ENTRY K01317 KO SYMBOL ACR NAME acrosin [EC:3.4.21.10] DISEASE H01282 Spermatogenic failure BRITE KEGG Orthology (KO) [BR:ko00001] 09180 Brite Hierarchies 09181 Protein families: metabolism 01002 Peptidases and inhibitors K01317 ACR; acrosin 09182 Protein families: genetic information processing 04131 Membrane trafficking K01317 ACR; acrosin Enzymes [BR:ko01000] 3. Hydrolases 3.4 Acting on peptide bonds (peptidases) 3.4.21 Serine endopeptidases 3.4.21.10 acrosin K01317 ACR; acrosin Peptidases and inhibitors [BR:ko01002] Serine peptidases Family S1: chymotrypsin family K01317 ACR; acrosin Membrane trafficking [BR:ko04131] Exocytosis Calcium ion-dependent exocytosis Acrosomal exocytosis proteins K01317 ACR; acrosin GENES HSA: 49(ACR) PTR: 458950(ACR) PPS: 100979160(ACR) GGO: 101144239(ACR) PON: 100448292(ACR) PPYG: 129023123(ACR) NLE: 100586140(ACR) HMH: 116458999(ACR) SSYN: 129467815(ACR) MCC: 716579(ACR) MCF: 102115325(ACR) MTHB: 126964017 MNI: 105489733(ACR) CSAB: 103223579 103223651(ACR) PANU: 101010633 116270711 TGE: 112633283(ACR) MLEU: 105543589(ACR) RRO: 104655563(ACR) RBB: 108545017(ACR) TFN: 117096242(ACR) PTEH: 111549166(ACR) CANG: 105512002(ACR) CJC: 100406660(ACR) SBQ: 101047167(ACR) CIMI: 108286851(ACR) ANAN: 105706695(ACR) CSYR: 103271503(ACR) MMUR: 105884990(ACR) LCAT: 123640348(ACR) PCOQ: 105813926(ACR) OGA: 100963151(ACR) MMU: 11434(Acr) MCAL: 110310440(Acr) MPAH: 110334980(Acr) RNO: 24163(Acr) MCOC: 116078085(Acr) ANU: 117718981(Acr) ASYL: 127667705(Acr) MMIU: 308437770(ACR) MUN: 110566471(Acr) CGE: 100754856(Acr) MAUA: 101839533(Acr) PROB: 127225965(Acr) PLEU: 114693039(Acr) PMAV: 102925156(Acr) MORG: 121461410(Acr) AAMP: 119823273(Acr) CNL: 130888961(Acr) NGI: 103735496(Acr) HGL: 101712354(Acr) CPOC: 100717414(Acr) CCAN: 109693070(Acr) DORD: 105992722(Acr) DMER: 138811929(Acr) NCAR: 124982996 SVUL: 306661930(ACR) MMMA: 107160221(Acr) ITI: 101961747(Acr) OCU: 100009184(ACR) OPI: 101522965(ACR) OCZ: 121164017(ACR) TUP: 102477933(ACR) GVR: 103591321(ACR) CFA: 606765(ACR) CLUD: 112665305(ACR) VVP: 112935879(ACR) VLG: 121492162(ACR) NPO: 129512087(ACR) AML: 100482745(ACR) UMR: 103674103(ACR) UAH: 113241583(ACR) UAR: 123803812(ACR) ELK: 111157685 MPUF: 101682369(ACR) MNP: 132020422(ACR) MLK: 131839677(ACR) NVS: 122891694(ACR) MMAQ: 308347977(ACR) ORO: 101363888 101379789(ACR) EJU: 114203158 114203159 114203316 114218308(ACR) ZCA: 113909159 113909160 113922803 113933199 113933897 118355967 MLX: 117997712(ACR) MANO: 123837557(ACR) NSU: 110578315(ACR) LWW: 102727815(ACR) FCA: 101083949(ACR) PYU: 121040095(ACR) PCOO: 112863376(ACR) PBG: 122473012(ACR) PVIV: 125170322(ACR) LRUF: 124502535 LGF: 123590898(ACR) AJU: 106987633 PTG: 102954045(ACR) PPAD: 109265792(ACR) PUC: 125919756 PLEZ: 122225308(ACR) HHV: 120233554(ACR) CCRU: 144226478(ACR) BTA: 280711(ACR) BOM: 102270129(ACR) BJV: 133248604(ACR) BBUB: 102391015(ACR) BKE: 129641264(ACR) BBIS: 104980012(ACR) CHX: 102191416(ACR) OAS: 443195(ACR) OCAN: 138436213(ACR) BTAX: 128049003(ACR) CSUM: 138079329(ACR) ODA: 120857786(ACR) CCAD: 122423039(ACR) MREE: 136160680(ACR) OVR: 110125051(ACR) MBEZ: 129537237(ACR) SSC: 397098(ACR) CFR: 102504353(ACR) CBAI: 105070825(ACR) CDK: 105106149(ACR) VPC: 102543078(ACR) BACU: 103017313(ACR) BMUS: 118902739(ACR) LVE: 103072664(ACR) OOR: 101282422(ACR) LALB: 132529224(ACR) GMF: 115852559(ACR) DDP: 132434361(ACR) SCOO: 307193918(ACR) PCRS: 137202963(ACR) DLE: 111186384(ACR) PCAD: 102982720(ACR) PSIU: 116760485(ACR) PPHC: 136130748(ACR) NASI: 112394593(ACR) HAMP: 307060404(ACR) ECB: 100057028(ACR) EPZ: 103543987(ACR) EAI: 106846026(ACR) MYB: 102256900(ACR) MYD: 102774021(ACR) MMYO: 118657372(ACR) MLF: 102426257(ACR) MDT: 132225977(ACR) MYUM: 139006552(ACR) PKL: 118714759(ACR) EFUS: 103298716(ACR) MNA: 107536030(ACR) DRO: 112321661(ACR) SHON: 118989694(ACR) 119003110 AJM: 119060332(ACR) PDIC: 114496816 114513967(ACR) PHAS: 123816028(ACR) 123831647 MMF: 118641119(ACR) PPAM: 129068320(ACR) HAI: 109396613(ACR) RFQ: 117028267(ACR) PALE: 102886339(ACR) PGIG: 120602806(ACR) PVP: 105308288(ACR) RAY: 107500248(ACR) TOD: 119248216(ACR) SARA: 101548761(ACR) SFUM: 130016409(ACR) SETR: 126006164(ACR) LAV: 100674496(ACR) TMU: 101350147 ETF: 101649792(ACR) DNM: 101443016(ACR) MDO: 103093639 GAS: 123250441(ACR) SHR: 100916052 100932714(ACR) AFZ: 127538776 127564743 127564929 PCW: 110201632 110202102 110205953 110213369 TVP: 118849515 118851405 118851917 PBRV: 138172437 138172984 138172997 GGA: 426864(ACR) 769176(ACRL) PCOC: 116238651 116238654 MGP: 100539639 692129(ACR) CJO: 107306626 107318185 107319775(ACR) TPAI: 128091957 128091964 LMUT: 125684144 125684147 NMEL: 110392172(ACR) 110392173 APLA: 101793578 101795648 BCLA: 308442227(LOC308442227) ABRC: 308196859(LOC308196859) CATA: 118259617 118259630 AFUL: 116485356 116502165 TGU: 100221796 100222616 100224801 100226600 100229676 100230182 100230310 105759945 115492572 115492576 115492597 115494525 116806618 116808091 LSR: 110471229 110473210 110479258 110479484 110480942 110482998 110483008 110483013 110483020 116184413 VMC: 128804836 128804837 128805267 128806265 128808157 128808159 128821826 128821936 VCHA: 128781771 128781890 128786153 128786155 128786277 128786886 128788097 AIB: 137467633 137471358 137471359 137471360 137471362 137474927 SCAN: 103819459 103821213 103821538 103821544 103821545 103821704 103822492 103826285 115484943 115484944 115484945 115485249 115485250 PMOA: 120496586 120498862 120498864 120498865 120498866 120500129 120502776 120509454 120512090 OTC: 121334138 121334139 121334140 121334141 121334143 121334176 121334177 121334178 121334180 121337836 121338543 121339675 121339796 121347555 121347803 121347903 PRUF: 121351071 121355021 121355048 121355049 121355079 121356475 121356480 121358543 121358661 121358663 121358665 121358666 121362311 121363619 121365244 ATRC: 139585640 139585644 139587622 139587663 139587664 139588633 139589413 139589418 139589438 139589475 139592089 139600308 139600316 139600319 139600326 139600336 139601538 MATE: 118699567 118700197 118700198 118700203 MAEN: 136568467 136568468 136569208 136569361 GFR: 102032254 102032420 102034420 102034591 102034751 102034910 102036222 102039449 102040074 102040400 102042777 FAB: 101805845 101806079 101806420 101807419 101810525(ACR) 101810913 101813807 101815502 101821184 101821498 101822159 OMA: 130248527 130248529 130248530 130248713 130250517 130250519 130250522 130250523 130250524 130250525 130252239 130262551 130263069 130264157 130265236 130265655 PHI: 102099449 102100182 102100356 102100726 102100912 102101252 102103033 102104135 102104469 102106778 102109508 102109747 102110299 102110481 102112356 106628778 PMAJ: 107198756 107199113 107201238 107201239 107203286 107204160 107204248 107215191 107215761 107215800 CCAE: 111923201 111926213 111926214 111926220 111926221 111926222 111926224 111928838 111940106 111940691 111941730 111942340 111944320 111945825 CCW: 104685158 104685740 104689773 104697239 104697783 120411926 CBRC: 103612817 103612821 103612825 103614592 103616380 103617098 103622407 103624576 ACOE: 138099179 138100218 138103526 138104447 138104451 138104509 138104510 138107181 138107182 138107184 138107185 138107186 138107805 138107807 138107809 138109456 138120518 ETL: 114056934 114056935 114057344 114060836(ACR) 114069705 114070062 114070831 114072025 114072026 ZAB: 102063828 102064750 102066368 102070519 102071220 102071394 102071579 102072285 102073834 113460530 ZLE: 135441487 135442849 135442874 135442879 135444992 135444993 135444994 135444995 135444996 135444997 135445151 135445153 135447398 135458291 135458550 135458666 135458674 135459805 135459828 ACHL: 103801502 103801658 103801918 103803315 103805198 103808654 SVG: 106853546 106855615 106855676 106859658 106861997 106862003 106862021 106862952 106862953 106864001 MMEA: 130577607 130579218 130579476 130579838 130581446 130585769 130585773 130585810 130586619 130587811 HRT: 120748066 120749750 120749752 120749754 120749758 120749760 120749761 120749762 120751486 120752061 120753126 120763828 120765488 120765605 SATI: 136358482 136358483 136358559 136358560 136358561 136358562 136358563 136358565 136358566 136358567 136361207 136361555 136361557 136361619 136362000 136362001 136372112 136373638 136374294 CCIC: 134041964 134041965 134041966 134041967 134041968 134042180 134042182 134043306 134043308 134043311 134043314 134043317 134043318 134043733 134043808 134043809 134043810 134043811 134043812 134043814 134043815 134043816 134043817 134043818 134043819 134043820 134043821 134043822 134043823 134043824 134043825 134043826 134043828 134043829 134043830 134043831 134043832 134043833 134043841 134044437 134053479 134055497 134056771 134056985 NNT: 104406223 104408143 SHAB: 115601755(ACR) FPG: 101920858 FCH: 102053562 102058125 ACUN: 113479662 113487369 113487370 113489756 113490271 113490487 113490852 113490873 113490890 113490949 TALA: 116959616 116959617 116964185 122153390 122153391 122153392 122153397 122153398 122153399 122153400 122153401 122153403 122153404 122153405 122153406 122153421 122153464 122154133 122154134 122154135 122154136 ACHC: 115341357 115341358 115342214(ACR) HALD: 104322403(ACR) HLE: 104833452(ACR) AGEN: 126044256 126044257 HHAR: 128142596 128142597 128142603 BBUT: 142029649 142030500 142030501 LDI: 104348808 104349430 DPUB: 104300448 104300680 104306213 PPUS: 135174780(ACR) 135176416 135176417 135179785 135179786 135179787 135191808 EGZ: 104122507 NNI: 104019823 PCRI: 104031627 104035799 PCAO: 104050265 PARX: 142048606 142048619 142048671 142048672 142048674 142050271 PADL: 103924103(ACR) AFOR: 103893174 103895289(ACR) FGA: 104077990 CBOR: 142078273 142078355 142078405 142078430 CBOY: 140643558 140643574 140649100 140649205 140649210 140651919 MAME: 142411516 142411572 142411620(ACR) 142420345 CLV: 102087611 102095569(ACR) 106145737 CNIC: 135995929 135999470 135999615 MUI: 104545267 PGUU: 104460770 PLET: 104627099 CMAC: 104475581 104478175 104482174 CUCA: 104061494 128849706 128850158 128850744 128850856 128852481 128852499 128852510 128852640 128852655 128852671 128852675 128852683 128853739 128853790 ACAR: 104523418 104527929 CPEA: 104388655 104389105 104389332 104391094(ACR) RTD: 128900496 128902883 128904288 128910479 CRID: 134510472(ACR) 134511374 134512303 134512370 LMIC: 141737652 141737653 141738019 141738021 AAM: 106496144 AROW: 112968660 112968683 NPD: 112953970 112953971 DNE: 112989979 112989984 SCAM: 104145754 ASN: 102370826 102371080 102384412 AMJ: 102561178 102574978 106737926 GGN: 109292091(ACR) CIZ: 142007570(ACR) CMY: 102938344(ACR) CCAY: 125625502 125637426 LKP: 140911307(ACR) NDS: 141993430(ACR) DCC: 119861292 119861356 CPIC: 101943992(ACR) TST: 117873481 117873487 CABI: 116838331 116838335 MRV: 120393791 120396067 EMQ: 137148852 ACS: 100558380 107983695 ASAO: 132775562 132775563 132775564 132775565 PVT: 110070564 110070565 110070568 110070571 110084405 110084406 110084408(ACR) 110084420 SUND: 121930811 121930815 121932298 121932299(ACR) 121932300 PBI: 103055962 103067049 107326529 112542530 112542531 PMUR: 107297332 114923114 114923390 114923503 CTIG: 120303702 120303703 120303704 TSR: 106547407 PGUT: 117672950 117672959 117672961 117672962 117672963 PCAE: 139319678 139319953 APRI: 131202624 131202625 131202626 PTEX: 113451581 113451582 113451583 NSS: 113427774 113427776 113427777 113429754 VKO: 123023716(ACR) PMUA: 114604849 114604850 114604851 114604852 114604853 114604859 114606012 PRAF: 128421972 128421986 128421988 128421990 ZVI: 118091564 118091572 118091573 118091575 HCG: 128328408 GJA: 107118562(ACR) 107120174 STOW: 125434607 125434608 EMC: 129335733 129335736 129335737 XLA: 108695414 108695553(acr.2.L) 108707440 108707950 108713848 108714853 108719368 108719374 108719674 734611(XB5892359.L) XTR: 100487305 100487784 100490933 100497024 100497408 100497443 101731233 101732810 101733280 108645680 108645681(acr.2) 108647852 116408674 116408790 116411577 116411715 116412122 733551 NPR: 108802724 RTEM: 120916063 120920625 120930362 ACAT: 141133926 PADS: 140321281 140322520 140342286 BBUF: 120986103 120986112 120986123 BGAR: 122925776 122925777 DTC: 141063509 141095089 141095091 141095093 141100521 141100522 PWL: 138288580 MUO: 115479025(ACR) 115479026 GSH: 117366883 117367084 PSPA: 121299590 121300198 121318214 ARUT: 117419697 117426277 117965962 LCM: 102354559 CMK: 103182529 103190823 CPLA: 122561507 122564217 HOC: 132826581 SCAU: 119973800 119975214 LERI: 129710807 ABRU: 129971942 BARL: 143292067 LJP: 135473810 CCLM: 134198479 REFERENCE PMID:22729485 AUTHORS Ferrer M, Rodriguez H, Zara L, Yu Y, Xu W, Oko R TITLE MMP2 and acrosin are major proteinases associated with the inner acrosomal membrane and may cooperate in sperm penetration of the zona pellucida during fertilization. JOURNAL Cell Tissue Res 349:881-95 (2012) DOI:10.1007/s00441-012-1429-1 REFERENCE PMID:2493394 AUTHORS Baba T, Watanabe K, Kashiwabara S, Arai Y TITLE Primary structure of human proacrosin deduced from its cDNA sequence. JOURNAL FEBS Lett 244:296-300 (1989) DOI:10.1016/0014-5793(89)80549-6 SEQUENCE [hsa:49] ///