ENTRY hsa00232 Pathway NAME Caffeine metabolism - Homo sapiens (human) CLASS Metabolism; Biosynthesis of other secondary metabolites PATHWAY_MAP hsa00232 Caffeine metabolism DRUG D09786 Topiroxostat (JAN/INN) DBLINKS UMBBD: caf caf2 ORGANISM Homo sapiens (human) [GN:hsa] GENE 1544 CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1] 10 NAT2; N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5] 9 NAT1; N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5] 1548 CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.14.-] 1549 CYP2A7; cytochrome P450 family 2 subfamily A member 7 [KO:K17683] [EC:1.14.14.-] 7498 XDH; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2] COMPOUND C00048 Glyoxylate C00385 Xanthine C01762 Xanthosine C07130 Theophylline C07480 Theobromine C07481 Caffeine C13747 1,7-Dimethylxanthine C16352 7-Methylxanthosine C16353 7-Methylxanthine C16355 7-Methyluric acid C16356 1,7-Dimethyluric acid C16357 3-Methylxanthine C16358 1-Methylxanthine C16359 1-Methyluric acid C16360 3,7-Dimethyluric acid C16361 1,3,7-Trimethyluric acid C16362 3,6,8-Trimethylallantoin C16363 N-Methylurea C16364 N,N'-Dimethylurea C16365 5-Acetylamino-6-formylamino-3-methyluracil C16366 5-Acetylamino-6-amino-3-methyluracil C21144 1,3,7-Trimethyl-5-hydroxyisourate REFERENCE PMID:9705852 AUTHORS Madyastha KM, Sridhar GR. TITLE A novel pathway for the metabolism of caffeine by a mixed culture consortium. JOURNAL Biochem Biophys Res Commun 249:178-81 (1998) DOI:10.1006/bbrc.1998.9102 REFERENCE PMID:14977550 AUTHORS Mazzafera P. TITLE Catabolism of caffeine in plants and microorganisms. JOURNAL Front Biosci 9:1348-59 (2004) DOI:10.2741/1339 REFERENCE PMID:11393735 AUTHORS Nyeki A, Biollaz J, Kesselring UW, Decosterd LA. TITLE Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment. JOURNAL J Chromatogr B Biomed Sci Appl 755:73-84 (2001) DOI:10.1016/S0378-4347(00)00616-2 REFERENCE PMID:11544129 AUTHORS Ashihara H, Crozier A. TITLE Caffeine: a well known but little mentioned compound in plant science. JOURNAL Trends Plant Sci 6:407-13 (2001) DOI:10.1016/S1360-1385(01)02055-6 REFERENCE PMID:16333668 AUTHORS Yoneyama N, Morimoto H, Ye CX, Ashihara H, Mizuno K, Kato M. TITLE Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme. JOURNAL Mol Genet Genomics 275:125-35 (2006) DOI:10.1007/s00438-005-0070-z REL_PATHWAY hsa00230 Purine metabolism hsa00630 Glyoxylate and dicarboxylate metabolism KO_PATHWAY ko00232 ///