ENTRY       ko02024                     Pathway
NAME        Quorum sensing
DESCRIPTION Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
CLASS       Cellular Processes; Cellular community - prokaryotes
PATHWAY_MAP ko02024  Quorum sensing
DRUG        D10453  Bezlotoxumab (USAN/INN)
DBLINKS     GO: 0009372
ORTHOLOGY   K00494  luxA; alkanal monooxygenase alpha chain [EC:1.14.14.3]
            K01114  plc; phospholipase C [EC:3.1.4.3]
            K01218  gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78]
            K01318  sspA; glutamyl endopeptidase [EC:3.4.21.19]
            K01364  speB; streptopain [EC:3.4.22.10]
            K01399  lasB; pseudolysin [EC:3.4.24.26]
            K01497  ribA, RIB1; GTP cyclohydrolase II [EC:3.5.4.25]
            K01580  E4.1.1.15, gadB, gadA, GAD; glutamate decarboxylase [EC:4.1.1.15]
            K01626  E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
            K01635  lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40]
            K01657  trpE; anthranilate synthase component I [EC:4.1.3.27]
            K01658  trpG; anthranilate synthase component II [EC:4.1.3.27]
            K01728  pel; pectate lyase [EC:4.2.2.2]
            K01897  ACSL, fadD; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]
            K01995  livG; branched-chain amino acid transport system ATP-binding protein
            K01996  livF; branched-chain amino acid transport system ATP-binding protein
            K01997  livH; branched-chain amino acid transport system permease protein
            K01998  livM; branched-chain amino acid transport system permease protein
            K01999  livK; branched-chain amino acid transport system substrate-binding protein
            K02031  ddpD; peptide/nickel transport system ATP-binding protein
            K02032  ddpF; peptide/nickel transport system ATP-binding protein
            K02033  ABC.PE.P; peptide/nickel transport system permease protein
            K02034  ABC.PE.P1; peptide/nickel transport system permease protein
            K02035  ABC.PE.S; peptide/nickel transport system substrate-binding protein
            K02052  ABC.SP.A; putative spermidine/putrescine transport system ATP-binding protein
            K02053  ABC.SP.P; putative spermidine/putrescine transport system permease protein
            K02054  ABC.SP.P1; putative spermidine/putrescine transport system permease protein
            K02055  ABC.SP.S; putative spermidine/putrescine transport system substrate-binding protein
            K02250  comK; competence protein ComK
            K02251  comQ; competence protein ComQ
            K02252  comS; competence protein ComS
            K02253  comX; competence protein ComX
            K02402  flhC; flagellar transcriptional activator FlhC
            K02403  flhD; flagellar transcriptional activator FlhD
            K02490  spo0F; two-component system, response regulator, stage 0 sporulation protein F
            K03070  secA; preprotein translocase subunit SecA [EC:7.4.2.8]
            K03071  secB; preprotein translocase subunit SecB
            K03073  secE; preprotein translocase subunit SecE
            K03075  secG; preprotein translocase subunit SecG
            K03076  secY; preprotein translocase subunit SecY
            K03106  SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]
            K03110  ftsY; fused signal recognition particle receptor
            K03210  yajC; preprotein translocase subunit YajC
            K03217  yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase
            K03400  luxC; long-chain-fatty-acyl-CoA reductase [EC:1.2.1.50]
            K03666  hfq; host factor-I protein
            K06046  luxE; long-chain-fatty-acid---luciferin-component ligase [EC:6.2.1.19]
            K06352  phrA; phosphatase RapA inhibitor
            K06353  phrC; phosphatase RapC regulator
            K06354  phrE; phosphatase RapE regulator
            K06355  phrF; phosphatase RapF regulator
            K06356  phrG; phosphatase RapG regulator
            K06358  phrK; phosphatase RapK regulator
            K06359  rapA, spo0L; response regulator aspartate phosphatase A (stage 0 sporulation protein L) [EC:3.1.-.-]
            K06360  rapB; response regulator aspartate phosphatase B [EC:3.1.-.-]
            K06361  rapC; response regulator aspartate phosphatase C [EC:3.1.-.-]
            K06363  rapE; response regulator aspartate phosphatase E [EC:3.1.-.-]
            K06364  rapF; response regulator aspartate phosphatase F [EC:3.1.-.-]
            K06365  rapG; response regulator aspartate phosphatase G [EC:3.1.-.-]
            K06366  rapH; response regulator aspartate phosphatase H [EC:3.1.-.-]
            K06369  rapK; response regulator aspartate phosphatase K [EC:3.1.-.-]
            K06375  spo0B; stage 0 sporulation protein B (sporulation initiation phosphotransferase) [EC:2.7.-.-]
            K06998  phzF; trans-2,3-dihydro-3-hydroxyanthranilate isomerase [EC:5.3.3.17]
            K07173  luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]
            K07344  trbL; type IV secretion system protein TrbL
            K07645  qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
            K07666  qseB; two-component system, OmpR family, response regulator QseB
            K07667  kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
            K07680  comP; two-component system, NarL family, sensor histidine kinase ComP [EC:2.7.13.3]
            K07691  comA; two-component system, NarL family, competent response regulator ComA
            K07692  degU; two-component system, NarL family, response regulator DegU
            K07699  spo0A; two-component system, response regulator, stage 0 sporulation protein A
            K07706  agrC, blpH, fsrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
            K07707  agrA, blpR, fsrA; two-component system, LytTR family, response regulator AgrA
            K07711  glrK, qseE; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
            K07715  glrR, qseF; two-component system, NtrC family, response regulator GlrR
            K07781  rcsA; LuxR family transcriptional regulator, capsular biosynthesis positive transcription factor
            K07782  sdiA; LuxR family transcriptional regulator, quorum-sensing system regulator SdiA
            K07800  agrD; AgrD protein
            K07813  agrB; accessory gene regulator B
            K08321  lsrF; 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase [EC:2.3.1.245]
            K08605  gelE; coccolysin [EC:3.4.24.30]
            K08642  lasA; LasA protease [EC:3.4.24.-]
            K08777  nprB; neutral peptidase B [EC:3.4.24.-]
            K09823  zur; Fur family transcriptional regulator, zinc uptake regulator
            K09936  TC.BAT2; bacterial/archaeal transporter family-2 protein
            K10555  lsrB; AI-2 transport system substrate-binding protein
            K10556  lsrC; AI-2 transport system permease protein
            K10557  lsrD; AI-2 transport system permease protein
            K10558  lsrA, ego; AI-2 transport system ATP-binding protein
            K10715  rpfC; two-component system, sensor histidine kinase RpfC [EC:2.7.13.3]
            K10823  oppF; oligopeptide transport system ATP-binding protein
            K10909  luxQ; two-component system, autoinducer 2 sensor kinase/phosphatase LuxQ [EC:2.7.13.3 3.1.3.-]
            K10910  luxP; autoinducer 2-binding periplasmic protein LuxP
            K10911  luxU; two-component system, phosphorelay protein LuxU
            K10912  luxO; two-component system, repressor protein LuxO
            K10913  hapR, luxR, litR; TetR/AcrR family transcriptional regulator, hemagglutinin/protease regulatory protein
            K10914  crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
            K10915  cqsA; CAI-1 autoinducer synthase [EC:2.3.-.-]
            K10916  cqsS; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-]
            K10917  aphA; PadR family transcriptional regulator, regulatory protein AphA
            K11006  stxA; shiga toxin subunit A
            K11007  stxB; shiga toxin subunit B
            K11031  slo; thiol-activated cytolysin
            K11033  nheA; non-hemolytic enterotoxin A
            K11034  nheBC; non-hemolytic enterotoxin B/C
            K11035  hblAB; hemolysin BL binding component
            K11036  hblC; hemolysin BL lytic component L2
            K11037  hblD; hemolysin BL lytic component L1
            K11039  hld; delta-hemolysin
            K11063  tcdAB; toxin A/B
            K11216  lsrK; autoinducer-2 kinase [EC:2.7.1.189]
            K11530  lsrG; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase [EC:5.3.1.32]
            K11531  lsrR; lsr operon transcriptional repressor
            K11752  ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]
            K12257  secDF; SecD/SecF fusion protein
            K12292  comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
            K12293  comB; competence factor transport accessory protein ComB
            K12294  comD; two-component system, LytTR family, sensor histidine kinase ComD [EC:2.7.13.3]
            K12295  comE; two-component system, LytTR family, response regulator ComE
            K12296  comX1_2; competence protein ComX
            K12415  comC; competence-stimulating peptide
            K12789  tccP; Tir-cytoskeleton coupling protein
            K12990  rfbF, rhlC; rhamnosyltransferase [EC:2.4.1.-]
            K13060  lasI; acyl homoserine lactone synthase [EC:2.3.1.184]
            K13061  rhlI, phzI, solI, cepI, tofI; acyl homoserine lactone synthase [EC:2.3.1.184]
            K13062  ainS, luxM; acyl homoserine lactone synthase [EC:2.3.1.184]
            K13063  phzE; 2-amino-4-deoxychorismate synthase [EC:2.6.1.86]
            K13075  ahlD, aiiA, attM, blcC; N-acyl homoserine lactone hydrolase [EC:3.1.1.81]
            K13815  rpfG; two-component system, response regulator RpfG
            K13816  rpfF; DSF synthase
            K14051  gmr, pdeR; c-di-GMP phosphodiesterase Gmr [EC:3.1.4.52]
            K14645  K14645; serine protease [EC:3.4.21.-]
            K14982  ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
            K14983  ciaR; two-component system, OmpR family, response regulator CiaR
            K15580  oppA, mppA; oligopeptide transport system substrate-binding protein
            K15581  oppB; oligopeptide transport system permease protein
            K15582  oppC; oligopeptide transport system permease protein
            K15583  oppD; oligopeptide transport system ATP-binding protein
            K15654  srfAA, licA, lchAA; surfactin/lichenysin synthetase A
            K15655  srfAB, licB, lchAB; surfactin/lichenysin synthetase B
            K15656  srfAC, licC, lchAC; surfactin/lichenysin synthetase C
            K15657  srfATE, srfAD, lchAD; external thioesterase TEII
            K15850  luxN; two-component system, autoinducer 1 sensor kinase/phosphatase LuxN [EC:2.7.13.3 3.1.3.-]
            K15851  qrr; quorum regulatory RNA Qrr
            K15852  luxR, vanR; LuxR family transcriptional regulator, transcriptional activator of the bioluminescence operon
            K15853  luxD; acyl transferase [EC:2.3.1.-]
            K15854  luxB; alkanal monooxygenase beta chain [EC:1.14.14.3]
            K16619  plc, cpa; phospholipase C / alpha-toxin [EC:3.1.4.3]
            K17940  pqsH; 2-heptyl-3-hydroxy-4(1H)-quinolone synthase [EC:1.14.13.182]
            K18000  pqsA; anthranilate-CoA ligase [EC:6.2.1.32]
            K18001  pqsB; 2-heptyl-4(1H)-quinolone synthase subunit PqsB [EC:2.3.1.230]
            K18002  pqsC; 2-heptyl-4(1H)-quinolone synthase subunit PqsC [EC:2.3.1.230]
            K18003  pqsD; anthraniloyl-CoA anthraniloyltransferase [EC:2.3.1.262]
            K18096  bjaI, rpaI, braI, rhiI; acyl-homoserine lactone synthase [EC:2.3.1.228 2.3.1.229 2.3.1.-]
            K18098  bjaR1, rpaR, rhiR; LuxR family transcriptional regulator, quorum-sensing system regulator BjaR1
            K18099  rhlR, phzR; LuxR family transcriptional regulator, quorum-sensing system regulator RhlR
            K18100  rhlA; rhamnosyltransferase subunit A [EC:2.4.1.-]
            K18101  rhlB; rhamnosyltransferase subunit B [EC:2.4.1.-]
            K18139  oprM, emhC, ttgC, cusC, adeK, smeF, mtrE, cmeC, gesC; outer membrane protein, multidrug efflux system
            K18304  lasR; LuxR family transcriptional regulator, quorum-sensing system regulator LasR
            K18306  mexH; membrane fusion protein, multidrug efflux system
            K18307  mexI; multidrug efflux pump
            K18315  cpmC, carC; (5R)-carbapenem-3-carboxylate synthase [EC:1.14.20.3]
            K18316  cpmA, carA; carbapenam-3-carboxylate synthase [EC:6.3.3.6]
            K18317  cpmB, carB; carboxymethylproline synthase [EC:2.3.1.226]
            K18318  cpmD, carD; carbapenem biosynthesis protein, putative proline dehydrogenase [EC:1.5.-.-]
            K18319  cpmE, carE; carbapenem biosynthesis protein CpmE
            K19666  solR, cepR, tofR; LuxR family transcriptional regulator, quorum-sensing system regulator SolR
            K19731  cciR; LuxR family transcriptional regulator, quorum-sensing system regulator CciR
            K19732  traR; LuxR family transcriptional regulator, activator of conjugal transfer of Ti plasmids
            K19733  sinR, avsR; LuxR family transcriptional regulator, quorum-sensing system regulator SinR
            K19734  expR; LuxR family transcriptional regulator, quorum-sensing system regulator ExpR
            K19735  mvfR, pqsR; LysR family transcriptional regulator, quorum-sensing system regulator MvfR
            K20086  vioA; tryptophan oxidase VioA [EC:1.4.3.-]
            K20087  vioB; violacein biosynthesis protein VioB
            K20088  vioE; violacein biosynthesis protein VioE
            K20089  vioD; protodeoxyviolaceinate monooxygenase [EC:1.14.13.217]
            K20090  vioC; violacein synthase [EC:1.14.13.224]
            K20248  cinI; acyl homoserine lactone synthase [EC:2.3.1.184]
            K20249  raiI; acyl homoserine lactone synthase [EC:2.3.1.184]
            K20250  cciI; acyl homoserine lactone synthase [EC:2.3.1.184]
            K20252  cinR; LuxR family transcriptional regulator, quorum-sensing system regulator CinR
            K20253  bisR; LuxR family transcriptional regulator, quorum-sensing system regulator BisR
            K20256  luxG; flavin reductase [EC:1.-.-.-]
            K20257  pqsE; 2-aminobenzoylacetyl-CoA thioesterase [EC:3.1.2.32]
            K20258  lecA; PA-I galactophilic lectin
            K20259  lecB; PA-IIL fucose-binding lectin
            K20260  phzA_B; phenazine biosynthesis protein
            K20261  phzD; trans-2,3-dihydro-3-hydroxyanthranilic acid synthase [EC:3.3.2.15]
            K20262  phzG; dihydrophenazinedicarboxylate synthase [EC:1.10.3.16]
            K20263  fusK; two-component system, NarL family, sensor histidine kinase FusK [EC:2.7.13.3]
            K20264  fusR; two-component system, NarL family, response regulator FusR
            K20265  gadC; glutamate:GABA antiporter
            K20266  trbJ; type IV secretion system protein TrbJ
            K20267  trbH; type IV secretion system protein TrbH
            K20268  rhiA; rhizosphere induced protein
            K20269  rhiB; rhizosphere induced protein
            K20270  rhiC; rhizosphere induced protein
            K20271  accR; DeoR family transcriptional regulator, repressor of opine catabolism and conjugal transfer
            K20272  traM; TraR antiactivator
            K20273  zmpA; zinc metalloprotease ZmpA
            K20274  zmpB; zinc metalloprotease ZmpB
            K20275  aidA; nematocidal protein AidA
            K20276  bapA; large repetitive protein
            K20277  bcl; mannose-binding lectin
            K20321  nlmA; mutacin IV
            K20322  nlmB; mutacin IV
            K20323  nlmC, cipB; mutacin V
            K20324  nlmD; mutacin VI
            K20325  fhrR; TetR/AcrR family transcriptional regulator, Clp-modulated transcription factor
            K20326  xagA; protein XagA
            K20327  xagB; glycosyltransferase XagB
            K20328  xagC; membrane protein XagC
            K20329  qsmR; IclR family transcriptional regulator, positive regulator for flagellar biogenesis
            K20330  toxJ; LuxR family transcriptional regulator, activator of tox operons
            K20331  toxA; toxoflavin synthase [EC:2.1.1.349]
            K20332  toxC; toxoflavin biosynthesis protein ToxC
            K20333  toxD; toxoflavin biosynthesis protein ToxD
            K20334  cviR; LuxR family transcriptional regulator, quorum-sensing system regulator CviR
            K20335  psmA1_2; phenol-soluble modulin alpha 1/2
            K20336  psmA3; phenol-soluble modulin alpha 3
            K20337  psmB; phenol-soluble modulin beta
            K20338  rot; MarR family transcriptional regulator, global regulator for virulence
            K20339  agrC2; two-component system, LytTR family, sensor histidine kinase AgrC2 [EC:2.7.13.3]
            K20340  agrA2; two-component system, LytTR family, response regulator AgrA2
            K20341  blpL, cipI; immunity protein
            K20342  comR; HTH-type transcriptional regulator, regulator for ComX
            K20343  blpC; peptide pheromone BlpC
            K20344  blpA, lagD; ATP-binding cassette, subfamily C, bacteriocin exporter
            K20345  blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter
            K20373  rgg2; HTH-type transcriptional regulator, SHP2-responsive activator
            K20374  rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor
            K20375  ropB, rgg1; HTH-type transcriptional regulator, pheromone-responsive regulator
            K20376  prgQ; peptide inhibitor iCF10
            K20377  prgX; HTH-type transcriptional regulator, major conjugation operon repressor
            K20378  iad1; sex pheromone inhibitor iAD1
            K20379  cad; sex pheromone cAD1
            K20380  traA; HTH-type transcriptional regulator, pheromone-responsive repressor
            K20381  traE1; regulatory protein
            K20382  asa1; aggregation substance
            K20383  cylLL; CylL-L protein
            K20384  cylLS; CylL-S protein
            K20385  cylM; CylM protein
            K20386  cylB; ATP-binding cassette, subfamily B, bacterial CylB
            K20387  cylR1; regulatory protein CylR1
            K20388  cylR2; HTH-type transcriptional regulator, cytolysin regulator
            K20389  phrH; phosphatase RapH regulator
            K20390  papR; regulatory peptide PapR
            K20391  plcR; HTH-type transcriptional regulator, pleiotropic regulator of extracellular virulence genes
            K20480  nprR, nprA; HTH-type transcriptional regulator, quorum sensing regulator NprR
            K20481  nprX, nprRB; regulatory peptide NprX
            K20482  nisA, spaS, epiA; lantibiotic bacteriocin
            K20483  lanB, nisB, spaB, epiB; class I lanthipeptide synthase [EC:3.13.2.4]
            K20484  lanC, nisC, spaC, epiC; class I lanthipeptide synthase [EC:3.13.2.4]
            K20485  nisT, spaT; ATP-binding cassette, subfamily B, bacterial NisT/SpaT
            K20486  nisP, epiP; lantibiotic leader peptide-processing serine protease [EC:3.4.21.-]
            K20487  nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3]
            K20488  nisR, spaR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR
            K20489  nisI; lantibiotic immunity protein
            K20490  nisF, spaF, cprA, epiF; lantibiotic transport system ATP-binding protein
            K20491  nisE, spaE, cprB, epiE; lantibiotic transport system permease protein
            K20492  nisG, spaG, cprC; lantibiotic transport system permease protein
            K20494  epiG; lantibiotic transport system permease protein
            K20527  trbB; type IV secretion system protein TrbB [EC:7.4.2.8]
            K20528  trbC; type IV secretion system protein TrbC
            K20529  trbD; type IV secretion system protein TrbD
            K20530  trbE; type IV secretion system protein TrbE [EC:7.4.2.8]
            K20531  trbF; type IV secretion system protein TrbF
            K20532  trbG; type IV secretion system protein TrbG
            K20533  trbI; type IV secretion system protein TrbI
            K20539  blcR; IclR family transcriptional regulator, blcABC operon repressor
            K20540  cepR2; LuxR family transcriptional regulator, quorum-sensing system regulator CepR2
            K20552  ler; transcriptional regulator of LEE operons
            K20554  rnaIII; small regulatory RNA RNAIII
            K20555  trbK; type IV secretion system protein TrbK
            K22954  luxI; acyl homoserine lactone synthase
            K22955  traI, avsI; acyl homoserine lactone synthase
            K22956  expI, esaI; acyl homoserine lactone synthase
            K22957  cviI; acyl homoserine lactone synthase
            K22968  sinI, avsI; acyl homoserine lactone synthase
            K23133  comC; competence-stimulating peptide
            K25873  raiR; LuxR family transcriptional regulator, quorum-sensing system regulator RaiR
COMPOUND    C00007  Oxygen
            C00009  Orthophosphate
            C00059  Sulfate
            C00232  Succinate semialdehyde
            C00334  4-Aminobutanoate
            C00547  L-Noradrenaline
            C00788  L-Adrenaline
            C01019  L-Fucose
            C11837  N-Butyryl-L-homoserine lactone
            C11841  N-(3-Oxooctanoyl)homoserine lactone
            C11844  N-Heptanoylhomoserine lactone
            C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
            C11848  2-Heptyl-3-hydroxy-quinolone
            C16421  AI-2
            C16463  3',5'-Cyclic diGMP
            C16640  CAI-1
            C18049  N-Acyl-L-homoserine lactone
            C18206  cis-11-Methyl-2-dodecenoic acid
            C20643  2-Heptyl-4(1H)-quinolone
            C20677  N-(4-Coumaroyl)-L-homoserine lactone
            C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
            C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
            C21197  N-Hexanoyl-L-homoserine lactone
            C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
            C21199  N-Octanoyl-L-homoserine lactone
            C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
            C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
            C21202  cis-2-Dodecenoic acid
            C21220  AIP-1
            C21221  CSP
            C21222  CSP
            C21223  Blp
            C21224  SHP2
            C21225  SHP3
            C21226  cCF10
            C21227  iCF10
            C21228  cAD1
            C21229  iAD1
            C21230  ComX pheromone
            C21231  PhrA pentapeptide
            C21232  PhrC pentapeptide
            C21233  PhrE pentapeptide
            C21234  PhrF pentapeptide
            C21235  PhrG pentapeptide
            C21236  PhrH pentapeptide
            C21237  PhrK pentapeptide
            C21238  NprX peptide
            C21239  PapR peptide
            C21241  AIP-2
            C21242  AIP-3
            C21243  AIP-4
            C21244  AgrD peptide
            C21245  AgrD1 peptide
            C21246  GBAP
            C21382  R-THMF
REFERENCE   PMID:22712853
  AUTHORS   Pereira CS, Thompson JA, Xavier KB
  TITLE     AI-2-mediated signalling in bacteria.
  JOURNAL   FEMS Microbiol Rev 37:156-81 (2013)
            DOI:10.1111/j.1574-6976.2012.00345.x
REFERENCE   PMID:23965960
  AUTHORS   Verma SC, Miyashiro T
  TITLE     Quorum sensing in the squid-Vibrio symbiosis.
  JOURNAL   Int J Mol Sci 14:16386-401 (2013)
            DOI:10.3390/ijms140816386
REFERENCE   PMID:24348467
  AUTHORS   Norsworthy AN, Visick KL
  TITLE     Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
  JOURNAL   Front Microbiol 4:356 (2013)
            DOI:10.3389/fmicb.2013.00356
REFERENCE   PMID:24065108
  AUTHORS   Papaioannou E, Utari PD, Quax WJ
  TITLE     Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
  JOURNAL   Int J Mol Sci 14:19309-40 (2013)
            DOI:10.3390/ijms140919309
REFERENCE   PMID:20738404
  AUTHORS   Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
  TITLE     Quinolones: from antibiotics to autoinducers.
  JOURNAL   FEMS Microbiol Rev 35:247-74 (2011)
            DOI:10.1111/j.1574-6976.2010.00247.x
REFERENCE   PMID:25866808
  AUTHORS   Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
  TITLE     The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
  JOURNAL   Biomed Res Int 2015:759348 (2015)
            DOI:10.1155/2015/759348
REFERENCE   PMID:11544214
  AUTHORS   Whiteley M, Greenberg EP
  TITLE     Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
  JOURNAL   J Bacteriol 183:5529-34 (2001)
            DOI:10.1128/JB.183.19.5529-5534.2001
REFERENCE   PMID:11497469
  AUTHORS   Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
  TITLE     Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
  JOURNAL   Mol Plant Microbe Interact 14:969-79 (2001)
            DOI:10.1094/MPMI.2001.14.8.969
REFERENCE   PMID:19696934
  AUTHORS   Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  TITLE     The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  JOURNAL   PLoS Pathog 5:e1000553 (2009)
            DOI:10.1371/journal.ppat.1000553
REFERENCE   PMID:22144490
  AUTHORS   Njoroge J, Sperandio V
  TITLE     Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  JOURNAL   Infect Immun 80:688-703 (2012)
            DOI:10.1128/IAI.05921-11
REFERENCE   PMID:23160491
  AUTHORS   Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  TITLE     Fucose sensing regulates bacterial intestinal colonization.
  JOURNAL   Nature 492:113-7 (2012)
            DOI:10.1038/nature11623
REFERENCE   PMID:22778415
  AUTHORS   Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  TITLE     Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  JOURNAL   Proc Natl Acad Sci U S A 109:12141-6 (2012)
            DOI:10.1073/pnas.1200243109
REFERENCE   PMID:14617175
  AUTHORS   Danino VE, Wilkinson A, Edwards A, Downie JA
  TITLE     Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  JOURNAL   Mol Microbiol 50:511-25 (2003)
            DOI:10.1046/j.1365-2958.2003.03699.x
REFERENCE   PMID:12448738
  AUTHORS   Wisniewski-Dye F, Downie JA
  TITLE     Quorum-sensing in Rhizobium.
  JOURNAL   Antonie Van Leeuwenhoek 81:397-407 (2002)
            DOI:10.1023/A:1020501104051
REFERENCE   PMID:10368158
  AUTHORS   Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  TITLE     Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  JOURNAL   J Bacteriol 181:3816-23 (1999)
            DOI:10.1128/JB.181.12.3816-3823.1999
REFERENCE   PMID:24550924
  AUTHORS   Lang J, Faure D
  TITLE     Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  JOURNAL   Front Plant Sci 5:14 (2014)
            DOI:10.3389/fpls.2014.00014
REFERENCE   PMID:23710277
  AUTHORS   Planamente S, Morera S, Faure D
  TITLE     In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
  JOURNAL   Commun Integr Biol 6:e23692 (2013)
            DOI:10.4161/cib.23692
REFERENCE   PMID:16943991
  AUTHORS   Barnard AM, Salmond GP
  TITLE     Quorum sensing in Erwinia species.
  JOURNAL   Anal Bioanal Chem 387:415-23 (2007)
            DOI:10.1007/s00216-006-0701-1
REFERENCE   PMID:17360277
  AUTHORS   Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
  TITLE     Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
            DOI:10.1098/rstb.2007.2042
REFERENCE   PMID:19843225
  AUTHORS   Carlier A, Burbank L, von Bodman SB
  TITLE     Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
  JOURNAL   Mol Microbiol 74:903-13 (2009)
            DOI:10.1111/j.1365-2958.2009.06906.x
REFERENCE   PMID:7665477
  AUTHORS   Beck von Bodman S, Farrand SK
  TITLE     Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
  JOURNAL   J Bacteriol 177:5000-8 (1995)
            DOI:10.1128/JB.177.17.5000-5008.1995
REFERENCE   PMID:19761612
  AUTHORS   O'Grady EP, Viteri DF, Malott RJ, Sokol PA
  TITLE     Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
  JOURNAL   BMC Genomics 10:441 (2009)
            DOI:10.1186/1471-2164-10-441
REFERENCE   PMID:16041013
  AUTHORS   Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
  TITLE     Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
  JOURNAL   Infect Immun 73:4982-92 (2005)
            DOI:10.1128/IAI.73.8.4982-4992.2005
REFERENCE   PMID:22949660
  AUTHORS   Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
  TITLE     Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
  JOURNAL   Proc Natl Acad Sci U S A 109:15479-84 (2012)
            DOI:10.1073/pnas.1205037109
REFERENCE   PMID:23799665
  AUTHORS   Suppiger A, Schmid N, Aguilar C, Pessi G, Eberl L
  TITLE     Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.
  JOURNAL   Virulence 4:400-9 (2013)
            DOI:10.4161/viru.25338
REFERENCE   PMID:21166386
  AUTHORS   Deng Y, Wu J, Tao F, Zhang LH
  TITLE     Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria.
  JOURNAL   Chem Rev 111:160-73 (2011)
            DOI:10.1021/cr100354f
REFERENCE   PMID:21227698
  AUTHORS   Ryan RP, Dow JM
  TITLE     Communication with a growing family: diffusible signal factor (DSF) signaling in bacteria.
  JOURNAL   Trends Microbiol 19:145-52 (2011)
            DOI:10.1016/j.tim.2010.12.003
REFERENCE   PMID:15522077
  AUTHORS   Kim J, Kim JG, Kang Y, Jang JY, Jog GJ, Lim JY, Kim S, Suga H, Nagamatsu T, Hwang I
  TITLE     Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.
  JOURNAL   Mol Microbiol 54:921-34 (2004)
            DOI:10.1111/j.1365-2958.2004.04338.x
REFERENCE   PMID:17376080
  AUTHORS   Kim J, Kang Y, Choi O, Jeong Y, Jeong JE, Lim JY, Kim M, Moon JS, Suga H, Hwang I
  TITLE     Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae.
  JOURNAL   Mol Microbiol 64:165-79 (2007)
            DOI:10.1111/j.1365-2958.2007.05646.x
REFERENCE   PMID:21622734
  AUTHORS   Stauff DL, Bassler BL
  TITLE     Quorum sensing in Chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor.
  JOURNAL   J Bacteriol 193:3871-8 (2011)
            DOI:10.1128/JB.05125-11
REFERENCE   PMID:21504831
  AUTHORS   Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM
  TITLE     A strategy for antagonizing quorum sensing.
  JOURNAL   Mol Cell 42:199-209 (2011)
            DOI:10.1016/j.molcel.2011.04.003
REFERENCE   PMID:16513747
  AUTHORS   Hao G, Burr TJ
  TITLE     Regulation of long-chain N-acyl-homoserine lactones in Agrobacterium vitis.
  JOURNAL   J Bacteriol 188:2173-83 (2006)
            DOI:10.1128/JB.188.6.2173-2183.2006
REFERENCE   PMID:20514483
  AUTHORS   Savka MA, Le PT, Burr TJ
  TITLE     LasR receptor for detection of long-chain quorum-sensing signals: identification of N-acyl-homoserine lactones encoded by the avsI locus of Agrobacterium vitis.
  JOURNAL   Curr Microbiol 62:101-10 (2011)
            DOI:10.1007/s00284-010-9679-1
REFERENCE   PMID:26579084
  AUTHORS   Le KY, Otto M
  TITLE     Quorum-sensing regulation in staphylococci-an overview.
  JOURNAL   Front Microbiol 6:1174 (2015)
            DOI:10.3389/fmicb.2015.01174
REFERENCE   PMID:18851841
  AUTHORS   Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M
  TITLE     RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus.
  JOURNAL   Mol Cell 32:150-8 (2008)
            DOI:10.1016/j.molcel.2008.08.005
REFERENCE   PMID:25714717
  AUTHORS   Darkoh C, DuPont HL, Norris SJ, Kaplan HB
  TITLE     Toxin synthesis by Clostridium difficile is regulated through quorum signaling.
  JOURNAL   MBio 6:e02569 (2015)
            DOI:10.1128/mBio.02569-14
REFERENCE   PMID:25824838
  AUTHORS   Vidal JE, Shak JR, Canizalez-Roman A
  TITLE     The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms.
  JOURNAL   Infect Immun 83:2430-42 (2015)
            DOI:10.1128/IAI.00240-15
REFERENCE   PMID:19363118
  AUTHORS   Ohtani K, Yuan Y, Hassan S, Wang R, Wang Y, Shimizu T
  TITLE     Virulence gene regulation by the agr system in Clostridium perfringens.
  JOURNAL   J Bacteriol 191:3919-27 (2009)
            DOI:10.1128/JB.01455-08
REFERENCE   PMID:22736963
  AUTHORS   Li YH, Tian X
  TITLE     Quorum sensing and bacterial social interactions in biofilms.
  JOURNAL   Sensors (Basel) 12:2519-38 (2012)
            DOI:10.3390/s120302519
REFERENCE   PMID:22407687
  AUTHORS   Berg KH, Biornstad TJ, Johnsborg O, Havarstein LS
  TITLE     Properties and biological role of streptococcal fratricins.
  JOURNAL   Appl Environ Microbiol 78:3515-22 (2012)
            DOI:10.1128/AEM.00098-12
REFERENCE   PMID:25475081
  AUTHORS   Conrads G, de Soet JJ, Song L, Henne K, Sztajer H, Wagner-Dobler I, Zeng AP
  TITLE     Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level.
  JOURNAL   J Oral Microbiol 6:26189 (2014)
            DOI:10.3402/jom.v6.26189
REFERENCE   PMID:25309879
  AUTHORS   Jimenez JC, Federle MJ
  TITLE     Quorum sensing in group A Streptococcus.
  JOURNAL   Front Cell Infect Microbiol 4:127 (2014)
            DOI:10.3389/fcimb.2014.00127
REFERENCE   PMID:24118108
  AUTHORS   Cook LC, Federle MJ
  TITLE     Peptide pheromone signaling in Streptococcus and Enterococcus.
  JOURNAL   FEMS Microbiol Rev 38:473-92 (2014)
            DOI:10.1111/1574-6976.12046
REFERENCE   PMID:9680220
  AUTHORS   Podbielski A, Leonard BA
  TITLE     The group A streptococcal dipeptide permease (Dpp) is involved in the uptake of essential amino acids and affects the expression of cysteine protease.
  JOURNAL   Mol Microbiol 28:1323-34 (1998)
            DOI:10.1046/j.1365-2958.1998.00898.x
REFERENCE   PMID:8885277
  AUTHORS   Podbielski A, Pohl B, Woischnik M, Korner C, Schmidt KH, Rozdzinski E, Leonard BA
  TITLE     Molecular characterization of group A streptococcal (GAS) oligopeptide permease (opp) and its effect on cysteine protease production.
  JOURNAL   Mol Microbiol 21:1087-99 (1996)
            DOI:10.1046/j.1365-2958.1996.661421.x
REFERENCE   PMID:22636768
  AUTHORS   Anbalagan S, Dmitriev A, McShan WM, Dunman PM, Chaussee MS
  TITLE     Growth phase-dependent modulation of Rgg binding specificity in Streptococcus pyogenes.
  JOURNAL   J Bacteriol 194:3961-71 (2012)
            DOI:10.1128/JB.06709-11
REFERENCE   PMID:22016844
  AUTHORS   Clewell DB
  TITLE     Tales of conjugation and sex pheromones: A plasmid and enterococcal odyssey.
  JOURNAL   Mob Genet Elements 1:38-54 (2011)
            DOI:10.4161/mge.1.1.15409
REFERENCE   PMID:20734751
  AUTHORS   Wardal E, Sadowy E, Hryniewicz W
  TITLE     Complex nature of enterococcal pheromone-responsive plasmids.
  JOURNAL   Pol J Microbiol 59:79-87 (2010)
REFERENCE   PMID:19683678
  AUTHORS   Roux A, Payne SM, Gilmore MS
  TITLE     Microbial telesensing: probing the environment for friends, foes, and food.
  JOURNAL   Cell Host Microbe 6:115-24 (2009)
            DOI:10.1016/j.chom.2009.07.004
REFERENCE   PMID:25089349
  AUTHORS   Slamti L, Perchat S, Huillet E, Lereclus D
  TITLE     Quorum sensing in Bacillus thuringiensis is required for completion of a full infectious cycle in the insect.
  JOURNAL   Toxins (Basel) 6:2239-55 (2014)
            DOI:10.3390/toxins6082239
REFERENCE   PMID:20030732
  AUTHORS   Lopez D, Kolter R
  TITLE     Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis.
  JOURNAL   FEMS Microbiol Rev 34:134-49 (2010)
            DOI:10.1111/j.1574-6976.2009.00199.x
REFERENCE   PMID:12897006
  AUTHORS   Stephenson S, Mueller C, Jiang M, Perego M
  TITLE     Molecular analysis of Phr peptide processing in Bacillus subtilis.
  JOURNAL   J Bacteriol 185:4861-71 (2003)
            DOI:10.1128/JB.185.16.4861-4871.2003
REFERENCE   PMID:17666034
  AUTHORS   Lanigan-Gerdes S, Dooley AN, Faull KF, Lazazzera BA
  TITLE     Identification of subtilisin, Epr and Vpr as enzymes that produce CSF, an extracellular signalling peptide of Bacillus subtilis.
  JOURNAL   Mol Microbiol 65:1321-33 (2007)
            DOI:10.1111/j.1365-2958.2007.05869.x
REFERENCE   PMID:15374644
  AUTHORS   Kleerebezem M
  TITLE     Quorum sensing control of lantibiotic production; nisin and subtilin autoregulate their own biosynthesis.
  JOURNAL   Peptides 25:1405-14 (2004)
            DOI:10.1016/j.peptides.2003.10.021
REFERENCE   PMID:23125205
  AUTHORS   Rutherford ST, Bassler BL
  TITLE     Bacterial quorum sensing: its role in virulence and possibilities for its control.
  JOURNAL   Cold Spring Harb Perspect Med 2:a012427 (2012)
            DOI:10.1101/cshperspect.a012427
REFERENCE   PMID:23471618
  AUTHORS   LaSarre B, Federle MJ
  TITLE     Exploiting quorum sensing to confuse bacterial pathogens.
  JOURNAL   Microbiol Mol Biol Rev 77:73-111 (2013)
            DOI:10.1128/MMBR.00046-12
REFERENCE   PMID:18781869
  AUTHORS   Sifri CD
  TITLE     Healthcare epidemiology: quorum sensing: bacteria talk sense.
  JOURNAL   Clin Infect Dis 47:1070-6 (2008)
            DOI:10.1086/592072
REL_PATHWAY ko00405  Phenazine biosynthesis
            ko02040  Flagellar assembly
            ko05130  Pathogenic Escherichia coli infection
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