ENTRY ko02020 Pathway NAME Two-component system DESCRIPTION Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription. CLASS Environmental Information Processing; Signal transduction PATHWAY_MAP ko02020 Two-component system MODULE M00651 Vancomycin resistance, D-Ala-D-Lac type [PATH:ko02020] M00652 Vancomycin resistance, D-Ala-D-Ser type [PATH:ko02020] DBLINKS GO: 0000160 ORTHOLOGY K00027 ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38] K00066 algD; GDP-mannose 6-dehydrogenase [EC:1.1.1.132] K00244 frdA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1] K00245 frdB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1] K00246 frdC; succinate dehydrogenase subunit C K00247 frdD; succinate dehydrogenase subunit D K00370 narG, narZ, nxrA; nitrate reductase / nitrite oxidoreductase, alpha subunit [EC:1.7.5.1 1.7.99.-] K00371 narH, narY, nxrB; nitrate reductase / nitrite oxidoreductase, beta subunit [EC:1.7.5.1 1.7.99.-] K00373 narJ, narW; nitrate reductase molybdenum cofactor assembly chaperone NarJ/NarW K00374 narI, narV; nitrate reductase gamma subunit [EC:1.7.5.1 1.7.99.-] K00404 ccoN; cytochrome c oxidase cbb3-type subunit I [EC:7.1.1.9] K00405 ccoO; cytochrome c oxidase cbb3-type subunit II K00406 ccoP; cytochrome c oxidase cbb3-type subunit III K00407 ccoQ; cytochrome c oxidase cbb3-type subunit IV K00410 fbcH; ubiquinol-cytochrome c reductase cytochrome b/c1 subunit K00411 UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8] K00412 CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit K00413 CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit K00424 cydX; cytochrome bd-I ubiquinol oxidase subunit X [EC:7.1.1.7] K00425 cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7] K00426 cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7] K00494 luxA; alkanal monooxygenase alpha chain [EC:1.14.14.3] K00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80] K00626 ACAT, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] K00689 E2.4.1.5; dextransucrase [EC:2.4.1.5] K00692 sacB; levansucrase [EC:2.4.1.10] K00990 glnD; [protein-PII] uridylyltransferase [EC:2.7.7.59] K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] K01051 E3.1.1.11; pectinesterase [EC:3.1.1.11] K01077 E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1] K01113 phoD; alkaline phosphatase D [EC:3.1.3.1] K01179 E3.2.1.4; endoglucanase [EC:3.2.1.4] K01425 glsA, GLS; glutaminase [EC:3.5.1.2] K01467 ampC; beta-lactamase class C [EC:3.5.2.6] K01545 kdpF; potassium-transporting ATPase KdpF subunit K01546 kdpA; potassium-transporting ATPase potassium-binding subunit K01547 kdpB; potassium-transporting ATPase ATP-binding subunit [EC:7.2.2.6] K01548 kdpC; potassium-transporting ATPase KdpC subunit K01643 citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10] K01644 citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34] K01646 citD; citrate lyase subunit gamma (acyl carrier protein) K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] K01910 citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22] K01915 glnA, GLUL; glutamine synthetase [EC:6.3.1.2] K01991 wza, gfcE; polysaccharide biosynthesis/export protein K02040 pstS; phosphate transport system substrate-binding protein K02106 atoE; short-chain fatty acids transporter K02252 comS; competence protein ComS K02253 comX; competence protein ComX K02259 COX15, ctaA; heme a synthase [EC:1.17.99.9] K02279 cpaB, rcpC; pilus assembly protein CpaB K02280 cpaC, rcpA; pilus assembly protein CpaC K02282 cpaE, tadZ; pilus assembly protein CpaE K02283 cpaF, tadA; pilus assembly protein CpaF [EC:7.4.2.8] K02313 dnaA; chromosomal replication initiator protein K02398 flgM; negative regulator of flagellin synthesis FlgM K02402 flhC; flagellar transcriptional activator FlhC K02403 flhD; flagellar transcriptional activator FlhD K02405 fliA, whiG; RNA polymerase sigma factor FliA K02406 fliC, hag; flagellin K02472 wecC; UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [EC:1.1.1.336] K02488 pleD; two-component system, cell cycle response regulator [EC:2.7.7.65] K02489 hk1; two-component system, glycerol uptake and utilization sensor kinase [EC:2.7.13.3] K02490 spo0F; two-component system, response regulator, stage 0 sporulation protein F K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3] K02556 motA; chemotaxis protein MotA K02584 nifA; Nif-specific regulatory protein K02650 pilA; type IV pilus assembly protein PilA K02651 flp, pilA; pilus assembly protein Flp/PilA K02657 pilG; twitching motility two-component system response regulator PilG K02658 pilH; twitching motility two-component system response regulator PilH K02659 pilI; twitching motility protein PilI K02660 pilJ; twitching motility protein PilJ K02661 pilK; type IV pilus assembly protein PilK K02667 pilR, pehR; two-component system, NtrC family, response regulator PilR K02668 pilS, pehS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3] K03092 rpoN; RNA polymerase sigma-54 factor K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] K03400 luxC; long-chain-fatty-acyl-CoA reductase [EC:1.2.1.50] K03406 mcp; methyl-accepting chemotaxis protein K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] K03408 cheW; purine-binding chemotaxis protein CheW K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV K03532 torC; trimethylamine-N-oxide reductase (cytochrome c), cytochrome c-type subunit TorC K03533 torD; TorA specific chaperone K03563 csrA; carbon storage regulator K03620 hyaC; Ni/Fe-hydrogenase 1 B-type cytochrome subunit K03739 dltB; membrane protein involved in D-alanine export K03740 dltD; D-alanine transfer protein K03776 aer; aerotaxis receptor K04751 glnB; nitrogen regulatory protein P-II 1 K04771 degP, htrA; serine protease Do [EC:3.4.21.107] K05338 lrgA; holin-like protein K05339 lrgB; holin-like protein LrgB K05597 aspQ, ansB, ansA; glutamin-(asparagin-)ase [EC:3.5.1.38] K05874 tsr; methyl-accepting chemotaxis protein I, serine sensor receptor K05875 tar; methyl-accepting chemotaxis protein II, aspartate sensor receptor K05876 trg; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor K05877 tap; methyl-accepting chemotaxis protein IV, peptide sensor receptor K05964 citX; holo-ACP synthase [EC:2.7.7.61] K05966 citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52] K06046 luxE; long-chain-fatty-acid---luciferin-component ligase [EC:6.2.1.19] K06080 rcsF; RcsF protein K06281 hyaB, hybC; hydrogenase large subunit [EC:1.12.99.6] K06282 hyaA, hybO; hydrogenase small subunit [EC:1.12.99.6] K06347 kapB; kinase-associated protein B K06375 spo0B; stage 0 sporulation protein B (sporulation initiation phosphotransferase) [EC:2.7.-.-] K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator) K06597 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase) K06598 chpC; chemosensory pili system protein ChpC K07165 fecR; transmembrane sensor K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] K07346 fimC; fimbrial chaperone protein K07347 fimD, fimC, mrkC, htrE, cssD; outer membrane usher protein K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3] K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3] K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3] K07642 baeS, smeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3] K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3] K07644 cusS, copS, silS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3] K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3] K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] K07650 cssS; two-component system, OmpR family, sensor histidine kinase CssS [EC:2.7.13.3] K07651 resE; two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3] K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] K07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3] K07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3] K07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3] K07656 trcS; two-component system, OmpR family, sensor histidine kinase TrcS [EC:2.7.13.3] K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB K07658 phoB1, phoP; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR K07660 phoP; two-component system, OmpR family, response regulator PhoP K07661 rstA; two-component system, OmpR family, response regulator RstA K07662 cpxR; two-component system, OmpR family, response regulator CpxR K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB K07664 baeR, smeR; two-component system, OmpR family, response regulator BaeR K07665 cusR, copR, silR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR K07666 qseB; two-component system, OmpR family, response regulator QseB K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE K07668 vicR; two-component system, OmpR family, response regulator VicR K07669 mprA; two-component system, OmpR family, response regulator MprA K07670 mtrA; two-component system, OmpR family, response regulator MtrA K07671 prrA; two-component system, OmpR family, response regulator PrrA K07672 trcR; two-component system, OmpR family, response regulator TrcR K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3] K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3] K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3] K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] K07678 barA, gacS, varS; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3] K07679 evgS, bvgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] K07680 comP; two-component system, NarL family, sensor histidine kinase ComP [EC:2.7.13.3] K07681 vraS; two-component system, NarL family, vancomycin resistance sensor histidine kinase VraS [EC:2.7.13.3] K07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3] K07683 nreB; two-component system, NarL family, sensor histidine kinase NreB [EC:2.7.13.3] K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ K07689 uvrY, gacA, varA; two-component system, NarL family, invasion response regulator UvrY K07690 evgA, bvgA; two-component system, NarL family, response regulator EvgA K07691 comA; two-component system, NarL family, competent response regulator ComA K07692 degU; two-component system, NarL family, response regulator DegU K07693 desR; two-component system, NarL family, response regulator DesR K07694 vraR; two-component system, NarL family, vancomycin resistance associated response regulator VraR K07695 devR; two-component system, NarL family, response regulator DevR K07696 nreC; two-component system, NarL family, response regulator NreC K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3] K07698 kinC; two-component system, sporulation sensor kinase C [EC:2.7.13.3] K07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A K07700 dpiB, citA; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3] K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3] K07702 dpiA, citB; two-component system, CitB family, response regulator CitB K07703 dcuR; two-component system, CitB family, response regulator DcuR K07704 lytS; two-component system, LytTR family, sensor histidine kinase LytS [EC:2.7.13.3] K07705 lytT, lytR; two-component system, LytTR family, response regulator LytT K07706 agrC, blpH, fsrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] K07707 agrA, blpR, fsrA; two-component system, LytTR family, response regulator AgrA K07708 glnL, ntrB; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] K07709 zraS, hydH; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3] K07710 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3] K07711 glrK, qseE; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3] K07712 glnG, ntrC; two-component system, NtrC family, nitrogen regulation response regulator GlnG K07713 zraR, hydG; two-component system, NtrC family, response regulator HydG K07714 atoC; two-component system, NtrC family, response regulator AtoC K07715 glrR, qseF; two-component system, NtrC family, response regulator GlrR K07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3] K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3] K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] K07719 glnL; two-component system, response regulator GlnL K07720 yesN; two-component system, response regulator YesN K07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3] K07769 nblS, dfr, dspA, hik33; two-component system, OmpR family, sensor histidine kinase NblS [EC:2.7.13.3] K07770 cssR; two-component system, OmpR family, response regulator CssR K07771 basR; two-component system, OmpR family, response regulator BasR K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA K07774 tctD; two-component system, OmpR family, response regulator TctD K07775 resD; two-component system, OmpR family, response regulator ResD K07776 regX3; two-component system, OmpR family, response regulator RegX3 K07777 degS; two-component system, NarL family, sensor histidine kinase DegS [EC:2.7.13.3] K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3] K07780 appY; AraC family transcriptional regulator, transcriptional regulator required for anaerobic and stationary phase induction of genes K07781 rcsA; LuxR family transcriptional regulator, capsular biosynthesis positive transcription factor K07782 sdiA; LuxR family transcriptional regulator, quorum-sensing system regulator SdiA K07783 uhpC; MFS transporter, OPA family, sugar phosphate sensor protein UhpC K07784 uhpT; MFS transporter, OPA family, hexose phosphate transport protein UhpT K07785 nrsD, nreB; MFS transporter, NRE family, putaive nickel resistance protein K07786 emrY; MFS transporter, DHA2 family, multidrug resistance protein K07787 cusA, silA; copper/silver efflux system protein K07788 mdtB; multidrug efflux pump K07789 mdtC; multidrug efflux pump K07790 pagO; putative membrane protein PagO K07792 dcuB; anaerobic C4-dicarboxylate transporter DcuB K07793 tctA; putative tricarboxylic transport membrane protein K07794 tctB; putative tricarboxylic transport membrane protein K07795 tctC; putative tricarboxylic transport membrane protein K07796 cusC, silC; outer membrane protein, copper/silver efflux system K07797 emrK; multidrug resistance protein K K07798 cusB, silB; membrane fusion protein, copper/silver efflux system K07799 mdtA; membrane fusion protein, multidrug efflux system K07800 agrD; AgrD protein K07801 pagK; PhoPQ-activated protein K07803 zraP; zinc resistance-associated protein K07804 pagC; putatice virulence related protein PagC K07805 pagD; putative membrane protein PagD K07806 arnB, pmrH; UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [EC:2.6.1.87] K07810 cusF; Cu(I)/Ag(I) efflux system periplasmic protein CusF K07811 torA; trimethylamine-N-oxide reductase (cytochrome c) [EC:1.7.2.3] K07813 agrB; accessory gene regulator B K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3] K08083 algR; two-component system, LytTR family, response regulator AlgR K08177 oxlT; MFS transporter, OFA family, oxalate/formate antiporter K08348 fdnG; formate dehydrogenase-N, alpha subunit [EC:1.17.5.3] K08349 fdnH; formate dehydrogenase-N, beta subunit K08350 fdnI; formate dehydrogenase-N, gamma subunit K08357 ttrA; tetrathionate reductase subunit A K08358 ttrB; tetrathionate reductase subunit B K08359 ttrC; tetrathionate reductase subunit C K08372 pepD; putative serine protease PepD [EC:3.4.21.-] K08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3] K08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA K08477 pgtE; outer membrane protease E [EC:3.4.21.-] K08478 pgtC; phosphoglycerate transport regulatory protein PgtC K08479 sasA; two-component system, OmpR family, clock-associated histidine kinase SasA [EC:2.7.13.3] K08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22] K08738 CYC; cytochrome c K08926 pufA; light-harvesting complex 1 alpha chain K08927 pufB; light-harvesting complex 1 beta chain K08928 pufL; photosynthetic reaction center L subunit K08929 pufM; photosynthetic reaction center M subunit K08930 pucA; light-harvesting protein B-800-850 alpha chain K08939 pucB; light-harvesting protein B-800-850 beta chain K09474 phoN; acid phosphatase (class A) [EC:3.1.3.2] K09475 ompC; outer membrane pore protein C K09476 ompF; outer membrane pore protein F K09477 citT; citrate:succinate antiporter K09696 natB; sodium transport system permease protein K09697 natA; sodium transport system ATP-binding protein [EC:7.2.2.4] K10001 gltI, aatJ; glutamate/aspartate transport system substrate-binding protein K10002 gltK, aatM; glutamate/aspartate transport system permease protein K10003 gltJ, aatQ; glutamate/aspartate transport system permease protein K10004 gltL, aatP; glutamate/aspartate transport system ATP-binding protein [EC:7.4.2.1] K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD K10255 FAD6, desA; acyl-lipid omega-6 desaturase (Delta-12 desaturase) [EC:1.14.19.23 1.14.19.45] K10681 saeS; two-component system, OmpR family, sensor histidine kinase SaeS [EC:2.7.13.3] K10682 saeR; two-component system, OmpR family, response regulator SaeR K10697 rpaA; two-component system, OmpR family, response regulator RpaA K10715 rpfC; two-component system, sensor histidine kinase RpfC [EC:2.7.13.3] K10850 narT; MFS transporter, NNP family, putative nitrate transporter K10851 nreA; nitrogen regulatory protein A K10909 luxQ; two-component system, autoinducer 2 sensor kinase/phosphatase LuxQ [EC:2.7.13.3 3.1.3.-] K10910 luxP; autoinducer 2-binding periplasmic protein LuxP K10911 luxU; two-component system, phosphorelay protein LuxU K10912 luxO; two-component system, repressor protein LuxO K10913 hapR, luxR, litR; TetR/AcrR family transcriptional regulator, hemagglutinin/protease regulatory protein K10914 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein K10916 cqsS; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-] K10941 flrA, fleQ, flaK; sigma-54 dependent transcriptional regulator, flagellar regulatory protein K10942 flrB, fleS, flaL; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3] K10943 flrC, fleR, flaM; two-component system, response regulator FlrC K11103 dctA; aerobic C4-dicarboxylate transport protein K11230 SSK2; mitogen-activated protein kinase kinase kinase [EC:2.7.11.25] K11231 SLN1; osomolarity two-component system, sensor histidine kinase SLN1 [EC:2.7.13.3] K11232 YPD1; osomolarity two-component system, phosphorelay intermediate protein YPD1 K11233 SSK1; osomolarity two-component system, response regulator SSK1 K11326 nrsA, czcA; cation efflux system protein involved in nickel and cobalt tolerance K11327 nrsB; membrane fusion protein, cation efflux system K11328 nrsS, rppB; two-component system, OmpR family, Ni(II)-sensor and/or redox sensor kinase NrsS [EC:2.7.13.3] K11329 rpaB; two-component system, OmpR family, response regulator RpaB K11330 nrsR, rppA; two-component system, OmpR family, Ni(II)-responsive and/or redox-responsive regulator NrsR K11331 nrsC; cation efflux system protein involved in nickel and cobalt tolerance [EC:3.2.1.17] K11332 nblR; two-component system, OmpR family, response regulator NblR K11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3] K11355 rcp1; two-component system, chemotaxis family, response regulator Rcp1 K11356 cikA; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] K11357 divJ; two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3] K11382 pgtP; MFS transporter, OPA family, phosphoglycerate transporter protein K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3] K11384 algB; two-component system, NtrC family, response regulator AlgB K11443 divK; two-component system, cell cycle response regulator DivK K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65] K11520 manS; two-component system, OmpR family, manganese sensing sensor histidine kinase [EC:2.7.13.3] K11521 manR; two-component system, OmpR family, manganese sensing response regulator K11522 pixG; two-component system, chemotaxis family, response regulator PixG K11523 pixH; two-component system, chemotaxis family, response regulator PixH K11524 pixI; positive phototaxis protein PixI K11525 pixJ; methyl-accepting chemotaxis protein PixJ K11526 pixL; two-component system, chemotaxis family, sensor histidine kinase and response regulator PixL K11601 mntC; manganese transport system substrate-binding protein K11602 mntB; manganese transport system permease protein K11603 mntA; manganese transport system ATP-binding protein [EC:7.2.2.5] K11614 yufL, malK; two-component system, CitB family, sensor histidine kinase MalK [EC:2.7.13.3] K11615 malR; two-component system, CitB family, response regulator MalR K11616 maeN; malate:Na+ symporter K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] K11618 liaR; two-component system, NarL family, response regulator LiaR K11619 liaI; lia operon protein LiaI K11620 liaH; lia operon protein LiaH K11621 liaG; lia operon protein LiaG K11622 liaF; lia operon protein LiaF K11623 ydfH; two-component system, NarL family, sensor histidine kinase YdfH [EC:2.7.13.3] K11624 ydfI; two-component system, NarL family, response regulator YdfI K11625 ydfJ; membrane protein YdfJ K11626 glnT; putative sodium/glutamine symporter K11629 bceS; two-component system, OmpR family, bacitracin resistance sensor histidine kinase BceS [EC:2.7.13.3] K11630 bceR; two-component system, OmpR family, bacitracin resistance response regulator BceR K11631 bceA, vraD; bacitracin transport system ATP-binding protein K11632 bceB, vraE; bacitracin transport system permease protein K11633 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3] K11634 yxdJ; two-component system, OmpR family, response regulator YxdJ K11635 yxdL; putative ABC transport system ATP-binding protein K11636 yxdM; putative ABC transport system permease protein K11637 citS; two-component system, CitB family, sensor histidine kinase CitS [EC:2.7.13.3] K11638 K11638, citT; two-component system, CitB family, response regulator CitT K11639 citM; Mg2+/citrate complex secondary transporter K11640 natK; two-component system, LytTR family, sensor histidine kinase NatK [EC:2.7.13.3] K11641 natR; two-component system, LytTR family, response regulator NatR K11688 dctP, yiaO; TRAP-type transport system periplasmic protein K11689 dctQ, yiaM; TRAP-type transport system small permease protein K11690 dctM, yiaN; TRAP-type transport system large permease protein K11691 K11691, dctS; two-component system, CitB family, sensor histidine kinase DctS [EC:2.7.13.3] K11692 K11692, dctR; two-component system, CitB family, response regulator DctR K11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3] K11712 dctR; two-component system, LuxR family, response regulator DctR K12292 comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-] K12293 comB; competence factor transport accessory protein ComB K12294 comD; two-component system, LytTR family, sensor histidine kinase ComD [EC:2.7.13.3] K12295 comE; two-component system, LytTR family, response regulator ComE K12296 comX1_2; competence protein ComX K12340 tolC, bepC, cyaE, raxC, sapF, rsaF, hasF; outer membrane protein K12415 comC; competence-stimulating peptide K12510 tadB; tight adherence protein B K12511 tadC; tight adherence protein C K12530 rtxB, fitA; ATP-binding cassette, subfamily B, bacterial RtxB K12531 rtxE, fitC; ATP-binding cassette, subfamily B, bacterial RtxE K12532 rtxD, fitB; membrane fusion protein, RTX toxin transport system K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3] K13041 ttrR; two-component system, LuxR family, response regulator TtrR K13061 rhlI, phzI, solI, cepI, tofI; acyl homoserine lactone synthase [EC:2.3.1.184] K13486 wspC; chemotaxis protein methyltransferase WspC K13487 wspA; methyl-accepting chemotaxis protein WspA K13488 wspB; chemotaxis-related protein WspB K13489 wspD; chemotaxis-related protein WspD K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61] K13532 kinD; two-component system, sporulation sensor kinase D [EC:2.7.13.3] K13533 kinE; two-component system, sporulation sensor kinase E [EC:2.7.13.3] K13584 ctrA; two-component system, cell cycle response regulator CtrA K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3] K13588 chpT; histidine phosphotransferase ChpT K13589 cpdR; two-component system, cell cycle response regulator CpdR K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3] K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX K13815 rpfG; two-component system, response regulator RpfG K13816 rpfF; DSF synthase K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] K13927 citXG; holo-ACP synthase / triphosphoribosyl-dephospho-CoA synthase [EC:2.7.7.61 2.4.2.52] K13991 puhA; photosynthetic reaction center H subunit K13994 pufX; photosynthetic reaction center PufX protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] K14205 mprF, fmtC; phosphatidylglycerol lysyltransferase [EC:2.3.2.3] K14978 ssrA; two-component system, LuxR family, secretion system sensor histidine kinase SsrA K14979 ssrB; two-component system, LuxR family, secretion system response regulator SsrB K14980 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3] K14981 chvI; two-component system, OmpR family, response regulator ChvI K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] K14983 ciaR; two-component system, OmpR family, response regulator CiaR K14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3] K14987 fixJ; two-component system, LuxR family, response regulator FixJ K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK K14989 salR; two-component system, NarL family, secretion system response regulator SalR K15011 regB, regS, actS; two-component system, sensor histidine kinase RegB [EC:2.7.13.3] K15012 regA, regR, actR; two-component system, response regulator RegA K15739 vanB, vanA, vanD; D-alanine---(R)-lactate ligase [EC:6.1.2.1] K15841 glmY; small regulatory RNA GlmY K15850 luxN; two-component system, autoinducer 1 sensor kinase/phosphatase LuxN [EC:2.7.13.3 3.1.3.-] K15851 qrr; quorum regulatory RNA Qrr K15853 luxD; acyl transferase [EC:2.3.1.-] K15854 luxB; alkanal monooxygenase beta chain [EC:1.14.14.3] K15859 SKN7; osomolarity two-component system, response regulator SKN7 K15860 ciaX; regulatory peptide CiaX K15861 fixK; CRP/FNR family transcriptional regulator, nitrogen fixation regulation protein K15862 ccoNO; cytochrome c oxidase cbb3-type subunit I/II [EC:7.1.1.9] K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] K16712 epsE; EPS I polysaccharide export inner membrane protein EpsE K16713 epsF; EPS I polysaccharide export inner membrane protein EpsF K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3] K17061 aauR; two-component system, response regulator AauR K18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3] K18073 parR; two-component system, OmpR family, response regulator ParR K18093 oprD; imipenem/basic amino acid-specific outer membrane pore [EC:3.4.21.-] K18094 mexX, amrA; membrane fusion protein, multidrug efflux system K18095 mexY, amrB; multidrug efflux pump K18321 smeA; membrane fusion protein, multidrug efflux system K18322 smeB; multidrug efflux pump K18323 smeC; outer membrane protein, multidrug efflux system K18324 acrD; multidrug efflux pump K18326 mdtD; MFS transporter, DHA2 family, multidrug resistance protein K18344 vanRB, vanR, vanRD; two-component system, OmpR family, response regulator VanR K18345 vanSB, vanS, vanSD; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3] K18346 vanW; vancomycin resistance protein VanW K18347 vanH; D-specific alpha-keto acid dehydrogenase [EC:1.1.1.-] K18348 vanT; serine/alanine racemase [EC:5.1.1.18 5.1.1.1] K18349 vanRC, vanRE, vanRG; two-component system, OmpR family, response regulator VanR K18350 vanSC, vanSE, vanSG; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3] K18351 vanSAc; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3] K18352 vanRAc; two-component system, OmpR family, response regulator VanR K18353 vanJ; vancomycin resistance protein VanJ K18354 vanK; vancomycin resistance protein VanK K18444 rrp1; two-component system, glycerol uptake and utilization response regulator K18856 vanC, vanE, vanG; D-alanine---D-serine ligase [EC:6.3.2.35] K18866 vanXY; zinc D-Ala-D-Ala dipeptidase/carboxypeptidase [EC:3.4.13.22 3.4.17.14] K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] K18941 arlR; two-component system, OmpR family, response regulator ArlR K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] K18987 irr; two-component system, OmpR family, response regulator Irr K19077 graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3] K19078 graR; two-component system, OmpR family, response regulator protein GraR K19079 vraF; cationic antimicrobial peptide transport system ATP-binding protein K19080 vraG; cationic antimicrobial peptide transport system permease protein K19081 braS, bceS; two-component system, OmpR family, sensor histidine kinase BraS/BceS [EC:2.7.13.3] K19082 braR, bceR; two-component system, OmpR family, response regulator protein BraR/BceR K19083 braD, bceA; bacitracin transport system ATP-binding protein K19084 braE, bceB; bacitracin transport system permease protein K19609 pfeS, pirS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3] K19610 pfeR, pirR; two-component system, OmpR family, response regulator PfeR K19611 fepA, pfeA, iroN, pirA; ferric enterobactin receptor K19615 fitD, mcf; insecticidal toxin K19616 fitF; two-component system, sensor histidine kinase and response regulator FitF [EC:2.7.13.3] K19617 fitH; two-component system, response regulator FitH K19618 fitG; LysR family transcriptional regulator, activator of insecticidal toxin K19620 phcB; extracellular factor (EF) 3-hydroxypalmitic acid methyl ester biosynthesis protein K19621 phcS; two-component system, sensor histidine kinase PhcS [EC:2.7.13.3] K19622 phcR; two-component system, response regulator PhcR K19624 phcA; LysR family transcriptional regulator, virulence genes transcriptional regulator K19641 hupR, hoxA; two-component system, NtrC family, response regulator HupR/HoxA K19661 hupT, hoxJ; two-component system, NtrC family, sensor histidine kinase HupT/HoxJ [EC:2.7.13.3] K19666 solR, cepR, tofR; LuxR family transcriptional regulator, quorum-sensing system regulator SolR K19667 xpsR; transcriptional activator of eps genes K19668 CBH2, cbhA; cellulose 1,4-beta-cellobiosidase [EC:3.2.1.91] K19690 CHK1; osomolarity two-component system, sensor histidine kinase CHK1 [EC:2.7.13.3] K19691 NIK1, TCSC; osomolarity two-component system, sensor histidine kinase NIK1 [EC:2.7.13.3] K19692 TCSA; osomolarity two-component system, sensor histidine kinase TcsA [EC:2.7.13.3] K20263 fusK; two-component system, NarL family, sensor histidine kinase FusK [EC:2.7.13.3] K20264 fusR; two-component system, NarL family, response regulator FusR K20339 agrC2; two-component system, LytTR family, sensor histidine kinase AgrC2 [EC:2.7.13.3] K20340 agrA2; two-component system, LytTR family, response regulator AgrA2 K20482 nisA, spaS, epiA; lantibiotic bacteriocin K20483 lanB, nisB, spaB, epiB; class I lanthipeptide synthase [EC:3.13.2.4] K20484 lanC, nisC, spaC, epiC; class I lanthipeptide synthase [EC:3.13.2.4] K20485 nisT, spaT; ATP-binding cassette, subfamily B, bacterial NisT/SpaT K20486 nisP, epiP; lantibiotic leader peptide-processing serine protease [EC:3.4.21.-] K20487 nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3] K20488 nisR, spaR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR K20489 nisI; lantibiotic immunity protein K20490 nisF, spaF, cprA, epiF; lantibiotic transport system ATP-binding protein K20491 nisE, spaE, cprB, epiE; lantibiotic transport system permease protein K20492 nisG, spaG, cprC; lantibiotic transport system permease protein K20494 epiG; lantibiotic transport system permease protein K20552 ler; transcriptional regulator of LEE operons K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3] K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3] K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3] K20976 hptB; histidine phosphotransfer protein HptB K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator K20978 hsbA; HptB-dependent secretion and biofilm anti anti-sigma factor K21393 dctQM, siaT; TRAP-type transport system permease protein K22501 appX; cytochrome bd-II ubiquinol oxidase subunit AppX [EC:7.1.1.7] K23236 safA; two-component-system connector protein SafA K23514 fecI, prhI; RNA polymerase sigma-19 factor, ECF subfamily K23548 hupU; uptake hydrogenase small subunit K23549 hupV; uptake hydrogenase large subunit K23676 btsT; pyruvate/proton symporter K25211 hptA; hexose phosphate transport regulatory protein HptA K25212 hptS; two-component system, sensor histidine kinase HptS K25213 hptR; two-component system, response regulator HptR K25307 wzb, etp; low molecular weight protein-tyrosine phosphatase K25864 mzrA; modulator protein MzrA K27076 pprA; two-component system, NarL family, sensor histidine kinase PprA K27077 pprB; two-component system, NarL family, response regulator PprB K27078 cupE; spore coat protein U domain-containing protein, fimbrial subunit CupE1/2/3/6 K27079 tadD; tight adherence protein D K27080 tadG; tight adherence protein G K27105 dosT; two-component system, NarL family, sensor histidine kinase DosT K27882 btsS; two-component system, LytTR family, low-concentration pyruvate sensor kinase K27883 btsR; two-component system, LytTR family, low-concentration pyruvate response regulator K27884 pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase K27885 pyrR; two-component system, LytTR family, high-concentration pyruvate response regulator COMPOUND C00007 Oxygen C00009 Orthophosphate C00022 Pyruvate C00025 L-Glutamate C00031 D-Glucose C00034 Manganese C00036 Oxaloacetate C00038 Zinc cation C00042 Succinate C00049 L-Aspartate C00064 L-Glutamine C00070 Copper C00088 Nitrite C00092 D-Glucose 6-phosphate C00122 Fumarate C00149 (S)-Malate C00158 Citrate C00164 Acetoacetate C00237 CO C00238 Potassium cation C00244 Nitrate C00282 Hydrogen C00291 Nickel C00305 Magnesium cation C00399 Ubiquinone C00533 Nitric oxide C00547 L-Noradrenaline C00697 Nitrogen C00788 L-Adrenaline C00828 Menaquinone C01019 L-Fucose C01104 Trimethylamine N-oxide C01667 Bacitracin C02084 Tetrathionate C05757 (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein] C05818 2-Demethylmenaquinone C06230 Fe-enterobactin C06689 Vancomycin C06696 Lead C11612 Polymyxin B C11842 N-(3-(S)-Hydroxybutyryl)homoserine lactone C11849 3-Hydroxy-palmitic acid methyl ester C12008 Ramoplanin A2 C13768 Colistin sulfate C14819 Fe3+ C16421 AI-2 C16463 3',5'-Cyclic diGMP C16640 CAI-1 C16665 12-Methyltetradecanoic acid C18206 cis-11-Methyl-2-dodecenoic acid C21220 AIP-1 C21221 CSP C21241 AIP-2 C21242 AIP-3 C21243 AIP-4 C21245 AgrD1 peptide D07746 Colistin (INN) D08401 Polymyxin B (INN) REFERENCE PMID:15522865 AUTHORS Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A. 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JOURNAL Microbiology 142 ( Pt 8):2041-7 (1996) DOI:10.1099/13500872-142-8-2041 REL_PATHWAY ko00190 Oxidative phosphorylation ko00195 Photosynthesis ko00550 Peptidoglycan biosynthesis ko00910 Nitrogen metabolism ko02030 Bacterial chemotaxis ko02040 Flagellar assembly ko03070 Bacterial secretion system ko04011 MAPK signaling pathway - yeast ko04112 Cell cycle - Caulobacter ///