ENTRY K12554 KO SYMBOL murN NAME alanine adding enzyme [EC:2.3.2.-] PATHWAY map00550 Peptidoglycan biosynthesis map01100 Metabolic pathways REACTION R08780 L-alanyl-tRNA:undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine alanyltransferase BRITE KEGG Orthology (KO) [BR:ko00001] 09100 Metabolism 09107 Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis K12554 murN; alanine adding enzyme 09180 Brite Hierarchies 09181 Protein families: metabolism 01011 Peptidoglycan biosynthesis and degradation proteins K12554 murN; alanine adding enzyme Peptidoglycan biosynthesis and degradation proteins [BR:ko01011] Precursor biosynthesis Amino acid ligase K12554 murN; alanine adding enzyme DBLINKS COG: COG2348 GENES SDO: SD1155_04360 SHA: SH1666(fmhC) SHH: ShL2_01599(fmhA_2) SLG: SLGD_01647 SLN: SLUG_16500(epr) SWA: A284_11690 SPAS: STP1_1421 SHU: SHYC_08580 SSCH: LH95_09955 SSCZ: RN70_10715 SAGQ: EP23_01840 SKL: C7J89_00610 C7J89_01355 SFQ: C7J90_04585 SCAR: DWB96_13040 SSIM: SAMEA4384339_2322(femA_3) SLLO: ISP08_12700 SFF: FOB90_09495 SSTE: SAMEA4384403_0183(femA_1) MVT: I6J10_12385 MCL: MCCL_0128 MCAK: MCCS_02390(femA_1) JEA: JEM45_01595 SBAC: BVH56_00945 LGR: LCGT_0582 LCGT_0583 LGV: LCGL_0601 LCGL_0602 LPK: LACPI_0938 LRN: CMV25_01210 LCAR: BHS00_06330 LPET: lgb_00584(femA) lgb_00585 LFO: LMK00_02870 LMK00_02875 SPY: SPy_0615(murN) SPZ: M5005_Spy0510 SPYM: M1GAS476_1932(murN) SPYA: A20_0552c(murN) SPM: spyM18_0682(femA) SPG: SpyM3_0434(murN) SPS: SPs1421 SPH: MGAS10270_Spy0504 SPI: MGAS10750_Spy0529 SPJ: MGAS2096_Spy0522 SPK: MGAS9429_Spy0500 SPF: SpyM51353(murN) SPA: M6_Spy0531 SPB: M28_Spy0489 STG: MGAS15252_0536(murN) STX: MGAS1882_0533(murN) SOZ: Spy49_0517c(murN) STZ: SPYALAB49_000542 SPYH: L897_02750 SPN: SP_0616(fibB) SPD: SPD_0536(fibB) SPR: spr0541(murN) SPW: SPCG_0576(murN) SJJ: SPJ_0567 SNV: SPNINV200_05430(murN) SPX: SPG_0559 SNT: SPT_0641 SND: MYY_0665 SPNN: T308_02905 SNE: SPN23F05550(murN) SPV: SPH_0709 SNC: HMPREF0837_10905 SNM: SP70585_0677 SPP: SPP_0630 SNI: INV104_05140(murN) SPNG: HMPREF1038_00637 SNB: SP670_0674 SNP: SPAP_0602 SNX: SPNOXC05620(murN) SNU: SPNA45_01490(murN) SPNE: SPN034156_16120(murN) SPNU: SPN034183_05650(murN) SPNM: SPN994038_05530(murN) SPNO: SPN994039_05540(murN) SAG: SAG0508(fibB) SAG1349 SAN: gbs0554 gbs1419 SAK: SAK_0658(fibB) SAK_1380 SGC: A964_0539(murN) A964_1263(murN) SAGS: SaSA20_0493 SaSA20_1089 SAGL: GBS222_0485(fibB) SAGM: BSA_14280 BSA_5960 SAGI: MSA_14700 MSA_6110 SAGR: SAIL_13990 SAIL_6250 SAGP: V193_02830 SAGC: DN94_02830 SAGT: GBSCOH1_0491 GBSCOH1_1210 SAGE: EN72_02925 EN72_07505 SAGG: EN73_03000 EN73_06635 SAGN: W903_0685 W903_1363 SAGJ: ID870_02900 ID870_06730 SMU: SMU_716(murN) SMC: SmuNN2025_1281(murN) SMUT: SMUGS5_03155 SMJ: SMULJ23_1282(murN) SMUA: SMUFR_0624(murN) STC: str0348(murO) str0596(murN) STL: stu0348(murO) stu0596(murN) STE: STER_0386 STER_0644 STN: STND_0596 STU: STH8232_0446 STH8232_0785(murN) STW: Y1U_C0333 Y1U_C0572 STHE: T303_04145 STHS: AVT04_01930 AVT04_03155 SSA: SSA_0861(murN) SSK: SSUD12_0368 SSUI: T15_0382 SGO: SGO_1624(murN) SEZ: Sez_1320(murN) SEQ: SZO_06480 SEZO: SeseC_01705 SEU: SEQ_1502 SUB: SUB0606(murN) SDS: SDEG_0636 SDG: SDE12394_03420 SDA: GGS_0611(murN) SDC: SDSE_0677(murN) SDQ: SDSE167_0690 SGA: GALLO_1509 GALLO_1729 SGG: SGGBAA2069_c15310(murN) SGGBAA2069_c16880(murN1) SGT: SGGB_1504(murN) SGGB_1716 SMB: smi_1583(fibB) STB: SGPB_1405(murN) SGPB_1542 SCP: HMPREF0833_10856 SCF: Spaf_1437 SSR: SALIVB_1613(femB) STF: Ssal_01687(murN) STJ: SALIVA_0323(murO) SALIVA_0611(murN) STRS: SSAL8618_03150 SSAH: HSISS4_00275(murO) HSISS4_00517(murN) STD: SPPN_03245 SMN: SMA_1516 SMA_1639(femB) SIF: Sinf_1330 Sinf_1467(fibB) SIE: SCIM_0529 SIB: SIR_1112(murN) SIU: SII_1133(murN) SANG: SAIN_0585(murN) SAIN_1335 SANC: SANR_0597(murN) SANR_1557 SANS: DK43_07240 SCG: SCI_0622(murN) SCON: SCRE_0602(murN) SCOS: SCR2_0602(murN) SOI: I872_02750 SIK: K710_1339 SIQ: DQ08_06200 SIO: DW64_06195 SIZ: SI82_06350 SLU: KE3_1459 KE3_1571 SIG: N596_04270 SIP: N597_06115 SPAT: A0O21_02755 STRA: ATM98_03935 SSOB: DK181_03425 SEQI: A6J79_05975 SKI: D7D50_06400 SPEI: EHW89_02745 SRAT: FY406_06915 SPLR: C0J00_06925 C0J00_07770 SVB: NCTC12167_00374(murO) NCTC12167_00631(murN) SMEN: SAMEA4412692_0953(femA) SFER: NCTC12278_01322(femA) SCAI: NCTC12191_02001(murN) SPSU: NCTC13786_01917(murN) SCHJ: DDV21_008040 SPOC: NCTC10925_01240(murN) SLAT: J4854_07440 SAUP: NCTC3168_01368(fibB) SURN: NCTC13766_01448(murO) NCTC13766_01665(femB) SACO: SAME_01701(femB) SAME_01879(femA) SVF: NCTC3166_01380(fibB) STOY: STYK_15250(murN) SRUM: GPZ88_01520 GPZ88_02055 SACY: O6R09_06445 O6R09_07000 SMIE: NCTC11169_00545(murN_1) SRUN: LPB404_07200 SPAM: SP4011_16610(murN) LROS: LROSL1_0108 LROSL1_0951 LROSL1_2143 LROSL1_2356 OOE: OEOE_0882 OEOE_1442 OEN: DSM07_01575 DSM07_03025 OSI: DLJ48_01405 DLJ48_02030 LME: LEUM_0327 LMM: MI1_01380 LMK: LMES_0268 LCI: LCK_00234 LKI: LKI_04855 LEC: LGMK_07570 LCN: C270_06850 LGS: LEGAS_1646(murN) LGE: C269_07870 LLF: BCR17_02945 LGC: A9176_01445 LSU: A6B45_01570 LPSE: FGL85_00435 WKO: WKK_01735 WCE: WS08_0909 WTR: KHQ32_05115 WCT: WS74_0975 WCI: WS105_0972 WCB: AO080_00850 WJO: FOL01_0258 WPA: CO680_07010 WSO: WSWS_00405(murN) WHE: EFA59_01170 EFA59_05000 WDI: H9L19_01625 WVR: IE337_01970 WCO: G7084_03075 EFA: EF2150 EFL: EF62_2450 EFI: OG1RF_11691 EFD: EFD32_1741 EFS: EFS1_1750 EFN: DENG_02191(murN) EFQ: DR75_987 ESS: ATZ33_13085 MPS: MPTP_0306 MPTP_0445 MPX: MPD5_1461 AUR: HMPREF9243_1543 AUN: AWM73_02215 ACG: AWM71_01515 ALOY: CJ190_002385 AMIT: DBT49_0002820 ATJ: DBT50_008535 GEG: LK443_09150 CLO: HMPREF0868_0292 EUU: ADJ67_01570 PCAT: Pcatena_03990(femA) ARX: ARZXY2_3017(murN) ARTH: C3B78_03725 ARTY: AHiyo4_08550 PUE: FV140_05120 PNV: JMY29_04500 PAYJ: HMI59_16735 PAGO: IRJ34_04710 ARZ: AUT26_04335 ACH: Achl_0886 APN: Asphe3_08070 PSUL: AU252_06300 PSNI: NIBR502771_00895 PSEY: GU243_20265 PDEL: JCQ34_03710 POK: SMD14_03975 PSLS: KTR40_03825 PSFE: NG819_21030 RSA: RSal33209_0818 XYL: ET495_05715 BLO: BL0282 BL0284 BLJ: BLD_1027 BLD_1029 BLN: Blon_0413 Blon_0414 Blon_0415 Blon_1303 BLON: BLIJ_0421 BLIJ_0422 BLIJ_0423 BLIJ_1344 BLF: BLIF_0324 BLIF_0325 BLIF_0326 BLL: BLJ_0388 BLJ_0390 BLB: BBMN68_1043 BBMN68_1045 BLM: BLLJ_0331 BLLJ_0332 BLLJ_0333 BLLJ_0908 BLK: BLNIAS_02318 BLNIAS_02321 BLG: BIL_15400 BIL_15410 BLZ: BLGT_02150 BLGT_02160 BLX: GS08_02030 GS08_02040 BLA: BLA_0276 BLC: Balac_0288 BLT: Balat_0288 BBB: BIF_00564 BBC: BLC1_0278 BNM: BALAC2494_00838 BLV: BalV_0281 BLW: W7Y_0286 BLS: W91_0295 BANI: BL12_01450 BANL: BLAC_01460 BNI: BANAN_01510 BANM: EN10_01465 BKA: AH68_01315 AH68_01320 BKS: BBKW_0248 BCAT: BBCT_0212 BBCT_0213 BPSP: AH67_01500 AH67_01505 BPSC: BBPC_0240 BBPC_0241 BSCA: BBSC_2155 BBSC_2156 BCHO: BcFMB_03770 BcFMB_03775 BLEM: BL8807_02250 BL8807_02255 BEU: BE0216_09315 BE0216_09320 BE0216_09325 REFERENCE PMID:18077448 AUTHORS Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG TITLE Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. JOURNAL J Biol Chem 283:6402-17 (2008) DOI:10.1074/jbc.M708105200 REFERENCE PMID:10759563 AUTHORS Filipe SR, Tomasz A TITLE Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes. JOURNAL Proc Natl Acad Sci U S A 97:4891-6 (2000) DOI:10.1073/pnas.080067697 SEQUENCE [spr:spr0541] ///