dunn KL, Espino PS, Drobic B, He S, Davie JR. TITLE The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling. JOURNAL Biochem Cell Biol 83:1-14 (2005) DOI:10.1139/o04-121 REFERENCE PMID:15551095 AUTHORS Williams SG, Stein JP. TITLE Molecular pathways in bladder cancer. JOURNAL Urol Res 32:373-85 (2004) DOI:10.1007/s00240-003-0345-y REFERENCE PMID:12878745 AUTHORS Nelson WG, De Marzo AM, Isaacs WB. TITLE Prostate cancer. JOURNAL N Engl J Med 349:366-81 (2003) DOI:10.1056/NEJMra021562 REFERENCE PMID:15724144 AUTHORS Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC. TITLE The emerging role of the PI3-K-Akt pathway in prostate cancer progression. JOURNAL Prostate Cancer Prostatic Dis 8:108-18 (2005) DOI:10.1038/sj.pcan.4500776 REFERENCE PMID:16551847 AUTHORS Pienta KJ, Bradley D. TITLE Mechanisms underlying the development of androgen-independent prostate cancer. JOURNAL Clin Cancer Res 12:1665-71 (2006) DOI:10.1158/1078-0432.CCR-06-0067 REFERENCE PMID:11900250 AUTHORS Feldman BJ, Feldman D. TITLE The development of androgen-independent prostate cancer. JOURNAL Nat Rev Cancer 1:34-45 (2001) DOI:10.1038/35094009 REFERENCE PMID:15082523 AUTHORS Heinlein CA, Chang C. TITLE Androgen receptor in prostate cancer. JOURNAL Endocr Rev 25:276-308 (2004) DOI:10.1210/er.2002-0032 REFERENCE PMID:9422516 AUTHORS Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP. TITLE Androgen receptor gene and hormonal therapy failure of prostate cancer. JOURNAL Am J Pathol 152:1-9 (1998) REFERENCE PMID:10835690 AUTHORS Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D. TITLE Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. JOURNAL Nat Med 6:703-6 (2000) DOI:10.1038/76287 REFERENCE PMID:10453277 AUTHORS Macri E, Loda M. TITLE Role of p27 in prostate carcinogenesis. JOURNAL Cancer Metastasis Rev 17:337-44 (1998) DOI:10.1023/A:1006133620914 REFERENCE PMID:11750244 AUTHORS Steers WD. TITLE 5alpha-reductase activity in the prostate. JOURNAL Urology 58:17-24; discussion 24 (2001) DOI:10.1016/S0090-4295(01)01299-7 REFERENCE PMID:8069858 AUTHORS Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF. TITLE Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis. JOURNAL Cancer Res 54:4920-6 (1994) REFERENCE PMID:11527574 AUTHORS Grimes CA, Jope RS. TITLE The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. JOURNAL Prog Neurobiol 65:391-426 (2001) DOI:10.1016/S0301-0082(01)00011-9 REFERENCE PMID:15947972 AUTHORS Ryan AJ, Susil B, Jobling TW, Oehler MK. TITLE Endometrial cancer. JOURNAL Cell Tissue Res 322:53-61 (2005) DOI:10.1007/s00441-005-1109-5 REFERENCE PMID:14747944 AUTHORS Lax SF. TITLE Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. JOURNAL Virchows Arch 444:213-23 (2004) DOI:10.1007/s00428-003-0947-3 REFERENCE PMID:16508724 AUTHORS Shiozawa T, Konishi I. TITLE Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment. JOURNAL Int J Clin Oncol 11:13-21 (2006) DOI:10.1007/s10147-005-0546-1 REFERENCE PMID:17028294 AUTHORS Hecht JL, Mutter GL. TITLE Molecular and pathologic aspects of endometrial carcinogenesis. JOURNAL J Clin Oncol 24:4783-91 (2006) DOI:10.1200/JCO.2006.06.7173 REFERENCE PMID:11431710 AUTHORS Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J. TITLE Molecular pathology of endometrial hyperplasia and carcinoma. JOURNAL Hum Pathol 32:569-77 (2001) DOI:10.1053/hupa.2001.25929 REFERENCE PMID:15284264 AUTHORS Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH. TITLE Her-2/neu overexpression and amplification in uterine papillary serous carcinoma. JOURNAL J Clin Oncol 22:3126-32 (2004) DOI:10.1200/JCO.2004.11.154 REFERENCE PMID:7585656 AUTHORS Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF. TITLE Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival. JOURNAL Cancer Res 55:5693-8 (1995) REFERENCE PMID:16248975 AUTHORS Kim D, Chung J. TITLE Akt: versatile mediator of cell survival and beyond. JOURNAL J Biochem Mol Biol 35:106-15 (2002) DOI:10.5483/bmbrep.2002.35.1.106 REFERENCE PMID:12711111 AUTHORS Sanchez-Cespedes M. TITLE Dissecting the genetic alterations involved in lung carcinogenesis. JOURNAL Lung Cancer 40:111-21 (2003) DOI:10.1016/S0169-5002(03)00033-3 REFERENCE PMID:11720739 AUTHORS Kaye FJ. TITLE Molecular biology of lung cancer. JOURNAL Lung Cancer 34 Suppl 2:S35-41 (2001) DOI:10.1016/S0169-5002(01)00342-7 REFERENCE PMID:12616528 AUTHORS Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF. TITLE Apoptosis and lung cancer: a review. JOURNAL J Cell Biochem 88:885-98 (2003) DOI:10.1002/jcb.10440 REFERENCE PMID:11807782 AUTHORS Sartorius UA, Krammer PH. TITLE Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. JOURNAL Int J Cancer 97:584-92 (2002) DOI:10.1002/ijc.10096 REFERENCE PMID:16064138 AUTHORS Adhikary S, Eilers M. TITLE Transcriptional regulation and transformation by Myc proteins. JOURNAL Nat Rev Mol Cell Biol 6:635-45 (2005) DOI:10.1038/nrm1703 REFERENCE PMID:11463388 AUTHORS Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI. TITLE A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. JOURNAL Mol Cell 7:639-50 (2001) DOI:10.1016/S1097-2765(01)00210-6 REFERENCE PMID:15109562 AUTHORS Buttery RC, Rintoul RC, Sethi T. TITLE Small cell lung cancer: the importance of the extracellular matrix. JOURNAL Int J Biochem Cell Biol 36:1154-60 (2004) DOI:10.1016/S1357-2725(03)00261-9 REFERENCE PMID:11559746 AUTHORS Yamada KM, Araki M. TITLE Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. JOURNAL J Cell Sci 114:2375-82 (2001) REFERENCE PMID:11905738 AUTHORS Rintoul RC, Sethi T. TITLE The role of extracellular matrix in small-cell lung cancer. JOURNAL Lancet Oncol 2:437-42 (2001) DOI:10.1016/S1470-2045(00)00421-6 REFERENCE PMID:12243753 AUTHORS Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B. TITLE Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells. JOURNAL Exp Cell Res 279:277-90 (2002) DOI:10.1006/excr.2002.5608 REFERENCE PMID:12379883 AUTHORS Osada H, Takahashi T. TITLE Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. JOURNAL Oncogene 21:7421-34 (2002) DOI:10.1038/sj.onc.1205802 REFERENCE PMID:12741677 AUTHORS Yokota J, Nishioka M, Tani M, Kohno T. TITLE Genetic alterations responsible for metastatic phenotypes of lung cancer cells. JOURNAL Clin Exp Metastasis 20:189-93 (2003) DOI:10.1023/a:1022978932215 REFERENCE PMID:16870043 AUTHORS Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS. TITLE K-ras mutations in non-small-cell lung carcinoma: a review. JOURNAL Clin Lung Cancer 8:30-8 (2006) DOI:10.3816/CLC.2006.n.030 REFERENCE PMID:15948711 AUTHORS Pfeifer GP, Dammann R. TITLE Methylation of the tumor suppressor gene RASSF1A in human tumors. JOURNAL Biochemistry (Mosc) 70:576-83 (2005) DOI:10.1007/s10541-005-0151-y REFERENCE PMID:11902573 AUTHORS Altucci L, Gronemeyer H. TITLE The promise of retinoids to fight against cancer. JOURNAL Nat Rev Cancer 1:181-93 (2001) DOI:10.1038/35106036 REFERENCE PMID:10944551 AUTHORS Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF. TITLE Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas. JOURNAL J Natl Cancer Inst 92:1303-7 (2000) DOI:10.1093/jnci/92.16.1303 REFERENCE PMID:12867060 AUTHORS Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA. TITLE Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies. JOURNAL Lung Cancer 41 Suppl 1:S29-42 (2003) DOI:10.1016/S0169-5002(03)00137-5 REFERENCE PMID:16112428 AUTHORS Panani AD, Roussos C. TITLE Cytogenetic and molecular aspects of lung cancer. JOURNAL Cancer Lett 239:1-9 (2006) DOI:10.1016/j.canlet.2005.06.030 REFERENCE PMID:12407699 AUTHORS Mitsuuchi Y, Testa JR. TITLE Cytogenetics and molecular genetics of lung cancer. JOURNAL Am J Med Genet 115:183-8 (2002) DOI:10.1002/ajmg.10692 REFERENCE PMID:15942304 AUTHORS Breuer RH, Postmus PE, Smit EF. TITLE Molecular pathology of non-small-cell lung cancer. JOURNAL Respiration 72:313-30 (2005) DOI:10.1159/000085376 REFERENCE PMID:11895903 AUTHORS Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE. TITLE Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung. JOURNAL Clin Cancer Res 8:734-44 (2002) REFERENCE PMID:16189154 AUTHORS Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K. TITLE Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung. JOURNAL J Clin Pathol 58:1076-80 (2005) DOI:10.1136/jcp.2004.025585 REFERENCE PMID:21193867 AUTHORS Lappano R, Maggiolini M TITLE G protein-coupled receptors: novel targets for drug discovery in cancer. JOURNAL Nat Rev Drug Discov 10:47-60 (2011) DOI:10.1038/nrd3320 REFERENCE PMID:24508914 AUTHORS O'Hayre M, Degese MS, Gutkind JS TITLE Novel insights into G protein and G protein-coupled receptor signaling in cancer. JOURNAL Curr Opin Cell Biol 27:126-35 (2014) DOI:10.1016/j.ceb.2014.01.005 REFERENCE PMID:17251915 AUTHORS Dorsam RT, Gutkind JS TITLE G-protein-coupled receptors and cancer. JOURNAL Nat Rev Cancer 7:79-94 (2007) DOI:10.1038/nrc2069 REL_PATHWAY hsa03320 PPAR signaling pathway hsa04010 MAPK signaling pathway hsa04020 Calcium signaling pathway hsa04024 cAMP signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04066 HIF-1 signaling pathway hsa04110 Cell cycle hsa04115 p53 signaling pathway hsa04150 mTOR signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04210 Apoptosis hsa04310 Wnt signaling pathway hsa04330 Notch signaling pathway hsa04340 Hedgehog signaling pathway hsa04350 TGF-beta signaling pathway hsa04370 VEGF signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04520 Adherens junction hsa04630 JAK-STAT signaling pathway hsa04915 Estrogen signaling pathway KO_PATHWAY ko05200 ///