ENTRY msm00010 Pathway NAME Glycolysis / Gluconeogenesis - Mycolicibacterium smegmatis MC2 155 DESCRIPTION Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003]. CLASS Metabolism; Carbohydrate metabolism PATHWAY_MAP msm00010 Glycolysis / Gluconeogenesis MODULE msm_M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:msm00010] msm_M00002 Glycolysis, core module involving three-carbon compounds [PATH:msm00010] msm_M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:msm00010] msm_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:msm00010] DBLINKS GO: 0006096 0006094 ORGANISM Mycolicibacterium smegmatis MC2 155 [GN:msm] GENE MSMEG_1363 glucokinase [KO:K25026] [EC:2.7.1.2] MSMEG_5541 pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9] MSMEG_3947 6-phosphofructokinase isozyme 2 [KO:K16370] [EC:2.7.1.11] MSMEG_5239 glpX; fructose-1,6-bisphosphatase, class II [KO:K02446] [EC:3.1.3.11] MSMEG_3507 fructose-bisphosphate aldolase class-I [KO:K01623] [EC:4.1.2.13] MSMEG_0752 fbaA; fructose-bisphosphate aldolase, class II [KO:K01624] [EC:4.1.2.13] MSMEG_1375 tagatose-1,6-bisphosphate aldolase GatY [KO:K01624] [EC:4.1.2.13] MSMEG_3086 tpiA; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1] MSMEG_3084 gap; glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12] MSMEG_3085 pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3] MSMEG_0935 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11] MSMEG_5415 eno; enolase [KO:K01689] [EC:4.2.1.11] MSMEG_3227 pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40] MSMEG_0154 pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40] MSMEG_3934 phosphoenolpyruvate synthase [KO:K01007] [EC:2.7.9.2] MSMEG_4323 pyruvate dehydrogenase E1 component [KO:K00163] [EC:1.2.4.1] MSMEG_2471 pyruvate dehydrogenase alpha subunit [KO:K00163] [EC:1.2.4.1] MSMEG_4283 sucB; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase [KO:K00627] [EC:2.3.1.12] MSMEG_0903 lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4] MSMEG_4646 pyruvate synthase [KO:K00174] [EC:1.2.7.3 1.2.7.11] MSMEG_4645 orB; alpha oxoglutarate ferredoxin oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.3 1.2.7.11] MSMEG_5866 alcohol dehydrogenase B [KO:K00121] [EC:1.1.1.284 1.1.1.1] MSMEG_0217 alcohol dehydrogenase B [KO:K00121] [EC:1.1.1.284 1.1.1.1] MSMEG_1138 alcohol dehydrogenase 1 [KO:K00121] [EC:1.1.1.284 1.1.1.1] MSMEG_3915 NAD-dependent alcohol dehydrogenase [KO:K13953] [EC:1.1.1.1] MSMEG_3615 zinc-binding alcohol dehydrogenase family protein [KO:K13953] [EC:1.1.1.1] MSMEG_6833 alcohol dehydrogenase [KO:K13953] [EC:1.1.1.1] MSMEG_2048 alcohol dehydrogenase [KO:K00001] [EC:1.1.1.1] MSMEG_3464 alcohol dehydrogenase [KO:K00001] [EC:1.1.1.1] MSMEG_0127 oxidoreductase, zinc-binding dehydrogenase family protein [KO:K00001] [EC:1.1.1.1] MSMEG_6834 alcohol dehydrogenase [KO:K00001] [EC:1.1.1.1] MSMEG_1037 alcohol dehydrogenase, zinc-containing [KO:K13979] [EC:1.1.1.2] MSMEG_2317 alcohol dehydrogenase, zinc-containing [KO:K13979] [EC:1.1.1.2] MSMEG_3726 alcohol dehydrogenase [KO:K00114] [EC:1.1.2.8] MSMEG_5859 aldehyde dehydrogenase (NAD) family protein [KO:K00128] [EC:1.2.1.3] MSMEG_0455 aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3] MSMEG_2238 aldehyde dehydrogenase (NAD) family protein [KO:K00128] [EC:1.2.1.3] MSMEG_0309 aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3] MSMEG_2881 aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3] MSMEG_3387 aldehyde dehydrogenase (NAD) family protein [KO:K00128] [EC:1.2.1.3] MSMEG_2552 aldehyde dehydrogenase (NAD) family protein [KO:K00128] [EC:1.2.1.3] MSMEG_4799 aldehyde dehydrogenase (NAD) family protein [KO:K00128] [EC:1.2.1.3] MSMEG_1306 aldehyde dehydrogenase (NAD) family protein [KO:K00138] [EC:1.2.1.-] MSMEG_0900 eptc-inducible aldehyde dehydrogenase [KO:K00138] [EC:1.2.1.-] MSMEG_1543 eptc-inducible aldehyde dehydrogenase [KO:K00138] [EC:1.2.1.-] MSMEG_3986 acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1] MSMEG_6179 acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1] MSMEG_0718 acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1] MSMEG_5650 AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1] MSMEG_0666 acetyl-CoA synthetase, putative [KO:K24012] [EC:6.2.1.13] MSMEG_0717 aldose 1-epimerase subfamily protein [KO:K01785] [EC:5.1.3.3] MSMEG_2136 pgm; phosphoglucomutase, alpha-D-glucose phosphate-specific [KO:K01835] [EC:5.4.2.2] MSMEG_2760 polyphosphate glucokinase [KO:K00886] [EC:2.7.1.63] MSMEG_0255 phosphoenolpyruvate carboxykinase [KO:K01596] [EC:4.1.1.32] MSMEG_0502 glucosidase [KO:K01222] [EC:3.2.1.86] MSMEG_2117 beta-glucoside-specific EII permease [KO:K02777] [EC:2.7.1.-] COMPOUND C00022 Pyruvate C00024 Acetyl-CoA C00031 D-Glucose C00033 Acetate C00036 Oxaloacetate C00068 Thiamin diphosphate C00074 Phosphoenolpyruvate C00084 Acetaldehyde C00085 D-Fructose 6-phosphate C00103 D-Glucose 1-phosphate C00111 Glycerone phosphate C00118 D-Glyceraldehyde 3-phosphate C00186 (S)-Lactate C00197 3-Phospho-D-glycerate C00221 beta-D-Glucose C00236 3-Phospho-D-glyceroyl phosphate C00267 alpha-D-Glucose C00354 D-Fructose 1,6-bisphosphate C00469 Ethanol C00631 2-Phospho-D-glycerate C00668 alpha-D-Glucose 6-phosphate C01159 2,3-Bisphospho-D-glycerate C01172 beta-D-Glucose 6-phosphate C01451 Salicin C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate C06186 Arbutin C06187 Arbutin 6-phosphate C06188 Salicin 6-phosphate C15972 Enzyme N6-(lipoyl)lysine C15973 Enzyme N6-(dihydrolipoyl)lysine C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine REFERENCE AUTHORS Nishizuka Y (ed). TITLE [Metabolic Maps] (In Japanese) JOURNAL Tokyo Kagaku Dojin (1980) REFERENCE AUTHORS Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds). TITLE [Cellular Functions and Metabolic Maps] (In Japanese) JOURNAL Tokyo Kagaku Dojin (1997) REFERENCE AUTHORS Michal G. TITLE Biochemical Pathways JOURNAL Wiley (1999) REL_PATHWAY msm00020 Citrate cycle (TCA cycle) msm00030 Pentose phosphate pathway msm00500 Starch and sucrose metabolism msm00620 Pyruvate metabolism msm00640 Propanoate metabolism KO_PATHWAY ko00010 ///