ENTRY K01317 KO SYMBOL ACR NAME acrosin [EC:3.4.21.10] DISEASE H01282 Spermatogenic failure BRITE KEGG Orthology (KO) [BR:ko00001] 09180 Brite Hierarchies 09181 Protein families: metabolism 01002 Peptidases and inhibitors K01317 ACR; acrosin 09182 Protein families: genetic information processing 04131 Membrane trafficking K01317 ACR; acrosin Enzymes [BR:ko01000] 3. Hydrolases 3.4 Acting on peptide bonds (peptidases) 3.4.21 Serine endopeptidases 3.4.21.10 acrosin K01317 ACR; acrosin Peptidases and inhibitors [BR:ko01002] Serine peptidases Family S1: chymotrypsin family K01317 ACR; acrosin Membrane trafficking [BR:ko04131] Exocytosis Calcium ion-dependent exocytosis Acrosomal exocytosis proteins K01317 ACR; acrosin GENES HSA: 49(ACR) PTR: 458950(ACR) PPS: 100979160(ACR) GGO: 101144239(ACR) PON: 100448292(ACR) PPYG: 129023123(ACR) NLE: 100586140(ACR) HMH: 116458999(ACR) SSYN: 129467815(ACR) MCC: 716579(ACR) MCF: 102115325(ACR) MTHB: 126964017 MNI: 105489733(ACR) CSAB: 103223579 103223651(ACR) PANU: 101010633 116270711 TGE: 112633283(ACR) MLEU: 105543589(ACR) RRO: 104655563(ACR) RBB: 108545017(ACR) TFN: 117096242(ACR) PTEH: 111549166(ACR) CANG: 105512002(ACR) CJC: 100406660(ACR) SBQ: 101047167(ACR) CIMI: 108286851(ACR) ANAN: 105706695(ACR) CSYR: 103271503(ACR) MMUR: 105884990(ACR) LCAT: 123640348(ACR) PCOQ: 105813926(ACR) OGA: 100963151(ACR) MMU: 11434(Acr) MCAL: 110310440(Acr) MPAH: 110334980(Acr) RNO: 24163(Acr) MCOC: 116078085(Acr) ANU: 117718981(Acr) MUN: 110566471(Acr) CGE: 100754856(Acr) MAUA: 101839533(Acr) PROB: 127225965(Acr) PLEU: 114693039(Acr) MORG: 121461410(Acr) AAMP: 119823273(Acr) NGI: 103735496(Acr) HGL: 101712354(Acr) CPOC: 100717414(Acr) CCAN: 109693070(Acr) DORD: 105992722(Acr) NCAR: 124982996 MMMA: 107160221(Acr) OCU: 100009184(ACR) OPI: 101522965(ACR) TUP: 102477933(ACR) GVR: 103591321(ACR) CFA: 606765(ACR) CLUD: 112665305(ACR) VVP: 112935879(ACR) VLG: 121492162(ACR) NPO: 129512087(ACR) AML: 100482745(ACR) UMR: 103674103(ACR) UAH: 113241583(ACR) UAR: 123803812(ACR) ELK: 111157685 MPUF: 101682369(ACR) MNP: 132020422(ACR) MLK: 131839677(ACR) NVS: 122891694(ACR) ORO: 101363888 101379789(ACR) EJU: 114203158 114203159 114203316 114218308(ACR) ZCA: 113909159 113909160 113922803 113933199 113933897 118355967 MLX: 117997712(ACR) NSU: 110578315(ACR) LWW: 102727815(ACR) FCA: 101083949(ACR) PYU: 121040095(ACR) PCOO: 112863376(ACR) PBG: 122473012(ACR) PVIV: 125170322(ACR) LRUF: 124502535 PTG: 102954045(ACR) PPAD: 109265792(ACR) PUC: 125919756 AJU: 106987633 HHV: 120233554(ACR) BTA: 280711(ACR) BOM: 102270129(ACR) BBUB: 102391015(ACR) BBIS: 104980012(ACR) CHX: 102191416(ACR) OAS: 443195(ACR) BTAX: 128049003(ACR) CSUM: 138079329(ACR) ODA: 120857786(ACR) CCAD: 122423039(ACR) MREE: 136160680(ACR) MBEZ: 129537237(ACR) SSC: 397098(ACR) CFR: 102504353(ACR) CBAI: 105070825(ACR) CDK: 105106149(ACR) VPC: 102543078(ACR) BACU: 103017313(ACR) BMUS: 118902739(ACR) LVE: 103072664(ACR) OOR: 101282422(ACR) DLE: 111186384(ACR) PCAD: 102982720(ACR) PSIU: 116760485(ACR) NASI: 112394593(ACR) ECB: 100057028(ACR) EPZ: 103543987(ACR) EAI: 106846026(ACR) MYB: 102256900(ACR) MYD: 102774021(ACR) MMYO: 118657372(ACR) MLF: 102426257(ACR) MDT: 132225977(ACR) PKL: 118714759(ACR) EFUS: 103298716(ACR) MNA: 107536030(ACR) DRO: 112321661(ACR) SHON: 118989694(ACR) 119003110 AJM: 119060332(ACR) PDIC: 114496816 114513967(ACR) PHAS: 123816028(ACR) 123831647 MMF: 118641119(ACR) PPAM: 129068320(ACR) HAI: 109396613(ACR) RFQ: 117028267(ACR) PALE: 102886339(ACR) PGIG: 120602806(ACR) PVP: 105308288(ACR) RAY: 107500248(ACR) TOD: 119248216(ACR) SARA: 101548761(ACR) SETR: 126006164(ACR) LAV: 100674496(ACR) TMU: 101350147 ETF: 101649792(ACR) DNM: 101443016(ACR) MDO: 103093639 GAS: 123250441(ACR) SHR: 100916052 100932714(ACR) AFZ: 127538776 127564743 127564929 PCW: 110201632 110202102 110205953 110213369 TVP: 118849515 118851405 118851917 PBRV: 138172437 138172984 138172997 GGA: 426864(ACR) 769176(ACRL) PCOC: 116238651 116238654 MGP: 100539639 692129(ACR) CJO: 107306626 107318185 107319775(ACR) TPAI: 128091957 128091964 LMUT: 125684144 125684147 NMEL: 110392172(ACR) 110392173 APLA: 101793578 101795648 CATA: 118259617 118259630 AFUL: 116485356 116502165 TGU: 100221796 100222616 100224801 100226600 100229676 100230182 100230310 105759945 115492572 115492576 115492597 115494525 116806618 116808091 LSR: 110471229 110473210 110479258 110479484 110480942 110482998 110483008 110483013 110483020 116184413 SCAN: 103819459 103821213 103821538 103821544 103821545 103821704 103822492 103826285 115484943 115484944 115484945 115485249 115485250 PMOA: 120496586 120498862 120498864 120498865 120498866 120500129 120502776 120509454 120512090 OTC: 121334138 121334139 121334140 121334141 121334143 121334176 121334177 121334178 121334180 121337836 121338543 121339675 121339796 121347555 121347803 121347903 PRUF: 121351071 121355021 121355048 121355049 121355079 121356475 121356480 121358543 121358661 121358663 121358665 121358666 121362311 121363619 121365244 GFR: 102032254 102032420 102034420 102034591 102034751 102034910 102036222 102039449 102040074 102040400 102042777 FAB: 101805845 101806079 101806420 101807419 101810525(ACR) 101810913 101813807 101815502 101821184 101821498 101822159 OMA: 130248527 130248529 130248530 130248713 130250517 130250519 130250522 130250523 130250524 130250525 130252239 130262551 130263069 130264157 130265236 130265655 PHI: 102099449 102100182 102100356 102100726 102100912 102101252 102103033 102104135 102104469 102106778 102109508 102109747 102110299 102110481 102112356 106628778 PMAJ: 107198756 107199113 107201238 107201239 107203286 107204160 107204248 107215191 107215761 107215800 CCAE: 111923201 111926213 111926214 111926220 111926221 111926222 111926224 111928838 111940106 111940691 111941730 111942340 111944320 111945825 CCW: 104685158 104685740 104689773 104697239 104697783 120411926 CBRC: 103612817 103612821 103612825 103614592 103616380 103617098 103622407 103624576 ETL: 114056934 114056935 114057344 114060836(ACR) 114069705 114070062 114070831 114072025 114072026 ZAB: 102063828 102064750 102066368 102070519 102071220 102071394 102071579 102072285 102073834 113460530 ZLE: 135441487 135442849 135442874 135442879 135444992 135444993 135444994 135444995 135444996 135444997 135445151 135445153 135447398 135458291 135458550 135458666 135458674 135459805 135459828 ACHL: 103801502 103801658 103801918 103803315 103805198 103808654 SVG: 106853546 106855615 106855676 106859658 106861997 106862003 106862021 106862952 106862953 106864001 MMEA: 130577607 130579218 130579476 130579838 130581446 130585769 130585773 130585810 130586619 130587811 HRT: 120748066 120749750 120749752 120749754 120749758 120749760 120749761 120749762 120751486 120752061 120753126 120763828 120765488 120765605 SATI: 136358482 136358483 136358559 136358560 136358561 136358562 136358563 136358565 136358566 136358567 136361207 136361555 136361557 136361619 136362000 136362001 136372112 136373638 136374294 FPG: 101920858 FCH: 102053562 102058125 NNT: 104406223 104408143 SHAB: 115601755(ACR) ACUN: 113479662 113487369 113487370 113489756 113490271 113490487 113490852 113490873 113490890 113490949 TALA: 116959616 116959617 116964185 122153390 122153391 122153392 122153397 122153398 122153399 122153400 122153401 122153403 122153404 122153405 122153406 122153421 122153464 122154133 122154134 122154135 122154136 ACHC: 115341357 115341358 115342214(ACR) HALD: 104322403(ACR) HLE: 104833452(ACR) AGEN: 126044256 126044257 LDI: 104348808 104349430 DPUB: 104300448 104300680 104306213 PPUS: 135174780(ACR) 135176416 135176417 135179785 135179786 135179787 135191808 EGZ: 104122507 NNI: 104019823 PCRI: 104031627 104035799 PCAO: 104050265 PADL: 103924103(ACR) AFOR: 103893174 103895289(ACR) FGA: 104077990 CLV: 102087611 102095569(ACR) 106145737 MUI: 104545267 PGUU: 104460770 PLET: 104627099 CMAC: 104475581 104478175 104482174 CUCA: 104061494 128849706 128850158 128850744 128850856 128852481 128852499 128852510 128852640 128852655 128852671 128852675 128852683 128853739 128853790 ACAR: 104523418 104527929 CPEA: 104388655 104389105 104389332 104391094(ACR) RTD: 128900496 128902883 128904288 128910479 AAM: 106496144 AROW: 112968660 112968683 NPD: 112953970 112953971 DNE: 112989979 112989984 SCAM: 104145754 ASN: 102370826 102371080 102384412 AMJ: 102561178 102574978 106737926 GGN: 109292091(ACR) PSS: 102455380 102455626 106731832 CMY: 102938344(ACR) CCAY: 125625502 125637426 DCC: 119861292 119861356 CPIC: 101943992 TST: 117873481 117873487 CABI: 116838331 116838335 MRV: 120393791 120396067 ACS: 100558380 107983695 ASAO: 132775562 132775563 132775564 132775565 PVT: 110070564 110070565 110070568 110070571 110084405 110084406 110084408(ACR) 110084420 SUND: 121930811 121930815 121932298 121932299(ACR) 121932300 PBI: 103055962 103067049 107326529 112542530 112542531 PMUR: 107297332 114923114 114923390 114923503 CTIG: 120303703 120320074 TSR: 106547407 PGUT: 117672950 117672959 117672961 117672962 117676845 APRI: 131202625 131202626 PTEX: 113451581 113451582 113451583 NSS: 113427774 113427776 113429754 VKO: 123023716(ACR) PMUA: 114604849 114604850 114604851 114604852 114604853 114604859 114606012 PRAF: 128421954 128421972 128421986 128421988 128421990 ZVI: 118091564 118091572 118091573 118091575 HCG: 128328408 GJA: 107118562(ACR) 107120174 STOW: 125434607 125434608 EMC: 129335733 129335736 129335737 XLA: 108695414 108695553(acr.2.L) 108707440 108707950 108713848 108714853 108719368 108719374 734611(XB5892359.L) XTR: 100487305 100487784 100490933 100497024 100497408 100497443 101731233 101732810 101733280 108645680 108645681(acr.2) 108647852 116408674 116408790 116411577 116411715 116412122 733551 NPR: 108802724 RTEM: 120916063 120920625 120930362 BBUF: 120986103 120986112 120986123 BGAR: 122925776 122925777 MUO: 115479025 115479026 GSH: 117366883 117367084 PSPA: 121299590 121300198 121318214 ARUT: 117419697 117426277 117965962 LCM: 102354559 CMK: 103182529 103190823 CPLA: 122561507 122564217 HOC: 132826581 LERI: 129710807 PMAC: 106721108 NLU: 111057367 TCF: 131882068 ABRU: 129971942 HRF: 124145417 OED: 125672436 LJP: 135473810 EHX: EMIHUDRAFT_124077 REFERENCE PMID:22729485 AUTHORS Ferrer M, Rodriguez H, Zara L, Yu Y, Xu W, Oko R TITLE MMP2 and acrosin are major proteinases associated with the inner acrosomal membrane and may cooperate in sperm penetration of the zona pellucida during fertilization. JOURNAL Cell Tissue Res 349:881-95 (2012) DOI:10.1007/s00441-012-1429-1 REFERENCE PMID:2493394 AUTHORS Baba T, Watanabe K, Kashiwabara S, Arai Y TITLE Primary structure of human proacrosin deduced from its cDNA sequence. JOURNAL FEBS Lett 244:296-300 (1989) DOI:10.1016/0014-5793(89)80549-6 SEQUENCE [hsa:49] ///