ENTRY ko03013 Pathway NAME Nucleocytoplasmic transport DESCRIPTION The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export. CLASS Genetic Information Processing; Translation PATHWAY_MAP ko03013 Nucleocytoplasmic transport DBLINKS GO: 0050658 ORTHOLOGY K03231 EEF1A; elongation factor 1-alpha K03345 SENP2, AXAM2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68] K07562 NMD3; 60S ribosomal export protein NMD3 K07936 RAN; GTP-binding nuclear protein Ran K09291 TPR, MLP1, MLP2; nucleoprotein TPR K10577 UBE2I, UBC9; ubiquitin-conjugating enzyme E2 I K12160 SUMO, SMT3; small ubiquitin-related modifier K12172 RANBP2, NUP358; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-] K12812 DDX39B, UAP56, SUB2; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7] K12875 ACIN1, ACINUS; apoptotic chromatin condensation inducer in the nucleus K12876 RBM8A, Y14; RNA-binding protein 8A K12877 MAGOH; protein mago nashi K12878 THOC1; THO complex subunit 1 K12879 THOC2; THO complex subunit 2 K12880 THOC3; THO complex subunit 3 K12881 THOC4, ALYREF; THO complex subunit 4 K12882 NCBP1, CBP80; nuclear cap-binding protein subunit 1 K12883 NCBP2, CBP20; nuclear cap-binding protein subunit 2 K13025 EIF4A3, FAL1; ATP-dependent RNA helicase [EC:5.6.2.7] K13114 PNN; pinin K13151 SNUPN, RNUT1; snurportin-1 K13171 SRRM1, SRM160; serine/arginine repetitive matrix protein 1 K13174 THOC5; THO complex subunit 5 K13175 THOC6; THO complex subunit 6 K13176 THOC7; THO complex subunit 7 K14004 SEC13; protein transport protein SEC13 K14284 NXF, TAP, MEX67; nuclear RNA export factor K14285 NXT1_2, P15; NTF2-related export protein 1/2 K14288 XPOT; exportin-T K14289 XPO5; exportin-5 K14290 XPO1, CRM1; exportin-1 K14291 PHAX; phosphorylated adapter RNA export protein K14293 KPNB1, IPO1; importin subunit beta-1 K14294 WIBG, PYM; partner of Y14 and mago K14295 NUP50, NPAP60; nuclear pore complex protein Nup50 K14296 NUP153; nuclear pore complex protein Nup153 K14297 NUP98, ADAR2, NUP116; nuclear pore complex protein Nup98-Nup96 K14298 RAE1, GLE2; mRNA export factor K14299 SEH1; nucleoporin SEH1 K14300 NUP133; nuclear pore complex protein Nup133 K14301 NUP107, NUP84; nuclear pore complex protein Nup107 K14302 NUP37; nuclear pore complex protein Nup37 K14303 NUP160, NUP120; nuclear pore complex protein Nup160 K14304 NUP85; nuclear pore complex protein Nup85 K14305 NUP43; nuclear pore complex protein Nup43 K14306 NUP62, NSP1; nuclear pore complex protein Nup62 K14307 NUPL1, NUP49; nucleoporin p58/p45 K14308 NUP54, NUP57; nuclear pore complex protein Nup54 K14309 NUP93, NIC96; nuclear pore complex protein Nup93 K14310 NUP205, NUP192; nuclear pore complex protein Nup205 K14311 NUP188; nuclear pore complex protein Nup188 K14312 NUP155, NUP170, NUP157; nuclear pore complex protein Nup155 K14313 NUP35, NUP53; nuclear pore complex protein Nup53 K14314 NUP210, GP210; nuclear pore complex protein Nup210 K14315 NDC1, TMEM48; nucleoporin NDC1 K14316 POM121, NUP121; nuclear pore complex protein Nup121 K14317 NUP214, CAN; nuclear pore complex protein Nup214 K14318 NUP88; nuclear pore complex protein Nup88 K14319 RANGAP1; Ran GTPase-activating protein 1 K14320 AAAS; aladin K14321 NUPL2, NUP42, CG1; nucleoporin-like protein 2 K14323 CASC3, MLN51; protein CASC3 K14324 SAP18; histone deacetylase complex subunit SAP18 K14325 RNPS1; RNA-binding protein with serine-rich domain 1 K14326 UPF1, RENT1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3] K14327 UPF2, RENT2; regulator of nonsense transcripts 2 K14328 UPF3, RENT3; regulator of nonsense transcripts 3 K14543 MTR2; mRNA transport regulator MTR2 K15042 KPNA5_6; importin subunit alpha-6/7 K15043 KPNA2_7; importin subunit alpha-1/8 K15436 TRPO3, MTR10; transportin-3 K18423 CSE1, CAS, XPO2; exportin-2 (importin alpha re-exporter) K18460 XPO7, EXP7; exportin-7 K18655 DDX19, DBP5; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7] K18717 ASM4, NUP59; nucleoporin ASM4 K18718 NUP60; nucleoporin NUP60 K18720 NUP145; nucleoporin NUP145 K18721 NUP1; nucleoporin NUP1 K18722 NUP2; nucleoporin NUP2 K18723 GLE1; nucleoporin GLE1 K18724 POM34; nucleoporin POM34 K18725 POM152; nucleoporin POM152 K18727 TNPO2, IPO3, KPNB2B; transportin-2 K18752 TNPO1, IPO2, KPNB2; transportin-1 K18755 IPO8, RANBP8; importin-8 K20221 IPO4, RANBP4; importin-4 K20222 IPO5, KPNB3, RANBP5; importin-5 K20223 IPO7, RANBP7; importin-7 K20224 IPO9, RANBP9; importin-9 K20724 TMEM33; transmembrane protein 33 K23583 KPNA3_4; importin subunit alpha-4/3 K23940 KPNA1; importin subunit alpha-5 K24115 RANBP17; Ran-binding protein 17 K25129 AHCTF1, ELYS; protein ELYS K25201 IPO11, RANBP11; importin-11 K25202 IPO13, RANBP13; importin-13 K25203 XPO4; exportin-4 K25204 XPO6, RANBP20; exportin-6 REFERENCE PMID:16777596 AUTHORS Tran EJ, Wente SR TITLE Dynamic nuclear pore complexes: life on the edge. JOURNAL Cell 125:1041-53 (2006) DOI:10.1016/j.cell.2006.05.027 REFERENCE PMID:15519698 AUTHORS Rodriguez MS, Dargemont C, Stutz F TITLE Nuclear export of RNA. JOURNAL Biol Cell 96:639-55 (2004) DOI:10.1016/j.biolcel.2004.04.014 REFERENCE PMID:18313922 AUTHORS Palancade B, Doye V TITLE Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties? JOURNAL Trends Cell Biol 18:174-83 (2008) DOI:10.1016/j.tcb.2008.02.001 REFERENCE PMID:15901496 AUTHORS Reed R, Cheng H TITLE TREX, SR proteins and export of mRNA. JOURNAL Curr Opin Cell Biol 17:269-73 (2005) DOI:10.1016/j.ceb.2005.04.011 REFERENCE PMID:16314458 AUTHORS Tange TO, Shibuya T, Jurica MS, Moore MJ TITLE Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. JOURNAL RNA 11:1869-83 (2005) DOI:10.1261/rna.2155905 REFERENCE PMID:28673770 AUTHORS Beck M, Schirmacher P, Singer S TITLE Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies. JOURNAL J Hepatol 67:1051-1061 (2017) DOI:10.1016/j.jhep.2017.06.021 REL_PATHWAY ko03015 mRNA surveillance pathway ///