ENTRY       M00173            Pathway   Module
NAME        Reductive citrate cycle (Arnon-Buchanan cycle)
DEFINITION  (K00169+K00170+K00171+K00172,K03737,K28726+K28727+K28728+K28729) ((K01007,K01006) K01595,K01959+K01960,K01958) K00024 (K01676,K01679,K01677+K01678) (K00239+K00240-K00241-K00242,K18556+K18557+K18558+K18559+K18560) (K01902+K01903) (K00174+K00175-K00177-K00176) K00031 (K27802,K01682) (K15230+K15231,K15232+K15233 K15234)
DIAGRAM     M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
CLASS       Pathway modules; Energy metabolism; Carbon fixation
PATHWAY     map00720  Other carbon fixation pathways
            map01200  Carbon metabolism
            map01100  Metabolic pathways
            map01120  Microbial metabolism in diverse environments
ORTHOLOGY   K00169,K00170,K00171,K00172 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196]
            K03737 pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.8.1] [RN:R01196 R10866]
            K28726,K28727,K28728,K28729 pyruvate synthase (flavodoxin) [EC:1.2.8.1] [RN:R10866]
            K01007 pyruvate,water dikinase [EC:2.7.9.2] [RN:R00199]
            K01006 pyruvate,orthophosphate dikinase [EC:2.7.9.1] [RN:R00206]
            K01595 phosphoenolpyruvate carboxylase [EC:4.1.1.31] [RN:R00345]
            K01959,K01960,K01958 pyruvate carboxylase subunit A [EC:6.4.1.1] [RN:R00344]
            K00024 malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
            K01676,K01679,K01677,K01678 fumarate hydratase [EC:4.2.1.2] [RN:R01082]
            K00239,K00240,K00241,K00242 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164]
            K18556,K18557,K18558,K18559,K18560 NADH-dependent fumarate reductase [EC:1.3.1.6] [RN:R00402]
            K01902,K01903 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405]
            K00174,K00175,K00177,K00176 2-oxoglutarate:ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197]
            K00031 isocitrate dehydrogenase [EC:1.1.1.42] [RN:R00267]
            K27802,K01682 aconitate hydratase [EC:4.2.1.3] [RN:R01900 R01325]
            K15230,K15231 ATP-citrate lyase [EC:2.3.3.8] [RN:R00352]
            K15232,K15233 citryl-CoA synthetase [EC:6.2.1.18] [RN:R01322]
            K15234 citryl-CoA lyase [EC:4.1.3.34] [RN:R00354]
COMPLETE    tdn  Sulfurimonas denitrificans
            sua  Sulfurimonas autotrophica
            sulg  Sulfurimonas lithotrophica
            spal  Sulfurimonas paralvinellae
            ssei  Sulfurimonas sediminis
            sbal  Sulfurimonas baltica
            smas  Sulfurimonas marisnigri
            smax  Sulfurimonas marina
            sdiz  Sulfurimonas diazotrophicus
            sku  Sulfuricurvum kujiense
            sulr  Sulfuricurvum sp. RIFRC-1
            tzh  Thiomicrolovo zhangzhouensis
            tsul  Thiomicrolovo sulfuroxydans
            tsub  Thiomicrolovo subterrani
            timm  Thiomicrolovo immobilis
            hmz  Hydrocurvibacter mobilis
            hsj  Hydrocurvibacter sulfurireducens
            sji  Sulfonitrofixus jiaomeiensis
            htm  Hydrogenimonas thermophila
            sinu  Sulfurovum indicum
            smab  Sulfurovum mangrovi
            cmed  Caminibacter mediatlanticus
            cte  Chlorobaculum tepidum
            cpc  Chlorobaculum parvum
            clz  Chlorobaculum limnaeum
            cph  Chlorobium phaeobacteroides DSM 266
            cpb  Chlorobium phaeobacteroides BS1
            cli  Chlorobium limicola
            plt  Pelodictyon luteolum
            pph  Pelodictyon phaeoclathratiforme
            pros  Prosthecochloris sp. GSB1
            proi  Prosthecochloris sp. SCSIO W1103
            cts  Chloroherpeton thalassium
            hya  Hydrogenobaculum sp. Y04AAS1
            hho  Hydrogenobaculum sp. HO
            hys  Hydrogenobaculum sp. SN
            hth  Hydrogenobacter thermophilus
            hte  Hydrogenobacter thermophilus
            tal  Thermocrinis albus
            tam  Thermovibrio ammonificans
            dte  Desulfurobacterium thermolithotrophum
REACTION    R01196,R10866 C00024 -> C00022
            R00199,R00206 C00022 -> C00074
            R00345 C00074 -> C00036
            R00344 C00022 -> C00036
            R00342 C00036 -> C00149
            R01082 C00149 -> C00122
            R02164,R00402 C00122 -> C00042
            R00405 C00042 -> C00091
            R01197 C00091 -> C00026
            R00267 C00026 -> C00311
            R01900 C00311 -> C00417
            R01325 C00417 -> C00158
            R00352 C00158 -> C00024
            R01322 C00158 -> C00566
            R00354 C00566 -> C00036 + C00024
COMPOUND    C00024  Acetyl-CoA
            C00022  Pyruvate
            C00074  Phosphoenolpyruvate
            C00036  Oxaloacetate
            C00149  (S)-Malate
            C00122  Fumarate
            C00042  Succinate
            C00091  Succinyl-CoA
            C00026  2-Oxoglutarate
            C00311  Isocitrate
            C00417  cis-Aconitate
            C00158  Citrate
            C00566  (3S)-Citryl-CoA
REFERENCE   PMID:15101982
  AUTHORS   Aoshima M, Ishii M, Igarashi Y
  TITLE     A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  JOURNAL   Mol Microbiol 52:763-70 (2004)
            DOI:10.1111/j.1365-2958.2004.04010.x
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