ENTRY       M00173            Pathway   Module
NAME        Reductive citrate cycle (Arnon-Buchanan cycle)
DEFINITION  (K00169+K00170+K00171+K00172,K03737) ((K01007,K01006) K01595,K01959+K01960,K01958) K00024 (K01676,K01679,K01677+K01678) (K00239+K00240-K00241-K00242,K18556+K18557+K18558+K18559+K18560) (K01902+K01903) (K00174+K00175-K00177-K00176) K00031 (K01681,K01682) (K15230+K15231,K15232+K15233 K15234)
ORTHOLOGY   K00169,K00170,K00171,K00172  pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196]
            K03737  pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-] [RN:R01196 R10866]
            K01007  pyruvate,water dikinase [EC:2.7.9.2] [RN:R00199]
            K01006  pyruvate,orthophosphate dikinase [EC:2.7.9.1] [RN:R00206]
            K01595  phosphoenolpyruvate carboxylase [EC:4.1.1.31] [RN:R00345]
            K01959,K01960,K01958  pyruvate carboxylase subunit A [EC:6.4.1.1] [RN:R00344]
            K00024  malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
            K01676,K01679,K01677,K01678  fumarate hydratase [EC:4.2.1.2] [RN:R01082]
            K00239,K00240,K00241,K00242  succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164]
            K18556,K18557,K18558,K18559,K18560  NADH-dependent fumarate reductase [EC:1.3.1.6] [RN:R00402]
            K01902,K01903  succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405]
            K00174,K00175,K00177,K00176  2-oxoglutarate:ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197]
            K00031  isocitrate dehydrogenase [EC:1.1.1.42] [RN:R00267]
            K01681,K01682  aconitate hydratase [EC:4.2.1.3] [RN:R01900 R01325]
            K15230,K15231  ATP-citrate lyase [EC:2.3.3.8] [RN:R00352]
            K15232,K15233  citryl-CoA synthetase [EC:6.2.1.18] [RN:R01322]
            K15234  citryl-CoA lyase [EC:4.1.3.34] [RN:R00354]
CLASS       Pathway modules; Energy metabolism; Carbon fixation
PATHWAY     map00720  Carbon fixation pathways in prokaryotes
            map01200  Carbon metabolism
            map01100  Metabolic pathways
            map01120  Microbial metabolism in diverse environments
REACTION    R01196,R10866  C00024 -> C00022
            R00199,R00206  C00022 -> C00074
            R00345  C00074 -> C00036
            R00344  C00022 -> C00036
            R00342  C00036 -> C00149
            R01082  C00149 -> C00122
            R02164,R00402  C00122 -> C00042
            R00405  C00042 -> C00091
            R01197  C00091 -> C00026
            R00267  C00026 -> C00311
            R01900  C00311 -> C00417
            R01325  C00417 -> C00158
            R00352  C00158 -> C00024
            R01322  C00158 -> C00566
            R00354  C00566 -> C00036 + C00024
COMPOUND    C00024  Acetyl-CoA
            C00022  Pyruvate
            C00074  Phosphoenolpyruvate
            C00036  Oxaloacetate
            C00149  (S)-Malate
            C00122  Fumarate
            C00042  Succinate
            C00091  Succinyl-CoA
            C00026  2-Oxoglutarate
            C00311  Isocitrate
            C00417  cis-Aconitate
            C00158  Citrate
            C00566  (3S)-Citryl-CoA
REFERENCE   PMID:15101982
  AUTHORS   Aoshima M, Ishii M, Igarashi Y
  TITLE     A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  JOURNAL   Mol Microbiol 52:763-70 (2004)
            DOI:10.1111/j.1365-2958.2004.04010.x
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