ENTRY ko05100 Pathway NAME Bacterial invasion of epithelial cells DESCRIPTION Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton. CLASS Human Diseases; Infectious disease: bacterial PATHWAY_MAP ko05100 Bacterial invasion of epithelial cells ORTHOLOGY K13730 internalin A K13731 internalin B K13732 fibronectin-binding protein A K13733 fibronectin-binding protein B K13925 plasmin and fibronectin-binding protein A K13734 fibronectin-binding protein 1 K13735 adhesin/invasin K05689 cadherin 1, type 1, E-cadherin K02105 catenin beta 1 K05691 catenin alpha K13736 Rho GTPase-activating protein 10 K05099 proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] K09593 GRB2-associated-binding protein 1 K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] K04438 C-crk adapter molecule crk K13708 dedicator of cytokinesis protein 1 K04393 cell division control protein 42 K04392 Ras-related C3 botulinum toxin substrate 1 K23612 neural Wiskott-Aldrich syndrome protein K05753 WAS protein family, member 1 K05748 WAS protein family, member 2 K17260 actin-related protein 2 K18584 actin-related protein 3 K05757 actin related protein 2/3 complex, subunit 1A/1B K05758 actin related protein 2/3 complex, subunit 2 K05756 actin related protein 2/3 complex, subunit 3 K05755 actin related protein 2/3 complex, subunit 4 K05754 actin related protein 2/3 complex, subunit 5 K05692 actin beta/gamma 1 K13737 septin 1 K16942 septin 2 K16938 septin 3/9/12 K16939 septin 6/8/11 K04707 E3 ubiquitin-protein ligase CBL [EC:2.3.2.27] K06279 SHC-transforming protein 1 K17447 SHC-transforming protein 2 K17448 SHC-transforming protein 3 K17449 SHC-transforming protein 4 K13738 CD2-associated protein K01528 dynamin 1/3 [EC:3.6.5.5] K23484 dynamin 2 [EC:3.6.5.5] K04644 clathrin light chain A K04645 clathrin light chain B K04646 clathrin heavy chain K06278 caveolin 1 K12958 caveolin 2 K12959 caveolin 3 K06106 cortactin K05704 tyrosine-protein kinase Src [EC:2.7.10.2] K05725 focal adhesion kinase 1 [EC:2.7.10.2] K05726 breast cancer anti-estrogen resistance 1 K05760 paxillin K05717 fibronectin 1 K06484 integrin alpha 5 K05719 integrin beta 1 K06272 integrin-linked kinase [EC:2.7.11.1] K13287 invasin D K13286 invasin C K13285 invasin B K13739 secreted effector protein SopD K13284 invasin A K13740 secreted effector protein SptP K13741 guanine nucleotide exchange factor SopE K13085 phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78] K13742 protein IpgB1 K13743 protein IpgB2 K12785 LEE-encoded effector EspG K13728 mitotic spindle assembly checkpoint protein MAD2B K13744 Rho guanine nucleotide exchange factor 26 K07863 Ras homolog gene family, member G K12366 engulfment and cell motility protein 1 K18985 engulfment and cell motility protein 2 K19241 engulfment and cell motility protein 3 K04513 Ras homolog gene family, member A K05700 vinculin REFERENCE PMID:19296488 AUTHORS Mostowy S, Cossart P TITLE Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game. JOURNAL Cell Motil Cytoskeleton 66:816-23 (2009) DOI:10.1002/cm.20353 REFERENCE PMID:16406780 AUTHORS Hauck CR, Ohlsen K TITLE Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus. JOURNAL Curr Opin Microbiol 9:5-11 (2006) DOI:10.1016/j.mib.2005.12.002 REFERENCE PMID:17298394 AUTHORS Wang B, Li S, Dedhar S, Cleary PP TITLE Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion. JOURNAL Cell Microbiol 9:1519-28 (2007) DOI:10.1111/j.1462-5822.2007.00889.x REFERENCE PMID:19185531 AUTHORS Matsumoto H, Young GM TITLE Translocated effectors of Yersinia. JOURNAL Curr Opin Microbiol 12:94-100 (2009) DOI:10.1016/j.mib.2008.12.005 REFERENCE PMID:19157959 AUTHORS McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V TITLE Salmonella takes control: effector-driven manipulation of the host. JOURNAL Curr Opin Microbiol 12:117-24 (2009) DOI:10.1016/j.mib.2008.12.001 REFERENCE PMID:17719540 AUTHORS Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C TITLE A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. JOURNAL Cell 130:611-23 (2007) DOI:10.1016/j.cell.2007.06.043 REL_PATHWAY ko03070 Bacterial secretion system ko04110 Cell cycle ko04144 Endocytosis ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04810 Regulation of actin cytoskeleton ///