ENTRY ko03070 Pathway NAME Bacterial secretion system DESCRIPTION Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway. CLASS Environmental Information Processing; Membrane transport PATHWAY_MAP ko03070 Bacterial secretion system DBLINKS GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953 ORTHOLOGY K12340 outer membrane protein K11003 membrane fusion protein, hemolysin D K11004 ATP-binding cassette, subfamily B, bacterial HlyB/CyaB K03221 type III secretion protein F K04056 type III secretion protein O K04057 type III secretion protein P K04059 type III secretion protein X K03219 type III secretion protein C K04058 type III secretion protein W K03222 type III secretion protein J K03226 type III secretion protein R K03227 type III secretion protein S K03228 type III secretion protein T K03229 type III secretion protein U K03230 type III secretion protein V K03224 ATP synthase in type III secretion protein N [EC:7.4.2.8] K03225 type III secretion protein Q K03223 type III secretion protein L K02453 general secretion pathway protein D K02465 general secretion pathway protein S K02452 general secretion pathway protein C K02455 general secretion pathway protein F K02456 general secretion pathway protein G K02457 general secretion pathway protein H K02458 general secretion pathway protein I K02459 general secretion pathway protein J K02460 general secretion pathway protein K K02461 general secretion pathway protein L K02462 general secretion pathway protein M K02454 general secretion pathway protein E [EC:7.4.2.8] K02464 general secretion pathway protein O [EC:3.4.23.43 2.1.1.-] K03072 preprotein translocase subunit SecD K12257 SecD/SecF fusion protein K03074 preprotein translocase subunit SecF K03073 preprotein translocase subunit SecE K03075 preprotein translocase subunit SecG K03076 preprotein translocase subunit SecY K03210 preprotein translocase subunit YajC K03217 YidC/Oxa1 family membrane protein insertase K03070 preprotein translocase subunit SecA [EC:7.4.2.8] K13301 secretion monitor K03110 fused signal recognition particle receptor K03071 preprotein translocase subunit SecB K03106 signal recognition particle subunit SRP54 [EC:3.6.5.4] K03116 sec-independent protein translocase protein TatA K03117 sec-independent protein translocase protein TatB K03118 sec-independent protein translocase protein TatC K03425 sec-independent protein translocase protein TatE K11028 vacuolating cytotoxin K11017 hemolysin activation/secretion protein K11016 hemolysin K12341 adhesin YadA K12342 adhesin YadB/C K03194 type IV secretion system protein VirB1 K03197 type IV secretion system protein VirB2 K03198 type IV secretion system protein VirB3 K03200 type IV secretion system protein VirB5 K03202 type IV secretion system protein VirB7 K03204 type IV secretion system protein VirB9 K03201 type IV secretion system protein VirB6 K03203 type IV secretion system protein VirB8 K03195 type IV secretion system protein VirB10 K03199 type IV secretion system protein VirB4 [EC:7.4.2.8] K03196 type IV secretion system protein VirB11 [EC:7.4.2.8] K03205 type IV secretion system protein VirD4 [EC:7.4.2.8] K11904 type VI secretion system secreted protein VgrG K11903 type VI secretion system secreted protein Hcp K11906 type VI secretion system protein VasD K11891 type VI secretion system protein ImpL K11892 type VI secretion system protein ImpK K11907 type VI secretion system protein VasG K11912 serine/threonine-protein kinase PpkA [EC:2.7.11.1] K11913 type VI secretion system protein K11915 serine/threonine protein phosphatase Stp1 [EC:3.1.3.16] COMPOUND C00002 ATP REFERENCE PMID:11173102 AUTHORS Kim JF. 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