ENTRY ko03060 Pathway NAME Protein export DESCRIPTION The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role. CLASS Genetic Information Processing; Folding, sorting and degradation PATHWAY_MAP ko03060 Protein export DBLINKS GO: 0043952 0043953 ORTHOLOGY K03076 preprotein translocase subunit SecY K03073 preprotein translocase subunit SecE K03075 preprotein translocase subunit SecG K03072 preprotein translocase subunit SecD K03074 preprotein translocase subunit SecF K12257 SecD/SecF fusion protein K03210 preprotein translocase subunit YajC K03217 YidC/Oxa1 family membrane protein insertase K03070 preprotein translocase subunit SecA [EC:7.4.2.8] K03071 preprotein translocase subunit SecB K13301 secretion monitor K03106 signal recognition particle subunit SRP54 [EC:3.6.5.4] K01983 SRP RNA K03110 fused signal recognition particle receptor K10956 protein transport protein SEC61 subunit alpha K09481 protein transport protein SEC61 subunit beta K07342 protein transport protein SEC61 subunit gamma and related proteins K12275 translocation protein SEC62 K09540 translocation protein SEC63 K09490 endoplasmic reticulum chaperone BiP [EC:3.6.4.10] K03109 signal recognition particle subunit SRP9 K03104 signal recognition particle subunit SRP14 K03108 signal recognition particle subunit SRP72 K03107 signal recognition particle subunit SRP68 K03105 signal recognition particle subunit SRP19 K13431 signal recognition particle receptor subunit alpha K12272 signal recognition particle receptor subunit beta K01551 arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-] K23387 golgi to ER traffic protein 4 K23388 ubiquitin-like protein 4 K23390 large proline-rich protein BAG6 K16365 small glutamine-rich tetratricopeptide repeat-containing protein alpha K22384 tail-anchored protein insertion receptor K22386 GET complex subunit GET2 K27163 SRP-independent targeting protein 1 K27164 SRP-independent targeting protein 2 K27165 SRP-independent targeting protein 3 K03116 sec-independent protein translocase protein TatA K03117 sec-independent protein translocase protein TatB K03118 sec-independent protein translocase protein TatC K03425 sec-independent protein translocase protein TatE K03100 signal peptidase I [EC:3.4.21.89] K03101 signal peptidase II [EC:3.4.23.36] K12946 signal peptidase complex subunit 1 [EC:3.4.-.-] K12947 signal peptidase complex subunit 2 [EC:3.4.-.-] K12948 signal peptidase complex subunit 3 [EC:3.4.-.-] K13280 signal peptidase I [EC:3.4.21.89] K09647 mitochondrial inner membrane protease subunit 1 [EC:3.4.21.-] K09648 mitochondrial inner membrane protease subunit 2 [EC:3.4.21.-] REFERENCE PMID:10087917 AUTHORS Dalbey RE, Robinson C. TITLE Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane. JOURNAL Trends Biochem Sci 24:17-22 (1999) DOI:10.1016/S0968-0004(98)01333-4 REFERENCE PMID:10652088 AUTHORS Berks BC, Sargent F, Palmer T. TITLE The Tat protein export pathway. JOURNAL Mol Microbiol 35:260-74 (2000) DOI:10.1046/j.1365-2958.2000.01719.x REFERENCE PMID:10747959 AUTHORS Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T. TITLE TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export. JOURNAL J Biol Chem 275:16717-22 (2000) DOI:10.1074/jbc.M000800200 REFERENCE PMID:11007775 AUTHORS Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J. TITLE TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway. JOURNAL J Biol Chem 275:41350-7 (2000) DOI:10.1074/jbc.M004887200 REFERENCE PMID:18046402 AUTHORS Rapoport TA TITLE Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes. JOURNAL Nature 450:663-9 (2007) DOI:10.1038/nature06384 REFERENCE PMID:17368028 AUTHORS Flower AM TITLE The SecY translocation complex: convergence of genetics and structure. JOURNAL Trends Microbiol 15:203-10 (2007) DOI:10.1016/j.tim.2007.03.001 REFERENCE PMID:16212506 AUTHORS Osborne AR, Rapoport TA, van den Berg B TITLE Protein translocation by the Sec61/SecY channel. JOURNAL Annu Rev Cell Dev Biol 21:529-50 (2005) DOI:10.1146/annurev.cellbio.21.012704.133214 REFERENCE PMID:12475201 AUTHORS Paetzel M, Karla A, Strynadka NC, Dalbey RE TITLE Signal peptidases. JOURNAL Chem Rev 102:4549-80 (2002) DOI:10.1021/cr010166y REFERENCE PMID:10924740 AUTHORS Paetzel M, Dalbey RE, Strynadka NC TITLE The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target. JOURNAL Pharmacol Ther 87:27-49 (2000) DOI:10.1016/S0163-7258(00)00064-4 REFERENCE PMID:17259602 AUTHORS Ng SY, Chaban B, VanDyke DJ, Jarrell KF TITLE Archaeal signal peptidases. JOURNAL Microbiology 153:305-14 (2007) DOI:10.1099/mic.0.2006/003087-0 REFERENCE PMID:19299134 AUTHORS Desvaux M, Hebraud M, Talon R, Henderson IR TITLE Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue. JOURNAL Trends Microbiol 17:139-45 (2009) DOI:10.1016/j.tim.2009.01.004 REFERENCE PMID:15063851 AUTHORS Nakatogawa H, Murakami A, Ito K TITLE Control of SecA and SecM translation by protein secretion. JOURNAL Curr Opin Microbiol 7:145-50 (2004) DOI:10.1016/j.mib.2004.01.001 ///