ENTRY ko04112 Pathway NAME Cell cycle - Caulobacter DESCRIPTION Cell cycle progression of Caulobacter crescentus is implemented by an elaborate transcriptional regulatory network. During the life cycle, Caulobacter divides asymmetrically producing two distinct cell types with specialized development programs. The sessile stalked cell immediately initiates a new round of division cycle, whereas the motile swarmer cell remains in the G1 phase for a defined interval before differentiating into the stalked cell and entering into the S phase. The division process is centered around three master regulator proteins, DnaA, GcrA, and CtrA. DnaA and GcrA together drive the synthesis of proteins needed to complete DNA replication. CtrA controls the transcription of a diverse group of genes, which are required for essential morphological, metabolic, and cell cycle events. CLASS Cellular Processes; Cell growth and death PATHWAY_MAP ko04112 Cell cycle - Caulobacter DBLINKS GO: 0000278 ORTHOLOGY K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53] K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] K02313 dnaA; chromosomal replication initiator protein K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] K02488 pleD; two-component system, cell cycle response regulator [EC:2.7.7.65] K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] K02651 flp, pilA; pilus assembly protein Flp/PilA K03531 ftsZ; cell division protein FtsZ K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX K03588 ftsW, spoVE, rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28] K03589 ftsQ; cell division protein FtsQ K03590 ftsA; cell division protein FtsA K06985 K06985; aspartyl protease family protein K07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3] K11357 divJ; two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3] K11443 divK; two-component system, cell cycle response regulator DivK K11749 rseP; regulator of sigma E protease [EC:3.4.24.-] K13245 pdeA; c-di-GMP-specific phosphodiesterase [EC:3.1.4.52] K13581 ccrM; modification methylase [EC:2.1.1.72] K13582 podJ; localization factor PodJL K13583 gcrA; GcrA cell cycle regulator K13584 ctrA; two-component system, cell cycle response regulator CtrA K13585 hfaA; holdfast attachment protein HfaA K13586 hfaB; holdfast attachment protein HfaB K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3] K13588 chpT; histidine phosphotransferase ChpT K13589 cpdR; two-component system, cell cycle response regulator CpdR K13590 dgcB; diguanylate cyclase [EC:2.7.7.65] K13591 popA; two-component system, cell cycle response regulator PopA K13592 rcdA; regulator of CtrA degradation K13593 tipF; cyclic-di-GMP phosphodiesterase, flagellum assembly factor TipF COMPOUND C16463 3',5'-Cyclic diGMP REFERENCE PMID:18685108 AUTHORS Shen X, Collier J, Dill D, Shapiro L, Horowitz M, McAdams HH TITLE Architecture and inherent robustness of a bacterial cell-cycle control system. JOURNAL Proc Natl Acad Sci U S A 105:11340-5 (2008) DOI:10.1073/pnas.0805258105 REFERENCE PMID:20197497 AUTHORS Curtis PD, Brun YV TITLE Getting in the loop: regulation of development in Caulobacter crescentus. JOURNAL Microbiol Mol Biol Rev 74:13-41 (2010) DOI:10.1128/MMBR.00040-09 REFERENCE PMID:15031731 AUTHORS Skerker JM, Laub MT TITLE Cell-cycle progression and the generation of asymmetry in Caulobacter crescentus. JOURNAL Nat Rev Microbiol 2:325-37 (2004) DOI:10.1038/nrmicro864 REFERENCE PMID:19246239 AUTHORS Jenal U, Galperin MY TITLE Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics. JOURNAL Curr Opin Microbiol 12:152-60 (2009) DOI:10.1016/j.mib.2009.01.010 REFERENCE PMID:19854671 AUTHORS Thanbichler M TITLE Spatial regulation in Caulobacter crescentus. JOURNAL Curr Opin Microbiol 12:715-21 (2009) DOI:10.1016/j.mib.2009.09.013 REFERENCE PMID:19781638 AUTHORS Jenal U TITLE The role of proteolysis in the Caulobacter crescentus cell cycle and development. JOURNAL Res Microbiol 160:687-95 (2009) DOI:10.1016/j.resmic.2009.09.006 REFERENCE PMID:19287449 AUTHORS Hengge R TITLE Principles of c-di-GMP signalling in bacteria. JOURNAL Nat Rev Microbiol 7:263-73 (2009) DOI:10.1038/nrmicro2109 REFERENCE PMID:19687139 AUTHORS Goley ED, Toro E, McAdams HH, Shapiro L TITLE Dynamic chromosome organization and protein localization coordinate the regulatory circuitry that drives the bacterial cell cycle. JOURNAL Cold Spring Harb Symp Quant Biol 74:55-64 (2009) DOI:10.1101/sqb.2009.74.005 REFERENCE PMID:19680425 AUTHORS Li S, Brazhnik P, Sobral B, Tyson JJ TITLE Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus. JOURNAL PLoS Comput Biol 5:e1000463 (2009) DOI:10.1371/journal.pcbi.1000463 REL_PATHWAY ko02020 Two-component system ko02030 Bacterial chemotaxis ko02040 Flagellar assembly ///