ENTRY ko03440 Pathway NAME Homologous recombination DESCRIPTION Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. CLASS Genetic Information Processing; Replication and repair PATHWAY_MAP ko03440 Homologous recombination DBLINKS GO: 0000724 ORTHOLOGY K07462 single-stranded-DNA-specific exonuclease [EC:3.1.-.-] K03111 single-strand DNA-binding protein K03629 DNA replication and repair protein RecF K03584 DNA repair protein RecO (recombination protein O) K06187 recombination protein RecR K03553 recombination protein RecA K02335 DNA polymerase I [EC:2.7.7.7] K03550 holliday junction DNA helicase RuvA K03551 holliday junction DNA helicase RuvB [EC:5.6.2.4] K01159 crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10] K03655 ATP-dependent DNA helicase RecG [EC:5.6.2.4] K03582 exodeoxyribonuclease V beta subunit [EC:3.1.11.5] K03583 exodeoxyribonuclease V gamma subunit [EC:3.1.11.5] K03581 exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] K02337 DNA polymerase III subunit alpha [EC:2.7.7.7] K03763 DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] K02338 DNA polymerase III subunit beta [EC:2.7.7.7] K02343 DNA polymerase III subunit gamma/tau [EC:2.7.7.7] K02340 DNA polymerase III subunit delta [EC:2.7.7.7] K02341 DNA polymerase III subunit delta' [EC:2.7.7.7] K02342 DNA polymerase III subunit epsilon [EC:2.7.7.7] K14159 ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7] K02345 DNA polymerase III subunit theta [EC:2.7.7.7] K02339 DNA polymerase III subunit chi [EC:2.7.7.7] K02344 DNA polymerase III subunit psi [EC:2.7.7.7] K04066 primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] K02686 primosomal replication protein N K04067 primosomal replication protein N'' K02317 DNA replication protein DnaT K10866 DNA repair protein RAD50 [EC:3.6.-.-] K10865 double-strand break repair protein MRE11 K10868 DNA repair protein XRS2 K10867 nibrin K04728 serine-protein kinase ATM [EC:2.7.11.1] K10605 breast cancer type 1 susceptibility protein [EC:2.3.2.27] K10683 BRCA1-associated RING domain protein 1 K20773 DNA endonuclease RBBP8 [EC:3.1.-.-] K15362 fanconi anemia group J protein [EC:5.6.2.3] K10728 topoisomerase (DNA) II binding protein 1 K20774 BRCA1-A complex subunit Abraxas K20775 BRCA1-A complex subunit RAP80 K20776 BRISC and BRCA1-A complex member 1 K12173 BRCA1-A complex subunit BRE K11864 BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] K10897 partner and localizer of BRCA2 K08775 breast cancer 2 susceptibility protein K10881 26 proteasome complex subunit DSS1 K19528 synaptonemal complex protein 3 K10957 DNA repair protein RAD55 K10958 DNA repair protein RAD57 K07466 replication factor A1 K10739 replication factor A2 K10740 replication factor A3 K10741 replication factor A4 K04482 DNA repair protein RAD51 K10873 DNA repair and recombination protein RAD52 K10869 RAD51-like protein 1 K10870 RAD51-like protein 2 K10871 RAD51-like protein 3 K10879 DNA-repair protein XRCC2 K10880 DNA-repair protein XRCC3 K10959 DNA repair protein RAD59 K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-] K10877 DNA repair and recombination protein RAD54B [EC:5.6.2.-] K02327 DNA polymerase delta subunit 1 [EC:2.7.7.7] K02328 DNA polymerase delta subunit 2 K03504 DNA polymerase delta subunit 3 K03505 DNA polymerase delta subunit 4 K10901 bloom syndrome protein [EC:5.6.2.4] K03165 DNA topoisomerase III [EC:5.6.2.1] K08991 crossover junction endonuclease MUS81 [EC:3.1.22.-] K10882 crossover junction endonuclease EME1 [EC:3.1.22.-] REFERENCE PMID:18086882 AUTHORS Maloisel L, Fabre F, Gangloff S. TITLE DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension. JOURNAL Mol Cell Biol 28:1373-82 (2008) DOI:10.1128/MCB.01651-07 REFERENCE PMID:17571595 AUTHORS Haruta-Takahashi N, Iwasaki H. TITLE [Recombination mediators] JOURNAL Seikagaku 79:449-53 (2007) REFERENCE PMID:18430459 AUTHORS Ouyang KJ, Woo LL, Ellis NA. TITLE Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases. JOURNAL Mech Ageing Dev 129:425-40 (2008) DOI:10.1016/j.mad.2008.03.003 REFERENCE PMID:15902993 AUTHORS Kawabata M, Kawabata T, Nishibori M. TITLE Role of recA/RAD51 family proteins in mammals. JOURNAL Acta Med Okayama 59:1-9 (2005) DOI:10.18926/AMO/31987 REFERENCE PMID:12589470 AUTHORS Prado F, Cortes-Ledesma F, Huertas P, Aguilera A. TITLE Mitotic recombination in Saccharomyces cerevisiae. JOURNAL Curr Genet 42:185-98 (2003) DOI:10.1007/s00294-002-0346-3 REFERENCE PMID:16935872 AUTHORS Heyer WD, Li X, Rolfsmeier M, Zhang XP. TITLE Rad54: the Swiss Army knife of homologous recombination? JOURNAL Nucleic Acids Res 34:4115-25 (2006) DOI:10.1093/nar/gkl481 REFERENCE PMID:17395553 AUTHORS Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R. TITLE Recombination proteins and rescue of arrested replication forks. JOURNAL DNA Repair (Amst) 6:967-80 (2007) DOI:10.1016/j.dnarep.2007.02.016 ///