ENTRY       ko01210                     Pathway
NAME        2-Oxocarboxylic acid metabolism
DESCRIPTION 2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
PATHWAY_MAP ko01210  2-Oxocarboxylic acid metabolism
MODULE      M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:ko01210]
            M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:ko01210]
            M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ko01210]
            M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:ko01210]
            M00031  Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine [PATH:ko01210]
            M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:ko01210]
            M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:ko01210]
            M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:ko01210]
            M00370  Glucosinolate biosynthesis, tryptophan => glucobrassicin [PATH:ko01210]
            M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ko01210]
            M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate [PATH:ko01210]
            M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:ko01210]
            M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate [PATH:ko01210]
            M00763  Ornithine biosynthesis, mediated by LysW, glutamate => ornithine [PATH:ko01210]
REL_PATHWAY ko00020  Citrate cycle (TCA cycle)
            ko00220  Arginine biosynthesis
            ko00250  Alanine, aspartate and glutamate metabolism
            ko00260  Glycine, serine and threonine metabolism
            ko00270  Cysteine and methionine metabolism
            ko00290  Valine, leucine and isoleucine biosynthesis
            ko00300  Lysine biosynthesis
            ko00310  Lysine degradation
            ko00620  Pyruvate metabolism
            ko00640  Propanoate metabolism
            ko00680  Methane metabolism
            ko00966  Glucosinolate biosynthesis
///