ENTRY ko03070 Pathway NAME Bacterial secretion system DESCRIPTION Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway. CLASS Environmental Information Processing; Membrane transport PATHWAY_MAP ko03070 Bacterial secretion system DBLINKS GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953 ORTHOLOGY K02452 gspC; general secretion pathway protein C K02453 gspD; general secretion pathway protein D K02454 gspE; general secretion pathway protein E [EC:7.4.2.8] K02455 gspF; general secretion pathway protein F K02456 gspG; general secretion pathway protein G K02457 gspH; general secretion pathway protein H K02458 gspI; general secretion pathway protein I K02459 gspJ; general secretion pathway protein J K02460 gspK; general secretion pathway protein K K02461 gspL; general secretion pathway protein L K02462 gspM; general secretion pathway protein M K02464 gspO; general secretion pathway protein O [EC:3.4.23.43 2.1.1.-] K02465 gspS; general secretion pathway protein S K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] K03071 secB; preprotein translocase subunit SecB K03072 secD; preprotein translocase subunit SecD K03073 secE; preprotein translocase subunit SecE K03074 secF; preprotein translocase subunit SecF K03075 secG; preprotein translocase subunit SecG K03076 secY; preprotein translocase subunit SecY K03106 SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4] K03110 ftsY; fused signal recognition particle receptor K03116 tatA; sec-independent protein translocase protein TatA K03117 tatB; sec-independent protein translocase protein TatB K03118 tatC; sec-independent protein translocase protein TatC K03194 virB1; type IV secretion system protein VirB1 K03195 virB10, lvhB10; type IV secretion system protein VirB10 K03196 virB11, lvhB11; type IV secretion system protein VirB11 [EC:7.4.2.8] K03197 virB2, lvhB2; type IV secretion system protein VirB2 K03198 virB3, lvhB3; type IV secretion system protein VirB3 K03199 virB4, lvhB4; type IV secretion system protein VirB4 [EC:7.4.2.8] K03200 virB5, lvhB5; type IV secretion system protein VirB5 K03201 virB6, lvhB6; type IV secretion system protein VirB6 K03202 virB7, lvhB7; type IV secretion system protein VirB7 K03203 virB8, lvhB8; type IV secretion system protein VirB8 K03204 virB9, lvhB9; type IV secretion system protein VirB9 K03205 virD4, lvhD4; type IV secretion system protein VirD4 [EC:7.4.2.8] K03210 yajC; preprotein translocase subunit YajC K03217 yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase K03219 yscC, sctC, ssaC; type III secretion protein C K03221 yscF, sctF, ssaG, prgI; type III secretion protein F K03222 yscJ, sctJ, hrcJ, ssaJ; type III secretion protein J K03223 yscL, sctL; type III secretion protein L K03224 yscN, sctN, hrcN, ssaN; ATP synthase in type III secretion protein N [EC:7.4.2.8] K03225 yscQ, sctQ, hrcQ, ssaQ, spaO; type III secretion protein Q K03226 yscR, sctR, hrcR, ssaR; type III secretion protein R K03227 yscS, sctS, hrcS, ssaS; type III secretion protein S K03228 yscT, sctT, hrcT, ssaT; type III secretion protein T K03229 yscU, sctU, hrcU, ssaU; type III secretion protein U K03230 yscV, sctV, hrcV, ssaV, invA; type III secretion protein V K03425 tatE; sec-independent protein translocase protein TatE K04056 yscO, sctO; type III secretion protein O K04057 yscP, sctP; type III secretion protein P K04058 yscW, sctW; type III secretion protein W K04059 yscX, sctX; type III secretion protein X K11003 hlyD, cyaD; membrane fusion protein, hemolysin D K11004 hlyB, cyaB; ATP-binding cassette, subfamily B, bacterial HlyB/CyaB K11016 shlA, hhdA, hpmA; hemolysin K11017 shlB, hhdB, hpmB; hemolysin activation/secretion protein K11028 vacA; vacuolating cytotoxin K11891 impL, vasK, icmF; type VI secretion system protein ImpL K11892 impK, ompA, vasF, dotU; type VI secretion system protein ImpK K11903 hcp; type VI secretion system secreted protein Hcp K11904 vgrG; type VI secretion system secreted protein VgrG K11906 vasD, lip; type VI secretion system protein VasD K11907 vasG, clpV; type VI secretion system protein VasG K11912 ppkA; serine/threonine-protein kinase PpkA [EC:2.7.11.1] K11913 fha1; type VI secretion system protein K11915 stp1, pppA; serine/threonine protein phosphatase Stp1 [EC:3.1.3.16] K12257 secDF; SecD/SecF fusion protein K12340 tolC, bepC, cyaE, raxC, sapF, rsaF, hasF; outer membrane protein K12341 yadA; adhesin YadA K12342 yadB_C; adhesin YadB/C K13301 secM; secretion monitor COMPOUND C00002 ATP REFERENCE PMID:11173102 AUTHORS Kim JF. TITLE Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion. JOURNAL Trends Genet 17:65-9 (2001) DOI:10.1016/S0168-9525(00)02175-2 REFERENCE PMID:11309112 AUTHORS Plano GV, Day JB, Ferracci F. TITLE Type III export: new uses for an old pathway. JOURNAL Mol Microbiol 40:284-93 (2001) DOI:10.1046/j.1365-2958.2001.02354.x REFERENCE PMID:11413015 AUTHORS Gauthier A, Finlay BB. TITLE Bacterial pathogenesis: the answer to virulence is in the pore. JOURNAL Curr Biol 11:R264-7 (2001) DOI:10.1016/S0960-9822(01)00134-8 REFERENCE PMID:10047550 AUTHORS Burns DL. TITLE Biochemistry of type IV secretion. JOURNAL Curr Opin Microbiol 2:25-9 (1999) DOI:10.1016/S1369-5274(99)80004-6 REFERENCE PMID:10920394 AUTHORS Christie PJ, Vogel JP. TITLE Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells. JOURNAL Trends Microbiol 8:354-60 (2000) DOI:10.1016/S0966-842X(00)01792-3 REFERENCE PMID:11309113 AUTHORS Christie PJ. TITLE Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines. JOURNAL Mol Microbiol 40:294-305 (2001) DOI:10.1046/j.1365-2958.2001.02302.x REFERENCE PMID:10481178 AUTHORS Nunn D. TITLE Bacterial type II protein export and pilus biogenesis: more than just homologies? JOURNAL Trends Cell Biol 9:402-8 (1999) DOI:10.1016/S0962-8924(99)01634-7 REFERENCE PMID:11309111 AUTHORS Sandkvist M. TITLE Biology of type II secretion. JOURNAL Mol Microbiol 40:271-83 (2001) DOI:10.1046/j.1365-2958.2001.02403.x REFERENCE PMID:11349009 AUTHORS Sandkvist M. TITLE Type II secretion and pathogenesis. JOURNAL Infect Immun 69:3523-35 (2001) DOI:10.1128/IAI.69.6.3523-3535.2001 REFERENCE PMID:15546664 AUTHORS Delepelaire P TITLE Type I secretion in gram-negative bacteria. JOURNAL Biochim Biophys Acta 1694:149-61 (2004) DOI:10.1016/j.bbamcr.2004.05.001 REFERENCE PMID:18406342 AUTHORS Hazes B, Frost L TITLE Towards a systems biology approach to study type II/IV secretion systems. JOURNAL Biochim Biophys Acta 1778:1839-50 (2008) DOI:10.1016/j.bbamem.2008.03.011 REFERENCE PMID:16448494 AUTHORS Johnson TL, Abendroth J, Hol WG, Sandkvist M TITLE Type II secretion: from structure to function. JOURNAL FEMS Microbiol Lett 255:175-86 (2006) DOI:10.1111/j.1574-6968.2006.00102.x REFERENCE PMID:15546665 AUTHORS Filloux A TITLE The underlying mechanisms of type II protein secretion. JOURNAL Biochim Biophys Acta 1694:163-79 (2004) DOI:10.1016/j.bbamcr.2004.05.003 REFERENCE PMID:19396170 AUTHORS Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC TITLE A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system. JOURNAL Nat Struct Mol Biol 16:468-76 (2009) DOI:10.1038/nsmb.1603 REFERENCE PMID:15590783 AUTHORS Ghosh P TITLE Process of protein transport by the type III secretion system. JOURNAL Microbiol Mol Biol Rev 68:771-95 (2004) DOI:10.1128/MMBR.68.4.771-795.2004 REFERENCE PMID:12360191 AUTHORS Cornelis GR TITLE The Yersinia Ysc-Yop 'type III' weaponry. JOURNAL Nat Rev Mol Cell Biol 3:742-52 (2002) DOI:10.1038/nrm932 REFERENCE PMID:17215876 AUTHORS Baron C TITLE VirB8: a conserved type IV secretion system assembly factor and drug target. JOURNAL Biochem Cell Biol 84:890-9 (2006) DOI:10.1139/o06-148 REFERENCE PMID:17943123 AUTHORS Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S TITLE Helicobacter exploits integrin for type IV secretion and kinase activation. JOURNAL Nature 449:862-6 (2007) DOI:10.1038/nature06187 REFERENCE PMID:16092524 AUTHORS Christie PJ, Cascales E TITLE Structural and dynamic properties of bacterial type IV secretion systems (review). JOURNAL Mol Membr Biol 22:51-61 (2005) DOI:10.1080/09687860500063316 REFERENCE PMID:15546668 AUTHORS Christie PJ TITLE Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems. JOURNAL Biochim Biophys Acta 1694:219-34 (2004) DOI:10.1016/j.bbamcr.2004.02.013 REFERENCE PMID:15590781 AUTHORS Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D TITLE Type V protein secretion pathway: the autotransporter story. JOURNAL Microbiol Mol Biol Rev 68:692-744 (2004) DOI:10.1128/MMBR.68.4.692-744.2004 REFERENCE PMID:9778731 AUTHORS Henderson IR, Navarro-Garcia F, Nataro JP TITLE The great escape: structure and function of the autotransporter proteins. JOURNAL Trends Microbiol 6:370-8 (1998) DOI:10.1016/S0966-842X(98)01318-3 REFERENCE PMID:18524912 AUTHORS Filloux A, Hachani A, Bleves S TITLE The bacterial type VI secretion machine: yet another player for protein transport across membranes. JOURNAL Microbiology 154:1570-83 (2008) DOI:10.1099/mic.0.2008/016840-0 REFERENCE PMID:19251641 AUTHORS Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ TITLE Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin. JOURNAL Proc Natl Acad Sci U S A 106:4154-9 (2009) DOI:10.1073/pnas.0813360106 REFERENCE PMID:17603507 AUTHORS Kulasekara HD, Miller SI TITLE Threonine phosphorylation times bacterial secretion. JOURNAL Nat Cell Biol 9:734-6 (2007) DOI:10.1038/ncb0707-734 REFERENCE PMID:18078384 AUTHORS Driessen AJ, Nouwen N TITLE Protein translocation across the bacterial cytoplasmic membrane. JOURNAL Annu Rev Biochem 77:643-67 (2008) DOI:10.1146/annurev.biochem.77.061606.160747 REFERENCE PMID:14641032 AUTHORS Pool MR TITLE Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated? JOURNAL Biochem Soc Trans 31:1232-7 (2003) DOI:10.1042/bst0311232 REFERENCE PMID:19299134 AUTHORS Desvaux M, Hebraud M, Talon R, Henderson IR TITLE Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue. JOURNAL Trends Microbiol 17:139-45 (2009) DOI:10.1016/j.tim.2009.01.004 REFERENCE PMID:15063851 AUTHORS Nakatogawa H, Murakami A, Ito K TITLE Control of SecA and SecM translation by protein secretion. JOURNAL Curr Opin Microbiol 7:145-50 (2004) DOI:10.1016/j.mib.2004.01.001 ///