ENTRY K00399 KO SYMBOL mcrA NAME methyl-coenzyme M reductase alpha subunit [EC:2.8.4.1] PATHWAY map00680 Methane metabolism map01100 Metabolic pathways map01120 Microbial metabolism in diverse environments map01200 Carbon metabolism MODULE M00356 Methanogenesis, methanol => methane M00357 Methanogenesis, acetate => methane M00563 Methanogenesis, methylamine/dimethylamine/trimethylamine => methane M00567 Methanogenesis, CO2 => methane REACTION R04541 2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase BRITE KEGG Orthology (KO) [BR:ko00001] 09100 Metabolism 09102 Energy metabolism 00680 Methane metabolism K00399 mcrA; methyl-coenzyme M reductase alpha subunit Enzymes [BR:ko01000] 2. Transferases 2.8 Transferring sulfur-containing groups 2.8.4 Transferring alkylthio groups 2.8.4.1 coenzyme-B sulfoethylthiotransferase K00399 mcrA; methyl-coenzyme M reductase alpha subunit DBLINKS GO: 0050524 GENES MJA: MJ_0083 MJ_0846 MFE: Mefer_0938 MVU: Metvu_0149 Metvu_1194 MFS: MFS40622_0424 MFS40622_1315 MIF: Metin_0281 MJH: JH146_0503 JH146_1056 MESG: MLAUSG7_0353(mcrA) MESA: MLASG1_1532(mcrA) MIG: Metig_0445 Metig_1237 MMP: MMP1559(mcrA) MMQ: MmarC5_0017 MMX: MmarC6_1111 MMZ: MmarC7_0806 MMD: GYY_08645 MMAK: MMKA1_17890(mcrA) MMAO: MMOS7_16710(mcrA) MMAD: MMJJ_12770(mcrA) MAE: Maeo_1268 MVN: Mevan_0872 MVO: Mvol_1128 MOK: Metok_0956 METF: CFE53_01190(mcrA) MTH: MTH_1129 MTH_1164 MMG: MTBMA_c15120(mrtA) MTBMA_c15480(mcrA) MWO: MWSIV6_1521(mrtA) MWSIV6_1556(mcrA) MTEE: MTTB_02580(mcrA) METC: MTCT_1022 MTCT_1058 METE: tca_01085 tca_01121 METZ: METMT2_1172 METK: FVF72_05765(mcrA) FVF72_05940(mcrA) MTHM: FZP57_07280(mcrA) FZP57_07455(mcrA) METJ: FZP68_03220(mcrA) FZP68_03395(mcrA) MST: Msp_0321(mrtA) METB: AW729_05480 MEIS: PXD04_05405(mcrA) MRU: mru_1924(mcrA) MSI: Msm_0902 Msm_1015 MEB: Abm4_1526(mcrA) MMIL: sm9_1353(mrtA) sm9_2027(mcrA) MEYE: TL18_09320 MOL: YLM1_1111 YLM1_1379 MARO: MarbSA_15420 METV: K4897_06390(mcrA) MEL: Metbo_0353 Metbo_2281 MEW: MSWAN_2056 METH: MBMB1_1682(mcrA) MBMB1_1825(mrtA) MFC: BRM9_0935(mcrA) BRM9_2156(mrtA) MFI: DSM1535_0905(mcrA) DSM1535_1095(mrtA) MCUB: MCBB_1985(mcrA) MSUB: BK009_07405 BK009_08295 METN: BK008_03060 BK008_03970 METT: CIT01_01115(mcrA) CIT01_03630(mcrA) METO: CIT02_08450(mcrA) CIT02_09480(mcrA) MEME: HYG87_00780(mcrA) HYG87_04985(mcrA) MFEG: GCM10025860_02820 GCM10025860_04460 MEER: NKF70_05230(mcrA) NKF70_08695(mcrA) MFV: Mfer_0734 Mfer_0784 MKA: MK0655(mcrA) MBA: Mbar_A0893 MBY: MSBRM_0101 MBW: MSBRW_0105 MBAR: MSBR2_2279 MBAK: MSBR3_2340 MAC: MA_4546 MMA: MM_1240 MMAZ: MmTuc01_1281 MMJ: MSMAS_0073 MMAC: MSMAC_0072 MVC: MSVAZ_3413 MEK: MSKOL_3374 MLS: MSLAZ_0156 METM: MSMTP_0100 MEF: MSWH1_0089 MEQ: MSWHS_0092 MSJ: MSSAC_4255 MSZ: MSSIH_3759 MSW: MSSIT_3838 MTHR: MSTHT_1644 MTHE: MSTHC_1645 MHOR: MSHOH_0084 MFZ: AOB57_007335(mcrA) MBU: Mbur_2417(mcrA) MMET: MCMEM_0559 MELO: J7W08_00830(mcrA) MMH: Mmah_0612 MHAZ: BHR79_00310 MPOT: BKM01_08085 MEV: Metev_0902 MZH: Mzhil_0857 MPY: Mpsy_0828 MZI: HWN40_04520(mcrA) MMAV: RE476_05650(mcrA) MSEB: RE474_02905(mcrA) MHZ: Metho_1670 MEHF: MmiHf6_13350 MEES: MmiEs2_15770 MTP: Mthe_0569 MCJ: MCON_0759(mcrA) MHI: Mhar_0498 MHU: Mhun_2148 MRTJ: KHC33_15130(mcrA) MLA: Mlab_1068 Mlab_1561 MEM: Memar_0378 Memar_0613 MBG: BN140_1521(mcrA1) BN140_1738(mcrA3) MEMA: MMAB1_1952(mcrA) MMAB1_2235(mcrA) MCHK: MchiMG62_05030 MchiMG62_07420 MSUM: OH143_08590(mcrA) OH143_09785(mcrA) MRC: R6Y96_02650(mcrA) R6Y96_02995(mcrA) MPI: Mpet_1991 Mpet_2415 MEND: L6E24_09505(mcrA) MEFW: F1737_00900(mcrA) MAQE: RJ40_03780(mcrA) RJ40_06095(mcrA) MFK: E2N92_03845(mcrA) E2N92_06225(mcrA) MOU: OU421_03070(mcrA) OU421_03510(mcrA) MESB: L1S32_07110(mcrA) MANQ: L1994_01320(mcrA) MBN: Mboo_0582 MFO: Metfor_0874 Metfor_2609 MESK: METHP_00388 MPL: Mpal_2309 MPD: MCP_0516(mcrA) MEZ: Mtc_0908(mcrA) RCI: RCIX2063(mcrA) MJK: N2V74_07320(mcrA) MELU: MTLP_00200 MTLP_01300 MEAM: MU439_05980(mcrA) MEAE: QEN48_04165(mcrA) QEN48_04170(mcrA) TAR: TALC_00472 MAX: MMALV_04000 MER: MMINT_15640 MEAR: Mpt1_c02010(mcrA) MEUZ: KRP56_02090(mcrA) MARC: AR505_1396 BARC: AOA65_0408(mcrA) BARB: AOA66_1761(mcrA) REFERENCE PMID:9367957 AUTHORS Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK TITLE Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation. JOURNAL Science 278:1457-62 (1997) DOI:10.1126/science.278.5342.1457 SEQUENCE [mmg:MTBMA_c15480] ///