ENTRY K05363 KO SYMBOL murM NAME serine/alanine adding enzyme [EC:2.3.2.10] PATHWAY map00550 Peptidoglycan biosynthesis map01100 Metabolic pathways REACTION R08779 L-alanyl-tRNA:undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase BRITE KEGG Orthology (KO) [BR:ko00001] 09100 Metabolism 09107 Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis K05363 murM; serine/alanine adding enzyme 09180 Brite Hierarchies 09181 Protein families: metabolism 01011 Peptidoglycan biosynthesis and degradation proteins K05363 murM; serine/alanine adding enzyme Enzymes [BR:ko01000] 2. Transferases 2.3 Acyltransferases 2.3.2 Aminoacyltransferases 2.3.2.10 UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase K05363 murM; serine/alanine adding enzyme Peptidoglycan biosynthesis and degradation proteins [BR:ko01011] Precursor biosynthesis Amino acid ligase K05363 murM; serine/alanine adding enzyme DBLINKS COG: COG2348 GO: 0047206 GENES AMH: I633_14530 AMAA: amad1_14030 AMAD: I636_13635 AMAI: I635_14005 BACO: OXB_0272 GMO: NCTC11323_00057(femB_1) GSA: FOC50_04790 GHA: NCTC10459_01694(femX) PLN: Plano_2272 Plano_2278 PKU: AUO94_04290 AUO94_04295 AUO94_04375 PRT: AUC31_15470 AUC31_15485 AUC31_15490 AUC31_15495 PLL: I858_011440 I858_011445 I858_011520 PANA: BBH88_07570 BBH88_07575 PDG: BCM40_03825 BCM40_03870 BCM40_03895 PHC: BBI08_08615 BBI08_08640 BBI08_08685 PPLA: BBI15_07090 BBI15_07095 BBI15_07100 BBI15_07115 PFAE: AJGP001_13170 AJGP001_13250 PLX: CW734_13135 CW734_13140 CW734_13145 CW734_13160 PMAT: BBI11_12575 PDEC: H1Q58_11865 PGQ: FK545_02085 FK545_02090 FK545_02320 FK545_02325 PLAY: DNR44_008505 SPOR: SporoP33_05385 SPOP: SporoP37_05875 SURE: SporoP32a_05895 SPOS: DV702_09585 LLK: LLKF_2319(murM) LLX: NCDO2118_2181(murM) LLM: llmg_2352(murM) LLC: LACR_2372 LLR: llh_12055 LLN: LLNZ_12160 LLI: uc509_2051(murM) LLW: kw2_2131(murM) LGR: LCGT_0589 LGV: LCGL_0608 LPK: LACPI_0939 LRN: CMV25_01205 LCAR: BHS00_06325 LPAA: BHS01_06840 LPET: lgb_00592(femX) LFO: LMK00_02910 SPY: SPy_0616(murM) SPy_1205 SPZ: M5005_Spy0511(murM) M5005_Spy0920 SPYM: M1GAS476_0565(murM) M1GAS476_0975 SPYA: A20_0553c(murM) A20_0956c(murM) SPM: spyM18_0683(femB) spyM18_1156 SPG: SpyM3_0435(murM.1) SpyM3_0846(murM.2) SPS: SPs1046 SPs1420 SPH: MGAS10270_Spy0505(murM) MGAS10270_Spy1034 SPI: MGAS10750_Spy0530(murM) MGAS10750_Spy1069 SPJ: MGAS2096_Spy0523(murM) MGAS2096_Spy0979 SPK: MGAS9429_Spy0501(murM) MGAS9429_Spy1022 SPF: SpyM50878(murM) SpyM51352(murM) SPA: M6_Spy0532 M6_Spy0909 SPB: M28_Spy0490(murM) M28_Spy0892 STG: MGAS15252_0537(murM) MGAS15252_0917 STX: MGAS1882_0534(murM) MGAS1882_0912 SOZ: Spy49_0518c(murM.1) Spy49_0951c(murM2) STZ: SPYALAB49_000543 SPYH: L897_02755 L897_04550 SPN: SP_0615(fibA) SPD: SPD_0535(murM_fibA) SPR: spr0540(murM) SPW: SPCG_0575(murM) SJJ: SPJ_0566 SNV: SPNINV200_05420(murM) SPX: SPG_0558 SNT: SPT_0640 SND: MYY_0664 SPNN: T308_02900 SNE: SPN23F05540(murM) SPV: SPH_0708 SNC: HMPREF0837_10904 SNM: SP70585_0676 SPP: SPP_0629 SNI: INV104_05130(murM) SPNG: HMPREF1038_00636 SNB: SP670_0673 SNP: SPAP_0601 SNX: SPNOXC05610(murM) SNU: SPNA45_01491(murM) SPNE: SPN034156_16110(murM) SPNU: SPN034183_05640(murM) SPNM: SPN994038_05520(murM) SPNO: SPN994039_05530(murM) SAG: SAG0509(fibA) SAG0510 SAN: gbs0555 gbs0556 SAK: SAK_0659 SAK_0660 SGC: A964_0540(murM) A964_0541(murM) SAGS: SaSA20_0494 SaSA20_0495 SAGL: GBS222_0486 SAGM: BSA_5970 BSA_5980 SAGI: MSA_6120 MSA_6130 SAGR: SAIL_6260 SAIL_6280 SAGP: V193_02835 SAGC: DN94_02835 SAGT: GBSCOH1_0492 GBSCOH1_0493 SAGE: EN72_02930 EN72_02935 SAGG: EN73_03005 EN73_03010 SAGN: W903_0686 W903_0687 SAGJ: ID870_06720 ID870_06725 SMU: SMU_717(murM) SMC: SmuNN2025_1280(murM) SMUT: SMUGS5_03160 SMJ: SMULJ23_1281(murM) SMUA: SMUFR_0625(murM) STC: str1155(murM) STL: stu1155(murM) STE: STER_1112 STN: STND_1074 STU: STH8232_1341(murM) STW: Y1U_C0774 STHE: T303_06625 STHS: AVT04_09070 SSA: SSA_0862(murM) SSK: SSUD12_0367 SSUI: T15_0381(murM) SGO: SGO_1623(murM) SEZ: Sez_1015(murM) Sez_1319(murM) SEQ: SZO_06490 SZO_09500 SEZO: SeseC_01341 SeseC_01704 SEQU: Q426_02530 Q426_04025 SEU: SEQ_1178 SEQ_1501 SUB: SUB0607(murM) SDS: SDEG_0637(murM) SDEG_0947 SDG: SDE12394_03425 SDE12394_05320 SDA: GGS_0612(murM) GGS_0917(murM) SDC: SDSE_0678(murM) SDSE_0983 SDQ: SDSE167_0691(murM) SDSE167_1051 SGA: GALLO_1508 SGG: SGGBAA2069_c15300(murM) SGT: SGGB_1503(murM) SMB: smi_1584(fibA) SOR: SOR_1963(murM) STK: STP_0096 STP_0414(murM) STB: SGPB_1404(murM) SCP: HMPREF0833_10855 SCF: Spaf_1436 SSR: SALIVB_1141(femX) STF: Ssal_01216(murM) STJ: SALIVA_0993(murM) STRS: SSAL8618_04945 SSAH: HSISS4_00840(murM) STD: SPPN_03240 SMN: SMA_1515 SIF: Sinf_1329 SIE: SCIM_0530(murM) SIB: SIR_1111(murM) SIU: SII_1132(murM) SANG: SAIN_0586(murM) SANC: SANR_0598(murM) SANS: DK43_07235 SCG: SCI_0623(murM) SCON: SCRE_0603(murM) SCOS: SCR2_0603(murM) SOI: I872_02755 SIK: K710_0130 K710_1338 SIQ: DQ08_00640 DQ08_06195 SIO: DW64_00640 DW64_06190 SIZ: SI82_00740 SI82_06345 SLU: KE3_1458 SIG: N596_04265 SIP: N597_06110 SPAT: A0O21_02760 STRA: ATM98_03930 SSOB: DK181_03430 SEQI: A6J79_07615 SKI: D7D50_06405 SPEI: EHW89_02750 SRAT: FY406_06920 SGW: D7D53_09215 SPLR: C0J00_06920 SVB: NCTC12167_01073(murM) SMEN: SAMEA4412692_0952(murM) SFER: NCTC12278_00174(murM) NCTC12278_01321(femX) SCAI: NCTC12191_01576(murM) NCTC12191_02000(femX) SPSU: NCTC13786_00865(murM_1) NCTC13786_00965(murM_2) NCTC13786_01918(murM_3) SCHJ: DDV21_008035 SPOC: NCTC10925_00256(femX) NCTC10925_00366(murM_1) NCTC10925_01239(murM_2) SLAT: J4854_07435 SAUP: NCTC3168_01369(murM) SURN: NCTC13766_01447(murM) SACO: SAME_01700(murM) SVF: NCTC3166_01379(murM) STOY: STYK_15260(murM) SRUM: GPZ88_01515 SACY: O6R09_06440 SMIE: NCTC11169_00546(murM) SRUN: LPB404_07195 SPAM: SP4011_16620(fibA) FPEN: KIW23_03760 KIW23_06815 LSN: LSA_00260 LROS: LROSL1_1092 OOE: OEOE_1444 OEN: DSM07_03035 OSI: DLJ48_01415 LME: LEUM_1773 LMM: MI1_07685 LMK: LMES_1540 LCI: LCK_01455 LKI: LKI_07255 LEC: LGMK_04890 LCN: C270_01475 LGS: LEGAS_0406 LGE: C269_01960 LLF: BCR17_05370 LGC: A9176_03910 LSU: A6B45_08485 LPSE: FGL85_03835 WKO: WKK_02350 WCE: WS08_1006 WTR: KHQ32_05625 WCT: WS74_1072 WCI: WS105_1068 WCB: AO080_04420 AO080_09985 WJO: FOL01_1588 WPA: CO680_00890 WCF: C6P13_02120 WSO: WSWS_00295 WSWS_01363(murM) WHE: EFA59_07215 WDI: H9L19_02390 WVR: IE337_01505 WCO: G7084_02380 WEI: EQG49_04135 EFA: EF2658 EFL: EF62_2819(murM) EFI: OG1RF_12030(fibA) EFD: EFD32_2218(murM) EFS: EFS1_2129 EFN: DENG_02594(murM) EFQ: DR75_1359 ESS: ATZ33_07540 MPS: MPTP_1602 MPX: MPD5_0449 VHY: G7082_03765 FSA: C5Q98_07305 EUU: ADJ67_01780 PBQ: C3V37_07730 APR: Apre_0286 AVG: I6H45_04225 AOB: I6H46_07520 EUC: EC1_13930 FRO: AALO17_10780 BULL: JOS54_03215 AMUO: KWG62_09260 ERB: A4V01_18985 CIU: G4D55_16050 GOC: CXX93_07025 AUM: AURMO_00310 LEU: Leucomu_05180 LEB: G7066_09835 LVI: G7068_03835 AGG: C1N71_10935 ART: Arth_0771 ARR: ARUE_c09440 ARM: ART_3681 ARE: AL755_04505 AAQ: AOC05_01375 ARW: MB46_00885 ARU: ASPU41_09360 ARQ: BWQ92_06145 ARN: CGK93_05130 ARTH: C3B78_03720 ARTP: E5206_18910 AAGI: NCTC2676_1_00491(femX_1) APOA: J0916_01120 AOD: Q8Z05_11825 ARTU: E7Y32_02315 ARTZ: FCN77_04335 ARI: UM93_16200 AAU: AAur_0993 PUE: FV140_05115 PSUL: AU252_06305 PSEY: GU243_20260 SATK: SA2016_1068 CCYC: SCMU_08430 SERJ: SGUI_1444 SERW: FY030_01845 ORN: DV701_14665 DV701_14675 AHE: Arch_0164 ARCA: HC352_00785 HC352_02060 HC352_02065 HC352_02070 APHO: JTE88_00775 TPY: CQ11_04900 TPYO: X956_02825 TBW: NCTC13354_00579(femX) TBER: QPC17_01840 BAST: BAST_1252 GVG: HMPREF0421_20446 GVH: HMPREF9231_1109 RRS: RoseRS_3975 RCA: Rcas_1415 HAU: Haur_0083 SBE: RAAC3_TM7C01G0351 MMA: MM_2112 MMAZ: MmTuc01_2165 MEQ: MSWHS_0743 MSW: MSSIT_3014 MHOR: MSHOH_0633 MSHOH_3235 AG: AAG21689(femX) REFERENCE PMID:10759563 AUTHORS Filipe SR, Tomasz A TITLE Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes. JOURNAL Proc Natl Acad Sci U S A 97:4891-6 (2000) DOI:10.1073/pnas.080067697 SEQUENCE [spr:spr0540] ///