ENTRY ko05203 Pathway NAME Viral carcinogenesis DESCRIPTION There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers. CLASS Human Diseases; Cancer: overview PATHWAY_MAP ko05203 Viral carcinogenesis DRUG D06555 Amolimogene bepiplasmid (USAN) D06666 Verpasep caltespen (USAN/INN) D12744 Ravidasvir (USAN/INN) D12745 Ravidasvir hydrochloride (USAN) ORTHOLOGY K21854 Orthohepadnavirus protein X K05704 tyrosine-protein kinase Src [EC:2.7.10.2] K02833 GTPase HRas K07827 GTPase KRas K07828 GTPase NRas K04371 mitogen-activated protein kinase 1/3 [EC:2.7.11.24] K05870 cyclic AMP-responsive element-binding protein 1 K04450 cyclic AMP-dependent transcription factor ATF-2 K04374 cyclic AMP-dependent transcription factor ATF-4 K09048 cyclic AMP-responsive element-binding protein 3 K09047 cyclic AMP-responsive element-binding protein 5 K09049 cyclic AMP-dependent transcription factor ATF-6 beta K10610 DNA damage-binding protein 1 K16197 14-3-3 protein beta/theta/zeta K06630 14-3-3 protein epsilon K16198 14-3-3 protein gamma/eta K11217 Janus kinase 1 [EC:2.7.10.2] K04692 signal transducer and activator of transcription 3 K11223 signal transducer and activator of transcription 5A K11224 signal transducer and activator of transcription 5B K02187 caspase 3 [EC:3.4.22.56] K08665 hepsin [EC:3.4.21.106] K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta K04735 transcription factor p65 K09254 c-Rel proto-oncogene protein K04469 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 K02580 nuclear factor NF-kappa-B p105 subunit K04451 tumor protein p53 K06626 G1/S-specific cyclin-E1 K02206 cyclin-dependent kinase 2 [EC:2.7.11.22] K12496 early growth response protein 2 K12497 early growth response protein 3 K15041 voltage-dependent anion channel protein 3 K22271 Hepatitis C virus core protein K03159 lymphotoxin beta receptor TNFR superfamily member 3 K15413 nuclear body protein Sp100 K12886 heterogeneous nuclear ribonucleoprotein K K06625 cyclin-dependent kinase inhibitor 1A K11594 ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] K16195 eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1] K22273 Hepatitis C virus serine protease / helicase NS3 [EC:3.4.21.98 3.6.1.15 5.6.2.6] K04345 protein kinase A [EC:2.7.11.11] K11252 histone H2B K11254 histone H4 K22275 Hepatitis C virus non-structural protein 5A K02159 apoptosis regulator BAX K04364 growth factor receptor-bound protein 2 K03171 tumor necrosis factor receptor type 1-associated DEATH domain protein K02087 cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23] K03120 transcription initiation factor TFIID TATA-box-binding protein K19461 Lymphocryptovirus nuclear antigen 1 K19456 Lymphocryptovirus nuclear antigen leader protein K19457 Lymphocryptovirus nuclear antigen 2 K21855 Lymphocryptovirus nuclear antigen 3 K21856 Lymphocryptovirus nuclear antigen 4 K19458 Lymphocryptovirus nuclear antigen 6 K19459 Lymphocryptovirus latent membrane protein 1 K19460 Lymphocryptovirus latent membrane protein 2A K11838 ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12] K06643 E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27] K06053 recombining binding protein suppressor of hairless K06063 SNW domain-containing protein 1 K03141 transcription initiation factor TFIIH subunit 1 K03142 transcription initiation factor TFIIH subunit 2 K03143 transcription initiation factor TFIIH subunit 3 K03144 transcription initiation factor TFIIH subunit 4 K03136 transcription initiation factor TFIIE subunit alpha K03137 transcription initiation factor TFIIE subunit beta K15979 staphylococcal nuclease domain-containing protein 1 K04498 E1A/CREB-binding protein [EC:2.3.1.48] K03124 transcription initiation factor TFIIB K04503 G1/S-specific cyclin-D1 K10151 G1/S-specific cyclin-D2 K10152 G1/S-specific cyclin-D3 K02091 cyclin-dependent kinase 6 [EC:2.7.11.22] K06627 cyclin-A K03875 F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2) K16174 small subunit ribosomal protein S18b, mitochondrial K03172 TNF receptor-associated factor 1 K03173 TNF receptor-associated factor 2 [EC:2.3.2.27] K03174 TNF receptor-associated factor 3 K09849 TNF receptor-associated factor 5 K11218 Janus kinase 3 [EC:2.7.10.2] K05854 tyrosine-protein kinase Lyn [EC:2.7.10.2] K05855 spleen tyrosine kinase [EC:2.7.10.2] K21812 Alphapapillomavirus protein E5 K21807 Alphapapillomavirus protein E6 K21809 Alphapapillomavirus protein E7 K02146 V-type H+-transporting ATPase subunit d K10587 ubiquitin-protein ligase E3 A [EC:2.3.2.26] K12076 disks large protein 1 K16175 protein scribble K05760 paxillin K14021 Bcl-2 homologous antagonist/killer K05411 interferon regulatory factor 3 K03062 26S proteasome regulatory subunit T2 K06618 retinoblastoma-associated protein K04681 retinoblastoma-like protein 1 K16332 retinoblastoma-like protein 2 K06624 cyclin-dependent kinase inhibitor 1B K10691 E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] K04448 transcription factor AP-1 K11643 chromodomain-helicase-DNA-binding protein 4 [EC:5.6.2.-] K06067 histone deacetylase 1/2 [EC:3.5.1.98] K11404 histone deacetylase 3 [EC:3.5.1.98] K11406 histone deacetylase 4/5 [EC:3.5.1.98] K11407 histone deacetylase 6 [EC:3.5.1.98] K11408 histone deacetylase 7 [EC:3.5.1.98] K11405 histone deacetylase 8 [EC:3.5.1.98] K11409 histone deacetylase 9 [EC:3.5.1.98] K18671 histone deacetylase 10 [EC:3.5.1.98] K11418 histone deacetylase 11 [EC:3.5.1.98] K00873 pyruvate kinase [EC:2.7.1.40] K04693 interferon regulatory factor 9 K09504 DnaJ homolog subfamily A member 3 K21857 Deltaretrovirus protein Tax-1 K06062 histone acetyltransferase [EC:2.3.1.48] K03122 transcription initiation factor TFIIA large subunit K03123 transcription initiation factor TFIIA small subunit K04378 serum response factor K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma K04734 NF-kappa-B inhibitor alpha K08053 Ras GTPase-activating protein 2 K04393 cell division control protein 42 K04392 Ras-related C3 botulinum toxin substrate 1 K04513 Ras homolog gene family, member A K05768 gelsolin K05699 actinin alpha 1/4 K02089 cyclin-dependent kinase 4 [EC:2.7.11.22] K06621 cyclin-dependent kinase inhibitor 2A K04685 cyclin-dependent kinase inhibitor 2B K02216 serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] K03363 cell division cycle 20, cofactor of APC complex K06679 mitotic spindle assembly checkpoint protein MAD1 K15305 vacuole morphology and inheritance protein 14 K15306 Ran-binding protein 1 K02330 DNA polymerase beta [EC:2.7.7.7 4.2.99.-] K21653 KSHV interferon regulatory factor-like protein 1 K21654 KSHV interferon regulatory factor-like protein 2 K21652 KSHV interferon regulatory factor-like protein 3 K21858 KSHV interferon regulatory factor-like protein 4 K21859 KSHV transcription activator ORF45 K21650 KSHV transcription activator ORF50 K21670 KSHV interleukin 6 K21659 KSHV protein K6 K21657 KSHV macrophage inflammatory protein 2 K21658 KSHV protein vCCL3 K21656 KSHV protein K12 K21662 KSHV FLICE inhibitory protein K21661 KSHV inhibitor of apoptosis protein K21664 KSHV latency-associated nuclear antigen K21663 KSHV cyclin homolog K21660 KSHV apoptosis regulator BCL2 homolog K21649 KSHV complement control protein K21665 KSHV E3 ubiquitin-protein ligase MIR1 [EC:2.3.2.36] K21666 KSHV E3 ubiquitin-protein ligase MIR2 [EC:2.3.2.36] K21667 KSHV G-protein coupled receptor K21669 KSHV protein K1 K21651 KSHV signal transducing membrane protein K21860 KSHV OX-2 membrane glycoprotein K21861 KSHV protein ORF35 K09447 interferon regulatory factor 7 K05060 interleukin 6 signal transducer K04180 C-C chemokine receptor type 5 K04183 C-C chemokine receptor type 8 K04178 C-C chemokine receptor type 3 K04179 C-C chemokine receptor type 4 K04443 mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1] K04398 caspase 8 [EC:3.4.22.61] K02158 Bcl-2-antagonist of cell death K10131 phorbol-12-myristate-13-acetate-induced protein 1 K03990 complement component 3 K06751 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JOURNAL J Virol 79:7396-401 (2005) DOI:10.1128/JVI.79.12.7396-7401.2005 REL_PATHWAY ko03022 Basal transcription factors ko03320 PPAR signaling pathway ko04010 MAPK signaling pathway ko04062 Chemokine signaling pathway ko04064 NF-kappa B signaling pathway ko04110 Cell cycle ko04115 p53 signaling pathway ko04142 Lysosome ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04630 JAK-STAT signaling pathway ko04662 B cell receptor signaling pathway ko04810 Regulation of actin cytoskeleton ko05160 Hepatitis C ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05166 Human T-cell leukemia virus 1 infection ko05167 Kaposi sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ///