ENTRY ko01055 Pathway NAME Biosynthesis of vancomycin group antibiotics CLASS Metabolism; Metabolism of terpenoids and polyketides PATHWAY_MAP ko01055 Biosynthesis of vancomycin group antibiotics ORTHOLOGY K16421 4-hydroxymandelate synthase [EC:1.13.11.46] K16422 4-hydroxymandelate oxidase [EC:1.1.3.46] K16423 (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] K16424 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246] K16425 isomerase DpgB K16426 dehydration protein DpgD K16427 (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] K16428 nonribosomal peptide synthetase CepA K16429 nonribosomal peptide synthetase CepB K16430 nonribosomal peptide synthetase CepC K16431 FAD-dependent halogenase [EC:1.14.19.-] K16432 nonribosomal peptide synthetase CepK K16433 hydroxylation protein CepL K16434 thioesterase CepJ K01710 dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] K16435 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase [EC:4.2.1.159] K16436 dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase [EC:2.6.1.- 2.6.1.106] K16437 methylation protein EvaC K16438 5-epimerase [EC:5.1.3.-] K16439 reductase EvaE K18836 reductase VcaE K16440 chloroorienticin B synthase [EC:2.4.1.311] K16442 glycosyltransferase GtfC K16443 desvancosaminyl-vancomycin vancosaminetransferase [EC:2.4.1.322] K16444 vancomycin aglycone glucosyltransferase [EC:2.4.1.310] K16445 oxidation protein CepE K16446 oxidation protein CepF K16447 oxidation protein CepG K16448 methylation protein MtfA COMPOUND C00082 L-Tyrosine C00083 Malonyl-CoA C00842 dTDP-glucose C01179 3-(4-Hydroxyphenyl)pyruvate C03198 (S)-4-Hydroxymandelate C03590 4-Hydroxyphenylglyoxylate C06620 dTDP-3,4-dioxo-2,6-dideoxy-D-glucose C06689 Vancomycin C11907 dTDP-4-oxo-6-deoxy-D-glucose C12014 Chloroeremomycin C12026 3,5-Dihydroxy-phenylglycine C12318 dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose C12319 dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose C12320 dTDP-L-4-oxovancosamine C12321 dTDP-L-epivancosamine C12322 dTDP-L-vancosamine C12323 L-4-Hydroxyphenylglycine C12324 3,5-Dihydroxyphenylacetyl-CoA C12325 3,5-Dihydroxyphenylglyoxylate REFERENCE PMID:24884615 AUTHORS Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W TITLE Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis. JOURNAL BMC Genomics 15:363 (2014) DOI:10.1186/1471-2164-15-363 REFERENCE PMID:12596194 AUTHORS Hubbard BK, Walsh CT. TITLE Vancomycin assembly: nature's way. JOURNAL Angew Chem Int Ed Engl 42:730-65 (2003) DOI:10.1002/anie.200390202 REFERENCE PMID:11035791 AUTHORS Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD. TITLE Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis. JOURNAL Proc Natl Acad Sci U S A 97:11942-7 (2000) DOI:10.1073/pnas.210395097 REFERENCE PMID:9545426 AUTHORS van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ. TITLE Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic. JOURNAL Chem Biol 5:155-62 (1998) DOI:10.1016/S1074-5521(98)90060-6 REL_PATHWAY ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis ko00520 Amino sugar and nucleotide sugar metabolism ko00620 Pyruvate metabolism ///