ENTRY K21219 KO SYMBOL thiDN NAME hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3] PATHWAY map00730 Thiamine metabolism map01100 Metabolic pathways map01240 Biosynthesis of cofactors MODULE M00127 Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP M00896 Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP M00899 Thiamine salvage pathway, HMP/HET => TMP REACTION R03223 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase R03471 ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase R04509 ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase R10712 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase BRITE KEGG Orthology (KO) [BR:ko00001] 09100 Metabolism 09108 Metabolism of cofactors and vitamins 00730 Thiamine metabolism K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase Enzymes [BR:ko01000] 2. Transferases 2.5 Transferring alkyl or aryl groups, other than methyl groups 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) 2.5.1.3 thiamine phosphate synthase K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase 2.7 Transferring phosphorus-containing groups 2.7.1 Phosphotransferases with an alcohol group as acceptor 2.7.1.49 hydroxymethylpyrimidine kinase K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase 2.7.4 Phosphotransferases with a phosphate group as acceptor 2.7.4.7 phosphooxymethylpyrimidine kinase K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase DBLINKS COG: COG0351 COG1992 GO: 0008902 0008972 0004789 GENES DSA: Desal_1774 DHY: DESAM_22422 DAS: Daes_1844 DPI: BN4_10299 DEJ: AWY79_13195 PPRF: DPRO_0943 PSEL: GM415_15090(thiD) DDN: DND132_0246 PTHE: LF599_07845(thiD) DSX: GD604_11660(thiD) DSD: GD606_06665(thiD) DAO: Desac_0182 DTI: Desti_1539 DMP: FAK_14580 TID: Thein_0524 TAV: G4V39_04455(thiD) TMAI: FVE67_03190 DAW: HS1_000273 DHR: LGS26_00335(thiD) CALK: HUE98_09900(thiD) TTK: TST_1656(thiD) TMA: TM0790 TMM: Tmari_0791 TMI: THEMA_00700 TMW: THMA_0809 TMQ: THMB_0809 TMX: THMC_0809 TPT: Tpet_0139 TNP: Tnap_0140 TRQ: TRQ2_0137 TNA: CTN_1788 THQ: T2812B_00700 THZ: CELL2_00725 THR: TRQ7_00700 TLE: Tlet_1753 TTA: Theth_1371 TME: Tmel_1594 TAF: THA_1801 THP: BG95_08675 THER: Y592_08780 TFE: JYK00_09425 FNO: Fnod_1419 FPE: Ferpe_0643 FIA: NA23_03505 FRR: IB67_05350 OCY: OSSY52_15610(thiDN) MPZ: Marpi_0891 MARN: LN42_04900 MAEO: JRV97_03760 NLI: G3M70_00760(thiD) NVA: G3M78_13560(thiD) MJA: MJ_0236 MFE: Mefer_0443 MVU: Metvu_1681 MFS: MFS40622_1814 MIF: Metin_1371 MJH: JH146_1565 MESG: MLAUSG7_0473(thiDN) MESA: MLASG1_0039(thiDN) MIG: Metig_0827 MMP: MMP1639 MMQ: MmarC5_1769 MMX: MmarC6_1032 MMZ: MmarC7_0912 MMD: GYY_09050 MMAK: MMKA1_18710 MMAO: MMOS7_17530 MMAD: MMJJ_11980(thiD) MAE: Maeo_0460 MVN: Mevan_0944 MVO: Mvol_1254 MOK: Metok_0333 METF: CFE53_02505 MKA: MK0589(thiD) AVE: Arcve_1968 GAC: GACE_1547 GAH: GAH_00126 PFU: PF1333 PFI: PFC_05880 PHO: PH1155(PH1155) PAB: PAB1646 PYN: PNA2_1764 PYA: PYCH_04500 PYS: Py04_0935 PYC: TQ32_06000 TKO: TK0435 TGA: TGAM_1271(thiD) TSI: TSIB_0462 TBA: TERMP_00508 THE: GQS_02020 THM: CL1_0035 TLT: OCC_04964 THS: TES1_0593 TNU: BD01_0514 TEU: TEU_09500 TGY: X802_10055 THV: ADU37_CDS03940 TCH: CHITON_1447 TPEP: A0127_02265 TPIE: A7C91_09065 TCE: A3L02_01990 TTD: A3L14_05485 TPRF: A3L09_06400 TPAF: A3L08_06890 THY: A3L12_05215 TIC: FH039_06455(thiD) TCQ: TIRI35C_0993 THEM: FPV09_02935(thiD) THEI: K1720_05435 PPAC: PAP_03995 MBA: Mbar_A3501 MBY: MSBRM_1279 MBW: MSBRW_1232 MBAR: MSBR2_1128 MBAK: MSBR3_1454 MAC: MA_3197(thiD) MMA: MM_0338 MMAZ: MmTuc01_0345 MMJ: MSMAS_0963 MMAC: MSMAC_0965 MVC: MSVAZ_2169 MEK: MSKOL_2162 MLS: MSLAZ_2393 METM: MSMTP_2342 MEF: MSWH1_0616 MEQ: MSWHS_0635 MSJ: MSSAC_3239 MSZ: MSSIH_1070 MSW: MSSIT_1117 MTHR: MSTHT_1098 MTHE: MSTHC_2205 MHOR: MSHOH_3049 MFZ: AOB57_010930(thiD) MBU: Mbur_2182(thiD) MMET: MCMEM_0359 MELO: J7W08_11920(thiD) MMH: Mmah_0363 MHAZ: BHR79_01690 MPOT: BKM01_06780 MEV: Metev_0182 MZH: Mzhil_1367 MPY: Mpsy_2779 MZI: HWN40_08755(thiD) MMAV: RE476_01410(thiD) MSEB: RE474_11100(thiD) MHZ: Metho_0714 MEHF: MmiHf6_02060(pdxK) MEES: MmiEs2_07930(pdxK) MTP: Mthe_0828 MCJ: MCON_0806(thiD) MHI: Mhar_1899 MEZ: Mtc_2023(thiD) MJK: N2V74_01275(thiD) N2V74_04590(thiD) HAL: VNG_2606G(thiD) HSL: OE_4654F(thiDN) HANR: LJ422_10535(thiD) HHB: Hhub_1123(thiDN) HAGS: JT689_11970(thiD) HABO: JRZ79_10300(thiD) HNO: LT974_00710(thiD) HLU: LT972_12870(thiD) HSU: HLASF_1503(thiD2) HSF: HLASA_1490(thiD2) SALR: FQU85_03525(thiD) HALR: EFA46_013160(thiD) HJE: HacjB3_14355 HDO: MUK72_07985(thiD) HALX: M0R89_08610(thiD) HAXZ: M0R88_08720(thiD) HAYC: NGM10_06875(thiD) HAXY: NGM07_01035 SALI: L593_03780 SAIM: K0C01_06785(thiD) HARA: AArcS_2159(thiD) HMA: rrnAC2449(thiD) HHI: HAH_2882(thiD) HHN: HISP_14650 HAB: SG26_06785 HTA: BVU17_14015 HALJ: G9465_05525(thiD) HSIN: KDQ40_15050(thiD) NPH: NP_0546A(thiDN) NMO: Nmlp_3884(thiDN) NHO: HWV23_11230(thiD) NSAL: HWV07_13365(thiD) HUT: Huta_0491 HALA: Hrd1104_03805(thiD) HASV: SVXHr_1104(thiD) HABN: HBNXHr_1092(thiD) HMU: Hmuk_0364 HALZ: E5139_05105(thiD) HALL: LC1Hm_2892(thiDN) HAZP: GBQ70_05100(thiD) HALI: BV210_06075 HSN: DV733_06810(thiD) HDS: HSR122_0512(thiD) HRR: HZS55_11725(thiD) HPEL: HZS54_14065(thiD) HLT: I7X12_02440(thiD) HARC: HARCEL1_03120(thiD) HAAD: MW046_11495(thiD) HME: HFX_2683(thiD) HGI: ABY42_13360 HBO: Hbor_34650 HAQ: DU484_00925(thiD) HAJ: DU500_01490(thiD) HAER: DU502_16980(thiD) HRA: EI982_13975(thiD) HLM: DV707_08680(thiD) HLA: Hlac_2988 HALP: DOS48_04635(thiD) HALB: EKH57_11765(thiD) HEZZ: EO776_00410(thiD) HALQ: Hrr1229_006270 HSS: J7656_00820(thiD) HAZZ: KI388_14085(thiD) SRUB: C2R22_14585(thiD) HAE: halTADL_2323 HALN: B4589_006720(thiD) HALG: HUG10_08605(thiD) HALU: HUG12_18830(thiD) HMP: K6T50_02085(thiD) HRE: K6T36_01905(thiD) K6T36_15670(thiD) HRM: K6T25_14535(thiD) HACB: Hbl1158_08975(thiD) HDF: AArcSl_2693(thiDN) HAH: Halar_1066 HTU: Htur_3232 HSAL: JMJ58_12310(thiD) HAKZ: J0X25_03185(thiD) NMG: Nmag_1282(thiDN) HXA: Halxa_2106 NAT: NJ7G_2232 NPE: Natpe_0691 NVR: FEJ81_03720(thiD) NPL: FGF80_07090(thiD) NAY: HYG81_07270(thiD) HALY: HYG82_09440(thiD) HJT: DVR14_12795(thiD) HLO: J0X27_13600(thiD) NGE: Natgr_2394 HRU: Halru_0512 NOU: Natoc_2167 HLR: HALLA_17735 HLC: CHINAEXTREME07690 NAJ: B1756_10205 NAG: AArcMg_3169 NAN: AArc1_3078 NARA: QQ977_07445(thiD) NBG: DV706_09585(thiD) NAS: GCU68_02470(thiD) HDA: BB347_10160 MELU: MTLP_01760(thiD) MEAM: MU439_00150(thiD) MEAE: QEN48_02660(thiD) TAR: TALC_00624 MAX: MMALV_06080 MER: MMINT_13690 MEAR: Mpt1_c03150(thiDN) MEUZ: KRP56_05050(thiD) MARC: AR505_0650 APE: APE_2400.1(thiDN) ACJ: ACAM_1502(thiDN) SMR: Smar_0049 SHC: Shell_0767 IHO: Igni_0888 IIS: EYM_07800 DKA: DKAM_0714 DFD: Desfe_0794 DMU: Desmu_0544 IAG: Igag_1669 THG: TCELL_1024 HBU: Hbut_1459 PFM: Pyrfu_0689 PDL: Pyrde_0221 PABI: PABY_17310 STO: STK_05260(thiD) SOH: D1869_02465(thiD) SSO: SSO2393(thiD-2) SOL: Ssol_0200 SSOA: SULA_0192(thiD) SSOL: SULB_0193(thiD) SSOF: SULC_0192(thiD) SSHI: J5U23_01206 SCAS: SACC_19020 SAI: Saci_0953 SACN: SacN8_04625 SACR: SacRon12I_04615 SACS: SUSAZ_04375 SIS: LS215_0216 SIA: M1425_0185 SIM: M1627_0185 SID: M164_0204 SIY: YG5714_0189 SIN: YN1551_2791 SII: LD85_0189 SIH: SiH_0191 SIR: SiRe_0185 SIC: SiL_0178 SULA: BFU36_10645 SULE: GFS03_02475(thiD) SULO: GFS33_08750(thiD) SULL: EWF20_03990(thiD) MSE: Msed_0646 MEMJ: MJ1HA_0756 MCN: Mcup_1524 MHK: DFR87_02965(thiD) MPRU: DFR88_03350(thiD) MTEN: GWK48_09145(thiD) MJN: MjAS7_1409 AHO: Ahos_2188 AMAN: B6F84_03170 ABRI: DFR85_00670(thiD) ASUL: DFR86_03170(thiD) AAMB: D1866_05920(thiD) ACIH: HS5_09990 SACD: HS1genome_1443 SAZO: D1868_10230(thiD) CSTY: KN1_03220 STEP: IC006_2571 SMET: RQ359_001758(thiD) SAHS: HS7_16620 PAI: PAE2535 PIS: Pisl_1419 PCL: Pcal_0240 PAS: Pars_0839 PYR: P186_2074 POG: Pogu_1494 TNE: Tneu_1881 PYW: PYWP30_02058 CMA: Cmaq_0452 TTN: TTX_0857(thiD) TUZ: TUZN_0613 VDI: Vdis_2402 VMO: VMUT_0747 VSO: Vsou_21520 THF: MA03_04595 THEL: IG193_08165 ASC: ASAC_1274 ACIA: SE86_07465 CLG: Calag_0858 FFO: FFONT_0261 KCR: Kcr_0867 NMR: Nmar_0542 NIR: NSED_02730 NKR: NKOR_02800 NID: NPIRD3C_1734 NIN: NADRNF5_1639 NIW: Nisw_02165(thiD) NCL: C5F47_02780(thiD) NOX: C5F49_02960(thiD) NUE: C5F50_04155(thiD) NIP: NsoK4_05640(thiD) NZT: NZOSNM25_001471 NCT: NMSP_1131(thiDN) NIC: DSQ20_03015(thiD) NGA: Ngar_c15420(thiD) NVN: NVIE_006780(thiD) NEV: NTE_02040 TAA: NMY3_02518(thiD) NFN: NFRAN_0101(thiD) NCV: NCAV_1388(thiD) NDV: NDEV_0535 CSY: CENSYa_0221 CSU: CSUB_C1491 NBV: T478_0467(thiD) TAH: SU86_003375 NIU: DSQ19_02775(thiD) NCK: QVH35_06810(thiD) CCAI: NAS2_1199 BARC: AOA65_2405(thiDN) BARB: AOA66_0398(thiDN) FLT: Sv326_0186 REFERENCE PMID:12794638 AUTHORS Morett E, Korbel JO, Rajan E, Saab-Rincon G, Olvera L, Olvera M, Schmidt S, Snel B, Bork P TITLE Systematic discovery of analogous enzymes in thiamin biosynthesis. JOURNAL Nat Biotechnol 21:790-5 (2003) DOI:10.1038/nbt834 SEQUENCE [tma:TM0790] REFERENCE PMID:24583237 AUTHORS Hayashi M, Kobayashi K, Esaki H, Konno H, Akaji K, Tazuya K, Yamada K, Nakabayashi T, Nosaka K TITLE Enzymatic and structural characterization of an archaeal thiamin phosphate synthase. JOURNAL Biochim Biophys Acta 1844:803-9 (2014) DOI:10.1016/j.bbapap.2014.02.017 SEQUENCE [pcl:Pcal_0240] ///