ENTRY kpm00010 Pathway NAME Glycolysis / Gluconeogenesis - Klebsiella pneumoniae subsp. pneumoniae HS11286 DESCRIPTION Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003]. CLASS Metabolism; Carbohydrate metabolism PATHWAY_MAP kpm00010 Glycolysis / Gluconeogenesis MODULE kpm_M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:kpm00010] kpm_M00002 Glycolysis, core module involving three-carbon compounds [PATH:kpm00010] kpm_M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:kpm00010] kpm_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:kpm00010] DBLINKS GO: 0006096 0006094 ORGANISM Klebsiella pneumoniae subsp. pneumoniae HS11286 [GN:kpm] GENE KPHS_38100 glucokinase [KO:K00845] [EC:2.7.1.2] KPHS_02470 glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9] KPHS_00440 putative 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11] KPHS_00750 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11] KPHS_31750 6-phosphofructokinase [KO:K16370] [EC:2.7.1.11] KPHS_04690 fructose-1,6-bisphosphatase [KO:K03841] [EC:3.1.3.11] KPHS_51670 fructose 1,6-bisphosphatase II [KO:K02446] [EC:3.1.3.11] KPHS_36090 fructose-bisphosphate aldolase [KO:K11645] [EC:4.1.2.13] KPHS_10870 putative fructose-1,6-bisphosphate aldolase type II [KO:K01624] [EC:4.1.2.13] KPHS_00470 putative ketose-bisphosphate aldolase, class-II [KO:K01624] [EC:4.1.2.13] KPHS_44200 fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13] KPHS_51710 triosephosphate isomerase [KO:K01803] [EC:5.3.1.1] KPHS_26520 glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12] KPHS_24060 glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12] KPHS_20800 glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12] KPHS_44210 phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3] KPHS_15910 phosphoglyceromutase [KO:K01834] [EC:5.4.2.11] KPHS_07030 phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11] KPHS_51160 phosphoglyceromutase [KO:K15633] [EC:5.4.2.12] KPHS_42000 phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11] KPHS_33900 pyruvate kinase [KO:K00873] [EC:2.7.1.40] KPHS_31180 pyruvate kinase [KO:K00873] [EC:2.7.1.40] KPHS_31520 phosphoenolpyruvate synthase [KO:K01007] [EC:2.7.9.2] KPHS_08380 pyruvate dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1] KPHS_08390 dihydrolipoamide acetyltransferase [KO:K00627] [EC:2.3.1.12] KPHS_09960 dihydrolipoamide acetyltransferase [KO:K00627] [EC:2.3.1.12] KPHS_08400 dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4] KPHS_09950 dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4] KPHS_23530 putative oxidoreductase, Fe-S subunit [KO:K03737] [EC:1.2.7.1 1.2.7.-] KPHS_25620 putative malate dehydrogenase [KO:K00016] [EC:1.1.1.27] KPHS_29300 alcohol dehydrogenase class III [KO:K00121] [EC:1.1.1.284 1.1.1.1] KPHS_31950 bifunctional acetaldehyde-CoA/alcohol dehydrogenase [KO:K04072] [EC:1.2.1.10 1.1.1.1] KPHS_28230 alcohol dehydrogenase [KO:K13953] [EC:1.1.1.1] KPHS_00580 alcohol dehydrogenase [KO:K00001] [EC:1.1.1.1] KPHS_05370 putative alcohol dehydrogenase [KO:K12957] [EC:1.1.1.2 1.1.1.183] KPHS_51910 hypothetical protein [KO:K13979] [EC:1.1.1.2] KPHS_38570 ethanolamine utilization enzyme [KO:K04022] KPHS_30610 gluconate dehydrogenase cytochrome c subunit [KO:K22474] [EC:1.1.5.5] KPHS_40620 lactaldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3] KPHS_03180 acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1] KPHS_15920 aldose 1-epimerase [KO:K01785] [EC:5.1.3.3] KPHS_19020 glucose-1-phosphatase/inositol phosphatase [KO:K01085] [EC:3.1.3.10] KPHS_00300 phosphatase [KO:K20866] [EC:3.1.3.10] KPHS_15440 phosphoglucomutase [KO:K01835] [EC:5.4.2.2] KPHS_20790 hypothetical protein [KO:K01792] [EC:5.1.3.15] KPHS_32890 phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49] KPHS_49250 phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49] KPHS_21340 6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86] KPHS_04960 6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86] KPHS_22160 putative alpha-galactosidase/6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86] KPHS_16810 putative family 1 glycoside hydrolase [KO:K01223] [EC:3.2.1.86] KPHS_38950 6-phospho-beta-glucosidase [KO:K01223] [EC:3.2.1.86] KPHS_36400 putative phospho-beta-glucosidase [KO:K01223] [EC:3.2.1.86] KPHS_41250 cryptic 6-phospho-beta-glucosidase [KO:K01223] [EC:3.2.1.86] KPHS_43980 6-phospho-beta-glucosidase [KO:K01223] [EC:3.2.1.86] KPHS_41430 phospho-beta-glucosidase B, cryptic [KO:K01223] [EC:3.2.1.86] KPHS_43140 glycoside hydrolase [KO:K01223] [EC:3.2.1.86] KPHS_38320 glucose-specific PTS system component [KO:K02777] [EC:2.7.1.-] KPHS_19780 glucose-specific PTS system IIBC components [KO:K02779] [EC:2.7.1.199] KPHS_24160 PTS system maltose and glucose-specific transporter subunit IICB [KO:K02791] [EC:2.7.1.199 2.7.1.208] KPHS_41240 cellobiose/arbutin/salicin-specific PTS system components IIBC [KO:K02753] [EC:2.7.1.-] COMPOUND C00022 Pyruvate C00024 Acetyl-CoA C00031 D-Glucose C00033 Acetate C00036 Oxaloacetate C00068 Thiamin diphosphate C00074 Phosphoenolpyruvate C00084 Acetaldehyde C00085 D-Fructose 6-phosphate C00103 D-Glucose 1-phosphate C00111 Glycerone phosphate C00118 D-Glyceraldehyde 3-phosphate C00186 (S)-Lactate C00197 3-Phospho-D-glycerate C00221 beta-D-Glucose C00236 3-Phospho-D-glyceroyl phosphate C00267 alpha-D-Glucose C00354 D-Fructose 1,6-bisphosphate C00469 Ethanol C00631 2-Phospho-D-glycerate C00668 alpha-D-Glucose 6-phosphate C01159 2,3-Bisphospho-D-glycerate C01172 beta-D-Glucose 6-phosphate C01451 Salicin C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate C06186 Arbutin C06187 Arbutin 6-phosphate C06188 Salicin 6-phosphate C15972 Enzyme N6-(lipoyl)lysine C15973 Enzyme N6-(dihydrolipoyl)lysine C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine REFERENCE AUTHORS Nishizuka Y (ed). TITLE [Metabolic Maps] (In Japanese) JOURNAL Tokyo Kagaku Dojin (1980) REFERENCE AUTHORS Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds). TITLE [Cellular Functions and Metabolic Maps] (In Japanese) JOURNAL Tokyo Kagaku Dojin (1997) REFERENCE AUTHORS Michal G. TITLE Biochemical Pathways JOURNAL Wiley (1999) REL_PATHWAY kpm00020 Citrate cycle (TCA cycle) kpm00030 Pentose phosphate pathway kpm00500 Starch and sucrose metabolism kpm00620 Pyruvate metabolism kpm00640 Propanoate metabolism KO_PATHWAY ko00010 ///